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Last updated May 7, 2008
Papers published online before print
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7 May 2008
Cheng Fang, Jun Gu, Fang Xie, Melissa Behr, Weizhu Yang, Evan Dale Abel, and Xinxin Ding
Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated cardiac toxicity
Published May 7, 2008; doi: 10.1124/dmd.108.021881
[Abstract]
[PDF]
Robin E. Pearce, Wei Lu, YongQiang Wang, Jack P. Uetrecht, Maria Almira Correia, and J. Steven Leeder
Pathways of Carbamazepine Bioactivation
In Vitro
III: The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine
Published May 7, 2008; doi: 10.1124/dmd.107.019562
[Abstract]
[PDF]
[Data Supplement]
Wei Lu and Jack P Uetrecht
Peroxidase-Mediated Bioactivation of Hydroxylated Metabolites of Carbamazepine and Phenytoin
Published May 7, 2008; doi: 10.1124/dmd.107.019554
[Abstract]
[PDF]
5 May 2008
Elin Sjodin, Holger Fritsch, Ulf Eriksson, Ulrika Logren, Anders Nordgren, Patrik Forsell, Lars Knutson, and Hans Lennernas
Intestinal and hepatobiliary transport of ximelagatran and its metabolites in pigs
Published May 5, 2008; doi: 10.1124/dmd.108.020412
[Abstract]
[PDF]
William R Proctor, David L Bourdet, and Dhiren R Thakker
Mechanisms Underlying Saturable Intestinal Absorption of Metformin
Published May 5, 2008; doi: 10.1124/dmd.107.020180
[Abstract]
[PDF]
30 April 2008
Masakatsu Kotsuma, Taro Tokui, Stefan Freudenthaler, and Kenji Nishimura
Effects of ketoconazole and quinidine on pharmacokinetics of pactimibe and its plasma metabolite, R-125528, in human
Published April 30, 2008; doi: 10.1124/dmd.108.021394
[Abstract]
[PDF]
Divesh Aidasani, Matthew J. Zaya, Phyllis B. Malpas, and Charles W. Locuson
In vitro drug-drug interaction screens for canine veterinary medicines: Evaluation of cytochrome P450 reversible inhibition
Published April 30, 2008; doi: 10.1124/dmd.108.021196
[Abstract]
[PDF]
Markus Zollinger, Claudia Sayer, Robert Dannecker, Walter Schuler, and Richard Sedrani
The Macrolide Everolimus Forms an Unusual Metabolite in Animals and Humans: Identification of a Phosphocholine Ester
Published April 30, 2008; doi: 10.1124/dmd.108.020651
[Abstract]
[PDF]
28 April 2008
Kaori Hosoda, Takashi Furuta, Akitomo Yokokawa, Kenichiro Ogura, Akira Hiratsuka, and Kazuo Ishii
Plasma profiling of intact isoflavone metabolites by HPLC and mass spectrometric identification of flavone glycosides, daidzin and genistin in human plasma after administration of
kinako
Published April 28, 2008; doi: 10.1124/dmd.108.021006
[Abstract]
[PDF]
Nagdeep Giri, Guoyu Pan, Naveed Shaik, Tetsuya Terasaki, Chisato Mukai, Shinji Kitagaki, Naoki Miyakoshi, and William F. Elmquist
Investigation of the Role of Abcg2/Bcrp1 on Pharmacokinetics and CNS Penetration of Abacavir (ABC) and Zidovudine (AZT) in the Mouse
Published April 28, 2008; doi: 10.1124/dmd.108.020974
[Abstract]
[PDF]
Yijing He, Wei Zhang, Jianghua Tu, Julia Kirchheiner, Yao Chen, Dong Guo, Qin Li, Zhongyu Li, Hao Chen, Dongli Hu, Dan Wang, and Honghao Zhou
HNF1
INHIBITOR URSODEOXYCHOLIC ACID (UDCA) INFLUENCES PHARMACOKINETICS OF the OATP1B1 SUBSTRATE ROSUVASTATIN AND BILIRUBIN
Published April 28, 2008; doi: 10.1124/dmd.108.020503
[Abstract]
[PDF]
Tsuyoshi Minematsu, Tadashi Hashimoto, Toshiko Aoki, Takashi Usui, and Hidetaka Kamimura
