Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research Article

THE DISPOSITION OF PROPRANOLOL

VIII. General Implications of the Effects of Liver Blood Flow on Elimination from the Perfused Rat Liver

R. A. BRANCH, A. S. NIES and D. G. SHAND
Drug Metabolism and Disposition September 1973, 1 (5) 687-690;
R. A. BRANCH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. S. NIES
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. G. SHAND
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

VIII. General Implications of the Effects of Liver Blood Flow on Elimination from the Perfused Rat Liver

Abstract

The effects of varying flow from 5-20 ml/min on the elimination of propranolol by the perfused rat liver have been investigated. Both d- and dl-propranolol were handled similarly at all flows and doses employed. By using two doses (1 and 5 mg in a 100-ml reservoir) the effects of flow under three distinct kinetic conditions could be examined. At the low dose and during the α-phase with the high dose, disposition was entirely flow-dependent as drug clearance equalled liver blood flow. During the β-phase following the high dose, clearance was less and increased with flow until a limiting value was achieved when drug clearance was independent of flow. The effects of flow on total clearance of the high dose (including α- and β-phases) were intermediate. Theoretical analysis of the data shows that drug clearance should increase with flow until a limiting value is reached corresponding to the intrinsic first-order metabolic clearance of the drug, when elimination becomes flow-independent. As a result, hepatic extraction ratio decreases as flow increases in relation to metabolic clearance rate despite metabolism remaining first order. These data 1) suggest that the effect of flow on the clearance of any drug can be assessed from a single estimate of flow and extraction ratio and 2) quantitate the observation that the elimination of high-clearance drugs is more affected by flow changes than that of low-clearance drugs.

Footnotes

    • Received April 25, 1973.
  • Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics

 

DMD articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition
Vol. 1, Issue 5
1 Sep 1973
  • Table of Contents
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
THE DISPOSITION OF PROPRANOLOL
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research Article

THE DISPOSITION OF PROPRANOLOL

R. A. BRANCH, A. S. NIES and D. G. SHAND
Drug Metabolism and Disposition September 1, 1973, 1 (5) 687-690;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research Article

THE DISPOSITION OF PROPRANOLOL

R. A. BRANCH, A. S. NIES and D. G. SHAND
Drug Metabolism and Disposition September 1, 1973, 1 (5) 687-690;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics