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Drug Metabolism & Disposition

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Table of Contents

July 01, 1988; Volume 16,Issue 4
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    Distribution of [3H]diisopropylfluorophosphate, [3H]soman, [3H]sarin, and their metabolites in mouse brain.
    P J Little, J A Scimeca and B R Martin
    Drug Metabolism and Disposition July 1988, 16 (4) 515-520;
  • You have access
    The influence of diffusional barriers on presystemic gut elimination.
    P R Gwilt, S Comer, P R Chaturvedi and D H Waters
    Drug Metabolism and Disposition July 1988, 16 (4) 521-526;
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    Effect of galactosamine-induced hepatic UDP-glucuronic acid depletion on acetaminophen elimination in rats. Dispositional differences between hepatically and extrahepatically formed glucuronides of acetaminophen and other chemicals.
    Z Gregus, C Madhu, D Goon and C D Klaassen
    Drug Metabolism and Disposition July 1988, 16 (4) 527-533;
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    The disposition of [3H]diisopropylfluorophosphate in guinea pigs after inhalation.
    J A Scimeca and B R Martin
    Drug Metabolism and Disposition July 1988, 16 (4) 534-539;
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    Enantioselective disposition and protein binding of [(5,6-dichloro-9a-propyl-3-oxo-2,3,9,9a-tetrahydro-1-H-fluoren-7 -yl)-oxy] acetic acid, a new cerebral antiedemic agent, in rats.
    J H Lin and J Y Hsieh
    Drug Metabolism and Disposition July 1988, 16 (4) 540-545;
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    Dose-response behavior of the induction of alpha 1-acid glycoprotein by phenobarbital in the dog.
    F P Abramson
    Drug Metabolism and Disposition July 1988, 16 (4) 546-550;
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    Ascorbic acid deficiency and hepatic UDP-glucuronyltransferase.
    C M Neumann and V G Zannoni
    Drug Metabolism and Disposition July 1988, 16 (4) 551-556;
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    Distribution of microsomal monooxygenases in the rabbit respiratory tract.
    P J Sabourin, R E Tynes, R M Philpot, S Winquist and A R Dahl
    Drug Metabolism and Disposition July 1988, 16 (4) 557-562;
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    Species-dependent binding of disopyramide enantiomers.
    J J Lima
    Drug Metabolism and Disposition July 1988, 16 (4) 563-567;
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    Disposition and metabolism of prinomide in laboratory animals.
    H Egger, W Itterly, V John, R Rodebaugh, C Shimanskas, F Stancato and A Kapoor
    Drug Metabolism and Disposition July 1988, 16 (4) 568-575;
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    Coordinated maternal imprinting and paternal genotype determined the ultimate level of hepatic cytochrome P-450 and associated monooxygenase activities.
    V J Simpson, H E Zhau, M N Runner and L W Chung
    Drug Metabolism and Disposition July 1988, 16 (4) 576-581;
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    Foreign compound metabolism studies with human liver obtained as surgical waste. Relation to donor characteristics and effects of tissue storage.
    G Powis, I Jardine, R Van Dyke, R Weinshilboum, D Moore, T Wilke, W Rhodes, R Nelson, L Benson and C Szumlanski
    Drug Metabolism and Disposition July 1988, 16 (4) 582-589;
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    Cellular and subcellular localization of a binding protein for polychlorinated biphenyls in rat lung.
    J Lund, T Devereux, H Glaumann and J A Gustafsson
    Drug Metabolism and Disposition July 1988, 16 (4) 590-599;
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    Metabolism of N,N-diethyl-m-toluamide (DEET) by liver microsomes from male and female rats. Simultaneous quantitation of DEET and its metabolites by high performance liquid chromatography.
    J M Yeung and W G Taylor
    Drug Metabolism and Disposition July 1988, 16 (4) 600-604;
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    Metabolism of diazepam in vitro by human liver. Independent variability of N-demethylation and C3-hydroxylation.
    T Inaba, A Tait, M Nakano, W A Mahon and W Kalow
    Drug Metabolism and Disposition July 1988, 16 (4) 605-608;
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    Biopharmaceutical characterization of 450191-S, a ring-opened derivative of 1,4-benzodiazepine. II. Evidence for reduced first-pass extraction by rat liver.
    M Koike, S Futaguchi, S Takahashi and K Sugeno
    Drug Metabolism and Disposition July 1988, 16 (4) 609-615;
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    Stereoselective N-oxygenation of zimeldine and homozimeldine by the flavin-containing monooxygenase.
    J R Cashman, J Proudfoot, D W Pate and T Högberg
    Drug Metabolism and Disposition July 1988, 16 (4) 616-622;
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    Stereoselective pharmacokinetics of ketoprofen in the rat. Influence of route of administration.
    R T Foster and F Jamali
    Drug Metabolism and Disposition July 1988, 16 (4) 623-626;
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    Substrate specificity and enantioselectivity of arylcarboxylic acid glucuronidation.
    S Fournel-Gigleux, C Hamar-Hansen, N Motassim, B Antoine, O Mothe, D Decolin, J Caldwell and G Siest
    Drug Metabolism and Disposition July 1988, 16 (4) 627-634;
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    New aspects of metabolic conjugation of chloramphenicol.
    J M Wal, J C Peleran, E Perdu, D Rao and G Bories
    Drug Metabolism and Disposition July 1988, 16 (4) 635-639;
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    Possible hemodynamic basis to urethane anesthesia-induced reductions in renal clearance.
    M Gumbleton, P J Nicholls and G Taylor
    Drug Metabolism and Disposition July 1988, 16 (4) 640-644;
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    Nonlinear tissue distribution of ouabain in rabbits.
    H Harashima, Y Sugiyama, T Iga and M Hanano
    Drug Metabolism and Disposition July 1988, 16 (4) 645-649;
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    Glucuronidation in 4-chlorobiphenyl metabolism by rat and human liver microsomes.
    R P Volp
    Drug Metabolism and Disposition July 1988, 16 (4) 650-652;
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    Effect of enoxacin and 4-oxo-enoxacin on antipyrine disposition in the rat.
    D J Edwards, N M Waite and C K Svensson
    Drug Metabolism and Disposition July 1988, 16 (4) 653-655;
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    Isotope effects on formaldehyde oxidation.
    H D Heck and M Casanova
    Drug Metabolism and Disposition July 1988, 16 (4) 656-657;
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In this issue

Drug Metabolism and Disposition
Vol. 16, Issue 4
1 Jul 1988
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
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  • Most Cited
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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