Data Supplement
- Supplemental Tables -
Supplemental Table 1: The first data column in Supplemental Tables 1A-E summarizes quality control data for LogD, kinetic solubility, metabolic stability in HLM and permeability in Caco-2 cells.
Supplemental Table 2: Measured total CLint in HLM for a set of reference compounds and the predicted CLint using the global AP model for unbound CLint...
Supplemental Table 3: Measured Caco-2 Papp and predicted Papp from the in-house model for a set of reference compounds. Data is the mean of at least three independent experiments.
Supplemental Table 4: Analysis of variance for log transformed data shown in Supplemental Tables 2 and 3.