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Special Section of Bile Acids, Drug Metabolism, and Toxicity - freely accessible through October 31, 2022

Special Section on Drug Metabolism in Liver injury and Regeneration - freely accessible through December 31, 2022

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High-throughput Production of Diverse Xenobiotic Metabolites with P450-Transduced Huh7 Hepatoma Cell Lines
Choon-myung Lee, Ken H Liu, Grant Singer, Gary W Miller, Shuzhao Li, Dean P Jones and Eddie T. Morgan

Drug Metabolism and Disposition June 25, 2022, DMD-AR-2022-000900; DOI: https://doi.org/10.1124/dmd.122.000900
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HepaRG cells adopt zonal-like drug-metabolizing phenotypes under physiologically relevant oxygen tensions and Wnt/β-catenin signaling
Thomas J DiProspero, Lauren G Brown, Trevor D Fachko and Matthew R. Lockett

Drug Metabolism and Disposition June 14, 2022, DMD-AR-2022-000870; DOI: https://doi.org/10.1124/dmd.122.000870
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The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K Malhotra and Martin E Dowty

Drug Metabolism and Disposition June 14, 2022, DMD-AR-2022-000829; DOI: https://doi.org/10.1124/dmd.122.000829
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Cytochrome P450 2J (CYP2J) Genes in Dogs, Cats, and Pigs Are Expressed and Encode Functional Drug-Metabolizing Enzymes
Yasuhiro Uno, Norie Murayama, Moe Ijiri, Hiroaki Kawaguchi, Osamu Yamato, Mitsuya Shiraishi, Atsushi Asano, Hiroki Teraoka, Hazuki Mizukawa, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka and Hiroshi Yamazaki

Drug Metabolism and Disposition June 14, 2022, DMD-AR-2022-000930; DOI: https://doi.org/10.1124/dmd.122.000930
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In vitro CYP450 enzyme down-regulation by GLP-1/glucagon co-agonist does not translate to observed drug-drug interactions in the clinic
Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen

Drug Metabolism and Disposition June 9, 2022, DMD-AR-2022-000865; DOI: https://doi.org/10.1124/dmd.122.000865
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Characterization of JNJ-2482272 [4-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-yl)pyrimidine-2-amine] as a Strong AhR Activator in Rat and Human
Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P Scott, Judith Skaptason, Yuen Tam, Laurie P Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M Lim, Michael Hack and Tatiana Koudriakova

Drug Metabolism and Disposition June 9, 2022, DMD-AR-2021-000825; DOI: https://doi.org/10.1124/dmd.121.000825

About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

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