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Drug Metabolism & Disposition

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Table of Contents

July 01, 1989; Volume 17,Issue 4
  • You have access
    Investigations of the N-hydroxylation of 3'-hydroxyacetanilide, a non-hepatotoxic positional isomer of acetaminophen.
    M S Rashed, A J Streeter and S D Nelson
    Drug Metabolism and Disposition July 1989, 17 (4) 355-359;
  • You have access
    Isozyme-specific monoclonal antibody-directed assessment of induction of hepatic cytochrome p-450 by clotrimazole.
    W A Khan, C Kuhn, H F Merk, S S Park, H V Gelboin, D R Bickers and H Mukhtar
    Drug Metabolism and Disposition July 1989, 17 (4) 360-364;
  • You have access
    Influence of nutritional status on the pharmacokinetics and pharmacodynamics of pentobarbital.
    D Jung and P P Prasad
    Drug Metabolism and Disposition July 1989, 17 (4) 365-368;
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    Pharmacokinetics of recombinant human tumor necrosis factor-alpha in rats. Effects of size and number of doses and nephrectomy.
    B L Ferraiolo, J McCabe, S Hollenbach, B Hultgren, R Pitti and H Wilking
    Drug Metabolism and Disposition July 1989, 17 (4) 369-372;
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    Pharmacokinetics and excretion of the 21-aminosteroid antioxidant U-74006F in rat and perfused rat liver.
    J W Cox, P G Larson, M A Wynalda, V K Sood, M T Verburg and R N Pullen
    Drug Metabolism and Disposition July 1989, 17 (4) 373-379;
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    The role of flavin-containing monooxygenase in the N-oxidation of the pyrrolizidine alkaloid senecionine.
    D E Williams, R L Reed, B Kedzierski, D M Ziegler and D R Buhler
    Drug Metabolism and Disposition July 1989, 17 (4) 380-386;
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    Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver.
    D E Williams, R L Reed, B Kedzierski, G A Dannan, F P Guengerich and D R Buhler
    Drug Metabolism and Disposition July 1989, 17 (4) 387-392;
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    In vitro metabolic degradation of a bovine growth hormone-releasing factor analog Leu27-bGRF(1-29)NH2 in bovine and porcine plasma. Correlation with plasma dipeptidylpeptidase activity.
    T M Kubiak, C R Kelly and L F Krabill
    Drug Metabolism and Disposition July 1989, 17 (4) 393-397;
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    An active, aldehydic metabolite of the cell-differentiating agent hexamethylene bisacetamide.
    B Subramanyam, P S Callery, M J Egorin, S W Snyder and B A Conley
    Drug Metabolism and Disposition July 1989, 17 (4) 398-401;
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    Plasma pharmacokinetics and urinary excretion of thalidomide after oral dosing in healthy male volunteers.
    T L Chen, G B Vogelsang, B G Petty, R B Brundrett, D A Noe, G W Santos and O M Colvin
    Drug Metabolism and Disposition July 1989, 17 (4) 402-405;
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    Hydroxylation of 4,4'-methylenebis(2-chloroaniline) by canine, guinea pig, and rat liver microsomes.
    T H Chen, B I Kuslikis and W E Braselton
    Drug Metabolism and Disposition July 1989, 17 (4) 406-413;
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    Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man.
    S Iwakawa, T Suganuma, S F Lee, H Spahn, L Z Benet and E T Lin
    Drug Metabolism and Disposition July 1989, 17 (4) 414-419;
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    Disposition of flavodilol in laboratory animals.
    M Coan and R Simmons
    Drug Metabolism and Disposition July 1989, 17 (4) 420-425;
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    Dose-dependent kinetics of cilastatin in laboratory animals.
    J H Lin, I W Chen and E H Ulm
    Drug Metabolism and Disposition July 1989, 17 (4) 426-432;
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    Glucuronidation of E-10-hydroxynortriptyline in human liver, kidney, and intestine. Organ-specific differences in enantioselectivity.
    M L Dahl-Puustinen, E Dumont and L Bertilsson
    Drug Metabolism and Disposition July 1989, 17 (4) 433-436;
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    Doxofylline in rat brain in relation to locomotor activity.
    C Cravanzola, M C Reboani, G Grosa and J S Franzone
    Drug Metabolism and Disposition July 1989, 17 (4) 437-440;
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    3,3',4,4'-Tetrachlorobiphenyl. Excretion and tissue retention of hydroxylated metabolites in the mouse.
    E K Wehler, A Bergman, I Brandt, P O Darnerud and C A Wachtmeister
    Drug Metabolism and Disposition July 1989, 17 (4) 441-448;
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    In vitro formation of an inhibitory complex between an isosafrole metabolite and rat hepatic cytochrome P-450 PB-B.
    M Murray and G F Reidy
    Drug Metabolism and Disposition July 1989, 17 (4) 449-454;
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    Studies of metabolic pathways of trimebutine by simultaneous administration of trimebutine and its deuterium-labeled metabolite.
    Y Miura, S Chishima and S Takeyama
    Drug Metabolism and Disposition July 1989, 17 (4) 455-462;
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    Oxidation of tenoxicam by leukocyte peroxidases and H2O2 produces novel products.
    S Ichihara, H Tomisawa, H Fukazawa, M Tateishi, R Joly and R Heintz
    Drug Metabolism and Disposition July 1989, 17 (4) 463-468;
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In this issue

Drug Metabolism and Disposition
Vol. 17, Issue 4
1 Jul 1989
  • Table of Contents
  • Index by author
  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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