Data Supplement
- Supplemental Data -
Supplementary Figure 1 - Fitted metformin concentration-time profiles for maternal artery (solid line in A), fetal vein (dashed line in A) and tissue (solid line in B) in a closed perfusion system (Nanovskaya et al., 2006).
Supplementary Figure 2 - Simulated metformin concentration-time profiles for maternal artery (solid line) and fetal vein (dashed line) in a closed perfusion system (Kovo et al., 2008).
Supplementary Figure 3 - Simulated metformin TPT%-time profiles for the MF direction (solid line in A) and the FM direction (solid line in B) in an open perfusion system (Tertti et al., 2010).
Supplementary Text
Supplementary Table 1 - Parameters for calculation of passive permeability in the placental cotyledon for metformin.
Supplementary Table 2 - Parameters of experimental settings in the human placental perfusion study (Kovo et al., 2008) for the simulation in a closed system.
Supplementary Table 3 - Parameters of experimental settings in the human placental perfusion study (Tertti et al., 2010) for the simulation in an open system.
Supplementary Table 4 - Clinical PK study information of metformin at delivery used in the present study.
Supplementary References