Most read article(s)

Open Access
Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
Mary Alexandra Schleiff, Noah R. Flynn, Sasin Payakachat, Benjamin Mark Schleiff, Anna O. Pinson, Dennis W. Province, S. Joshua Swamidass, Gunnar Boysen and Grover P. Miller

Drug Metabolism and Disposition February 2021, 49 (2) 133-141; DOI: https://doi.org/10.1124/dmd.120.000254
You have access
The Reliability of Estimating K_i Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC₅₀ Values: A Retrospective Analysis of 343 Experiments
Lois J. Haupt, Faraz Kazmi, Brian W. Ogilvie, David B. Buckley, Brian D. Smith, Sarah Leatherman, Brandy Paris, Oliver Parkinson and Andrew Parkinson

Drug Metabolism and Disposition November 2015, 43 (11) 1744-1750; DOI: https://doi.org/10.1124/dmd.115.066597
Open Access
Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy
Satoshi Koyama, Kota Toshimoto, Wooin Lee, Yasunori Aoki and Yuichi Sugiyama

Drug Metabolism and Disposition April 2021, 49 (4) 298-304; DOI: https://doi.org/10.1124/dmd.120.000023
Open Access
Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi–Physiologically Based Modeling Approaches
Kefeng Sun and Devin Welty

Drug Metabolism and Disposition November 2021, 49 (11) 1025-1037; DOI: https://doi.org/10.1124/dmd.121.000493
You have access
Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification
Jennifer E. Sager, Jingjing Yu, Isabelle Ragueneau-Majlessi and Nina Isoherranen

Drug Metabolism and Disposition November 2015, 43 (11) 1823-1837; DOI: https://doi.org/10.1124/dmd.115.065920
Open Access
Preliminary Flow Modeling by Hybrid Automata Alternating Continuous Reaction and Discrete Transit for Pharmacokinetics
Satoshi Koyama

Drug Metabolism and Disposition July 2021, 49 (7) 521-529; DOI: https://doi.org/10.1124/dmd.120.000227
Open Access
Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease
Diede Fennema, Ian R. Phillips and Elizabeth A. Shephard

Drug Metabolism and Disposition November 2016, 44 (11) 1839-1850; DOI: https://doi.org/10.1124/dmd.116.070615
You have access
Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics
Dominique A. Ramirez, Keagan P. Collins, Allister E. Aradi, Katherine A. Conger and Daniel L. Gustafson

Drug Metabolism and Disposition March 2019, 47 (3) 257-268; DOI: https://doi.org/10.1124/dmd.118.083766
You have access
Metabolism of Oral Turinabol by Human Steroid Hormone–Synthesizing Cytochrome P450 Enzymes
Lina Schiffer, Simone Brixius-Anderko, Frank Hannemann, Josef Zapp, Jens Neunzig, Mario Thevis and Rita Bernhardt

Drug Metabolism and Disposition February 2016, 44 (2) 227-237; DOI: https://doi.org/10.1124/dmd.115.066829
You have access
Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
Franco Lombardo, Giuliano Berellini and R. Scott Obach

Drug Metabolism and Disposition November 2018, 46 (11) 1466-1477; DOI: https://doi.org/10.1124/dmd.118.082966

Main menu

User menu

Search

Most read article(s)

Pages

Navigate

More Information

ASPET's Other Journals