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A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance
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Drug Metabolism and Disposition June 2018, 46 (6) 865-878; DOI: https://doi.org/10.1124/dmd.117.079848
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Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders
Laurie P. Volak, Heide Marika Duevel, Sara Humphreys, David Nettleton, Colin Phipps, Andy Pike, Caroline Rynn, Paul Scott-Stevens, Donglu Zhang and Michael Zientek

Drug Metabolism and Disposition July 2023, 51 (7) 792-803; DOI: https://doi.org/10.1124/dmd.122.001154
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Metabolism and excretion of therapeutic peptides: current industry practices, perspectives, and recommendations
Minxia Michelle He, Sean Xiaochun Zhu, Joe R Cannon, Jesper Kammersgaard Christensen, Ruchia Duggal, Mithat Gunduz, Constanze Hilgendorf, Adam Hughes, Ivy Kekessie, Maximilian Kullmann, Dennis Leung, Carsten Terjung, Kai Wang and Frank Wesche

Drug Metabolism and Disposition August 17, 2023, DMD-AR-2023-001437; DOI: https://doi.org/10.1124/dmd.123.001437
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Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity
Linlin Sheng, Qi Luo and Ligong Chen

Drug Metabolism and Disposition September 2022, 50 (9) 1228-1237; DOI: https://doi.org/10.1124/dmd.121.000705
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Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants
Heather Eng, Elaine Tseng, Matthew A. Cerny, Theunis C. Goosen and R. Scott Obach

Drug Metabolism and Disposition June 2021, 49 (6) 442-450; DOI: https://doi.org/10.1124/dmd.121.000356
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Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A
Saki Izumi, Yoshitane Nozaki, Wooin Lee and Yuichi Sugiyama

Drug Metabolism and Disposition May 2022, 50 (5) 541-551; DOI: https://doi.org/10.1124/dmd.121.000783
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Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs
Philip Gardiner, Rhona J. Cox and Ken Grime

Drug Metabolism and Disposition August 2019, 47 (8) 865-873; DOI: https://doi.org/10.1124/dmd.119.087163
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Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
Kathryn Ball, Gerard Bruin, Enrique Escandón, Christoph Funk, Joao N.S. Pereira, Tong-Yuan Yang and Hongbin Yu

Drug Metabolism and Disposition June 2022, 50 (6) 858-866; DOI: https://doi.org/10.1124/dmd.121.000463
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Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators
Lucy Her and Hao-Jie Zhu

Drug Metabolism and Disposition March 2020, 48 (3) 230-244; DOI: https://doi.org/10.1124/dmd.119.089680
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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities
Donglu Zhang, Cornelis E.C.A. Hop, Gabriela Patilea-Vrana, Gautham Gampa, Herana Kamal Seneviratne, Jashvant D. Unadkat, Jane R. Kenny, Karthik Nagapudi, Li Di, Lian Zhou, Mark Zak, Matthew R. Wright, Namandjé N. Bumpus, Richard Zang, Xingrong Liu, Yurong Lai and S. Cyrus Khojasteh

Drug Metabolism and Disposition October 2019, 47 (10) 1122-1135; DOI: https://doi.org/10.1124/dmd.119.086744

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