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ASPET President-Elect Namandje N. Bumpus, PhD Elected to the National Academy of Medicine

Call for Abstracts - ASPET 2023 Annual Meeting - DUE DECEMBER 8

Special Section on Bile Acids, Drug Metabolism, and Toxicity - freely accessible through October 31, 2022

Special Section on Drug Metabolism in Liver injury and Regeneration - freely accessible through December 31, 2022

Special Section on Pharmacokinetics and ADME of Biological Therapeutics - freely accessible through January 31, 2023

Special Section on Drug Metabolism and Regulation - freely accessible through February 28, 2023

Special Section on New Era of Transporter Science: Unraveling the Functional Role of Orphan Transporters - freely accessible through March 31, 2023

Special Section on Mechanistic and Translational Research on Transporters in Toxicology - freely accessible through April 30, 2023

Latest Fast Forward Articles

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Opportunities for accelerating drug discovery and development by using engineered drug-metabolizing enzymes
Elizabeth M. J. Gillam and Valerie M Kramlinger

Drug Metabolism and Disposition December 2, 2022, DMD-MR-2021-000743; DOI: https://doi.org/10.1124/dmd.121.000743
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Comprehensive analyses of the intracellular and in vivo disposition of Fab-siRNA conjugate to identify key issues to improve its in vivo activity
Asami Toshima, Yasuhisa Shiraishi, Daisuke Shinmi, Yoshiyuki Kagawa and Junichi Enokizono

Drug Metabolism and Disposition December 2, 2022, DMD-AR-2022-001098; DOI: https://doi.org/10.1124/dmd.122.001098
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Quantitative CYP3A4 induction risk assessment using human hepatocytes complemented with pregnane X receptor (PXR)-activating profiles
Aynur Ekiciler, Wen Li Kelly Chen, Yan Bo, Alessandra Pugliano, Massimiliano Donzelli, Neil Parrott and Kenichi Umehara

Drug Metabolism and Disposition December 2, 2022, DMD-AR-2022-001132; DOI: https://doi.org/10.1124/dmd.122.001132
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Intravital microscopy reveals unforeseen biodistribution within the liver and kidney mechanistically connected to the clearance of a bifunctional antibody
Amita Datta-Mannan, Bruce A. Molitoris, Yiqing Feng, Michelle M. Martinez, Ruben M. Sandoval, Robin M Brown, Daniel Merkel, Johnny E. Croy and Kenneth W. Dunn

Drug Metabolism and Disposition December 2, 2022, DMD-AR-2022-001049; DOI: https://doi.org/10.1124/dmd.122.001049
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Quantification of accurate composition and total abundance of homologous proteins by conserved-plus-surrogate peptide (CPSP) approach: Quantification of UDP glucuronosyltransferases in human tissues
Deepak Ahire, Mitesh Patel, Sujal V Deshmukh and Bhagwat Prasad

Drug Metabolism and Disposition November 29, 2022, DMD-AR-2022-001155; DOI: https://doi.org/10.1124/dmd.122.001155
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Maternal and Fetal Exposure to (-)-Δ⁹-tetrahydrocannabinol and Its Major Metabolites in Pregnant Mice Is Differentially Impacted by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP)
Xin Chen, Jashvant D. Unadkat and Qingcheng Mao

Drug Metabolism and Disposition November 29, 2022, DMD-AR-2022-001110; DOI: https://doi.org/10.1124/dmd.122.001110

About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

For an alternate route to this Journal use this URL: http://intl-dmd.aspetjournals.org