7 May 2008

Cheng Fang, Jun Gu, Fang Xie, Melissa Behr, Weizhu Yang, Evan Dale Abel, and Xinxin Ding

Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated cardiac toxicity
Published May 7, 2008; doi: 10.1124/dmd.108.021881 [Abstract] [PDF]  

Robin E. Pearce, Wei Lu, YongQiang Wang, Jack P. Uetrecht, Maria Almira Correia, and J. Steven Leeder

Pathways of Carbamazepine Bioactivation In Vitro III: The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine
Published May 7, 2008; doi: 10.1124/dmd.107.019562 [Abstract] [PDF] [Data Supplement]  

Wei Lu and Jack P Uetrecht

Peroxidase-Mediated Bioactivation of Hydroxylated Metabolites of Carbamazepine and Phenytoin
Published May 7, 2008; doi: 10.1124/dmd.107.019554 [Abstract] [PDF]  

5 May 2008

Elin Sjodin, Holger Fritsch, Ulf Eriksson, Ulrika Logren, Anders Nordgren, Patrik Forsell, Lars Knutson, and Hans Lennernas

Intestinal and hepatobiliary transport of ximelagatran and its metabolites in pigs
Published May 5, 2008; doi: 10.1124/dmd.108.020412 [Abstract] [PDF]  

William R Proctor, David L Bourdet, and Dhiren R Thakker

Mechanisms Underlying Saturable Intestinal Absorption of Metformin
Published May 5, 2008; doi: 10.1124/dmd.107.020180 [Abstract] [PDF]  

30 April 2008

Masakatsu Kotsuma, Taro Tokui, Stefan Freudenthaler, and Kenji Nishimura

Effects of ketoconazole and quinidine on pharmacokinetics of pactimibe and its plasma metabolite, R-125528, in human
Published April 30, 2008; doi: 10.1124/dmd.108.021394 [Abstract] [PDF]  

Divesh Aidasani, Matthew J. Zaya, Phyllis B. Malpas, and Charles W. Locuson

In vitro drug-drug interaction screens for canine veterinary medicines: Evaluation of cytochrome P450 reversible inhibition
Published April 30, 2008; doi: 10.1124/dmd.108.021196 [Abstract] [PDF]  

Markus Zollinger, Claudia Sayer, Robert Dannecker, Walter Schuler, and Richard Sedrani

The Macrolide Everolimus Forms an Unusual Metabolite in Animals and Humans: Identification of a Phosphocholine Ester
Published April 30, 2008; doi: 10.1124/dmd.108.020651 [Abstract] [PDF]  

28 April 2008

Kaori Hosoda, Takashi Furuta, Akitomo Yokokawa, Kenichiro Ogura, Akira Hiratsuka, and Kazuo Ishii

Plasma profiling of intact isoflavone metabolites by HPLC and mass spectrometric identification of flavone glycosides, daidzin and genistin in human plasma after administration of kinako
Published April 28, 2008; doi: 10.1124/dmd.108.021006 [Abstract] [PDF]  

Nagdeep Giri, Guoyu Pan, Naveed Shaik, Tetsuya Terasaki, Chisato Mukai, Shinji Kitagaki, Naoki Miyakoshi, and William F. Elmquist

Investigation of the Role of Abcg2/Bcrp1 on Pharmacokinetics and CNS Penetration of Abacavir (ABC) and Zidovudine (AZT) in the Mouse
Published April 28, 2008; doi: 10.1124/dmd.108.020974 [Abstract] [PDF]  

Yijing He, Wei Zhang, Jianghua Tu, Julia Kirchheiner, Yao Chen, Dong Guo, Qin Li, Zhongyu Li, Hao Chen, Dongli Hu, Dan Wang, and Honghao Zhou

HNF1 INHIBITOR URSODEOXYCHOLIC ACID (UDCA) INFLUENCES PHARMACOKINETICS OF the OATP1B1 SUBSTRATE ROSUVASTATIN AND BILIRUBIN
Published April 28, 2008; doi: 10.1124/dmd.108.020503 [Abstract] [PDF]  

Tsuyoshi Minematsu, Tadashi Hashimoto, Toshiko Aoki, Takashi Usui, and Hidetaka Kamimura

ROLE OF ORGANIC ANION TRANSPORTERS IN THE PHARMACOKINETICS OF ZONAMPANEL, AN -AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONATE RECEPTOR ANTAGONIST, IN RATS
Published April 28, 2008; doi: 10.1124/dmd.107.019828 [Abstract] [PDF]  

24 April 2008

Lana X. Garmire and C. Anthony Hunt

In Silico Methods for Unraveling the Mechanistic Complexities of Intestinal Absorption: Metabolism–Efflux Transport Interactions
Published April 24, 2008; doi: 10.1124/dmd.107.020164 [Abstract] [PDF]  

Naoko Yoshida, Tappei Takada, Yoshikazu Yamamura, Isao Adachi, Hiroshi Suzuki, and Junichi Kawakami

Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport
Published April 24, 2008; doi: 10.1124/dmd.107.019513 [Abstract] [PDF]  

21 April 2008

Alison Parker and J Brian Houston

Rate limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir and ritonavir
Published April 21, 2008; doi: 10.1124/dmd.108.020917 [Abstract] [PDF]  

Ronald S Obach, Franco Lombardo, and Nigel J Waters

TREND ANALYSIS OF A DATABASE OF INTRAVENOUS PHARMACOKINETIC PARAMETERS IN HUMANS FOR 670 DRUG COMPOUNDS
Published April 21, 2008; doi: 10.1124/dmd.108.020479 [Abstract] [PDF] [Data Supplement]  

Stuart W Paine, Alison J Parker, Philip Gardiner, Peter J H Webborn, and Robert J Riley

Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes
Published April 21, 2008; doi: 10.1124/dmd.107.019455 [Abstract] [PDF] [Data Supplement]  

17 April 2008

Jamie Henshall, Aleksandra Galetin, Anthony Harrison, and J. Brian Houston

Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications
Published April 17, 2008; doi: 10.1124/dmd.108.021279 [Abstract] [PDF]  

Lesley A McLaughlin, Leslie J Dickmann, C Roland Wolf, and Colin James Henderson

Functional expression and comparative characterisation of nine murine cytochrome P450s by fluorescent inhibition screening
Published April 17, 2008; doi: 10.1124/dmd.108.021261 [Abstract] [PDF] [Data Supplement]  

Melinda J Reese, Robert M Wurm, Keith Muir, Grant Generaux, Lisa St. John-Williams, and Donavon McConn

An in Vitro Mechanistic Study to Elucidate the Desipramine / Bupropion Clinical Drug-Drug Interaction
Published April 17, 2008; doi: 10.1124/dmd.107.020198 [Abstract] [PDF]  

John W. Nichols, Alex D. Hoffman, Patrick N. Fitzsimmons, Gregory J. Lien, and Correne T. Jenson

Use of on-line microdialysis sampling to determine the in vivo rate of phenol glucuronidation in rainbow trout
Published April 17, 2008; doi: 10.1124/dmd.107.020123 [Abstract] [PDF]  

Zhi-wei Ye, Patrick Augustijns, and Pieter Annaert

Cellular accumulation of cholyl-glycylamido-fluorescein in sandwich-cultured rat hepatocytes: kinetic characterization, transport mechanisms and effect of HIV protease inhibitors
Published April 17, 2008; doi: 10.1124/dmd.107.019398 [Abstract] [PDF]  

Lisa J. Christopher, Donghui Cui, Chiyuan Wu, Roger Luo, James A. Manning, Samuel J. Bonacorsi, Michael Lago, Alban Allentoff, Francis Y. F. Lee, Betty McCann, Susan Galbriath, Donald P Reitberg, Kan He, Anthony Barros Jr., Anne Blackwood Chirchir, W Griffith Humphreys, and Ramaswamy Iyer

METABOLISM AND DISPOSITION OF DASATINIB AFTER ORAL ADMINISTRATION TO HUMANS
Published April 17, 2008; doi: 10.1124/dmd.107.018267 [Abstract] [PDF]  

Lisa J. Christopher, Donghui Cui, Wenying Li, Anthony Barros Jr., Vinod K. Arora, Haiying Zhang, Lifei Wang, Donglu Zhang, James A Manning, Kan He, Anthony M. Fletcher, Marc Ogan, Michael Lago, Samuel J. Bonacorsi, W. Griffith Humphreys, and Ramaswamy Iyer

