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Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Freely Accessible through Dec. 31

Dr. Xinxin Ding Chosen to Be Next DMD Editor

Dr. Rob Foti Named New Associate Editor

Latest Fast Forward Articles

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Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
Mary Alexandra Schleiff, Noah R. Flynn, Sasin Payakachat, Benjamin Mark Schleiff, Anna O. Pinson, Dennis W. Province, S. Joshua Swamidass, Gunnar Boysen and Grover P. Miller

Drug Metabolism and Disposition November 25, 2020, DMD-AR-2020-000254; DOI: https://doi.org/10.1124/dmd.120.000254
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Predicting Volume of Distribution in Humans: Performance of in silico Methods for A Large Set of Structurally Diverse Clinical Compounds
Neha Murad, Kishore K. Pasikanti, Benjamin D. Madej, Amanda Minnich, Juliet M. McComas, Sabrinia Crouch, Joseph W. Polli and Andrew D. Weber

Drug Metabolism and Disposition November 25, 2020, DMD-AR-2020-000202; DOI: https://doi.org/10.1124/dmd.120.000202
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Sex-, age-, and race/ethnicity-dependent variations in drug-processing and NRF2-regulated genes in human livers
Jie Liu, Julia Yue Cui, Yuan-Fu Lu, J. Christopher Corton and Curtis D. Klaassen

Drug Metabolism and Disposition November 8, 2020, DMD-AR-2020-000181; DOI: https://doi.org/10.1124/dmd.120.000181
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Regulation of intestinal UGT1A1 by the FXR agonist obeticholic acid (OCA) is controlled by CAR through intestinal maturation
Andre W Weber, Elvira Mennillo, Xiaojing Yang, Lori W.E. van der Schoor, Johan W Jonker, Shujuan Chen and Robert H. Tukey

Drug Metabolism and Disposition November 5, 2020, DMD-AR-2020-000240; DOI: https://doi.org/10.1124/dmd.120.000240
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Extension of the mechanistic tissue distribution model of Rodgers & Rowland by systematic incorporation of lysosomal trapping: impact on Kpu and volume of distribution predictions in the rat
Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker and Philip Lienau

Drug Metabolism and Disposition November 4, 2020, DMD-AR-2020-000161; DOI: https://doi.org/10.1124/dmd.120.000161
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Disposition and Metabolism of [¹⁴C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites
Takashi Ueno, Tomomi Ishida, Jagadeesh Aluri, Michiyuki Suzuki, Carsten Theodor Beuckmann, Takaaki Kameyama, Shoji Asakura and Kazutomi Kusano

Drug Metabolism and Disposition November 3, 2020, DMD-AR-2020-000229; DOI: https://doi.org/10.1124/dmd.120.000229

About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

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