ROLE OF ORGANIC ANION TRANSPORTERS IN THE PHARMACOKINETICS OF ZONAMPANEL, AN
-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONATE RECEPTOR ANTAGONIST, IN RATS
Published April 28, 2008; doi: 10.1124/dmd.107.019828
[Abstract]
[PDF]
24 April 2008
Lana X. Garmire and C. Anthony Hunt
In Silico Methods for Unraveling the Mechanistic Complexities of Intestinal Absorption: Metabolism–Efflux Transport Interactions
Published April 24, 2008; doi: 10.1124/dmd.107.020164
[Abstract]
[PDF]
Naoko Yoshida, Tappei Takada, Yoshikazu Yamamura, Isao Adachi, Hiroshi Suzuki, and Junichi Kawakami
Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport
Published April 24, 2008; doi: 10.1124/dmd.107.019513
[Abstract]
[PDF]
21 April 2008
Alison Parker and J Brian Houston
Rate limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir and ritonavir
Published April 21, 2008; doi: 10.1124/dmd.108.020917
[Abstract]
[PDF]
Ronald S Obach, Franco Lombardo, and Nigel J Waters
TREND ANALYSIS OF A DATABASE OF INTRAVENOUS PHARMACOKINETIC PARAMETERS IN HUMANS FOR 670 DRUG COMPOUNDS
Published April 21, 2008; doi: 10.1124/dmd.108.020479
[Abstract]
[PDF]
[Data Supplement]
Stuart W Paine, Alison J Parker, Philip Gardiner, Peter J H Webborn, and Robert J Riley
Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes
Published April 21, 2008; doi: 10.1124/dmd.107.019455
[Abstract]
[PDF]
[Data Supplement]
17 April 2008
Jamie Henshall, Aleksandra Galetin, Anthony Harrison, and J. Brian Houston
Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications
Published April 17, 2008; doi: 10.1124/dmd.108.021279
[Abstract]
[PDF]
Lesley A McLaughlin, Leslie J Dickmann, C Roland Wolf, and Colin James Henderson
Functional expression and comparative characterisation of nine murine cytochrome P450s by fluorescent inhibition screening
Published April 17, 2008; doi: 10.1124/dmd.108.021261
[Abstract]
[PDF]
[Data Supplement]
Melinda J Reese, Robert M Wurm, Keith Muir, Grant Generaux, Lisa St. John-Williams, and Donavon McConn
An in Vitro Mechanistic Study to Elucidate the Desipramine / Bupropion Clinical Drug-Drug Interaction
Published April 17, 2008; doi: 10.1124/dmd.107.020198
[Abstract]
[PDF]
John W. Nichols, Alex D. Hoffman, Patrick N. Fitzsimmons, Gregory J. Lien, and Correne T. Jenson
Use of on-line microdialysis sampling to determine the
in vivo rate
of phenol glucuronidation in rainbow trout
Published April 17, 2008; doi: 10.1124/dmd.107.020123
[Abstract]
[PDF]
Zhi-wei Ye, Patrick Augustijns, and Pieter Annaert
Cellular accumulation of cholyl-glycylamido-fluorescein in sandwich-cultured rat hepatocytes: kinetic characterization, transport mechanisms and effect of HIV protease inhibitors
Published April 17, 2008; doi: 10.1124/dmd.107.019398
[Abstract]
[PDF]
Lisa J. Christopher, Donghui Cui, Chiyuan Wu, Roger Luo, James A. Manning, Samuel J. Bonacorsi, Michael Lago, Alban Allentoff, Francis Y. F. Lee, Betty McCann, Susan Galbriath, Donald P Reitberg, Kan He, Anthony Barros Jr., Anne Blackwood Chirchir, W Griffith Humphreys, and Ramaswamy Iyer
METABOLISM AND DISPOSITION OF DASATINIB AFTER ORAL ADMINISTRATION TO HUMANS
Published April 17, 2008; doi: 10.1124/dmd.107.018267
[Abstract]
[PDF]
Lisa J. Christopher, Donghui Cui, Wenying Li, Anthony Barros Jr., Vinod K. Arora, Haiying Zhang, Lifei Wang, Donglu Zhang, James A Manning, Kan He, Anthony M. Fletcher, Marc Ogan, Michael Lago, Samuel J. Bonacorsi, W. Griffith Humphreys, and Ramaswamy Iyer
