Drug Metabolism and Disposition: 1 (1)

January 01, 1973; Volume 1,Issue 1

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STRUCTURAL ASPECTS OF THE ACTIVE SITE OF CYTOCHROME P-45O_cam
J. D. LIPSCOMB and I. C. GUNSALUS

Drug Metabolism and Disposition January 1973, 1 (1) 1-5;
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PARTIAL PURIFICATION AND SOME SPECTRAL PROPERTIES OF HEPATIC MICROSOMAL CYTOCHROME P-450
RYO SATO, HARUHIKO SATAKE and YOSHIO IMAI

Drug Metabolism and Disposition January 1973, 1 (1) 6-13;
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PSEUDOMONAS PUTIDA CYTOCHROME P-450: LIGANDS OF THE SUBSTRATE-FREE AND SUBSTRATE-BOUND STATES OF THE FERRIC HEMOPROTEIN
JULIAN A. PETERSON and BRENDA WALKER GRIFFIN

Drug Metabolism and Disposition January 1973, 1 (1) 14-20;
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CHEMISTRY OF CYTOCHROME P-450 PURIFIED FROM ENDOCRINE SYSTEMS
DAVID Y. COOPER, HEINZ SCHLEYER and OTTO ROSENTHAL

Drug Metabolism and Disposition January 1973, 1 (1) 21-28;
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CHARACTERIZATION OF PARTIALLY PURIFIED CYTOCHROMES P-450 AND P-448 FROM RAT LIVER MICROSOMES
ANTHONY Y. H. LU, SUSAN B. WEST, DENE RYAN and WAYNE LEVIN

Drug Metabolism and Disposition January 1973, 1 (1) 29-39;
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DIFFERENCES IN P-420 HEMOPROTEINS FROM UNTREATED AND 3-METHYLCHOLANTHRENE-TREATED RATS
D. W. SHOEMAN, FLOIE M. VANE and G. J. MANNERING

Drug Metabolism and Disposition January 1973, 1 (1) 40-44;
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OPTICAL AND MAGNETIC PROBES OF THE STRUCTURE OF CYTOCHROME P-450’S
J. PEISACH, J. O. STERN and W. E. BLUMBERG

Drug Metabolism and Disposition January 1973, 1 (1) 45-61;
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CYTOCHROME P-450 ASSOCIATED WITH FREE HEPATIC POLYRIBOSOMES
Y. ICHIKAWA and H. S. MASON

Drug Metabolism and Disposition January 1973, 1 (1) 62-65;
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DYNAMIC ORGANIZATION OF ENDOPLASMIC RETICULUM MEMBRANES
LARS ERNSTER and STEN ORRENIUS

Drug Metabolism and Disposition January 1973, 1 (1) 66-73;
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KINETICS AND INELASTIC LIGHT-SCATTERING STUDIES OF THE ROLE OF PHOSPHOLIPIDS IN THE MICROSOMAL MEMBRANE STRUCTURE
JORDAN L. HOLTZMAN, RICHARD R. ERICKSON, THEODORE E. GRAM, RAJ K. DEWAN and VICTOR A. BLOOMFIELD

Drug Metabolism and Disposition January 1973, 1 (1) 74-79;
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TURNOVER OF ENZYME PROTEINS IN MICROSOMAL MEMBRANE
MASAHIKO NEGISHI and TSUNEO OMURA

Drug Metabolism and Disposition January 1973, 1 (1) 80-83;
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THE SYNTHESIS AND DEGRADATION OF MEMBRANE PROTEINS
JOHN M. TAYLOR, PETER J. DEHLINGER, J. FRED DICE and ROBERT T. SCHIMKE

Drug Metabolism and Disposition January 1973, 1 (1) 84-91;
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ON THE MECHANISM OF HYDROXYLATION REACTIONS CATALYZED BY CYTOCHROME P-450
MINOR J. COON, HENRY W. STROBEL and RODNEY F. BOYER

Drug Metabolism and Disposition January 1973, 1 (1) 92-97;
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STUDIES ON THE MOLECULAR FUNCTION OF CYTOCHROME P-450 DURING DRUG METABOLISM
RONALD W. ESTABROOK, TAKASHI MATSUBARA, J. IAN MASON, JURGEN WERRINGLOER and JEFFREY BARON

Drug Metabolism and Disposition January 1973, 1 (1) 98-110;
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NEWER ASPECTS OF SUBSTRATE BINDING TO CYTOCHROME P-450
JOHN B. SCHENKMAN, DOMINICK L. CINTI, PETER W. MOLDEUS and STEN ORRENIUS

