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Drug Metabolism & Disposition

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Table of Contents

May 01, 1987; Volume 15,Issue 3
  • You have access
    Hepatic UDP-glucose and UDP-glucuronic acid synthesis rates in rats during a reduced energy state.
    R L Dills, S R Howell and C D Klaassen
    Drug Metabolism and Disposition May 1987, 15 (3) 281-288;
  • You have access
    Metabolism and distribution of 14C- and 35S-labeled carbon disulfide in immature rats of different ages.
    E G Snyderwine and A Hunter
    Drug Metabolism and Disposition May 1987, 15 (3) 289-294;
  • You have access
    In vivo and in vitro 1-methylxanthine metabolism in the rat. Evidence that the dehydrogenase form of xanthine oxidase predominates in intact perfused liver.
    L A Reinke, M Nakamura, L Logan, H D Christensen and J M Carney
    Drug Metabolism and Disposition May 1987, 15 (3) 295-299;
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    Pharmacokinetic and deuterium isotope effect studies on the metabolism of formaldehyde and formate to carbon dioxide in rats in vivo.
    L K Keefer, A J Streeter, L Y Leung, W C Perry, H S Hu and T A Baillie
    Drug Metabolism and Disposition May 1987, 15 (3) 300-304;
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    3,4-Dichlorobenzyloxyacetic acid is extensively metabolized to a taurine conjugate in rats.
    R C Peffer, D J Abraham, M A Zemaitis, L K Wong and J D Alvin
    Drug Metabolism and Disposition May 1987, 15 (3) 305-311;
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    Diazepam metabolism in cultured hepatocytes from rat, rabbit, dog, guinea pig, and man.
    R J Chenery, A Ayrton, H G Oldham, P Standring, S J Norman, T Seddon and R Kirby
    Drug Metabolism and Disposition May 1987, 15 (3) 312-317;
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    Disposition of 8-methoxypsoralen in the rat. Induction of metabolism in vivo and in vitro and identification of urinary metabolites by thermospray mass spectrometry.
    D C Mays, S G Hecht, S E Unger, C M Pacula, J M Climie, D E Sharp and N Gerber
    Drug Metabolism and Disposition May 1987, 15 (3) 318-328;
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    Effects of cisplatin-induced nephrotoxicity on gentamicin pharmacokinetics in rats.
    M S Engineer, G P Bodey, R A Newman and D H Ho
    Drug Metabolism and Disposition May 1987, 15 (3) 329-334;
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    Induction and inhibition of rat hepatic drug metabolism by N-substituted imidazole drugs.
    J K Ritter and M R Franklin
    Drug Metabolism and Disposition May 1987, 15 (3) 335-343;
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    Influence of cytochrome b5 on the stoichiometry of the different oxidative reactions catalyzed by liver microsomal cytochrome P-450.
    I Jansson and J B Schenkman
    Drug Metabolism and Disposition May 1987, 15 (3) 344-348;
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    The formation of glutathione conjugate derived from propranolol.
    H A Sasame, D J Liberato and J R Gillette
    Drug Metabolism and Disposition May 1987, 15 (3) 349-355;
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    The oxidation of acrolein by rat liver aldehyde dehydrogenases. Relation to allyl alcohol hepatotoxicity.
    L E Rikans
    Drug Metabolism and Disposition May 1987, 15 (3) 356-362;
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    The disposition and elimination of two sequential doses of 2,4,5,2',4',5'-hexachlorobiphenyl.
    L A Gallenberg and M J Vodicnik
    Drug Metabolism and Disposition May 1987, 15 (3) 363-366;
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    Absorption, distribution, metabolism, and excretion of 1,2-dihydro-2,2,4-trimethylquinoline in the male F344 rat.
    Y M Ioannou, L T Burka, J M Sanders, M P Moorman and H B Matthews
    Drug Metabolism and Disposition May 1987, 15 (3) 367-373;
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    Pharmacokinetics of griseofulvin in blood and skin suction blister fluid of rats.
    M Schäfer-Korting
    Drug Metabolism and Disposition May 1987, 15 (3) 374-376;
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    Tissue distribution, disposition, and metabolism of cyclosporine in rats.
    O Wagner, E Schreier, F Heitz and G Maurer
    Drug Metabolism and Disposition May 1987, 15 (3) 377-383;
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    Metabolism of cyclosporin A. I. Study in freshly isolated rabbit hepatocytes.
    G Fabre, P Bertault-Peres, I Fabre, P Maurel, S Just and J P Cano
    Drug Metabolism and Disposition May 1987, 15 (3) 384-390;
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    Metabolism of cyclosporin A. II. Implication of the macrolide antibiotic inducible cytochrome P-450 3c from rabbit liver microsomes.
    P Bertault-Peres, C Bonfils, G Fabre, S Just, J P Cano and P Maurel
    Drug Metabolism and Disposition May 1987, 15 (3) 391-398;
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    Urinary metabolites of busulfan in the rat.
    M Hassan and H Ehrsson
    Drug Metabolism and Disposition May 1987, 15 (3) 399-402;
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    Liver metabolism of budesonide in rat, mouse, and man. Comparative aspects.
    S Edsbäcker, P Andersson, C Lindberg, J Paulson, A Ryrfeldt and A Thalén
    Drug Metabolism and Disposition May 1987, 15 (3) 403-411;
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    Metabolic acetal splitting of budesonide. A novel inactivation pathway for topical glucocorticoids.
    S Edsbäcker, P Andersson, C Lindberg, A Ryrfeldt and A Thalén
    Drug Metabolism and Disposition May 1987, 15 (3) 412-417;
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    Glutathione conjugation of 1,2-dibromo-1-phenylethane in rats in vivo.
    C E Zoetemelk, W van Hove, W L van der Laan, B van Meeteren-Wälchli, A van der Gen and D D Breimer
    Drug Metabolism and Disposition May 1987, 15 (3) 418-425;
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    N-hydroxymethyl metabolites of 450191-S, a 1H-1,2,4,-triazolyl benzophenone derivative, in dog plasma.
    M Koike, R Norikura, S Futaguchi, T Yamaguchi, K Sugeno, K Iwatani, Y Ikenishi and Y Nakagawa
    Drug Metabolism and Disposition May 1987, 15 (3) 426-428;
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    Plasma concentration profiles of human recombinant interleukin-2 (HrIL-2) in the rat following administration by various systemic routes.
    W A Colburn, J Hakimi and I Bekersky
    Drug Metabolism and Disposition May 1987, 15 (3) 429-431;
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    Dose- and time-dependent effect of levamisole on the elimination of antipyrine in the rat.
    C K Svensson and L L Liu
    Drug Metabolism and Disposition May 1987, 15 (3) 432-434;
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In this issue

Drug Metabolism and Disposition
Vol. 15, Issue 3
1 May 1987
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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