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Drug Metabolism & Disposition

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ASPET Ends Page Charges for Open Access Articles

DMD Marks Its 50th Anniversary with Celebration Collection

Special Section on New Era of Transporter Science: Unraveling the Functional Role of Orphan Transporters - freely accessible through March 31, 2023

Special Section on Mechanistic and Translational Research on Transporters in Toxicology - freely accessible through April 30, 2023

  • Nicolò Milani
  • MSCs Pharmacokinetics Under Liver Diseases
  • ABC Transporters and Chemical-Induced Liver Injury
  • NASH increases ochratoxin A renal excretion
  • PCFAs and Transporters in HepaRG Cells
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Latest Fast Forward Articles

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    Epigenetic Mechanisms Contribute to Intraindividual Variations of Drug Metabolism Mediated by Cytochrome P450 Enzymes
    Jing Jin and Xiao-bo Zhong
    Drug Metabolism and Disposition March 27, 2023, DMD-MR-2022-001007; DOI: https://doi.org/10.1124/dmd.122.001007
  • You have access
    Human Absorption, Distribution, Metabolism and Excretion Studies - Origins, Innovations and Importance
    Matthew A. Cerny, Douglas K Spracklin and R. Scott Obach
    Drug Metabolism and Disposition March 27, 2023, DMD-MR-2022-001006; DOI: https://doi.org/10.1124/dmd.122.001006
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    A physiologically-based pharmacokinetic model for cannabidiol in healthy adults, hepatically-impaired adults, and children
    Sumit Bansal, Mayur K. Ladumor, Mary F. Paine and Jashvant D. Unadkat
    Drug Metabolism and Disposition March 27, 2023, DMD-AR-2022-001128; DOI: https://doi.org/10.1124/dmd.122.001128
  • You have access
    Combined oral contraceptives as victims of drug interactions
    Li Li, Xinning Yang, Doanh Tran, Shirley K Seo and Yanhui Lu
    Drug Metabolism and Disposition March 24, 2023, DMD-MR-2022-000854; DOI: https://doi.org/10.1124/dmd.122.000854
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    Recombinant Technologies Facilitate Drug Metabolism, Pharmacokinetics, and General Biomedical Research
    Joseph Cronin and Ai-Ming Yu
    Drug Metabolism and Disposition March 22, 2023, DMD-MR-2022-001008; DOI: https://doi.org/10.1124/dmd.122.001008
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    Characterization of Enzymes Involved in Nintedanib Metabolism in Humans
    Shimon Nakashima, Rei Sato, Tatsuki Fukami, Takashi Kudo, Shiori Hashiba, Gaku Morinaga, Masataka Nakano, Eva Ludwig-Schwellinger, Akiko Matsui, Naoki Ishiguro, Thomas Ebner and Miki Nakajima
    Drug Metabolism and Disposition March 16, 2023, DMD-AR-2022-001113; DOI: https://doi.org/10.1124/dmd.122.001113
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About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

Current issue

Drug Metabolism and Disposition: 51 (4)
Drug Metabolism and Disposition
Vol. 51, Issue 4
1 Apr 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)

DMD is published continuously. Articles are added as they are ready and assigned to monthly issues. Check this site for new content or sign up for content alerts.

EDITOR'S CHOICE ARTICLES FOR MARCH 2023:

  • Comprehensive Analyses of the Intracellular and in Vivo Disposition of Fab– Small Interfering RNA Conjugate to Identify Key Issues to Improve Its in Vivo Activity
  • Intravital Microscopy Reveals Unforeseen Biodistribution Within the Liver and Kidney Mechanistically Connected to the Clearance of a Bifunctional Antibody - open access
  • Most Cited
  • Most Read
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
More...
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