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Drug Metabolism & Disposition

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Most read article(s)

  • Open Access
    Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species
    Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang
    Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395
  • You have access
    Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
    Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh
    Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744
  • You have access
    Physiologically Based Pharmacokinetic Modeling for Sequential Metabolism: Effect of CYP2C19 Genetic Polymorphism on Clopidogrel and Clopidogrel Active Metabolite Pharmacokinetics
    Nassim Djebli, David Fabre, Xavier Boulenc, Gérard Fabre, Eric Sultan and Fabrice Hurbin
    Drug Metabolism and Disposition April 2015, 43 (4) 510-522; DOI: https://doi.org/10.1124/dmd.114.062596
  • Open Access
    Mechanisms Influencing the Pharmacokinetics and Disposition of Monoclonal Antibodies and Peptides
    Amita Datta-Mannan
    Drug Metabolism and Disposition October 2019, 47 (10) 1100-1110; DOI: https://doi.org/10.1124/dmd.119.086488
  • Open Access
    Physiology of the Neonatal Gastrointestinal System Relevant to the Disposition of Orally Administered Medications
    April Neal-Kluever, Jeffrey Fisher, Lawrence Grylack, Satoko Kakiuchi-Kiyota and Wendy Halpern
    Drug Metabolism and Disposition March 2019, 47 (3) 296-313; DOI: https://doi.org/10.1124/dmd.118.084418
  • Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds
    Open Access
    Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds
    Neha Murad, Kishore K. Pasikanti, Benjamin D. Madej, Amanda Minnich, Juliet M. McComas, Sabrinia Crouch, Joseph W. Polli and Andrew D. Weber
    Drug Metabolism and Disposition February 2021, 49 (2) 169-178; DOI: https://doi.org/10.1124/dmd.120.000202
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    Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification
    Jennifer E. Sager, Jingjing Yu, Isabelle Ragueneau-Majlessi and Nina Isoherranen
    Drug Metabolism and Disposition November 2015, 43 (11) 1823-1837; DOI: https://doi.org/10.1124/dmd.115.065920
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    Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
    Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
    Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055
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    The Major Facilitative Folate Transporters Solute Carrier 19A1 and Solute Carrier 46A1: Biology and Role in Antifolate Chemotherapy of Cancer
    Larry H. Matherly, Mike R. Wilson and Zhanjun Hou
    Drug Metabolism and Disposition April 2014, 42 (4) 632-649; DOI: https://doi.org/10.1124/dmd.113.055723
  • Plasma and Liver Protein Binding of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA
    You have access
    Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA
    Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M. Rock
    Drug Metabolism and Disposition October 2019, 47 (10) 1174-1182; DOI: https://doi.org/10.1124/dmd.119.086967

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