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Drug Metabolism & Disposition

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Most read article(s)

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    Tetrahydrocannabinol and Its Major Metabolites Are Not (or Are Poor) Substrates or Inhibitors of Human P-Glycoprotein [ATP-Binding Cassette (ABC) B1] and Breast Cancer Resistance Protein (ABCG2)
    Xin Chen, Jashvant D. Unadkat and Qingcheng Mao
    Drug Metabolism and Disposition October 2021, 49 (10) 910-918; DOI: https://doi.org/10.1124/dmd.121.000505
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    Quantitation of Plasma Membrane Drug Transporters in Kidney Tissue and Cell Lines Using a Novel Proteomic Approach Enabled a Prospective Prediction of Metformin Disposition
    Ryota Kikuchi, William J. Chiou, Kenneth R. Durbin, John P. Savaryn, Junli Ma, Arian Emami Riedmaier, Sonia M. de Morais, Gary J. Jenkins and Daniel A.J. Bow
    Drug Metabolism and Disposition October 2021, 49 (10) 938-946; DOI: https://doi.org/10.1124/dmd.121.000487
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    Cytochrome b5 Binds Tightly to Several Human Cytochrome P450 Enzymes
    Donghak Kim, Vitchan Kim, Yasuhiro Tateishi and F. Peter Guengerich
    Drug Metabolism and Disposition October 2021, 49 (10) 902-909; DOI: https://doi.org/10.1124/dmd.121.000475
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    Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate
    Chen Sun, Huimin Zhao, Wei Li, Yudi Jia, Yi Yang, Ying Peng and Jiang Zheng
    Drug Metabolism and Disposition October 2021, 49 (10) 892-901; DOI: https://doi.org/10.1124/dmd.121.000369
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    Finding Tmax and Cmax in Multicompartmental Models
    Yi Rang Han, Ping I. Lee and K. Sandy Pang
    Drug Metabolism and Disposition November 2018, 46 (11) 1796-1804; DOI: https://doi.org/10.1124/dmd.118.082636
  • The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
    Open Access
    The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
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    Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428
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    Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans
    Heather Eng, Alyssa L. Dantonio, Eugene P. Kadar, R. Scott Obach, Li Di, Jian Lin, Nandini C. Patel, Britton Boras, Gregory S. Walker, Jonathan J. Novak, Emi Kimoto, Ravi Shankar P. Singh and Amit S. Kalgutkar
    Drug Metabolism and Disposition May 2022, 50 (5) 576-590; DOI: https://doi.org/10.1124/dmd.121.000801
  • Open Access
    Determination of Acyl-, O-, and N-Glucuronide Using Chemical Derivatization Coupled with Liquid Chromatography–High-Resolution Mass Spectrometry
    Yukuang Guo, Abhi Shah, Eugene Oh, Swapan K. Chowdhury and Xiaochun Zhu
    Drug Metabolism and Disposition May 2022, 50 (5) 716-724; DOI: https://doi.org/10.1124/dmd.122.000832
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    Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters
    David J. Wagner, Jennifer E. Sager, Haichuan Duan, Nina Isoherranen and Joanne Wang
    Drug Metabolism and Disposition July 2017, 45 (7) 770-778; DOI: https://doi.org/10.1124/dmd.116.074708
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    Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities
    Brooke M. Rock and Robert S. Foti
    Drug Metabolism and Disposition October 2019, 47 (10) 1097-1099; DOI: https://doi.org/10.1124/dmd.119.088708

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