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Drug Metabolism & Disposition

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Table of Contents

March 01, 1989; Volume 17,Issue 2
  • You have access
    Methoxyflurane enhances allyl alcohol hepatotoxicity in rats. Possible involvement of increased acrolein formation.
    W C Kershaw, D A Barsotti, T B Leonard, J G Dent and G L Lage
    Drug Metabolism and Disposition March 1989, 17 (2) 117-122;
  • You have access
    The covalent binding to protein of valproic acid and its hepatotoxic metabolite, 2-n-propyl-4-pentenoic acid, in rats and in isolated rat hepatocytes.
    D J Porubek, M P Grillo and T A Baillie
    Drug Metabolism and Disposition March 1989, 17 (2) 123-130;
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    A characterization of chlordecone pretreatment-altered pharmacokinetics in mice.
    H M Carpenter and L R Curtis
    Drug Metabolism and Disposition March 1989, 17 (2) 131-138;
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    Role of pharmacokinetics and metabolism in the enhanced susceptibility of middle-aged male Sprague-Dawley rats to acetaminophen nephrotoxicity.
    J B Tarloff, R S Goldstein, B A Mico and J B Hook
    Drug Metabolism and Disposition March 1989, 17 (2) 139-146;
  • You have access
    Effect of experimental diabetes on elimination kinetics of diflunisal in rats.
    J H Lin, F A DeLuna, D J Tocco and E H Ulm
    Drug Metabolism and Disposition March 1989, 17 (2) 147-152;
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    Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking.
    A R Jeffcoat, M Perez-Reyes, J M Hill, B M Sadler and C E Cook
    Drug Metabolism and Disposition March 1989, 17 (2) 153-159;
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    On the antipyrine test in laboratory animals. Studies in the dog and monkey.
    F F Vickers, T A Bowman, B H Dvorchik, G T Passananti, D M Hughes and E S Vesell
    Drug Metabolism and Disposition March 1989, 17 (2) 160-165;
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    The physiological disposition of lovastatin.
    D E Duggan, I W Chen, W F Bayne, R A Halpin, C A Duncan, M S Schwartz, R J Stubbs and S Vickers
    Drug Metabolism and Disposition March 1989, 17 (2) 166-173;
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    Pharmacokinetics and metabolism of SK&F 86002 in male and female Sprague-Dawley rats.
    J F Newton, L P Yodis, D Keohane, R Eckardt, R Dewey, J Dent and B Mico
    Drug Metabolism and Disposition March 1989, 17 (2) 174-179;
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    N-methylation as a toxication route for xenobiotics. II. In vivo formation of N,N'-dimethyl-4,4'-bipyridyl ion (paraquat) from 4,4'-bipyridyl in the guinea pig.
    C S Godin and P A Crooks
    Drug Metabolism and Disposition March 1989, 17 (2) 180-185;
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    Spironolactone metabolism in target tissues. Characteristics of deacetylation in kidney, liver, adrenal cortex, and testes.
    N L Flowers, J P O'Donnell and H D Colby
    Drug Metabolism and Disposition March 1989, 17 (2) 186-189;
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    Renal tubular secretion of amiloride and its inhibition by cimetidine in humans and in an animal model.
    A A Somogyi, C M Hovens, M R Muirhead and F Bochner
    Drug Metabolism and Disposition March 1989, 17 (2) 190-196;
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    Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily.
    J Combalbert, I Fabre, G Fabre, I Dalet, J Derancourt, J P Cano and P Maurel
    Drug Metabolism and Disposition March 1989, 17 (2) 197-207;
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    The pharmacokinetics of albumin conjugates of D-penicillamine in rats.
    D A Joyce, D N Wade and B R Swanson
    Drug Metabolism and Disposition March 1989, 17 (2) 208-211;
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    Stereoselective metabolism and pharmacokinetics of racemic methylphenobarbital in humans.
    W H Lim and W D Hooper
    Drug Metabolism and Disposition March 1989, 17 (2) 212-217;
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    Metabolic interaction between morphine and naloxone in human liver. A common pathway of glucuronidation?
    A Wahlström, K Persson and A Rane
    Drug Metabolism and Disposition March 1989, 17 (2) 218-220;
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    Species differences in protein binding of diflunisal.
    J H Lin
    Drug Metabolism and Disposition March 1989, 17 (2) 221-223;
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    Tissue distribution of intravenously administered dimethyl sulfoxide in the normal rat.
    M C Nishimura, P Jacob, M E Cassel and L H Pitts
    Drug Metabolism and Disposition March 1989, 17 (2) 224-226;
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In this issue

Drug Metabolism and Disposition
Vol. 17, Issue 2
1 Mar 1989
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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