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Drug Metabolism & Disposition

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Table of Contents

March 01, 1990; Volume 18,Issue 2
  • You have access
    Role of P-450c in the formation of a reactive intermediate of chlorotrianisene (TACE) by hepatic microsomes from methylcholanthrene-treated rats.
    M J Juedes and D Kupfer
    Drug Metabolism and Disposition March 1990, 18 (2) 131-137;
  • You have access
    Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug.
    S Vickers, C A Duncan, I W Chen, A Rosegay and D E Duggan
    Drug Metabolism and Disposition March 1990, 18 (2) 138-145;
  • You have access
    Metabolism of temelastine (SK&F 93944) in hepatocytes from rat, dog, cynomolgus monkey and man.
    H G Oldham, P Standring, S J Norman, T J Blake, I Beattie, P J Cox and R J Chenery
    Drug Metabolism and Disposition March 1990, 18 (2) 146-152;
  • You have access
    Disposition in animals of a new anti-HIV agent: 2',3'-didehydro-3'-deoxythymidine.
    J W Russell, V J Whiterock, D Marrero and L J Klunk
    Drug Metabolism and Disposition March 1990, 18 (2) 153-157;
  • You have access
    Bioavailability assessment of cyclosporine in the rat. Influence of route of administration.
    D R Luke, L J Brunner and K Vadiei
    Drug Metabolism and Disposition March 1990, 18 (2) 158-162;
  • You have access
    Bioalkylation of benz[a]anthracene as a biochemical probe for carcinogenic activity. Lack of bioalkylation in a series of six noncarcinogenic polynuclear aromatic hydrocarbons.
    J W Flesher and S R Myers
    Drug Metabolism and Disposition March 1990, 18 (2) 163-167;
  • You have access
    Selective inactivation by chlorofluoroacetamides of the major phenobarbital-inducible form(s) of rat liver cytochrome P-450.
    J Halpert, J Y Jaw, C Balfour and L S Kaminsky
    Drug Metabolism and Disposition March 1990, 18 (2) 168-174;
  • You have access
    Distribution and metabolism of the retinoid, N-(4-methoxyphenyl)-all-trans-retinamide, the major metabolite of N-(4-hydroxyphenyl)-all-trans-retinamide, in female mice.
    T A Hultin, M S Filla and D L McCormick
    Drug Metabolism and Disposition March 1990, 18 (2) 175-179;
  • You have access
    Metabolite inhibition of parent drug biotransformation. Studies of diltiazem.
    S C Tsao, T H Dickinson and D R Abernethy
    Drug Metabolism and Disposition March 1990, 18 (2) 180-182;
  • You have access
    In vivo metabolism of isomeric naphthalene oxide glutathione conjugates.
    M Buonarati, A D Jones and A Buckpitt
    Drug Metabolism and Disposition March 1990, 18 (2) 183-189;
  • You have access
    The effect of the cytochrome P-450 suicide inactivator, 1-aminobenzotriazole, on the in vivo metabolism and pharmacologic activity of flurazepam.
    S Capello, L Henderson, F DeGrazia, D Liberato, W Garland and C Town
    Drug Metabolism and Disposition March 1990, 18 (2) 190-196;
  • You have access
    Determination of hepatic blood flow in the rat using sequential infusions of indocyanine green or galactose.
    G M Pollack, K L Brouwer, K B Demby and J A Jones
    Drug Metabolism and Disposition March 1990, 18 (2) 197-202;
  • You have access
    Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse.
    K P Vyas, P H Kari, S M Pitzenberger, R A Halpin, H G Ramjit, B Arison, J S Murphy, W F Hoffman, M S Schwartz and E H Ulm
    Drug Metabolism and Disposition March 1990, 18 (2) 203-211;
  • You have access
    Disposition of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl) dopamine (TA-870) in humans.
    M Yoshikawa, H Endo, K Komatsu, M Fujihara, O Takaiti, T Kagoshima, M Umehara and H Ishikawa
    Drug Metabolism and Disposition March 1990, 18 (2) 212-217;
  • You have access
    Biotransformation of lovastatin. II. In vitro metabolism by rat and mouse liver microsomes and involvement of cytochrome P-450 in dehydrogenation of lovastatin.
    K P Vyas, P H Kari, S R Prakash and D E Duggan
    Drug Metabolism and Disposition March 1990, 18 (2) 218-222;
  • You have access
    The effect of aspartame on the activity of rat liver xenobiotic-metabolizing enzymes.
    V A Tutelyan, L V Kravchenko and E E Kuzmina
    Drug Metabolism and Disposition March 1990, 18 (2) 223-225;
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    Pharmacokinetics and biotransformation of the cyclosporine metabolite M-17 in the rabbit.
    K Copeland, M Lukowski, R Yatscoff, J Thliveris and N Honcharik
    Drug Metabolism and Disposition March 1990, 18 (2) 226-230;
  • You have access
    Clearance of prednisone in isolated perfused livers of normal and uremic rats. Effects of acute and chronic cyclosporin A administration.
    M Egfjord, H Daugaard and K Olgaard
    Drug Metabolism and Disposition March 1990, 18 (2) 231-237;
  • You have access
    The disposition of valpromide in rats and the isolated perfused rat liver.
    H Billig, E Ziv, H Bar-On and M Bialer
    Drug Metabolism and Disposition March 1990, 18 (2) 238-244;
  • You have access
    Physiologically based pharmacokinetics of a new penem, SUN5555, for evaluation of in vivo efficacy.
    A Tsuji, H Sato, I Tamai, H Adachi, T Nishihara, M Ishiguro, N Ohnuma and T Noguchi
    Drug Metabolism and Disposition March 1990, 18 (2) 245-252;
  • You have access
    Relative contribution of the gut, liver, and lung to the first-pass hydrolysis (bioactivation) of orally administered 14C-fosinopril sodium in dogs. In vivo and in vitro studies.
    R A Morrison, S M Singhvi, A E Peterson, D A Pocetti and B H Migdalof
    Drug Metabolism and Disposition March 1990, 18 (2) 253-257;
  • You have access
    Effect of fat tissue volume on the distribution kinetics of biperiden as a function of age in rats.
    K Yokogawa, E Nakashima and F Ichimura
    Drug Metabolism and Disposition March 1990, 18 (2) 258-263;
  • You have access
    Enzymatic reduction of an epoxysuccinic acid derivative by rat cecal microflora.
    K Fukushima, M Arai, T Suwa and T Satoh
    Drug Metabolism and Disposition March 1990, 18 (2) 264-266;
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In this issue

Drug Metabolism and Disposition
Vol. 18, Issue 2
1 Mar 1990
  • Table of Contents
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  • Cannabinoid Metabolites as CYP450 Inhibitors
  • Physiology of the Neonatal Gastrointestinal System
  • Pharmacokinetics and Disposition of Biologics
  • Switch from CAR to PXR in the Presence of EGF
  • Alternative P450 Splicing Redirects Human Drug Metabolism
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