Drug Metabolism and Disposition: 12 (4)

July 01, 1984; Volume 12,Issue 4

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Exact mathematical equivalence of the venous equilibration ("well-stirred") model, the sinusoidal perfusion ("parallel-tube") model, and a specific two-compartment open model.
J G Wagner, G J Szpunar and J J Ferry

Drug Metabolism and Disposition July 1984, 12 (4) 385-388;
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The metabolism and excretion of 14C-styrene oxide-glutathione adducts administered to the winter flounder, Pseudopleuronectes americanus, a marine teleost. Identification of the corresponding S-cysteine derivatives as major urinary metabolites.
B Yagen, G L Foureman, Z Ben-Zvi, A J Ryan, O Hernandez, R H Cox and J R Bend

Drug Metabolism and Disposition July 1984, 12 (4) 389-395;
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Metabolism, disposition, and pharmacokinetics of tracazolate in rat and dog.
M D Melgar, F R Zuleski and J O Malbica

Drug Metabolism and Disposition July 1984, 12 (4) 396-402;
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Metabolism of 8-hydroxymethylbenz[a]anthracene by rat liver microsomes. Stereochemistry of dihydrodiol metabolites and the effect of enzyme induction.
S K Yang, M W Chou, F E Evans and P P Fu

Drug Metabolism and Disposition July 1984, 12 (4) 403-413;
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Biotransformation and elimination of 14C-flecainide acetate in humans.
R L McQuinn, G J Quarfoth, J D Johnson, E H Banitt, S V Pathre, S F Chang, R E Ober and G J Conard

Drug Metabolism and Disposition July 1984, 12 (4) 414-420;
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Metabolism of alcohol and ketone by cytochrome P-450 oxygenase: fluoren-9-ol in equilibrium with fluoren-9-one.
C Chen, R C Lefers, E L Brough and D P Gurka

Drug Metabolism and Disposition July 1984, 12 (4) 421-426;
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Oxidative and conjugative metabolism of xenobiotics by isolated rat and hamster acinar cells.
P Wiebkin, B K Schaeffer, D S Longnecker and T J Curphey

Drug Metabolism and Disposition July 1984, 12 (4) 427-431;
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Formation of nontoxic reactive metabolites of p-bromophenol. Identification of a new glutathione conjugate.
T J Monks, S S Lau and R J Highet

Drug Metabolism and Disposition July 1984, 12 (4) 432-437;
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Disposition of 14C-acetohydroxamic acid and 14C-acetamide in the rat.
L Putcha, D P Griffith and S Feldman

Drug Metabolism and Disposition July 1984, 12 (4) 438-443;
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Metabolic disposition of isoxicam in man, monkey, dog, and rat.
P E Borondy and B M Michniewicz

Drug Metabolism and Disposition July 1984, 12 (4) 444-451;
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The disposition and metabolism of a hypnotic benzodiazepine, quazepam, in the hamster and mouse.
J Hilbert, B Pramanik, S Symchowicz and N Zampaglione

Drug Metabolism and Disposition July 1984, 12 (4) 452-459;
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Selective inactivation of rat lung and liver microsomal NADPH-cytochrome c reductase by acrolein.
J M Patel, E Ortiz, C Kolmstetter and K C Leibman

Drug Metabolism and Disposition July 1984, 12 (4) 460-463;
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The metabolism of avermectin-H2B1a and -H2B1b by pig liver microsomes.
S H Chiu, E Sestokas, R Taub, J L Smith, B Arison and A Y Lu

Drug Metabolism and Disposition July 1984, 12 (4) 464-469;
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Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin.
L S Kaminsky, D A Dunbar, P P Wang, P Beaune, D Larrey, F P Guengerich, R G Schnellmann and I G Sipes

Drug Metabolism and Disposition July 1984, 12 (4) 470-477;
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Some chemical and biochemical aspects of liver microsomal metabolism of tamoxifen.
P C Ruenitz, J R Bagley and C W Pape

Drug Metabolism and Disposition July 1984, 12 (4) 478-483;
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The formation and toxicity of catechol metabolites of acetaminophen in mice.
A J Forte, J M Wilson, J T Slattery and S D Nelson

Drug Metabolism and Disposition July 1984, 12 (4) 484-491;
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Disposition and pharmacokinetics of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the rat.
M Hashida, A Kato, Y Takakura and H Sezaki

Drug Metabolism and Disposition July 1984, 12 (4) 492-499;
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Effect of pregnancy on tissue distribution of salicylate in rats.
T Yoshikawa, Y Sugiyama, Y Sawada, T Iga and M Hanano

Drug Metabolism and Disposition July 1984, 12 (4) 500-505;
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Separation, characterization, and analysis of epirubicin (4'-epidoxorubicin) and its metabolites from human urine.
G Cassinelli, E Configliacchi, S Penco, G Rivola, F Arcamone, A Pacciarini and L Ferrari

Drug Metabolism and Disposition July 1984, 12 (4) 506-510;
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Metabolism of aminoglutethimide in humans. Identification of four new urinary metabolites.
A B Foster, L J Griggs, I Howe, M Jarman, C S Leung, D Manson and M G Rowlands

Drug Metabolism and Disposition July 1984, 12 (4) 511-516;
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Biochemical studies on phthalic esters. IV. Metabolism of diheptyl phthalate in rats.
M Sato, T Adachi, A Tanaka and T Yamaha

Drug Metabolism and Disposition July 1984, 12 (4) 517-522;
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Evidence for the formation of a novel glutathione conjugate in the metabolism of an aromatic amine derivative.
D H Hutson, C J Logan and P D Regan

Drug Metabolism and Disposition July 1984, 12 (4) 523-524;

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