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Drug Metabolism & Disposition

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Table of Contents

March 01, 1988; Volume 16,Issue 2
  • You have access
    Metabolic activation of the halothane metabolite, [14C]2-chloro-1,1-difluoroethene, in hepatic microsomes.
    M T Baker and J N Bates
    Drug Metabolism and Disposition March 1988, 16 (2) 169-172;
  • You have access
    Regioselective and stereoselective metabolisms of pyrene and 1-bromopyrene by rat liver microsomes and effects of enzyme inducers.
    M Shou and S K Yang
    Drug Metabolism and Disposition March 1988, 16 (2) 173-183;
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    Regiochemistry and substrate stereoselectivity of O-demethylation of verapamil in the presence of the microsomal fraction from rat and human liver.
    W L Nelson, L D Olsen, D B Beitner and R J Pallow
    Drug Metabolism and Disposition March 1988, 16 (2) 184-188;
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    In vivo renal tubular secretion and metabolism of the disulfide of 2,3-dimercaptopropane-1-sulfonate.
    J R Stewart and G L Diamond
    Drug Metabolism and Disposition March 1988, 16 (2) 189-195;
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    The disposition of the hypolipidemic agent, o-(N-phthalimido)acetophenone, in Sprague-Dawley rats.
    I H Hall, D J Reynolds, S D Wyrick, J H Maguire and R P Shrewsbury
    Drug Metabolism and Disposition March 1988, 16 (2) 196-200;
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    Dose-dependent pharmacokinetics of recombinant tissue-type plasminogen activator in anesthetized dogs following intravenous infusion.
    K L Fong, C S Crysler, B A Mico, K E Boyle, G A Kopia, L Kopaciewicz and R K Lynn
    Drug Metabolism and Disposition March 1988, 16 (2) 201-206;
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    Regioisomeric aromatic dihydroxylation of propranolol. Use of monohydroxylated intermediates for structural assignments of the metabolites formed in vitro.
    R E Talaat and W L Nelson
    Drug Metabolism and Disposition March 1988, 16 (2) 207-211;
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    Regioisomeric aromatic dihydroxylation of propranolol. Synthesis and identification of 4,6- and 4,8-dihydroxypropranolol as metabolites in the rat and in man.
    R E Talaat and W L Nelson
    Drug Metabolism and Disposition March 1988, 16 (2) 212-216;
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    Regioisomeric products of propranolol metabolism. The monomethyl ethers of 3,4-dihydroxypropranolol and of 3,4-dihydroxypropranolol glycol.
    L M Gustavson and W L Nelson
    Drug Metabolism and Disposition March 1988, 16 (2) 217-221;
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    Relationship between the pharmacokinetic and pharmacodynamic profile of nilvadipine in the dog.
    W H Wu, B M Henderson, R Lanc, D Garnes, A Yacobi and B M Silber
    Drug Metabolism and Disposition March 1988, 16 (2) 222-227;
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    Dose-dependent tissue uptake of flecainide during chronic administration in rabbits.
    R Kannan and A Matin-Asgari
    Drug Metabolism and Disposition March 1988, 16 (2) 228-231;
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    In vitro metabolism and covalent binding among ortho-substituted bromobenzenes of varying hepatotoxicity.
    P E Weller, N Narasimhan, J A Buben and R P Hanzlik
    Drug Metabolism and Disposition March 1988, 16 (2) 232-237;
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    Effect of diet and gavage on the absorption and metabolism of fluperlapine in the rat.
    J G Dain and J M Jaffe
    Drug Metabolism and Disposition March 1988, 16 (2) 238-242;
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    Disposition and metabolism of double-labeled [3H and 14C] N-methyl-2-pyrrolidinone in the rat.
    D A Wells and G A Digenis
    Drug Metabolism and Disposition March 1988, 16 (2) 243-249;
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    Quantitative analysis of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolism in isolated rat hepatocytes.
    D Di Monte, T Shinka, M S Sandy, N Castagnoli and M T Smith
    Drug Metabolism and Disposition March 1988, 16 (2) 250-255;
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    Cyclosporine-phenytoin interaction.
    M J D'Souza, S H Pollock and H M Solomon
    Drug Metabolism and Disposition March 1988, 16 (2) 256-258;
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    N-benzylimidazole, a high magnitude inducer of rat hepatic cytochrome P-450 exhibiting both polycyclic aromatic hydrocarbon- and phenobarbital-type induction of phase I and phase II drug-metabolizing enzymes.
    D I Papac and M R Franklin
    Drug Metabolism and Disposition March 1988, 16 (2) 259-264;
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    Cytochrome P-450-dependent formation of ethylene from N-nitrosoethylamines.
    X X Ding and M J Coon
    Drug Metabolism and Disposition March 1988, 16 (2) 265-269;
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    Pharmacokinetics and tissue distribution of recombinant human tumor necrosis factor-alpha in mice.
    B L Ferraiolo, J A Moore, D Crase, P Gribling, H Wilking and R A Baughman
    Drug Metabolism and Disposition March 1988, 16 (2) 270-275;
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    Modulation of trans-4-acetylaminostilbene metabolism in the rat by methylcholanthrene and phenobarbital and its relevance for acute toxicity.
    A Pfeifer and H G Neumann
    Drug Metabolism and Disposition March 1988, 16 (2) 276-284;
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    Marked interspecies differences between humans and pigs in cyclosporine and prednisolone disposition.
    B M Frey, M Sieber, D Mettler, H Gänger and F J Frey
    Drug Metabolism and Disposition March 1988, 16 (2) 285-289;
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    Effect of serum from renal failure and cirrhotic patients on the blood-brain barrier permeability to DL-propranolol in rats.
    T H Lin, Y Sugiyama, Y Sawada, S Kawasaki, T Iga and M Hanano
    Drug Metabolism and Disposition March 1988, 16 (2) 290-295;
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    Metabolism of cyclosporin A. III. Interaction of the macrolide antibiotic, erythromycin, using rabbit hepatocytes and microsomal fractions.
    I Fabre, G Fabre, P Maurel, P Bertault-Peres and J P Cano
    Drug Metabolism and Disposition March 1988, 16 (2) 296-301;
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    The metabolism and disposition of fenofibrate in rat, guinea pig, and dog.
    A Weil, J Caldwell and M Strolin-Benedetti
    Drug Metabolism and Disposition March 1988, 16 (2) 302-309;
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    Pre- and postweaning development of drug-metabolizing enzyme activities in small intestine and liver of rats.
    I de Waziers, M Boisset and S Atteba
    Drug Metabolism and Disposition March 1988, 16 (2) 310-315;
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    The rat biliary and urinary metabolism of the N6-methylated derivative of elliptinium acetate, and antitumor agent.
    Y Braham, G Meunier and B Meunier
    Drug Metabolism and Disposition March 1988, 16 (2) 316-321;
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    Effect of pH on acyl migration and hydrolysis of tolmetin glucuronide.
    M L Hyneck, A Munafo and L Z Benet
    Drug Metabolism and Disposition March 1988, 16 (2) 322-324;
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    Identification of two metabolites of a penem (Sch 34343) in human urine.
    H Kim, B Pramanik, A Lapiguera, T M Chan, V M Girijavallabhan, S Symchowicz and C Lin
    Drug Metabolism and Disposition March 1988, 16 (2) 325-327;
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    Efflux of cimetidine from the rat cerebrospinal fluid.
    H Suzuki, Y Sawada, Y Sugiyama, T Iga and M Hanano
    Drug Metabolism and Disposition March 1988, 16 (2) 328-330;
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    Inhibition of cimetidine transport by creatinine in luminal membrane vesicles prepared from rabbit kidney.
    L G Gisclon and K M Giacomini
    Drug Metabolism and Disposition March 1988, 16 (2) 331-332;
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    Metabolism of 7-ethoxyresorufin by phenobarbital or Aroclor 1254 pretreated mice.
    S J Glass and R B van Lier
    Drug Metabolism and Disposition March 1988, 16 (2) 333-334;
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In this issue

Drug Metabolism and Disposition
Vol. 16, Issue 2
1 Mar 1988
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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