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Drug Metabolism & Disposition

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Bridget Morse and Eva Hansmann Receive James R. Gillette Awards

ASPET's Journals Are Plan S Compliant

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  • Transporter-Mediated Drug-Drug Interactions for E7766
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Latest Fast Forward Articles

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    Evaluation of Tissue Binding in 3 Tissues Across 5 Species, and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding
    Frederick Hsu, Yi-Chen Chen and Fabio Broccatelli
    Drug Metabolism and Disposition February 25, 2021, DMD-AR-2020-000337; DOI: https://doi.org/10.1124/dmd.120.000337
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    Clinical investigation of metabolic and renal clearance pathways contributing to the elimination of fevipiprant using probenecid as perpetrator
    H. Markus Weiss, Thomas Langenickel, Meredith Cain, Swarupa Kulkarni, Bharti Shah, Janardhana Vemula, Gholamreza Rahmanzadeh and Birk Poller
    Drug Metabolism and Disposition February 25, 2021, DMD-AR-2020-000273; DOI: https://doi.org/10.1124/dmd.120.000273
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    In Vivo Functional Effects of CYP2C9 M1L, a Novel and Common Variant in the Yup'ik Alaska Native Population
    Lindsay M. Henderson, Scarlett E. Hopkins, Bert B. Boyer, Timothy A. Thornton, Allan E. Rettie and Kenneth E. Thummel
    Drug Metabolism and Disposition February 25, 2021, DMD-AR-2020-000301; DOI: https://doi.org/10.1124/dmd.120.000301
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    Revisiting nonlinear bosentan pharmacokinetics by PBPK modeling: Target binding, albeit not a major contributor to nonlinearity, can offer prediction of target occupancy
    Satoshi Koyama, Kota Toshimoto, Wooin Lee, Yasunori Aoki and Yuichi Sugiyama
    Drug Metabolism and Disposition February 8, 2021, DMD-AR-2020-000023; DOI: https://doi.org/10.1124/dmd.120.000023
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    Maternal and fetal pharmacokinetic analysis of cannabidiol during pregnancy in mice
    Wataru Ochiai, Satoshi Kitaoka, Taisuke Kawamura, Jo Hatogai, Shohei Harada, Misa Iizuka, Mashu Ariumi, Seiya Takano, Tomomi Nagai, Masanaho Sasatsu and Kiyoshi Sugiyama
    Drug Metabolism and Disposition February 2, 2021, DMD-AR-2020-000270; DOI: https://doi.org/10.1124/dmd.120.000270
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    Functional proliferating human hepatocytes: in vitro hepatocyte model for drug metabolism, excretion and toxicity
    Shida Qiao, Sisi Feng, Zhitao Wu, Ting He, Chen Ma, Zhaoliang Peng, E Tian and Guoyu Pan
    Drug Metabolism and Disposition February 1, 2021, DMD-AR-2020-000275; DOI: https://doi.org/10.1124/dmd.120.000275
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About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

Current issue

Drug Metabolism and Disposition: 49 (3)
Drug Metabolism and Disposition
Vol. 49, Issue 3
1 Mar 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)

DMD is published continuously. Articles are added as they are ready and assigned to monthly issues. Check this site for new content or sign up for content alerts.

EDITOR'S CHOICE ARTICLES FOR March:

  • Tryptophan-75 Is a Low-Energy Channel-Gating Residue that Facilitates Substrate Egress/Access in Cytochrome P450 2D6
  • Impact of Plasma Protein Binding in Drug Clearance Prediction: A Data Base Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation
  • Aldehyde Oxidase Contributes to All-Trans-Retinoic Acid Biosynthesis in Human Liver
  • Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1′-Hydroxylation and Testosterone 6β-Hydroxylation
  • Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib
  • Most Read
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  • Metabolism and Disposition of Volanesorsen across Species
  • Tissue Drug Concentrations: Beyond the Free Drug Hypothesis
  • PBPK Modeling for Clopidogrel and Its Active Metabolite
  • Pharmacokinetics and Disposition of Biologics
  • Physiology of the Neonatal Gastrointestinal System
More...
For an alternate route to this Journal use this URL: http://intl-dmd.aspetjournals.org
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