Data Supplement
- Supplemental Data -
Supplemental Figure 1 - Metabolism of testosterone (probe substrate) in HLM, MLM and human hepatocytes.
Supplemental Figure 2 - Epoxide hydrolysis of cis-SO and trans-SO in HLM & MLM, human & monkey cytosol and recombinant mEH & sEHs.
Supplemental Figure 3 - Inhibition of epoxide hydrolysis of cis-SO in HLMs, MLM, and recombinant human mEH by NSPA.
Supplemental Figure 4 - Metabolism of cis-SO, trans-SO and testosterone in monkey hepatocytes.
Supplemental Table 1 - Effect of Selective CYP Inhibitors on the Clearance of KZR-616 by HLM.