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Special Section Focusing on Drug Metabolism and Precision Medicine - freely accessible through October 31, 2023

Latest Fast Forward Articles

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The Potentially Significant Role of CYP3A-Mediated Oxidative Metabolism of Dabigatran Etexilate and its Intermediate Metabolites in Drug-Drug Interaction Assessments Using Microdose Dabigatran Etexilate
Udomsak Udomnilobol, Suree Jianmongkol and Thomayant Prueksaritanont

Drug Metabolism and Disposition May 25, 2023, DMD-AR-2023-001353; DOI: https://doi.org/10.1124/dmd.123.001353
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Adipocyte-derived PXR signaling is dispensable for diet-induced obesity and metabolic disorders in mice
Fang Wang, Jingwei Liu, Rebecca Hernandez, Se-Hyung Park, Ying-Jing Lai, Shuxia Wang, Bruce Blumberg and Changcheng Zhou

Drug Metabolism and Disposition May 25, 2023, DMD-AR-2023-001311; DOI: https://doi.org/10.1124/dmd.123.001311
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Systemic Exposure, Metabolism, and Elimination of [14C]-Labeled Amino Lipid, Lipid 5,After a Single Administration of mRNA Encapsulating Lipid Nanoparticles to Sprague Dawley Rats
Douglas Burdette, Lei Ci, Barclay Shilliday, Richard Slauter, Andrew Auerbach, Matthew Kenney, Örn Almarsson, Eugene Cheung and Tracy Hendrick

Drug Metabolism and Disposition May 19, 2023, DMD-AR-2022-001194; DOI: https://doi.org/10.1124/dmd.122.001194
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The inhibitor preincubation effect is universal to SLC transporter assays and is only partially eliminated in the presence of extracellular protein
Peter Tatrai, Csilla Temesszentandrási-Ambrus, Tamás Varga and Zsuzsanna Gáborik

Drug Metabolism and Disposition May 19, 2023, DMD-AR-2022-001191; DOI: https://doi.org/10.1124/dmd.122.001191
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Biodistribution of Lipid 5, mRNA, and Its Translated Protein Following Intravenous Administration of mRNA-Encapsulated Lipid Nanoparticles in Rats
Lei Ci, Marjie Hard, Hannah Zhang, Srujan Gandham, Serenus Hua, John Wickwire, Tod Wehrman, Richard Slauter, Andrew Auerbach, Matthew Kenney, Greg Mercer, Tracy Hendrick, Örn Almarsson, Eugene Cheung and Douglas Burdette

Drug Metabolism and Disposition May 19, 2023, DMD-AR-2022-000980; DOI: https://doi.org/10.1124/dmd.122.000980
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Assumptions Underlying Hepatic Clearance Models: Recognizing the Influence of Saturable Protein Binding on Driving Force Concentration and Discrimination Between Models of Hepatic Clearance
Julia A Schulz Pauly, Jin Wang, Colin J. Phipps and John Cory Kalvass

Drug Metabolism and Disposition May 15, 2023, DMD-AR-2023-001326; DOI: https://doi.org/10.1124/dmd.123.001326

About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

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