Most cited article(s)

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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
D J Newton, R W Wang and A Y Lu

Drug Metabolism and Disposition January 1995, 23 (1) 154-158;
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Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
R. Scott Obach

Drug Metabolism and Disposition November 1999, 27 (11) 1350-1359;
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THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
Mary F. Paine, Heather L. Hart, Shana S. Ludington, Robert L. Haining, Allan E. Rettie and Darryl C. Zeldin

Drug Metabolism and Disposition May 2006, 34 (5) 880-886; DOI: https://doi.org/10.1124/dmd.105.008672
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DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
J. Andrew Williams, Ruth Hyland, Barry C. Jones, Dennis A. Smith, Susan Hurst, Theunis C. Goosen, Vincent Peterkin, Jeffrey R. Koup and Simon E. Ball

Drug Metabolism and Disposition November 2004, 32 (11) 1201-1208; DOI: https://doi.org/10.1124/dmd.104.000794
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In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
J. Brian Houston and Kathryn E. Kenworthy

Drug Metabolism and Disposition March 2000, 28 (3) 246-254;
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THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE
Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, Volker Fischer, Lawrence Gan, Scott Grimm, John Kao, S. Peter King, Gerald Miwa, Lan Ni, Gondi Kumar, James McLeod, R. Scott Obach, Stanley Roberts, Amy Roe, Anita Shah, Fred Snikeris, John T. Sullivan, Donald Tweedie, Jose M. Vega, John Walsh and Steven A. Wrighton

Drug Metabolism and Disposition July 2003, 31 (7) 815-832; DOI: https://doi.org/10.1124/dmd.31.7.815
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Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions
R. Scott Obach, Robert L. Walsky and Karthik Venkatakrishnan

Drug Metabolism and Disposition February 2007, 35 (2) 246-255; DOI: https://doi.org/10.1124/dmd.106.012633
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Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity
Stephanie R. Faucette, Roy L. Hawke, Edward L. Lecluyse, Stacy S. Shord, Bingfang Yan, Ronald M. Laethem and Celeste M. Lindley

Drug Metabolism and Disposition October 2000, 28 (10) 1222-1230;
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Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki

Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
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HUMAN UDP-GLUCURONOSYLTRANSFERASES: ISOFORM SELECTIVITY AND KINETICS OF 4-METHYLUMBELLIFERONE AND 1-NAPHTHOL GLUCURONIDATION, EFFECTS OF ORGANIC SOLVENTS, AND INHIBITION BY DICLOFENAC AND PROBENECID
Verawan Uchaipichat, Peter I. Mackenzie, Xiao-Hui Guo, Dione Gardner-Stephen, Aleksandra Galetin, J. Brian Houston and John O. Miners

Drug Metabolism and Disposition April 2004, 32 (4) 413-423; DOI: https://doi.org/10.1124/dmd.32.4.413

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