BIOTRANSFORMATION OF [¹⁴C]DASATINIB: IN VITRO STUDIES IN RAT, MONKEY AND HUMAN AND DISPOSITION AFTER ADMINISTRATION TO RATS AND MONKEYS
Published April 17, 2008; doi: 10.1124/dmd.107.018234 [Abstract] [PDF]  

14 April 2008

Tao Zhang, Cathie D Xiang, David Gale, Samantha Carreiro, Ellen Y Wu, and Eric Y Zhang

Drug Transporter and CYP P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition
Published April 14, 2008; doi: 10.1124/dmd.108.021121 [Abstract] [PDF]  

Furong Qiu, Rong Zhang, JianGuo Sun, JiYe A, HaiPing Hao, Ying Peng, Hua Ai, and Guangji Wang

Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzymes in human liver microsomes
Published April 14, 2008; doi: 10.1124/dmd.108.021030 [Abstract] [PDF]  

Peter J. Kilford, Michael Gertz, J. Brian Houston, and Aleksandra Galetin

Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data
Published April 14, 2008; doi: 10.1124/dmd.108.020834 [Abstract] [PDF]  

Ping Kang, Deepak Dalvie, Evan Smith, and Sue Zhou

Bioactivation of Flutamide Metabolites by Human Liver Microsomes
Published April 14, 2008; doi: 10.1124/dmd.108.020370 [Abstract] [PDF] [Data Supplement]  

Peter H Bui, Arnulfo Quesada, Adrian Handforth, and Oliver Hankinson

The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil
Published April 14, 2008; doi: 10.1124/dmd.107.020115 [Abstract] [PDF]  

3 April 2008

Hajime Fukuda, Rikiya Ohashi, Minoru Tsuda-Tsukimoto, and Ikumi Tamai

Effect of plasma protein binding on in vitro-in vivo correlation of biliary excretion of drugs evaluated by sandwich-cultured rat hepatocytes
Published April 3, 2008; doi: 10.1124/dmd.107.019026 [Abstract] [PDF]  

2 April 2008

Kajsa P. Kanebratt and Tommy B. Andersson

Evaluation of HepaRG Cells as an In Vitro Model for Human Drug Metabolism Studies
Published April 2, 2008; doi: 10.1124/dmd.107.020016 [Abstract] [PDF] [Data Supplement]  

Wenxia Zhang and Lee-Yong Lim

EFFECTS OF SPICE CONSTITUENTS ON P-GP-MEDIATED TRANSPORT AND CYP3A4-MEDIATED METABOLISM IN VITRO
Published April 2, 2008; doi: 10.1124/dmd.107.019737 [Abstract] [PDF]  

1 April 2008

Shinji Yamazaki, Judith Skaptason, David Romero, Joseph H Lee, Helen Y Zou, James G Christensen, Jeffrey R Koup, Bill J. Smith, and Tatiana Koudriakova

Pharmacokinetic-Pharmacodynamic Modeling of Biomarker Response and Tumor Growth Inhibition to an Orally Available c-Met Kinase Inhibitor in Human Tumor Xenograft Mouse Models
Published April 1, 2008; doi: 10.1124/dmd.107.019711 [Abstract] [PDF]  

Chuang Lu, Cicely Berg, Shimoga R Prakash, Frank W Lee, and Suresh K Balani

PREDICTION OF PHARMACOKINETIC DRUG-DRUG INTERACTIONS USING HUMAN HEPATOCYTE SUSPENSION IN PLASMA - PART III. IN VITRO-IN VIVO CORRELATION WITH FLUCONAZOLE
Published April 1, 2008; doi: 10.1124/dmd.107.019000 [Abstract] [PDF]  

Chuang Lu, Panos Hatsis, Cicely Berg, Frank W Lee, and Shresh K Balani

PREDICTION OF PHARMACOKINETIC DRUG-DRUG INTERACTIONS USING HUMAN HEPATOCYTE SUSPENSION IN PLASMA AND CYP PHENOTYPIC DATA - PART II. IN VITRO-IN VIVO CORRELATION WITH KETOCONAZOLE
Published April 1, 2008; doi: 10.1124/dmd.107.018796 [Abstract] [PDF]  