Drug Metabolism and Disposition January 1973, 1 (1) 111-120;
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NADPH-CYTOCHROME c REDUCTASE AND ITS ROLE IN MICROSOMAL CYTOCHROME P-450-DEPENDENT REACTIONS
BETTIE SUE SILER MASTERS, EDWARD B. NELSON, BRENT A. SCHACTER, JEFFREY BARON and ELIZABETH L. ISAACSON

Drug Metabolism and Disposition January 1973, 1 (1) 121-128;
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THE ROLE OF OXYGENATED CYTOCHROME P-450 AND OF CYTOCHROME b₅ IN HEPATIC MICROSOMAL DRUG OXIDATIONS
JEFFREY BARON, ALFRED G. HILDEBRANDT, JULIAN A. PETERSON and RONALD W. ESTABROOK

Drug Metabolism and Disposition January 1973, 1 (1) 129-138;
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DPNH SYNERGISM OF TPNH-DEPENDENT MIXED FUNCTION OXIDASE REACTIONS
MARIA ALMIRA CORREIA and G. J. MANNERING

Drug Metabolism and Disposition January 1973, 1 (1) 139-149;
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RELATIONSHIP BETWEEN NADH AND NADPH OXIDATION DURING DRUG METABOLISM
HENRY A. SASAME, JERRY R. MITCHELL, SNORRI THORGEIRSSON and JAMES R. GILLETTE

Drug Metabolism and Disposition January 1973, 1 (1) 150-155;
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ROLE OF PHOSPHOLIPID IN THE RECONSTITUTED LIVER MICROSOMAL MIXED FUNCTION OXIDASE SYSTEM CONTAINING CYTOCHROME P-450 AND NADPH-CYTOCHROME P-450 REDUCTASE
ANNE P. AUTOR, ROBERT M. KASCHNITZ, JOANNE K. HEIDEMA, THEODORE A. VAN DER HOEVEN, WILFRIED DUPPEL and MINOR J. COON

Drug Metabolism and Disposition January 1973, 1 (1) 156-161;
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EFFECTS OF INHIBITORS ON DRUG METABOLISM
K. J. NETTER

Drug Metabolism and Disposition January 1973, 1 (1) 162-163;
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MECHANISMS OF INHIBITION OF DRUG METABOLIC REACTIONS
J. GILLETTE, H. SASAME and B. STRIPP

Drug Metabolism and Disposition January 1973, 1 (1) 164-175;
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FORMATION AND BINDING OF CARBANIONS BY CYTOCHROME P-450 OF LIVER MICROSOMES
V. ULLRICH and K. H. SCHNABEL

Drug Metabolism and Disposition January 1973, 1 (1) 176-183;
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METYRAPONE AND OTHER MODIFIERS OF MICROSOMAL DRUG METABOLISM
KENNETH C. LEIBMAN and ELSA ORTIZ

Drug Metabolism and Disposition January 1973, 1 (1) 184-190;
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ENHANCEMENT OF TYPE II SUBSTRATE OXIDATION AND OF AZO REDUCTION IN THE ISOLATED RAT LIVER AND IN VITRO BY METYRAPONE
G. F. KAHL, K. MINCK and K. J. NETTER

Drug Metabolism and Disposition January 1973, 1 (1) 191-193;
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DETERMINATION OF ACTIVE CENTERS OF HEPATIC MICROSOMAL CYTOCHROME P-450 BY METYRAPONE, APPLYING MUTUAL DEPLETION SYSTEM KINETICS
I. ROOTS and A. G. HILDEBRANDT

Drug Metabolism and Disposition January 1973, 1 (1) 194-198;
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EFFECT OF ENZYME INDUCERS ON SUBSTRATE SPECIFICITY OF THE CYTOCHROME P-450’S
A. H. CONNEY, ANTHONY Y. H. LU, WAYNE LEVIN, ARPAD SOMOGYI, SUSAN WEST, MARTIN JACOBSON, DENE RYAN and RONALD KUNTZMAN

Drug Metabolism and Disposition January 1973, 1 (1) 199-210;
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EFFECT OF ANALGESICS AND EXPOSURE TO CIGARETTE SMOKE ON THE METABOLISM OF ACETOPHENETIDIN BY RAT TISSUES
R. M. WELCH, J. CAVALLITO and D. D. GILLESPIE

Drug Metabolism and Disposition January 1973, 1 (1) 211-215;
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EFFECT OF STEROIDS ON DRUG METABOLISM IN MALE AND FEMALE RATS
B. STRIPP, R. H. MENARD, N. G. ZAMPAGLIONE, M. E. HAMRICK and J. R. GILLETTE

Drug Metabolism and Disposition January 1973, 1 (1) 216-223;
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INDUCTION OF THE UNSPECIFIC MICROSOMAL HYDROXYLASE IN THE HUMAN LIVER
H. REMMER, B. SCHOENE and R. A. FLEISCHMANN

Drug Metabolism and Disposition January 1973, 1 (1) 224-230;
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GENETIC DIFFERENCES IN CYTOCHROME P-450 DURING INDUCTION OF MONO-OXYGENASE ACTIVITIES
DANIEL W. NEBERT, NOREEN CONSIDINE and HIDEO KON

Drug Metabolism and Disposition January 1973, 1 (1) 231-238;
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INITIATION FACTOR ACTIVITY IN LIVER AFTER 3-METHYLCHOLANTHRENE ADMINISTRATION
K. D. LANCLOS and EDWARD BRESNICK

Drug Metabolism and Disposition January 1973, 1 (1) 239-247;
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THE EFFECT OF PHENOBARBITAL ON THE TURNOVER OF MESSENGER RNA’S FOR MICROSOMAL ENZYMES
SUEO MATSUMURA and TSUNEO OMURA

Drug Metabolism and Disposition January 1973, 1 (1) 248-250;
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IMPAIRED DRUG METABOLISM IN RATS WITH ADJUVANT-INDUCED ARTHRITIS: A BRIEF REVIEW
MICHAEL W. WHITEHOUSE and FRANCES J. BECK

Drug Metabolism and Disposition January 1973, 1 (1) 251-255;
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SYNTHESIS AND DEGRADATION OF MICROSOMAL HEMOPROTEINS
RUDI SCHMID

Drug Metabolism and Disposition January 1973, 1 (1) 256-258;
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THE REGULATION OF HEME SYNTHESIS RELATED TO DRUG METABOLISM
T. R. TEPHLY, C. WEBB, P. TRUSSLER, F. KNIFFEN, E. HASEGAWA and W. PIPER

Drug Metabolism and Disposition January 1973, 1 (1) 259-266;
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DRUG-INDUCED DESTRUCTION OF CYTOCHROME P-450
F. DE MATTEIS

Drug Metabolism and Disposition January 1973, 1 (1) 267-274;
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BREAKDOWN OF CYTOCHROME P-450 HEME BY SECOBARBITAL AND OTHER ALLYL-CONTAINING BARBITURATES
W. LEVIN, M. JACOBSON, E. SERNATINGER and R. KUNTZMAN

Drug Metabolism and Disposition January 1973, 1 (1) 275-285;
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HEME AND HEMOPROTEIN CATABOLISM DURING STIMULATION OF MICROSOMAL LIPID PEROXIDATION
BRENT A. SCHACTER, HARVEY S. MARVER and URS A. MEYER

Drug Metabolism and Disposition January 1973, 1 (1) 286-292;
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THE POSSIBLE IMPLICATION OF HEME TRANSFER FROM CYTOCHROME P-420 TO ALBUMIN IN THE METABOLISM OF CYTOCHROME P-450
M. D. MAINES and M. W. ANDERS

Drug Metabolism and Disposition January 1973, 1 (1) 293-298;
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THE ROLE OF CYTOCHROME P-450 IN THE N-OXIDATION OF INDIVIDUAL AMINES
HARTMUT UEHLEKE

Drug Metabolism and Disposition January 1973, 1 (1) 299-313;
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MICROSOMAL FLAVOPROTEIN-CATALYZED N-OXIDATION OF ARYLAMINES
D. M. ZIEGLER, E. M. Mc KEE and L. L. POULSEN

Drug Metabolism and Disposition January 1973, 1 (1) 314-321;
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OXIDATION OF AN AMINO CARBINOL BY AN NAD⁺-DEPENDENT MICROSOMAL DEHYDROGENASE
MORTON A. SCHWARTZ and STANLEY J. KOLIS

Drug Metabolism and Disposition January 1973, 1 (1) 322-331;
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PHENYLACETONE OXIME—AN INTERMEDIATE IN AMPHETAMINE DEAMINATION
HOWARD B. HUCKER

Drug Metabolism and Disposition January 1973, 1 (1) 332-336;
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THE MECHANISM OF MICROSOMAL DEAMINATION: HEAVY ISOTOPE STUDIES
C. JOHN PARLI and ROBERT E. McMAHON

Drug Metabolism and Disposition January 1973, 1 (1) 337-341;
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THE INFLUENCE OF SOME HEPATIC ENZYME INDUCERS AND INHIBITORS ON EXTRAHEPATIC DRUG METABOLISM
BRIAN G. LAKE, ROBERT HOPKINS, JAGADISH CHAKRABORTY, JAMES W. BRIDGES and DENNIS V. W. PARKE

