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Impact of Genetic Polymorphisms and Drug-Drug Interactions Mediated by Carboxylesterase1 on Remimazolam Deactivation
Zhuo Wang, Zachary McCalla, Li Lin, Dominic Tornichio, Yaw Agyemang, John A. Bastulli, Xiaochun Susan Zhang, Hao-Jie Zhu and Xinwen Wang

Drug Metabolism and Disposition November 5, 2024, DMD-AR-2024-001916; DOI: https://doi.org/10.1124/dmd.124.001916
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Pharmacokinetics and ADME Profiling of Tanimilast Following an Intravenous ¹⁴C-Microtracer co-administered with an Inhaled Dose in Healthy Male Individuals
Michele Bassi, Veronica Puviani, Debora Santoro, Sonia Biondaro, Aida Emirova and Mirco Govoni

Drug Metabolism and Disposition October 29, 2024, DMD-AR-2024-001895; DOI: https://doi.org/10.1124/dmd.124.001895
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Uncovering the Impact of COVID-19 Mediated Bidirectional Dysregulation of CYP3A4 on Systemic and Pulmonary Drug Concentrations Using Physiologically Based Pharmacokinetic Modeling
Chukwunonso K. Nwabufo

Drug Metabolism and Disposition October 29, 2024, DMD-AR-2024-001893; DOI: https://doi.org/10.1124/dmd.124.001893
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Heterotropic Allosteric Modulation of CYP3A4 In Vitro by Progesterone: Evidence for Improvement in Prediction of Time Dependent Inhibition for Macrolides
Luc R.A. Rougee, Pooja V. Hegde, Kaitlin Shin, Trent L. Abraham, Alec Bell and Stephen D. Hall

Drug Metabolism and Disposition October 29, 2024, DMD-AR-2024-001820; DOI: https://doi.org/10.1124/dmd.124.001820
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Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone
Rei Sato, Tatsuki Fukami, Kazuya Shimomura, Yongjie Zhang, Masataka Nakano and Miki Nakajima

Drug Metabolism and Disposition October 29, 2024, DMD-AR-2024-001917; DOI: https://doi.org/10.1124/dmd.124.001917
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Environmentally Persistent Free Radicals stimulate CYP2E1-mediated generation of reactive oxygen species at the expense of substrate metabolism
George F Cawley, J. Patrick Connick, Marilyn K Eyer and Wayne L. Backes

Drug Metabolism and Disposition October 21, 2024, DMD-AR-2024-001939; DOI: https://doi.org/10.1124/dmd.124.001939

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DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

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