31 March 2008

Caroline MacLean, Ursula Moenning, Andreas Reichel, and Gert Fricker

Closing the gaps - A full-scan of the intestinal expression of Pgp, Bcrp and Mrp2 in male and female rats
Published March 31, 2008; doi: 10.1124/dmd.108.020859 [Abstract] [PDF]  

Vikas Kumar, Richard C. Brundage, William S. Oetting, Ilo E. Leppik, and Timothy S. Tracy

Differential Genotype Dependent Inhibition of CYP2C9 in Humans
Published March 31, 2008; doi: 10.1124/dmd.108.020396 [Abstract] [PDF]  

Choong Yeol Ahn, Soo Kyung Bae, Young Seok Jung, Inchul Lee, Young Chul Kim, Myung Gull Lee, and Wan Gyoon Shin

Pharmacokinetic Parameters of Chlorzoxazone and its Main Metabolite, 6-Hydroxychlorzoxazone, after Intravenous and Oral Administration of Chlorzoxazone to Liver Cirrhotic Rats with Diabetes Mellitus
Published March 31, 2008; doi: 10.1124/dmd.107.017442 [Abstract] [PDF]  

27 March 2008

Chandra Prakash, Kim A Johnson, and Mark J Gardner

DISPOSITION OF LASOFOXIFENE, A NEXT GENERATION SELECTIVE ESTROGEN RECEPTOR MODULATOR, IN HEALTHY MALE SUBJECTS
Published March 27, 2008; doi: 10.1124/dmd.108.020404 [Abstract] [PDF]  

Eric T. Williams, Karen O. Jones, G. Douglas Ponsler, Shane M. Lowery, Everett J. Perkins, Steven A. Wrighton, Kenneth J. Ruterbories, Miho Kazui, and Nagy A Farid

The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2
Published March 27, 2008; doi: 10.1124/dmd.107.020248 [Abstract] [PDF]  

Gabriela Rodriguez-Fuentes, Rosaura Aparicio-Fabre, Li Qi, and Daniel Schlenk

Osmotic regulation of a novel flavin-containing monooxygenase in primary cultured cells from rainbow trout (Oncorhynchus mykiss)
Published March 27, 2008; doi: 10.1124/dmd.107.019968 [Abstract] [PDF]  

24 March 2008

Andrew Rowland, Kathleen M Knights, Peter I Mackenzie, and John O Miners

The 'albumin effect' and drug glucuronidation: Bovine serum albumin and fatty acid free serum albumin enhance the glucuronidation of UGT1A9 substrates but not UGT1A1 and UGT1A6 activities
Published March 24, 2008; doi: 10.1124/dmd.108.021105 [Abstract] [PDF]  

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue, and Hajime Mizukami

Down-regulation of a hepatic transporter Mrp2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury
Published March 24, 2008; doi: 10.1124/dmd.108.021089 [Abstract] [PDF]  

Yukio Yamamoto and Masahiko Negishi

The Anti-Apoptotic Factor GADD45B Regulates the Nuclear Receptor CAR-Mediated Transcription
Published March 24, 2008; doi: 10.1124/dmd.108.020628 [Abstract] [PDF]  

Souzan B. Yanni, Pieter P. Annaert, Patrick Augustijns, Arlene Bridges, Yan Gao, Daniel K. Benjamin, and Dhiren R. Thakker

Role of Flavin-containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes
Published March 24, 2008; doi: 10.1124/dmd.107.019646 [Abstract] [PDF]  

20 March 2008

Dermot F McGinnity, Nigel J Waters, James Tucker, and Rob J. Riley

Integrated in vitro analysis for the in vivo prediction of cytochrome P450 mediated drug-drug interactions
Published March 20, 2008; doi: 10.1124/dmd.108.020446 [Abstract] [PDF]  

Lanyan Fang and Duxin Sun

Predictive Physiologically-Based Pharmacokinetic (PBPK) Model for Antibody-Directed Enzyme Prodrug Therapy (ADEPT)
Published March 20, 2008; doi: 10.1124/dmd.107.019182 [Abstract] [PDF]  

Vijaya M. Lakshmi, Fong Fu Hsu, and Terry V. Zenser

N-Demethylation is a major route of 2-amino-3-methylimidazo[4,5-f]quinoline metabolism in mouse
Published March 20, 2008; doi: 10.1124/dmd.107.019166 [Abstract] [PDF]  