Drug Metabolism and Disposition January 1973, 1 (1) 342-349;
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THE CYTOCHROME P-450-CONTAINING MONO-OXYGENASE SYSTEM OF RAT KIDNEY CORTEX MICROSOMES
STEN ORRENIUS, ÅKE ELLIN, STEN V. JAKOBSSON, HJÖRDIS THOR, DOMINICK L. CINTI, JOHN B. SCHENKMAN and RONALD W. ESTABROOK

Drug Metabolism and Disposition January 1973, 1 (1) 350-357;
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CHARACTERIZATION OF LUNG MICROSOMES AS RELATED TO DRUG METABOLISM
JOHN R. BEND, GARY E. R. HOOK and THEODORE E. GRAM

Drug Metabolism and Disposition January 1973, 1 (1) 358-367;
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THE ROLE OF CYTOCHROME P-450 OF PLACENTA IN FACILITATED OXYGEN DIFFUSION
G. H. GURTNER and B. BURNS

Drug Metabolism and Disposition January 1973, 1 (1) 368-373;
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A SPECIFIC CARRIER FOR OXYGEN AND CARBON MONOXIDE IN THE LUNG AND PLACENTA
BARRY BURNS and GAIL H. GURTNER

Drug Metabolism and Disposition January 1973, 1 (1) 374-379;
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SOME SELECTED STUDIES ON HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES—ENVIRONMENT INTERACTIONS
JAMES R. FOUTS

Drug Metabolism and Disposition January 1973, 1 (1) 380-385;
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INDUCTION OF ARYL HYDROCARBON HYDROXYLASE IN HUMAN SKIN
A. P. ALVARES, S. LEIGH, A. KAPPAS, W. LEVIN and A. H. CONNEY

Drug Metabolism and Disposition January 1973, 1 (1) 386-390;
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EFFECT OF SYNERGISTS ON DRUG METABOLISM
ERNEST HODGSON, R. M. PHILPOT, R. C. BAKER and R. B. MAILMAN

Drug Metabolism and Disposition January 1973, 1 (1) 391-401;
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INHIBITION OF DRUG METABOLISM IN MAN
ELLIOT S. VESELL and G. THOMAS PASSANANTI

Drug Metabolism and Disposition January 1973, 1 (1) 402-410;
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INTERINDIVIDUAL DIFFERENCES IN RATES OF DRUG OXIDATION IN MAN
DONALD S. DAVIES, S. S. THORGEIRSSON, A. BRECKENRIDGE and M. ORME

Drug Metabolism and Disposition January 1973, 1 (1) 411-417;
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DRUG METABOLISM AS A CAUSE OF DRUG TOXICITY
J. R. MITCHELL, D. J. JOLLOW, J. R. GILLETTE and B. B. BRODIE

Drug Metabolism and Disposition January 1973, 1 (1) 418-423;
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EFFECTS OF PHENOBARBITAL TREATMENT ON BILIARY EXCRETION IN MAN
T. JÁVOR, Á. GÓGL, TÜNDE HORVÁTH and I. TÉNYI

Drug Metabolism and Disposition January 1973, 1 (1) 424-427;
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THE SIGNIFICANCE AND CHARACTERIZATION OF HEPATIC MICROSOMAL ETHANOL OXIDATION IN THE LIVER
CHARLES S. LIEBER and LEONORE M. DECARLI

Drug Metabolism and Disposition January 1973, 1 (1) 428-440;
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THE ROLE OF HYDROGEN PEROXIDE AND CATALASE IN HEPATIC MICROSOMAL ETHANOL OXIDATION
RONALD G. THURMAN and ROLAND SCHOLZ

Drug Metabolism and Disposition January 1973, 1 (1) 441-448;
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ETHANOL METABOLISM: OXIDATIVE AND PEROXIDATIVE MECHANISMS
KURT J. ISSELBACHER and EDWARD A. CARTER

Drug Metabolism and Disposition January 1973, 1 (1) 449-454;
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THE ROLE OF NADPH-CYTOCHROME c REDUCTASE IN THE MICROSOMAL OXIDATION OF ETHANOL AND METHANOL
EDWARD B. NELSON, KAREN B. KOHL and BETTIE SUE SILER MASTERS

Drug Metabolism and Disposition January 1973, 1 (1) 455-460;
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TETRAHYDROCANNABINOL METABOLISM IN MAN
LOUIS LEMBERGER

Drug Metabolism and Disposition January 1973, 1 (1) 461-468;
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INTERINDIVIDUAL DIFFERENCES IN DRUG OXIDATION: CLINICAL IMPORTANCE
FOLKE SJÖQVIST and CHRISTER VON BAHR

Drug Metabolism and Disposition January 1973, 1 (1) 469-482;

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