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Drug Metabolism & Disposition

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Table of Contents

March 01, 1985; Volume 13,Issue 2
  • You have access
    Relationships among the venous equilibration ("well-stirred") model, the sinusoidal perfusion ("parallel-tube") model, and a specific two-compartment open model.
    J G Wagner
    Drug Metabolism and Disposition March 1985, 13 (2) 119-120;
  • You have access
    Studies on the fate of the glutathione and cysteine conjugates of acetaminophen in mice.
    L J Fischer, M D Green and A W Harman
    Drug Metabolism and Disposition March 1985, 13 (2) 121-126;
  • You have access
    The pharmacokinetics of cyclosporine. I. Single dose and constant rate infusion studies in the rabbit.
    W M Awni and R J Sawchuk
    Drug Metabolism and Disposition March 1985, 13 (2) 127-132;
  • You have access
    The pharmacokinetics of cyclosporine. II. Blood plasma distribution and binding studies.
    W M Awni and R J Sawchuk
    Drug Metabolism and Disposition March 1985, 13 (2) 133-138;
  • You have access
    Tracazolate metabolites in rat tissue.
    F R Zuleski, K M Kirkland, M D Melgar and J O Malbica
    Drug Metabolism and Disposition March 1985, 13 (2) 139-147;
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    Genetic differences in 2-aminofluorene pharmacokinetics between intact C57BL/6J and A/J mice.
    T A Hultin and W W Weber
    Drug Metabolism and Disposition March 1985, 13 (2) 148-150;
  • You have access
    Mephenytoin metabolism in vitro by human liver.
    M Jurima, T Inaba and W Kalow
    Drug Metabolism and Disposition March 1985, 13 (2) 151-155;
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    The effect of ketoconazole on hepatic oxidative drug metabolism in the rat in vivo and in vitro.
    C G Meredith, A L Maldonado and K V Speeg
    Drug Metabolism and Disposition March 1985, 13 (2) 156-162;
  • You have access
    Drug metabolism by isolated fetal human hepatocytes in suspension and primary culture.
    P Wiebkin, J H Dees, J M Mathis and R A Prough
    Drug Metabolism and Disposition March 1985, 13 (2) 163-168;
  • You have access
    Evaluation of the role of free hydroxyl radicals in the cytochrome P-450-catalyzed oxidation of benzene and cyclohexanol.
    L D Gorsky and M J Coon
    Drug Metabolism and Disposition March 1985, 13 (2) 169-174;
  • You have access
    Stereospecific in vivo N-methylation of nicotine in the guinea pig.
    K C Cundy, M Sato and P A Crooks
    Drug Metabolism and Disposition March 1985, 13 (2) 175-185;
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    Development of UDP-glucuronosyltransferase activity toward digitoxigenin-monodigitoxoside in neonatal rats.
    J B Watkins and C D Klaassen
    Drug Metabolism and Disposition March 1985, 13 (2) 186-191;
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    Prevention of chlorphentermine-induced pulmonary phospholipidosis in rats by phenobarbital.
    M J Reasor and M E Davis
    Drug Metabolism and Disposition March 1985, 13 (2) 192-196;
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    Polyamine effects on cytochrome P-450- and flavin-containing monooxygenase-mediated oxidation of xenobiotics.
    T G Osimitz and A P Kulkarni
    Drug Metabolism and Disposition March 1985, 13 (2) 197-203;
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    Quantitative account of propranolol metabolism in urine of normal man.
    T Walle, U K Walle and L S Olanoff
    Drug Metabolism and Disposition March 1985, 13 (2) 204-209;
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    Effect of chronic ethanol consumption on activation of nitrosopyrrolidine to a mutagen by rat upper alimentary tract, lung, and hepatic tissue.
    F Farinati, Z Zhou, J Bellah, C S Lieber and A J Garro
    Drug Metabolism and Disposition March 1985, 13 (2) 210-214;
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    Studies on the beta-oxidative metabolism of delta 1- and delta 6-tetrahydrocannabinol in the mouse. The in vivo biotransformation of metabolites oxidized in the side chain.
    D J Harvey and J T Leuschner
    Drug Metabolism and Disposition March 1985, 13 (2) 215-219;
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    Metabolic disposition of 2-chloroethyl nitrosocarbamoylcystamine in rats.
    D Godeneche, J C Madelmont, M F Moreau, J Duprat, J L Chabard, R Plagne and G Meyniel
    Drug Metabolism and Disposition March 1985, 13 (2) 220-226;
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    Pharmacokinetics of paraxanthine, one of the primary metabolites of caffeine, in the rat.
    A Bortolotti, L Jiritano and M Bonati
    Drug Metabolism and Disposition March 1985, 13 (2) 227-231;
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    Glucuronidation of morphine and six beta 2-sympathomimetics in isolated rat intestinal epithelial cells.
    A S Koster, A C Frankhuijzen-Sierevogel and J Noordhoek
    Drug Metabolism and Disposition March 1985, 13 (2) 232-238;
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    Species differences in the metabolism of suprofen in laboratory animals and man.
    Y Mori, N Kuroda, Y Sakai, F Yokoya, K Toyoshi and S Baba
    Drug Metabolism and Disposition March 1985, 13 (2) 239-245;
  • You have access
    In vitro metabolism of the new cardiotonic agent denopamine (TA-064) by rat and rabbit liver preparations. Oxidation, methylation, and glucuronidation.
    T Suzuki, Y Hashimura and S Takeyama
    Drug Metabolism and Disposition March 1985, 13 (2) 246-254;
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    The in vitro metabolism of hydralazine.
    A J Streeter and J A Timbrell
    Drug Metabolism and Disposition March 1985, 13 (2) 255-259;
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    Pharmacokinetic analysis of potassium cyanate in mice using whole blood and expired air.
    J D Johnson, P R Mayer and G E Isom
    Drug Metabolism and Disposition March 1985, 13 (2) 260-262;
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    n-Butylglycidyl ether: the formation of a novel metabolite of an epoxide.
    C V Eadsforth, C J Logan, J A Page and P D Regan
    Drug Metabolism and Disposition March 1985, 13 (2) 263-264;
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In this issue

Drug Metabolism and Disposition
Vol. 13, Issue 2
1 Mar 1985
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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