Phillip Krueger, Rambod Daneshfar, Gunter P. Eckert, Jochen Klein, Dietrich A. Volmer, Ute Bahr, Walter E. Mueller, Michael Karas, Manfred Schubert-Zsilavecz, and Mona Abdel-Tawab

Metabolism of boswellic acids in vitro and in vivo
Published March 20, 2008; doi: 10.1124/dmd.107.018424 [Abstract] [PDF]  

17 March 2008

Rozenn Josse, Caroline Aninat, Denise Glaise, Julie Dumont, Valerie Fessard, Fabrice Morel, Jean-Michel Poul, Christiane Guguen-Guillouzo, and Andre Guillouzo

Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies
Published March 17, 2008; doi: 10.1124/dmd.107.019901 [Abstract] [PDF]  

Stefan Harmsen, Andries Koster, J.H. Beijnen, J.H.M. Schellens, and Irma Meijerman

COMPARISON OF TWO IMMORTALIZED HUMAN CELL LINES TO STUDY NUCLEAR RECEPTOR MEDIATED CYP3A4 INDUCTION
Published March 17, 2008; doi: 10.1124/dmd.107.017335 [Abstract] [PDF]  

C. Edwin Garner, Eric Solon, Chii-Ming Lai, Jianrong Lin, Gang Luo, Kevin Jones, Liang-Shang Gan, MingXin Qian, Shimoga R Prakash, Carl P. Decicco, Jingwu Duan, Thomas Maduskuie, Stephen Mercer, Huey-Shin Shen, and Frank W Lee

Role of Intestinal P-Glycoprotein in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents
Published March 17, 2008; doi: 10.1124/dmd.107.017038 [Abstract] [PDF]  

13 March 2008

Sara K. Quinney, Raymond E. Galinsky, Vanida A. Jiyamapa-Serna, Yong Chen, Mitchell A. Hamman, Stephen D. Hall, and Robert E. Kimura

Hydroxyitraconazole, Formed During Intestinal First-Pass Metabolism of Itraconazole, Controls the Time Course of Hepatic CYP3A Inhibition and the Bioavailability of Itraconazole in Rats
Published March 13, 2008; doi: 10.1124/dmd.108.020644 [Abstract] [PDF]  

Tadahiro Hashita, Tsutomu Sakuma, Mami Akada, Asuka Nakajima, Hirofumi Yamahara, Sumiyo Ito, Hidekazu Takesako, and Nobuo Nemoto

FoxA2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene
Published March 13, 2008; doi: 10.1124/dmd.107.019729 [Abstract] [PDF]  

Yukio Kato, Seiko Takahara, Sayaka Kato, Yoshiyuki Kubo, Yoshimichi Sai, Ikumi Tamai, Hikaru Yabuuchi, and Akira Tsuji

Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of -lactam antibiotics
Published March 13, 2008; doi: 10.1124/dmd.107.019125 [Abstract] [PDF]  

10 March 2008

Niresh Hariparsad, Brian A. Carr, Raymond Evers, and Xiaoyan Chu

COMPARISON OF IMMORTALIZED Fa2N-4 CELLS AND HUMAN HEPATOCYTES AS IN VITRO MODELS FOR CYTOCHROME P450 INDUCTION
Published March 10, 2008; doi: 10.1124/dmd.108.020677 [Abstract] [PDF]  

Ken-ichi Umehara, Megumi Iwai, Yasuhisa Adachi, Takafumi Iwatsubo, Takashi Usui, and Hidetaka Kamimura

Hepatic uptake and excretion of YM758, a novel If channel inhibitor, in rats and humans
Published March 10, 2008; doi: 10.1124/dmd.108.020669 [Abstract] [PDF]  

Jonathan N Bauman, Kosea Frederick, Aarti Sawant, Robert Walsky, Loretta Cox, Ronald Obach, and Amit S. Kalgutkar

Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug
Published March 10, 2008; doi: 10.1124/dmd.108.020545 [Abstract] [PDF]  

Doreen Mitschke, Andreas Reichel, Gert Fricker, and Ursula Moenning

Characterization of Cytochrome P450 protein expression along the entire length of the intestine of male and female rats
Published March 10, 2008; doi: 10.1124/dmd.107.019687 [Abstract] [PDF]  

