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Addressing today's ADME challenges in the translation of in vitro absorption, distribution, metabolism and excretion characteristics to human: A case study of the SMN2 mRNA splicing modifier risdiplam
Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Guenther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole A. Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich W. Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier

Drug Metabolism and Disposition October 7, 2021, DMD-MR-2021-000563; DOI: https://doi.org/10.1124/dmd.121.000563
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Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition
Jennifer Tang, Hong Shen, Xiaofeng Zhao, Vinay K. Holenarsipur, T. Thanga Mariappan, Yueping Zhang, Erika Panfen, Jim Zheng, W. Griffith Humphreys and Yurong Lai

Drug Metabolism and Disposition December 2021, 49 (12) 1063-1069; DOI: https://doi.org/10.1124/dmd.121.000486
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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh

Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744
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Pharmacokinetics and ADME characterization of intravenous and oral [¹⁴C]-linerixibat in healthy male volunteers
Maciej J. Zamek-Gliszczynski, David Kenworthy, David A. Bershas, Mitesh Sanghvi, Adrian I. Pereira, Jennypher Mudunuru, Lee Crossman, Jill L. Pirhalla, Karl M. Thorpe, Jeremy M.T.J. Dennison, Megan M. McLaughlin, Matthew Allinder, Brandon Swift, Robin L. O'Connor-Semmes and Graeme C. Young

Drug Metabolism and Disposition October 8, 2021, DMD-AR-2021-000595; DOI: https://doi.org/10.1124/dmd.121.000595
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Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group

Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
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Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species
Noah Post, Rosie Yu, Sarah Greenlee, Hans Gaus, Eunju Hurh, John Matson and Yanfeng Wang

Drug Metabolism and Disposition October 2019, 47 (10) 1164-1173; DOI: https://doi.org/10.1124/dmd.119.087395
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Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome
Ying Fang, Henry Johnson, Janet L. Anderl, Tony Muchamuel, Dustin McMinn, Christophe Morisseau, Bruce D. Hammock, Christopher Kirk and Jinhai Wang

Drug Metabolism and Disposition September 2021, 49 (9) 810-821; DOI: https://doi.org/10.1124/dmd.120.000307
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Metabolism and Hepatotoxicity of Pyrazinamide, an Antituberculosis Drug
Zahir Hussain, Junjie Zhu and Xiaochao Ma

Drug Metabolism and Disposition August 2021, 49 (8) 679-682; DOI: https://doi.org/10.1124/dmd.121.000389
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Cytochrome P450 Binding and Bioactivation of Tumor-targeted Duocarmycin Agents
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott

Drug Metabolism and Disposition October 4, 2021, DMD-AR-2021-000642; DOI: https://doi.org/10.1124/dmd.121.000642
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Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds
Neha Murad, Kishore K. Pasikanti, Benjamin D. Madej, Amanda Minnich, Juliet M. McComas, Sabrinia Crouch, Joseph W. Polli and Andrew D. Weber

Drug Metabolism and Disposition February 2021, 49 (2) 169-178; DOI: https://doi.org/10.1124/dmd.120.000202

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