Data Supplement
- Supplemental Data -
Methods
References
Supplemental Figure 1 - Prediction of intestinal water profile in the stomach and small intestine after a water intake of 240 mL.
Supplemental Figure 2 - Simulated movements of 99mTc-DTPA in the gastrointestinal tract by ATOM with fixed dispersion number.Supplemental Figure 3 - Simulated movements of 99mTc-DTPA in the gastrointestinal tract using CAT model with the reported transit times to the observed distribution.
Supplemental Fig - 4 Definitions of apical and basolateral permeability.
Supplemental Figure 5 - Effect of fent on the midazolam accumulation into the portal vein in linear conditions.
Supplemental Figure 6 - Plasma concentration of itraconazole (A) and clarithromycin (B) in DI simulations.
Supplemental Table 1 - Optimized parameters for intestinal water movement in ATOM.
Supplemental Table 2 - Optimized parameters for transit rate from stomach to intestine, dispersion constants and intestinal flow rates using 99mTc-DTPA distribution in the lumen in ATOM.Supplemental Table 3 - Reported and optimized transit times in CAT using 99mTc-DTPA distribution in the lumen in both fasted and fed state.
Supplemental Table 4 - Pharmacokinetic parameters of compounds.
Supplemental Table 5 - Physiological parameters used in ATOM and CAT.
Supplemental Table 6 - Dataset for FG prediction about CYP3A or P-gp/CYP3A substrates and predicted or reported FG values.
Supplemental Table 7 - Predictive performance of FG values using ATOM and TLM compared with reported FG values.
Supplemental Table 8 - Summary of AUCR ratio and FG or FA changes of digoxin and midazolam during DIs.