Drug Metabolism and Disposition: 10 (6)

November 01, 1982; Volume 10,Issue 6

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Analytical controls in drug metabolic studies. II. Artifact formation during chloroform extraction of drugs and metabolites with amine substituents.
E J Cone, W F Buchwald and W D Darwin

Drug Metabolism and Disposition November 1982, 10 (6) 561-567;
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Dose-dependent kinetics of quinidine in the perfused rat liver preparation. Kinetics of formation of active metabolites.
V C Yu, E de Lamirande, M G Horning and K S Pang

Drug Metabolism and Disposition November 1982, 10 (6) 568-572;
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Salicylate enhancement of renal glucuronide conjugation and tubular excretory transfer of phenols.
G L Diamond, M W Anders, L M Tremaine and A J Quebbemann

Drug Metabolism and Disposition November 1982, 10 (6) 573-578;
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Effects of three recombinant human leukocyte interferons on drug metabolism in mice.
A Parkinson, J Lasker, M J Kramer, M T Huang, P E Thomas, D E Ryan, L M Reik, R L Norman, W Levin and A H Conney

Drug Metabolism and Disposition November 1982, 10 (6) 579-585;
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Phenobarbital pharmacokinetics in rat as a function of age.
I M Kapetanovic, D J Sweeney and S I Rapoport

Drug Metabolism and Disposition November 1982, 10 (6) 586-589;
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Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous, and Wistar rat livers by pregnenolone-16 alpha-carbonitrile.
J B Watkins and C D Klaassen

Drug Metabolism and Disposition November 1982, 10 (6) 590-594;
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5-ethyl-5-phenylhydantoin N-glucuronide, the major urinary metabolite of 5-ethyl-5-phenylhydantoin (Nirvanol) in the dog.
J H Maguire, T C Butler and K H Dudley

Drug Metabolism and Disposition November 1982, 10 (6) 595-598;
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Metabolic formation of N- and O-glucuronides of 3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid. Rearrangement of the 1-o-acyl glucuronide.
F W Janssen, S K Kirkman, C Fenselau, M Stogniew, B R Hofmann, E M Young and H W Ruelius

Drug Metabolism and Disposition November 1982, 10 (6) 599-604;
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Species-related differences in the stereoselective glucuronidation of oxazepam.
S F Sisenwine, C O Tio, F V Hadley, A L Liu, H B Kimmel and H W Ruelius

Drug Metabolism and Disposition November 1982, 10 (6) 605-608;
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Electrophilic reactions of acyl-linked glucuronides. Formation of clofibrate mercapturate in humans.
M Stogniew and C Fenselau

Drug Metabolism and Disposition November 1982, 10 (6) 609-613;
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Urinary bivalent sulfur metabolites of phenanthrene excreted by the rat and guinea pig.
K Lertratanangkoon, M G Horning, B S Middleditch, W S Tsang and G W Griffin

Drug Metabolism and Disposition November 1982, 10 (6) 614-623;
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Identification of new sulfur-containing metabolites of naphthalene in mouse urine.
W G Stillwell, M G Horning, G W Griffin and W S Tsang

Drug Metabolism and Disposition November 1982, 10 (6) 624-631;
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The tissue distribution, metabolism, and excretion of octachlorostyrene in the rat.
I Chu, D C Villeneuve, V Secours, F M Benoit and A Viau

Drug Metabolism and Disposition November 1982, 10 (6) 632-635;
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Iminocyclophosphamide as a chemically reactive metabolite of cyclophosphamide.
C Fenselau, J P Lehman, A Myles, J Brandt, G S Yost, O M Friedman and O M Colvin

Drug Metabolism and Disposition November 1982, 10 (6) 636-640;
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A pharmacokinetic model to predict exposure of the bladder epithelium to urinary N-hydroxyarylamine carcinogens as a function of urine pH, voiding interval, and resorption.
J F Young and F F Kadlubar

