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Mechanisms by Which Inducers of Drug Metabolizing Enzymes Alter Thyroid Hormones in Rats
Nichole R Vansell

Drug Metabolism and Disposition January 19, 2022, DMD-MR-2021-000498; DOI: https://doi.org/10.1124/dmd.121.000498
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Prediction of Maternal and Fetoplacental Concentrations of Cefazolin, Cefuroxime and Amoxicillin during Pregnancy using bottom-up Physiologically based Pharmacokinetic Models
Khaled Abduljalil, Jia Ning, Amita Pansari, Xian Pan and Masoud Jamei

Drug Metabolism and Disposition January 19, 2022, DMD-AR-2021-000711; DOI: https://doi.org/10.1124/dmd.121.000711
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Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients.
Pablo Aviles, Raquel Altares, Lotte van Andel, Rubin Lubomirov, Salvador Fudio, Hilde Rosing, Francisco M Marquez del Pino, Matthijs M Tibben, Gonzalo Benedit, Lianda Nan-Offeringa, Xarles Erik Luepke Estefan, Andres Francesch, Ali Zeaiter, Carmen Cuevas, Jan H.M. Schellens and Jos H. Beijnen

Drug Metabolism and Disposition January 18, 2022, DMD-AR-2021-000668; DOI: https://doi.org/10.1124/dmd.121.000668
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Linezolid Metabolism is Catalyzed by CYP2J2, CYP4F2 and CYP1B1
R. Scott Obach

Drug Metabolism and Disposition January 18, 2022, DMD-AR-2021-000776; DOI: https://doi.org/10.1124/dmd.121.000776
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Usefulness of human jejunal spheroid-derived differentiated intestinal epithelial cells for the prediction of intestinal drug absorption in humans
Kazuyoshi Michiba, Kazuya Maeda, Osamu Shimomura, Yoshihiro Miyazaki, Shinji Hashimoto, Tatsuya Oda and Hiroyuki Kusuhara

Drug Metabolism and Disposition January 6, 2022, DMD-AR-2021-000796; DOI: https://doi.org/10.1124/dmd.121.000796
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Regulation of Placental Efflux Transporters During Pregnancy Complications
Danielle Kozlosky, Emily Barrett and Lauren M. Aleksunes

Drug Metabolism and Disposition January 6, 2022, DMD-MR-2021-000449; DOI: https://doi.org/10.1124/dmd.121.000449

About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

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