Abstract

In the rat, orally administered seclazone, which is stable in the gastrointestinal tract, is rapidly converted to its metabolite, 5-chlorosalicylic acid, by the intestinal wall. The absorption of the drug from the isolated intestine follows first-order kinetics with a half-life of 5 min. Under these conditions, the disappearance of seclazone and of 5-chlorosalicylic acid from the hepatic portal circulation follow apparent first-order kinetics with half-lives of about 5 and 30 min, respectively. No unchanged seclazone could be detected in the systemic circulation after oral administration of drug to either rats or dogs. Both seclazone and 5-chlorosalicylic acid, which was the only compound that could be detected in the blood after oral administration of seclazone, are bound appreciably to plasma proteins.