Drug Metabolism and Disposition November 1982, 10 (6) 641-644;
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Metabolism and disposition of diphacinone in rats and mice.
C C Yu, Y H Atallah and D M Whitacre

Drug Metabolism and Disposition November 1982, 10 (6) 645-648;
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Disposition and metabolism of codorphone in the rat, dog, and man.
J L Leeling, J V Evans, R J Helms and B A Ryerson

Drug Metabolism and Disposition November 1982, 10 (6) 649-653;
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Biliary metabolites of the anti-inflammatory drug 2-acetamido-4-(chloromethyl)thiazole.
J J Rafter and J E Bakke

Drug Metabolism and Disposition November 1982, 10 (6) 654-656;
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Pharmacokinetics of 2,2',4,4',5,5'-hexachlorobiphenyl (6-CB) in rats with decreasing adipose tissue mass. I. Effects of restricting food intake two weeks after administration of 6-CB.
P A Wyss, S Mühlebach and M H Bickel

Drug Metabolism and Disposition November 1982, 10 (6) 657-661;
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Main metabolites of 1-(2-chloroethyl)-3-[1'-(5'-p-nitrobenzoyl-2',3'-isopropylidene)-alpha, beta-D-ribofuranosyl]-1-nitrosourea and 1-(2-chloroethyl)-3-(2',3', 4'-tri-O-acetyl-alpha, beta-D-ribopyranosyl)-1-nitrosourea in rats.
J C Madelmont, M F Moreau, D Godeneche, J Duprat, R Plagne and G Meyniel

Drug Metabolism and Disposition November 1982, 10 (6) 662-666;
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Evidence for an arene oxide-NIH shift pathway in the metabolic conversion of phenytoin to 5-(4-hydroxyphenyl)-5-phenylhydantoin in the rat and in man.
M Claesen, M A Moustafa, J Adline, D Vandervorst and J H Poupaert

Drug Metabolism and Disposition November 1982, 10 (6) 667-671;
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Theobromine metabolism in man.
J O Miners, J Attwood and D J Birkett

Drug Metabolism and Disposition November 1982, 10 (6) 672-675;
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Tissue distribution of 14C-diazepam and its metabolites in rats.
Y Igari, Y Sugiyama, Y Sawada, T Iga and M Hanano

Drug Metabolism and Disposition November 1982, 10 (6) 676-679;
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Disposition of phencyclidine in mice after smoke exposure.
A S Freeman and B R Martin

Drug Metabolism and Disposition November 1982, 10 (6) 680-684;
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In vitro metabolism of 1-phenyl-1-cyclohexene, a pyrolysis product of phencyclidine.
B R Martin, B B Bailey, H Awaya, E L May and N Narasimhachari

Drug Metabolism and Disposition November 1982, 10 (6) 685-689;
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Metabolism of phencyclidine. The role of iminium ion formation in covalent binding to rabbit microsomal protein.
D P Ward, A J Trevor, A Kalir, J D Adams, T A Baillie and N Castagnoli

Drug Metabolism and Disposition November 1982, 10 (6) 690-695;
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A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro.
D F Eastman and H J Segall

Drug Metabolism and Disposition November 1982, 10 (6) 696-699;
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Cytochrome P-455-nm complex formation in the metabolism of phenylalkylamines. VI. Structure--activity relationships in metabolic intermediary complex formation with a series of alpha-substituted 2-phenylethylamines and corresponding N-hydroxylamines.
B Lindeke, U Paulsen-Sörman, G Hallström, A H Khuthier, A K Cho and R C Kammerer

Drug Metabolism and Disposition November 1982, 10 (6) 700-705;
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Tissue metabolism and distribution of methotrexate in rabbits.
M L Chen and W L Chiou

Drug Metabolism and Disposition November 1982, 10 (6) 706-707;
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A study of methylphenidate in man with respect to its major metabolite.
E Redalieu, M F Bartlett, L M Waldes, W R Darrow, H Egger and W E Wagner

Drug Metabolism and Disposition November 1982, 10 (6) 708-709;

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