Data Supplement
- Supplemental Data -
Supplementary Table 1 - Drug-specific input parameters used for model development.
Supplementary Table 2 - Characteristics of clinical data used for model development in healthy adults.
Supplementary Table 3 - Characteristics of clinical data used for model development in adult and children with asthma
Supplementary Table 4 - The observed/predicted ratio (Robs/Pre), average fold error (AFE) and root mean square error (RMSE) values for pharmacokinetic parameters in adults and children after intravenous and oral theophylline application.
Supplementary Figure 1 - Workflow diagram for developing physiologically based pharmacokinetic (PBPK) model in healthy and asthma (adult and pediatric) population.
Supplementary Figure 2 - Goodness-of –fit plots for model prediction in adult population.
Supplementary Figure 3 - Goodness-of –fit plots for model prediction in pediatric population.
Supplementary References