Supplemental Data
- Data Supplement -
Methods
Supplemental Table 1 - Modulated Activity Model individual tissue parameter estimates.
Supplemental Figure 1 - Time course of carbazeran depletion and 4-oxo-carbazeran formation in liver S9 fraction after incubation with 1 μM carbazeran (A).
Supplemental Figure 2 - Time course of 4-oxo-carbazeran formation after incubation with 1 μM (blue), 3 μM (red), 10 μM (yellow), 30 μM (purple) carbazeran in liver (A), kidney (B), lung (C), and iliac arterial vasculature (D) S9 fractions.
Supplemental Figure 3 - Time course of 2-oxo-zoniporide formation in kidney (A), lung (B), vasculature (C), and intestinal (D) S9 fractions (1 mg/mL) after incubation with 1 μM (), 3 μM (), 10 μM (), and 30 μM () zoniporide.