Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Abstract

Disposition of [14C]tri-o-cresyl phosphate and its metabolites in various tissues of the male cat following a single dermal application.

A A Nomeir and M B Abou-Donia
Drug Metabolism and Disposition November 1984, 12 (6) 705-711;
A A Nomeir
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M B Abou-Donia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The disposition and metabolism of a single dermal dose of 50 mg (5.8 muCi)/kg of tri-o-cresyl [phenyl-U-14C]phosphate (TOCP) were investigated in adult male cats. TOCP was applied on a preclipped area on the back of the animals neck. Three treated cats were sacrificed at each time interval 0.5, 1, 2, 5, and 10 days following application. Plasma, brain, spinal cord, sciatic nerve, liver, kidneys, and lungs were extracted and analyzed for TOCP and its various metabolites by high performance liquid chromatography and liquid scintillation counting. TOCP reached its highest concentration in plasma at 12 hr, while its metabolites attained their maximum concentration levels between 24 and 48 hr after dosing. The disappearance of TOCP from the plasma followed a monoexponential kinetics with a half-life of 1.2 days. Di-o-cresyl hydrogen phosphate and o-cresyl dihydrogen phosphate were the major metabolites in the plasma while dihydroxymethyl TOCP was present in trace amounts. Appreciable concentrations of saligenin cyclic-o-tolyl phosphate, which is believed to be the active neurotoxic metabolite, were detected in the plasma at all time points. TOCP was the predominant compound in the brain, spinal cord, and sciatic nerve, while the liver, kidneys, and lungs contained mostly metabolites. The major metabolite identified in the liver, kidneys, and lungs was o-hydroxybenzoic acid (salicylic acid) followed by di-o-cresyl hydrogen phosphate whereas di-o-cresyl hydrogen phosphate and o-cresyl dihydrogen phosphate were the most abundant metabolites in the brain, spinal cord, and sciatic nerve.(ABSTRACT TRUNCATED AT 250 WORDS)

 

DMD articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition
Vol. 12, Issue 6
1 Nov 1984
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Disposition of [14C]tri-o-cresyl phosphate and its metabolites in various tissues of the male cat following a single dermal application.
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract

Disposition of [14C]tri-o-cresyl phosphate and its metabolites in various tissues of the male cat following a single dermal application.

A A Nomeir and M B Abou-Donia
Drug Metabolism and Disposition November 1, 1984, 12 (6) 705-711;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Abstract

Disposition of [14C]tri-o-cresyl phosphate and its metabolites in various tissues of the male cat following a single dermal application.

A A Nomeir and M B Abou-Donia
Drug Metabolism and Disposition November 1, 1984, 12 (6) 705-711;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics