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Special Section of Bile Acids, Drug Metabolism, and Toxicity - freely accessible through October 31, 2022

Special Section on Drug Metabolism in Liver injury and Regeneration - freely accessible through December 31, 2022

Latest Fast Forward Articles

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Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic
Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000882; DOI: https://doi.org/10.1124/dmd.122.000882
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Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W Yucha, Swapan K. Chowdhury and Paresh P. Chothe

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000836; DOI: https://doi.org/10.1124/dmd.122.000836
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Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fc-fusion Proteins at Pharmacologically Active Doses
Zheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois D. Lehman-McKeeman, Paul Morin and Robert F Graziano

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2021-000799; DOI: https://doi.org/10.1124/dmd.121.000799
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Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of Cytochrome P450 3A
Lloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong Chan

Drug Metabolism and Disposition May 5, 2022, DMD-AR-2022-000895; DOI: https://doi.org/10.1124/dmd.122.000895
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Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models
Yuli Qian and John S. Markowitz

Drug Metabolism and Disposition May 5, 2022, DMD-AR-2021-000823; DOI: https://doi.org/10.1124/dmd.121.000823
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Impact of inflammation and infection on the expression of amino acid transporters in the placenta: A minireview
Eliza R McColl, Milena Hurtarte and Micheline Piquette-Miller

Drug Metabolism and Disposition May 5, 2022, DMD-MR-2021-000703; DOI: https://doi.org/10.1124/dmd.121.000703

About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

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