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Drug Metabolism & Disposition

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ASPET Ends Page Charges for Open Access Articles

DMD Marks Its 50th Anniversary with Celebration Collection

Special Section on Pharmacokinetics and ADME of Biological Therapeutics - freely accessible through January 31, 2023

Special Section on Drug Metabolism and Regulation - freely accessible through February 28, 2023

Special Section on New Era of Transporter Science: Unraveling the Functional Role of Orphan Transporters - freely accessible through March 31, 2023

Special Section on Mechanistic and Translational Research on Transporters in Toxicology - freely accessible through April 30, 2023

  • Andrew Huber
  • MSCs Pharmacokinetics Under Liver Diseases
  • ABC Transporters and Chemical-Induced Liver Injury
  • NASH increases ochratoxin A renal excretion
  • PCFAs and Transporters in HepaRG Cells
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Latest Fast Forward Articles

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    Detection and characterization of in vitro payload-containing catabolites of non-cleavable ADCs by high-resolution mass spectrometry and multiple data-mining tools
    Tingting Cai, Liqi Shi, Huihui Guo, Ruixing Li, Weiqun Cao, Liang Shen, Mingshe Zhu and Yi Tao
    Drug Metabolism and Disposition January 27, 2023, DMD-AR-2022-001135; DOI: https://doi.org/10.1124/dmd.122.001135
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    Impact of direction of transport on the evaluation of substrate recognition of mouse multidrug and toxin extrusion protein 1 (mMate1)
    Asami Saito, Tomoko Kito, Naoki Ishiguro, Masahito Takatani, Takashi Kudo, Bojan Bister and Hiroyuki Kusuhara
    Drug Metabolism and Disposition January 20, 2023, DMD-AR-2022-001115; DOI: https://doi.org/10.1124/dmd.122.001115
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    Newly Identified Tree Shrew Cytochrome P450 2A13 (CYP2A13) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A19
    Genki Ushirozako, Yutaro Noda, Norie Murayama, Hiroaki Kawaguchi, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki and Yasuhiro Uno
    Drug Metabolism and Disposition January 20, 2023, DMD-AR-2022-001152; DOI: https://doi.org/10.1124/dmd.122.001152
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    Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans
    Ulrik Jurva, Lars Weidolf, Ann-Sofie Sandinge, Carina Leandersson, Anja Ekdahl, Xue-Qing Li, Thomas Antonsson, Johan Sundell, Kristina Westerlund, Carl Amilon, Tord Inghardt and V. Sashi Gopaul
    Drug Metabolism and Disposition January 18, 2023, DMD-AR-2022-001099; DOI: https://doi.org/10.1124/dmd.122.001099
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    Unusual Biotransformation Reactions of Drugs and Drug Candidates
    Emre M. Isin
    Drug Metabolism and Disposition January 18, 2023, DMD-MR-2021-000744; DOI: https://doi.org/10.1124/dmd.121.000744
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    Fifty years of aryl hydrocarbon receptor research as reflected in the pages of Drug Metabolism and Disposition
    David S. Riddick
    Drug Metabolism and Disposition January 18, 2023, DMD-MR-2022-001009; DOI: https://doi.org/10.1124/dmd.122.001009
View more published ahead of print articles

About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

Current issue

Drug Metabolism and Disposition: 51 (2)
Drug Metabolism and Disposition
Vol. 51, Issue 2
1 Feb 2023
  • Table of Contents
  • About the Cover
  • Index by author

DMD is published continuously. Articles are added as they are ready and assigned to monthly issues. Check this site for new content or sign up for content alerts.

EDITOR'S CHOICE ARTICLES FOR FEBRUARY 2023:

  • The Function of Xenobiotic Receptors in Metabolic Diseases
  • Pharmacokinetic Interactions of a Licorice Dietary Supplement with Cytochrome P450 Enzymes in Female Participants
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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