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Drug Metabolism & Disposition

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Most read article(s)

  • You have access
    Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics
    Niall Heyes, Parth Kapoor and Ian D. Kerr
    Drug Metabolism and Disposition December 2018, 46 (12) 1886-1899; DOI: https://doi.org/10.1124/dmd.118.083030
  • Open Access
    Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions
    Shamema Nasrin, Christy J.W. Watson, Yadira X Perez-Paramo and Philip Lazarus
    Drug Metabolism and Disposition December 2021, 49 (12) 1070-1080; DOI: https://doi.org/10.1124/dmd.121.000442
  • The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
    Open Access
    The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
    Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
    Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428
  • You have access
    Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges
    Simone Schadt, Simon Hauri, Filipe Lopes, Martin R. Edelmann, Roland F. Staack, Roberto Villaseñor, Hubert Kettenberger, Adrian B. Roth, Franz Schuler, Wolfgang F. Richter and Christoph Funk
    Drug Metabolism and Disposition December 2019, 47 (12) 1443-1456; DOI: https://doi.org/10.1124/dmd.119.088997
  • Open Access
    Physiology of the Neonatal Gastrointestinal System Relevant to the Disposition of Orally Administered Medications
    April Neal-Kluever, Jeffrey Fisher, Lawrence Grylack, Satoko Kakiuchi-Kiyota and Wendy Halpern
    Drug Metabolism and Disposition March 2019, 47 (3) 296-313; DOI: https://doi.org/10.1124/dmd.118.084418
  • You have access
    Finding Tmax and Cmax in Multicompartmental Models
    Yi Rang Han, Ping I. Lee and K. Sandy Pang
    Drug Metabolism and Disposition November 2018, 46 (11) 1796-1804; DOI: https://doi.org/10.1124/dmd.118.082636
  • You have access
    Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters
    David J. Wagner, Jennifer E. Sager, Haichuan Duan, Nina Isoherranen and Joanne Wang
    Drug Metabolism and Disposition July 2017, 45 (7) 770-778; DOI: https://doi.org/10.1124/dmd.116.074708
  • You have access
    Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism
    Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen
    Drug Metabolism and Disposition April 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254
  • You have access
    Quantitative CYP3A4 induction risk assessment using human hepatocytes complemented with pregnane X receptor (PXR)-activating profiles
    Aynur Ekiciler, Wen Li Kelly Chen, Yan Bo, Alessandra Pugliano, Massimiliano Donzelli, Neil Parrott and Kenichi Umehara
    Drug Metabolism and Disposition December 2, 2022, DMD-AR-2022-001132; DOI: https://doi.org/10.1124/dmd.122.001132
  • Open Access
    Identification of 5-Hydroxycotinine in the Plasma of Nicotine-Treated Mice: Implications for Cotinine Metabolism and Disposition in Vivo
    Keiko Kanamori, Syed M. Ahmad, Chang Sung Shin, Abdul Hamid and Kabirullah Lutfy
    Drug Metabolism and Disposition December 2022, 50 (12) 1454-1463; DOI: https://doi.org/10.1124/dmd.122.001059

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