BIOTRANSFORMATION OF [
14
C]DASATINIB: IN VITRO STUDIES IN RAT, MONKEY AND HUMAN AND DISPOSITION AFTER ADMINISTRATION TO RATS AND MONKEYS
Published April 17, 2008; doi: 10.1124/dmd.107.018234
[Abstract]
[PDF]
14 April 2008
Tao Zhang, Cathie D Xiang, David Gale, Samantha Carreiro, Ellen Y Wu, and Eric Y Zhang
Drug Transporter and CYP P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition
Published April 14, 2008; doi: 10.1124/dmd.108.021121
[Abstract]
[PDF]
Furong Qiu, Rong Zhang, JianGuo Sun, JiYe A, HaiPing Hao, Ying Peng, Hua Ai, and Guangji Wang
Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzymes in human liver microsomes
Published April 14, 2008; doi: 10.1124/dmd.108.021030
[Abstract]
[PDF]
Peter J. Kilford, Michael Gertz, J. Brian Houston, and Aleksandra Galetin
Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data
Published April 14, 2008; doi: 10.1124/dmd.108.020834
[Abstract]
[PDF]
Ping Kang, Deepak Dalvie, Evan Smith, and Sue Zhou
Bioactivation of Flutamide Metabolites by Human Liver Microsomes
Published April 14, 2008; doi: 10.1124/dmd.108.020370
[Abstract]
[PDF]
[Data Supplement]
Peter H Bui, Arnulfo Quesada, Adrian Handforth, and Oliver Hankinson
The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil
Published April 14, 2008; doi: 10.1124/dmd.107.020115
[Abstract]
[PDF]
3 April 2008
Hajime Fukuda, Rikiya Ohashi, Minoru Tsuda-Tsukimoto, and Ikumi Tamai
Effect of plasma protein binding on in vitro-in vivo correlation of biliary excretion of drugs evaluated by sandwich-cultured rat hepatocytes
Published April 3, 2008; doi: 10.1124/dmd.107.019026
[Abstract]
[PDF]
2 April 2008
Kajsa P. Kanebratt and Tommy B. Andersson
Evaluation of HepaRG Cells as an
In Vitro
Model for Human Drug Metabolism Studies
Published April 2, 2008; doi: 10.1124/dmd.107.020016
[Abstract]
[PDF]
[Data Supplement]
Wenxia Zhang and Lee-Yong Lim
EFFECTS OF SPICE CONSTITUENTS ON P-GP-MEDIATED TRANSPORT AND CYP3A4-MEDIATED METABOLISM IN VITRO
Published April 2, 2008; doi: 10.1124/dmd.107.019737
[Abstract]
[PDF]
1 April 2008
Shinji Yamazaki, Judith Skaptason, David Romero, Joseph H Lee, Helen Y Zou, James G Christensen, Jeffrey R Koup, Bill J. Smith, and Tatiana Koudriakova
Pharmacokinetic-Pharmacodynamic Modeling of Biomarker Response and Tumor Growth Inhibition to an Orally Available c-Met Kinase Inhibitor in Human Tumor Xenograft Mouse Models
Published April 1, 2008; doi: 10.1124/dmd.107.019711
[Abstract]
[PDF]
Chuang Lu, Cicely Berg, Shimoga R Prakash, Frank W Lee, and Suresh K Balani
PREDICTION OF PHARMACOKINETIC DRUG-DRUG INTERACTIONS USING HUMAN HEPATOCYTE SUSPENSION IN PLASMA - PART III. IN VITRO-IN VIVO CORRELATION WITH FLUCONAZOLE
Published April 1, 2008; doi: 10.1124/dmd.107.019000
[Abstract]
[PDF]
Chuang Lu, Panos Hatsis, Cicely Berg, Frank W Lee, and Shresh K Balani
PREDICTION OF PHARMACOKINETIC DRUG-DRUG INTERACTIONS USING HUMAN HEPATOCYTE SUSPENSION IN PLASMA AND CYP PHENOTYPIC DATA - PART II. IN VITRO-IN VIVO CORRELATION WITH KETOCONAZOLE
Published April 1, 2008; doi: 10.1124/dmd.107.018796
[Abstract]
[PDF]
31 March 2008
Caroline MacLean, Ursula Moenning, Andreas Reichel, and Gert Fricker
