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Role of epoxide hydrolases and cytochrome P450s on metabolism of KZR-616, a first-in-class selective inhibitor of the immunoproteasome
Ying Fang, Henry Johnson, Janet L. Anderl, Tony Muchamuel, Dustin McMinn, Christophe Morisseau, Bruce D. Hammock, Christopher Kirk and Jinhai Wang

Drug Metabolism and Disposition July 7, 2021, DMD-AR-2020-000307; DOI: https://doi.org/10.1124/dmd.120.000307
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The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man
Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher R. Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Christopher Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu

Drug Metabolism and Disposition June 29, 2021, DMD-MR-2021-000428; DOI: https://doi.org/10.1124/dmd.121.000428
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Characterization of Hepatic UDP-Glucuronosyl Transferase Enzyme Abundance - Activity Correlations and Population Variability using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes
Ryan H. Takahashi, William F. Forrest, Alexander D. Smith, Justine Badée, NaHong Qiu, Stephan Schmidt, Abby C. Collier, Neil Parrott and Stephen Fowler

Drug Metabolism and Disposition June 29, 2021, DMD-AR-2021-000474; DOI: https://doi.org/10.1124/dmd.121.000474
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Silybin restored CYP3A expression through the SIRT2/NF-κB pathway in mouse nonalcoholic fatty liver disease
Ran Zhang, Dan Xu, Yirui Zhang, Rui Wang, Na Yang, Yunge Lou, Haokai Zhao, Jiye Aa, Guangji Wang and Yuan Xie

Drug Metabolism and Disposition June 28, 2021, DMD-AR-2021-000438; DOI: https://doi.org/10.1124/dmd.121.000438
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The inactivation of human aldehyde oxidase 1 by hydrogen peroxide and superoxide
Claudia Garrido and Silke Leimkuehler

Drug Metabolism and Disposition June 28, 2021, DMD-AR-2021-000549; DOI: https://doi.org/10.1124/dmd.121.000549
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Development of Robust QSAR Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition
Eric Gonzalez, Sankalp Jain, Pranav Shah, Nao Torimoto-Katori, Alexey Zakharov, Ðắc-Trung Nguyễn, Srilatha Sakamuru, Ruili Huang, Menghang Xia, R. Scott Obach, Cornelis E.C.A. Hop, Anton Simeonov and Xin Xu

Drug Metabolism and Disposition June 28, 2021, DMD-AR-2020-000320; DOI: https://doi.org/10.1124/dmd.120.000320

About Drug Metabolism & Disposition

DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.

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