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Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans
Heather Eng, Alyssa L. Dantonio, Eugene P. Kadar, R. Scott Obach, Li Di, Jian Lin, Nandini C. Patel, Britton Boras, Gregory S. Walker, Jonathan J. Novak, Emi Kimoto, Ravi Shankar P. Singh and Amit S. Kalgutkar

Drug Metabolism and Disposition May 2022, 50 (5) 576-590; DOI: https://doi.org/10.1124/dmd.121.000801
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Use of Traditional and Proteomic Methods in the Assessment of a Preclinical Model of Preeclampsia
Wanying Dai, Angela Pollinzi and Micheline Piquette-Miller

Drug Metabolism and Disposition October 2023, 51 (10) 1308-1315; DOI: https://doi.org/10.1124/dmd.122.001080
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Absorption, Distribution, Metabolism, and Excretion of [¹⁴C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro Studies
Alexander David James, Kenneth Kulmatycki, Birk Poller, Andrea A. Romeo, Jan Jaap Van Lier, Kai Klein and David Pearson

Drug Metabolism and Disposition July 2023, 51 (7) 873-883; DOI: https://doi.org/10.1124/dmd.123.001290
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Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds
Neha Murad, Kishore K. Pasikanti, Benjamin D. Madej, Amanda Minnich, Juliet M. McComas, Sabrinia Crouch, Joseph W. Polli and Andrew D. Weber

Drug Metabolism and Disposition February 2021, 49 (2) 169-178; DOI: https://doi.org/10.1124/dmd.120.000202
Open Access
Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metabolites
Shamema Nasrin, Christy J. W. Watson, Keti Bardhi, Gabriela Fort, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition December 2021, 49 (12) 1081-1089; DOI: https://doi.org/10.1124/dmd.121.000530
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Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
Donglu Zhang, Peter S. Dragovich, Shang-Fan Yu, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Wei Wang, Andrew Polson, S. Cyrus Khojasteh and Cornelis E.C.A. Hop

Drug Metabolism and Disposition October 2019, 47 (10) 1146-1155; DOI: https://doi.org/10.1124/dmd.119.087023
Open Access
Unusual Biotransformation Reactions of Drugs and Drug Candidates
Emre M. Isin

Drug Metabolism and Disposition April 2023, 51 (4) 413-426; DOI: https://doi.org/10.1124/dmd.121.000744
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Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants
Heather Eng, Elaine Tseng, Matthew A. Cerny, Theunis C. Goosen and R. Scott Obach

Drug Metabolism and Disposition June 2021, 49 (6) 442-450; DOI: https://doi.org/10.1124/dmd.121.000356
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Cytochrome P450 and Other Drug-Metabolizing Enzymes As Therapeutic Targets
Robert S. Foti

Drug Metabolism and Disposition August 2023, 51 (8) 936-949; DOI: https://doi.org/10.1124/dmd.122.001011
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Special Section On Drug Metabolism in Liver Injury and Repair—Editorial
Xiao-bo Zhong and Yurong Lai

Drug Metabolism and Disposition May 2022, 50 (5) 634-635; DOI: https://doi.org/10.1124/dmd.122.000869

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