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Drug Metabolism & Disposition

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ASPET 2024 Annual Meeting - Call for Abstracts - Submit by Dec. 7 for Posters/Awards/Talks. Submit by Feb. 22 for Posters Only

DMD Marks Its 50th Anniversary with Celebration Collection

Special Section on Perspective on Drug Metabolism and Disposition- Part 1 by DMD Associate Editors - freely accessible through December 31, 2023

Special Section on Mechanism-Based Predictive Methods in Drug Discovery and Development - freely accessible through April 30, 2024

  • Victoria Oyanna
  • MSCs Pharmacokinetics Under Liver Diseases
  • ABC Transporters and Chemical-Induced Liver Injury
  • NASH increases ochratoxin A renal excretion
  • PCFAs and Transporters in HepaRG Cells
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Latest Fast Forward Articles

  • You have access
    Novel independent trans- and cis-genetic variants associated with CYP2D6 expression and activity in human livers
    Dylan Smith, Bing He, Jian Shi, Hao-Jie Zhu and Xinwen Wang
    Drug Metabolism and Disposition November 29, 2023, DMD-AR-2023-001548; DOI: https://doi.org/10.1124/dmd.123.001548
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    Comparison of 1beta- and 5beta-hydroxylation of Deoxycholate and Glycodeoxycholate as In Vitro Index Reactions for CYP3A Activities
    Cuitong Wang, Bin Cheng, Wei Wei, Lanlan Gui, Wushuang Zeng, Yutong Wang, Yixuan Wang, Qi Chen, Liang Xu, Jia Miao and Ke Lan
    Drug Metabolism and Disposition November 29, 2023, DMD-AR-2023-001513; DOI: https://doi.org/10.1124/dmd.123.001513
  • You have access
    Deciphering the role of fatty acid metabolizing CYP4F11 in lung cancer and its potential as a drug target
    Huiting Jia, Bjoern Brixius, Caleb Bocianoski, Sutapa Ray, David R. Koes and Simone Brixius-Anderko
    Drug Metabolism and Disposition November 16, 2023, DMD-AR-2023-001463; DOI: https://doi.org/10.1124/dmd.123.001463
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    Involvement of proton-coupled SLC49A4-mediated transport in the export of lysosomally trapped pyrilamine
    Shogo Akino, Tomoya Yasujima, Rei Shibutani, Takahiro Yamashiro and Hiroaki Yuasa
    Drug Metabolism and Disposition November 14, 2023, DMD-AR-2023-001354; DOI: https://doi.org/10.1124/dmd.123.001354
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    Time-Dependent Inhibition of CYP1A2 by Stiripentol and Structurally Related Methylenedioxyphenyl Compounds via Metabolic Intermediate Complex Formation
    Yasuhiro Masubuchi, Chieko Takahashi and Rina Gendo
    Drug Metabolism and Disposition November 6, 2023, DMD-AR-2023-001511; DOI: https://doi.org/10.1124/dmd.123.001511
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    The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans
    Mitchell R. McGill
    Drug Metabolism and Disposition November 2, 2023, DMD-MR-2023-001281; DOI: https://doi.org/10.1124/dmd.123.001281
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About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

Current issue

Drug Metabolism and Disposition: 51 (12)
Drug Metabolism and Disposition
Vol. 51, Issue 12
1 Dec 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)

DMD is published continuously. Articles are added as they are ready and assigned to monthly issues. Check this site for new content or sign up for content alerts.

EDITOR'S CHOICE ARTICLES FOR DECEMBER 2023:

  • The African Liver Tissue Biorepository Consortium: Capacitating Population-Appropriate Drug Metabolism, Pharmacokinetics, and Pharmacogenetics Research in Drug Discovery and Development
  • Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
More...
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