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Drug Metabolism & Disposition

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Table of Contents

March 01, 1987; Volume 15,Issue 2
  • You have access
    Relationship between sulfotransferase activity and susceptibility to acetaminophen-induced liver necrosis in the hamster.
    M G Miller and D J Jollow
    Drug Metabolism and Disposition March 1987, 15 (2) 143-150;
  • You have access
    Dose-dependent pharmacokinetics of ibuprofen in the rat.
    A Shah and D Jung
    Drug Metabolism and Disposition March 1987, 15 (2) 151-154;
  • You have access
    Nonenzymatic bioreduction in rat liver and kidney of nitroxyl spin labels, potential contrast agents in magnetic resonance imaging.
    U G Eriksson, R C Brasch and T N Tozer
    Drug Metabolism and Disposition March 1987, 15 (2) 155-160;
  • You have access
    In vitro microsomal metabolism of the leukotriene receptor antagonist, 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid (SK&F 102,081).
    J F Newton, K M Straub, R H Dewey, C D Perchonock, T B Leonard, M E McCarthy, J G Gleason and R D Eckardt
    Drug Metabolism and Disposition March 1987, 15 (2) 161-167;
  • You have access
    In vivo metabolism of the leukotriene receptor antagonist, 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid (SK&F 102,081) in the guinea pig.
    J F Newton, K M Straub, G Y Kuo, C D Perchonock, M E McCarthy, J G Gleason and R K Lynn
    Drug Metabolism and Disposition March 1987, 15 (2) 168-176;
  • You have access
    Alterations in biliary excretory function by streptozotocin-induced diabetes.
    J B Watkins and T P Dykstra
    Drug Metabolism and Disposition March 1987, 15 (2) 177-183;
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    Uptake, metabolism, and secretion of 3'-methyl-N,N-dimethyl-4-aminoazobenzene by isolated perfused rat liver.
    A R Samuels, L Theilmann, Y R Stollman, A W Wolkoff and M M Bhargava
    Drug Metabolism and Disposition March 1987, 15 (2) 184-188;
  • You have access
    Uptake and disposition of putrescine, spermidine, and spermine by rabbit lungs.
    S B Rao and H M Mehendale
    Drug Metabolism and Disposition March 1987, 15 (2) 189-194;
  • You have access
    Conversion of melphalan to 4-(glutathionyl)phenylalanine. A novel mechanism for conjugation by glutathione-S-transferases.
    D M Dulik and C Fenselau
    Drug Metabolism and Disposition March 1987, 15 (2) 195-199;
  • You have access
    Conversion of N,N-dimethylaniline to N,N-dimethylaniline-N-oxide by a cytosolic flavin-containing enzyme from Trypanosoma cruzi.
    M Agosin and G T Ankley
    Drug Metabolism and Disposition March 1987, 15 (2) 200-203;
  • You have access
    Pharmacokinetic interaction between theophylline and chloramphenicol in rats.
    M Busby and L J Lesko
    Drug Metabolism and Disposition March 1987, 15 (2) 204-206;
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    The pharmacokinetics of all-trans-retinoic acid and N-(2-hydroxyethyl)retinamide in mice as determined with a sensitive and convenient procedure. Solid-phase extraction and reverse-phase high performance liquid chromatography.
    D M McPhillips, J R Kalin and D L Hill
    Drug Metabolism and Disposition March 1987, 15 (2) 207-211;
  • You have access
    Urinary excretion kinetics of famotidine in rats.
    J H Lin, L E Los, E H Ulm and D E Duggan
    Drug Metabolism and Disposition March 1987, 15 (2) 212-216;
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    In vivo and in vitro biotransformation of theobromine by phenobarbital- and 3-methylcholanthrene-inducible cytochrome P-450 monooxygenases in rat liver. Role of thiol compounds.
    C A Shively and E S Vesell
    Drug Metabolism and Disposition March 1987, 15 (2) 217-224;
  • You have access
    Effects of aging on the properties of rhesus monkey liver microsomal NADPH-cytochrome c (P-450) reductase.
    D L Schmucker and R K Wang
    Drug Metabolism and Disposition March 1987, 15 (2) 225-232;
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    Extraction of omega- and omega-1-hydroxylauric acids with ethyl acetate results in formation of acetoxy products.
    A S Salhab, J Applewhite, M W Couch, R T Okita and K T Shiverick
    Drug Metabolism and Disposition March 1987, 15 (2) 233-236;
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    Biotransformation of caffeine, paraxanthine, theophylline, and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome(s) P-450 in human liver microsomes.
    M E Campbell, D M Grant, T Inaba and W Kalow
    Drug Metabolism and Disposition March 1987, 15 (2) 237-249;
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    Pharmacokinetics of tetrabenazine and its major metabolite in man and rat. Bioavailability and dose dependency studies.
    R Mehvar, F Jamali, M W Watson and D Skelton
    Drug Metabolism and Disposition March 1987, 15 (2) 250-255;
  • You have access
    Flavin-containing monooxygenase activity in human liver microsomes.
    M E McManus, I Stupans, W Burgess, J A Koenig, P M Hall and D J Birkett
    Drug Metabolism and Disposition March 1987, 15 (2) 256-261;
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    Metabolism of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-oxazole-4-acetate, a new hypolipidemic agent, in the rat, rabbit, and dog. Glucuronidation of carboxyl group and cleavage of furan ring.
    T Kobayashi, H Ando, J Sugihara and S Harigaya
    Drug Metabolism and Disposition March 1987, 15 (2) 262-266;
  • You have access
    Mitotane (1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane) metabolism in perfusion studies with dog adrenal glands.
    J E Sinsheimer and C J Freeman
    Drug Metabolism and Disposition March 1987, 15 (2) 267-269;
  • You have access
    Comparison of hepatic and renal metabolism of acetaminophen in male and female miniature swine.
    J O Peggins, T F McMahon, W P Beierschmitt and M Weiner
    Drug Metabolism and Disposition March 1987, 15 (2) 270-273;
  • You have access
    In vivo inhibition of phenacetin oxidation by suicide substrate 1-aminobenzotriazole.
    B A Mico, D A Federowicz, E Burak and J E Swagzdis
    Drug Metabolism and Disposition March 1987, 15 (2) 274-276;
  • You have access
    Pharmacogenetic association between the formation of 4-hydroxymephenytoin and a new metabolite of S-mephenytoin in man.
    P J Wedlund, B J Sweetman, G R Wilkinson and R A Branch
    Drug Metabolism and Disposition March 1987, 15 (2) 277-279;
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In this issue

Drug Metabolism and Disposition
Vol. 15, Issue 2
1 Mar 1987
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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