Closing the gaps - A full-scan of the intestinal expression of Pgp, Bcrp and Mrp2 in male and female rats
Published March 31, 2008; doi: 10.1124/dmd.108.020859
[Abstract]
[PDF]
Vikas Kumar, Richard C. Brundage, William S. Oetting, Ilo E. Leppik, and Timothy S. Tracy
Differential Genotype Dependent Inhibition of CYP2C9 in Humans
Published March 31, 2008; doi: 10.1124/dmd.108.020396
[Abstract]
[PDF]
Choong Yeol Ahn, Soo Kyung Bae, Young Seok Jung, Inchul Lee, Young Chul Kim, Myung Gull Lee, and Wan Gyoon Shin
Pharmacokinetic Parameters of Chlorzoxazone and its Main Metabolite, 6-Hydroxychlorzoxazone, after Intravenous and Oral Administration of Chlorzoxazone to Liver Cirrhotic Rats with Diabetes Mellitus
Published March 31, 2008; doi: 10.1124/dmd.107.017442
[Abstract]
[PDF]
27 March 2008
Chandra Prakash, Kim A Johnson, and Mark J Gardner
DISPOSITION OF LASOFOXIFENE, A NEXT GENERATION SELECTIVE ESTROGEN RECEPTOR MODULATOR, IN HEALTHY MALE SUBJECTS
Published March 27, 2008; doi: 10.1124/dmd.108.020404
[Abstract]
[PDF]
Eric T. Williams, Karen O. Jones, G. Douglas Ponsler, Shane M. Lowery, Everett J. Perkins, Steven A. Wrighton, Kenneth J. Ruterbories, Miho Kazui, and Nagy A Farid
The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2
Published March 27, 2008; doi: 10.1124/dmd.107.020248
[Abstract]
[PDF]
Gabriela Rodriguez-Fuentes, Rosaura Aparicio-Fabre, Li Qi, and Daniel Schlenk
Osmotic regulation of a novel flavin-containing monooxygenase in primary cultured cells from rainbow trout (Oncorhynchus mykiss)
Published March 27, 2008; doi: 10.1124/dmd.107.019968
[Abstract]
[PDF]
24 March 2008
Andrew Rowland, Kathleen M Knights, Peter I Mackenzie, and John O Miners
The 'albumin effect' and drug glucuronidation: Bovine serum albumin and fatty acid free serum albumin enhance the glucuronidation of UGT1A9 substrates but not UGT1A1 and UGT1A6 activities
Published March 24, 2008; doi: 10.1124/dmd.108.021105
[Abstract]
[PDF]
Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue, and Hajime Mizukami
Down-regulation of a hepatic transporter Mrp2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury
Published March 24, 2008; doi: 10.1124/dmd.108.021089
[Abstract]
[PDF]
Yukio Yamamoto and Masahiko Negishi
The Anti-Apoptotic Factor GADD45B Regulates the Nuclear Receptor CAR-Mediated Transcription
Published March 24, 2008; doi: 10.1124/dmd.108.020628
[Abstract]
[PDF]
Souzan B. Yanni, Pieter P. Annaert, Patrick Augustijns, Arlene Bridges, Yan Gao, Daniel K. Benjamin, and Dhiren R. Thakker
Role of Flavin-containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes
Published March 24, 2008; doi: 10.1124/dmd.107.019646
[Abstract]
[PDF]
20 March 2008
Dermot F McGinnity, Nigel J Waters, James Tucker, and Rob J. Riley
Integrated in vitro analysis for the in vivo prediction of cytochrome P450 mediated drug-drug interactions
Published March 20, 2008; doi: 10.1124/dmd.108.020446
[Abstract]
[PDF]
Lanyan Fang and Duxin Sun
Predictive Physiologically-Based Pharmacokinetic (PBPK) Model for Antibody-Directed Enzyme Prodrug Therapy (ADEPT)
Published March 20, 2008; doi: 10.1124/dmd.107.019182
[Abstract]
[PDF]
Vijaya M. Lakshmi, Fong Fu Hsu, and Terry V. Zenser
N-Demethylation is a major route of 2-amino-3-methylimidazo[4,5-f]quinoline metabolism in mouse
Published March 20, 2008; doi: 10.1124/dmd.107.019166
[Abstract]
[PDF]
Phillip Krueger, Rambod Daneshfar, Gunter P. Eckert, Jochen Klein, Dietrich A. Volmer, Ute Bahr, Walter E. Mueller, Michael Karas, Manfred Schubert-Zsilavecz, and Mona Abdel-Tawab
Metabolism of boswellic acids in vitro and in vivo
Published March 20, 2008; doi: 10.1124/dmd.107.018424
[Abstract]
[PDF]
17 March 2008
Rozenn Josse, Caroline Aninat, Denise Glaise, Julie Dumont, Valerie Fessard, Fabrice Morel, Jean-Michel Poul, Christiane Guguen-Guillouzo, and Andre Guillouzo
Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies
Published March 17, 2008; doi: 10.1124/dmd.107.019901
[Abstract]
[PDF]
Stefan Harmsen, Andries Koster, J.H. Beijnen, J.H.M. Schellens, and Irma Meijerman
COMPARISON OF TWO IMMORTALIZED HUMAN CELL LINES TO STUDY NUCLEAR RECEPTOR MEDIATED CYP3A4 INDUCTION
Published March 17, 2008; doi: 10.1124/dmd.107.017335
[Abstract]
[PDF]
C. Edwin Garner, Eric Solon, Chii-Ming Lai, Jianrong Lin, Gang Luo, Kevin Jones, Liang-Shang Gan, MingXin Qian, Shimoga R Prakash, Carl P. Decicco, Jingwu Duan, Thomas Maduskuie, Stephen Mercer, Huey-Shin Shen, and Frank W Lee
Role of Intestinal P-Glycoprotein in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents
Published March 17, 2008; doi: 10.1124/dmd.107.017038
[Abstract]
[PDF]
13 March 2008
Sara K. Quinney, Raymond E. Galinsky, Vanida A. Jiyamapa-Serna, Yong Chen, Mitchell A. Hamman, Stephen D. Hall, and Robert E. Kimura
Hydroxyitraconazole, Formed During Intestinal First-Pass Metabolism of Itraconazole, Controls the Time Course of Hepatic CYP3A Inhibition and the Bioavailability of Itraconazole in Rats
Published March 13, 2008; doi: 10.1124/dmd.108.020644
[Abstract]
[PDF]
Tadahiro Hashita, Tsutomu Sakuma, Mami Akada, Asuka Nakajima, Hirofumi Yamahara, Sumiyo Ito, Hidekazu Takesako, and Nobuo Nemoto
FoxA2-mediated regulation of female-predominant expression of the mouse
Cyp2b9
gene
Published March 13, 2008; doi: 10.1124/dmd.107.019729
[Abstract]
[PDF]
Yukio Kato, Seiko Takahara, Sayaka Kato, Yoshiyuki Kubo, Yoshimichi Sai, Ikumi Tamai, Hikaru Yabuuchi, and Akira Tsuji
Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of
-lactam antibiotics
Published March 13, 2008; doi: 10.1124/dmd.107.019125
[Abstract]
[PDF]
10 March 2008
Niresh Hariparsad, Brian A. Carr, Raymond Evers, and Xiaoyan Chu
COMPARISON OF IMMORTALIZED Fa2N-4 CELLS AND HUMAN HEPATOCYTES AS IN VITRO MODELS FOR CYTOCHROME P450 INDUCTION
Published March 10, 2008; doi: 10.1124/dmd.108.020677
[Abstract]
[PDF]
Ken-ichi Umehara, Megumi Iwai, Yasuhisa Adachi, Takafumi Iwatsubo, Takashi Usui, and Hidetaka Kamimura
Hepatic uptake and excretion of YM758, a novel If channel inhibitor, in rats and humans
Published March 10, 2008; doi: 10.1124/dmd.108.020669
[Abstract]
[PDF]
Jonathan N Bauman, Kosea Frederick, Aarti Sawant, Robert Walsky, Loretta Cox, Ronald Obach, and Amit S. Kalgutkar
Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug
Published March 10, 2008; doi: 10.1124/dmd.108.020545
[Abstract]
[PDF]
Doreen Mitschke, Andreas Reichel, Gert Fricker, and Ursula Moenning
Characterization of Cytochrome P450 protein expression along the entire length of the intestine of male and female rats
Published March 10, 2008; doi: 10.1124/dmd.107.019687
[Abstract]
[PDF]
Hyunmi Kim, Kwon-Bok Kim, Hei-Young Ku, Soo Jin Park, Hoon Choi, Joon-Kwan Moon, Byeoung-Soo Park, Jeong-Han Kim, Sung Su Yea, Choong-Hwan Lee, Hye Suk Lee, Jae-Gook Shin, and Kwang-Hyeon Liu
Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China
Published March 10, 2008; doi: 10.1124/dmd.107.019612
[Abstract]
[PDF]
Maya Pascual, Maria Jose Gomez-Lechon, Jose V. Castell, and Ramiro Jover
ATF5 is a highly abundant liver-enriched transcription factor that cooperates with CAR in the transactivation of
CYP2B6
: Implications in hepatic stress responses
Published March 10, 2008; doi: 10.1124/dmd.107.019380
[Abstract]
[PDF]
Shigeyuki Kitamura, Kayoko Nitta, Yoshitaka Tayama, Chiaki Tanoue, Kazumi Sugihara, Tae Inoue, Tohru Horie, and Shigeru Ohta
Aldehyde Oxidase-Catalyzed Metabolism of
N
1
-Methylnicotinamide In vivo and In vitro in Chimeric Mice with Humanized Liver
Published March 10, 2008; doi: 10.1124/dmd.107.019075
[Abstract]
[PDF]
katrina l mealey, Stephen Greene, Rodney Bagley, John M Gay, Russ L Tucker, Patrick R Gavin, Kari Schmidt, and Frederick R Nelson
P-glycoprotein contributes to the blood-brain, but not blood-CSF, barrier in a spontaneous canine P-glycoprotein knockout model
Published March 10, 2008; doi: 10.1124/dmd.107.018978
[Abstract]
[PDF]
[Data Supplement]
Anshul Gupta, Ganesh Mugundu, Pankaj B. Desai, Kenneth E. Thummel, and Jashvant D. Unadkat
Intestinal human colon adenocarcinoma cell line, LS180, is an excellent model to study PXR- but not CAR-mediated CYP3A4 and MDR1 induction: studies with Anti-HIV Protease Inhibitors
Published March 10, 2008; doi: 10.1124/dmd.107.018689
[Abstract]
[PDF]
5 March 2008
Patrick Murphy
The development of drug metabolism research as expressed in the publications of ASPET Part 2-1959-1983
Published March 5, 2008; doi: 10.1124/dmd.108.021113
[Abstract]
[PDF]
Ryan H Takahashi, Onkar S Bains, Tom A Pfiefer, Thomas A Grigliatti, Ronald E Reid, and K. Wayne Riggs
Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro
Published March 5, 2008; doi: 10.1124/dmd.108.020388
[Abstract]
[PDF]
Tomoko Sugiura, Yukio Kato, Tomohiko Wakayama, David L. Silver, Yoshiyuki Kubo, Shoichi Iseki, and Akira Tsuji
PDZK1 REGULATES TWO INTESTINAL SOLUTE CARRIERS (Slc15a1 and Slc22a5) IN MICE
Published March 5, 2008; doi: 10.1124/dmd.107.020321
[Abstract]
[PDF]
Ryuichi Kitamura, Hisae Asanoma, Sekio Nagayama, and Masaki Otagiri
Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the anti-angiogenic agent TSU-68 ((
Z
)-5-[(1,2-dihydro-2-oxo-3
H
-indol-3-ylidene)methyl]-2,4-dimethyl-1
H
-pyrrole-3-propanoic acid)
Published March 5, 2008; doi: 10.1124/dmd.107.019877
[Abstract]
[PDF]
Junichi Enokizono, Hiroyuki Kusuhara, Atsuhi Ose, Alfred H. Schinkel, and Yuichi Sugiyama
Quantitative Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/
Abcg2
) in Limiting Brain and Testis Penetration of Xenobiotic Compounds
Published March 5, 2008; doi: 10.1124/dmd.107.019257
[Abstract]
[PDF]
28 February 2008
Hei-Young Ku, Hee-Jeong Ahn, Kyung-Ah Seo, Hyunmi Kim, Minkyung Oh, Soo Kyung Bae, Jae-Gook Shin, Ji-Hong Shon, and Kwang-Hyeon Liu
The contributions of cytochrome P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors (PDE5Is) sildenafil, udenafil, and vardenafil
Published February 28, 2008; doi: 10.1124/dmd.107.020099
[Abstract]
[PDF]
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Copyright © 2008 by the American Society for Pharmacology and Experimental Therapeutics.