Hyunmi Kim, Kwon-Bok Kim, Hei-Young Ku, Soo Jin Park, Hoon Choi, Joon-Kwan Moon, Byeoung-Soo Park, Jeong-Han Kim, Sung Su Yea, Choong-Hwan Lee, Hye Suk Lee, Jae-Gook Shin, and Kwang-Hyeon Liu

Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China
Published March 10, 2008; doi: 10.1124/dmd.107.019612 [Abstract] [PDF]  

Maya Pascual, Maria Jose Gomez-Lechon, Jose V. Castell, and Ramiro Jover

ATF5 is a highly abundant liver-enriched transcription factor that cooperates with CAR in the transactivation of CYP2B6: Implications in hepatic stress responses
Published March 10, 2008; doi: 10.1124/dmd.107.019380 [Abstract] [PDF]  

Shigeyuki Kitamura, Kayoko Nitta, Yoshitaka Tayama, Chiaki Tanoue, Kazumi Sugihara, Tae Inoue, Tohru Horie, and Shigeru Ohta

Aldehyde Oxidase-Catalyzed Metabolism of N¹-Methylnicotinamide In vivo and In vitro in Chimeric Mice with Humanized Liver
Published March 10, 2008; doi: 10.1124/dmd.107.019075 [Abstract] [PDF]  

katrina l mealey, Stephen Greene, Rodney Bagley, John M Gay, Russ L Tucker, Patrick R Gavin, Kari Schmidt, and Frederick R Nelson

P-glycoprotein contributes to the blood-brain, but not blood-CSF, barrier in a spontaneous canine P-glycoprotein knockout model
Published March 10, 2008; doi: 10.1124/dmd.107.018978 [Abstract] [PDF] [Data Supplement]  

Anshul Gupta, Ganesh Mugundu, Pankaj B. Desai, Kenneth E. Thummel, and Jashvant D. Unadkat

Intestinal human colon adenocarcinoma cell line, LS180, is an excellent model to study PXR- but not CAR-mediated CYP3A4 and MDR1 induction: studies with Anti-HIV Protease Inhibitors
Published March 10, 2008; doi: 10.1124/dmd.107.018689 [Abstract] [PDF]  

5 March 2008

Patrick Murphy

The development of drug metabolism research as expressed in the publications of ASPET Part 2-1959-1983
Published March 5, 2008; doi: 10.1124/dmd.108.021113 [Abstract] [PDF]  

Ryan H Takahashi, Onkar S Bains, Tom A Pfiefer, Thomas A Grigliatti, Ronald E Reid, and K. Wayne Riggs

Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro
Published March 5, 2008; doi: 10.1124/dmd.108.020388 [Abstract] [PDF]  

Tomoko Sugiura, Yukio Kato, Tomohiko Wakayama, David L. Silver, Yoshiyuki Kubo, Shoichi Iseki, and Akira Tsuji

PDZK1 REGULATES TWO INTESTINAL SOLUTE CARRIERS (Slc15a1 and Slc22a5) IN MICE
Published March 5, 2008; doi: 10.1124/dmd.107.020321 [Abstract] [PDF]  

Ryuichi Kitamura, Hisae Asanoma, Sekio Nagayama, and Masaki Otagiri

Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the anti-angiogenic agent TSU-68 ((Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid)
Published March 5, 2008; doi: 10.1124/dmd.107.019877 [Abstract] [PDF]  

Junichi Enokizono, Hiroyuki Kusuhara, Atsuhi Ose, Alfred H. Schinkel, and Yuichi Sugiyama

Quantitative Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting Brain and Testis Penetration of Xenobiotic Compounds
Published March 5, 2008; doi: 10.1124/dmd.107.019257 [Abstract] [PDF]  

28 February 2008

Hei-Young Ku, Hee-Jeong Ahn, Kyung-Ah Seo, Hyunmi Kim, Minkyung Oh, Soo Kyung Bae, Jae-Gook Shin, Ji-Hong Shon, and Kwang-Hyeon Liu

The contributions of cytochrome P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors (PDE5Is) sildenafil, udenafil, and vardenafil
Published February 28, 2008; doi: 10.1124/dmd.107.020099 [Abstract] [PDF]  

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