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Drug Metabolism & Disposition

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Most read article(s)

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    Effect of Human Plasma on Hepatic Uptake of Organic Anion–Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes
    Yi-an Bi, Sangwoo Ryu, David A. Tess, A. David Rodrigues and Manthena V. S. Varma
    Drug Metabolism and Disposition January 2021, 49 (1) 72-83; DOI: https://doi.org/10.1124/dmd.120.000134
  • You have access
    Microbiome Disturbances and Autism Spectrum Disorders
    Cheryl S. Rosenfeld
    Drug Metabolism and Disposition October 2015, 43 (10) 1557-1571; DOI: https://doi.org/10.1124/dmd.115.063826
  • Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1′-Hydroxylation and Testosterone 6<em>β</em>-Hydroxylation
    You have access
    Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1′-Hydroxylation and Testosterone 6β-Hydroxylation
    Masaki Kumondai, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Akiko Ueda, Sakae Saito, Daisuke Saigusa, Shu Tadaka, Kengo Kinoshita, Tomoki Nakayoshi, Akifumi Oda, Ai Abe, Masamitsu Maekawa, Nariyasu Mano, Noriyasu Hirasawa and Masahiro Hiratsuka
    Drug Metabolism and Disposition March 2021, 49 (3) 212-220; DOI: https://doi.org/10.1124/dmd.120.000261
  • In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics
    You have access
    In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics
    Kazuo Takayama, Kohei Ito, Akiko Matsui, Tomoki Yamashita, Kentaro Kawakami, Daisuke Hirayama, Wataru Kishimoto, Hiroshi Nakase and Hiroyuki Mizuguchi
    Drug Metabolism and Disposition March 2021, 49 (3) 221-232; DOI: https://doi.org/10.1124/dmd.120.000283
  • You have access
    Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions
    Hee Eun Kang, Melina M. Malinen, Chitra Saran, Paavo Honkakoski and Kim L.R. Brouwer
    Drug Metabolism and Disposition October 2019, 47 (10) 1222-1230; DOI: https://doi.org/10.1124/dmd.119.087676
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    The Reliability of Estimating Ki Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC50 Values: A Retrospective Analysis of 343 Experiments
    Lois J. Haupt, Faraz Kazmi, Brian W. Ogilvie, David B. Buckley, Brian D. Smith, Sarah Leatherman, Brandy Paris, Oliver Parkinson and Andrew Parkinson
    Drug Metabolism and Disposition November 2015, 43 (11) 1744-1750; DOI: https://doi.org/10.1124/dmd.115.066597
  • Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
    Open Access
    Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
    Mary Alexandra Schleiff, Noah R. Flynn, Sasin Payakachat, Benjamin Mark Schleiff, Anna O. Pinson, Dennis W. Province, S. Joshua Swamidass, Gunnar Boysen and Grover P. Miller
    Drug Metabolism and Disposition February 2021, 49 (2) 133-141; DOI: https://doi.org/10.1124/dmd.120.000254
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    Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters
    David J. Wagner, Jennifer E. Sager, Haichuan Duan, Nina Isoherranen and Joanne Wang
    Drug Metabolism and Disposition July 2017, 45 (7) 770-778; DOI: https://doi.org/10.1124/dmd.116.074708
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    Finding Tmax and Cmax in Multicompartmental Models
    Yi Rang Han, Ping I. Lee and K. Sandy Pang
    Drug Metabolism and Disposition November 2018, 46 (11) 1796-1804; DOI: https://doi.org/10.1124/dmd.118.082636
  • Open Access
    Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs
    Philip Gardiner, Rhona J. Cox and Ken Grime
    Drug Metabolism and Disposition August 2019, 47 (8) 865-873; DOI: https://doi.org/10.1124/dmd.119.087163

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