Drug Metabolism and Disposition: 18 (2)

March 01, 1990; Volume 18,Issue 2

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Role of P-450c in the formation of a reactive intermediate of chlorotrianisene (TACE) by hepatic microsomes from methylcholanthrene-treated rats.
M J Juedes and D Kupfer

Drug Metabolism and Disposition March 1990, 18 (2) 131-137;
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Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug.
S Vickers, C A Duncan, I W Chen, A Rosegay and D E Duggan

Drug Metabolism and Disposition March 1990, 18 (2) 138-145;
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Metabolism of temelastine (SK&F 93944) in hepatocytes from rat, dog, cynomolgus monkey and man.
H G Oldham, P Standring, S J Norman, T J Blake, I Beattie, P J Cox and R J Chenery

Drug Metabolism and Disposition March 1990, 18 (2) 146-152;
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Disposition in animals of a new anti-HIV agent: 2',3'-didehydro-3'-deoxythymidine.
J W Russell, V J Whiterock, D Marrero and L J Klunk

Drug Metabolism and Disposition March 1990, 18 (2) 153-157;
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Bioavailability assessment of cyclosporine in the rat. Influence of route of administration.
D R Luke, L J Brunner and K Vadiei

Drug Metabolism and Disposition March 1990, 18 (2) 158-162;
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Bioalkylation of benz[a]anthracene as a biochemical probe for carcinogenic activity. Lack of bioalkylation in a series of six noncarcinogenic polynuclear aromatic hydrocarbons.
J W Flesher and S R Myers

Drug Metabolism and Disposition March 1990, 18 (2) 163-167;
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Selective inactivation by chlorofluoroacetamides of the major phenobarbital-inducible form(s) of rat liver cytochrome P-450.
J Halpert, J Y Jaw, C Balfour and L S Kaminsky

Drug Metabolism and Disposition March 1990, 18 (2) 168-174;
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Distribution and metabolism of the retinoid, N-(4-methoxyphenyl)-all-trans-retinamide, the major metabolite of N-(4-hydroxyphenyl)-all-trans-retinamide, in female mice.
T A Hultin, M S Filla and D L McCormick

Drug Metabolism and Disposition March 1990, 18 (2) 175-179;
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Metabolite inhibition of parent drug biotransformation. Studies of diltiazem.
S C Tsao, T H Dickinson and D R Abernethy

Drug Metabolism and Disposition March 1990, 18 (2) 180-182;
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In vivo metabolism of isomeric naphthalene oxide glutathione conjugates.
M Buonarati, A D Jones and A Buckpitt

Drug Metabolism and Disposition March 1990, 18 (2) 183-189;
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The effect of the cytochrome P-450 suicide inactivator, 1-aminobenzotriazole, on the in vivo metabolism and pharmacologic activity of flurazepam.
S Capello, L Henderson, F DeGrazia, D Liberato, W Garland and C Town

Drug Metabolism and Disposition March 1990, 18 (2) 190-196;
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Determination of hepatic blood flow in the rat using sequential infusions of indocyanine green or galactose.
G M Pollack, K L Brouwer, K B Demby and J A Jones

Drug Metabolism and Disposition March 1990, 18 (2) 197-202;
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Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse.
K P Vyas, P H Kari, S M Pitzenberger, R A Halpin, H G Ramjit, B Arison, J S Murphy, W F Hoffman, M S Schwartz and E H Ulm

Drug Metabolism and Disposition March 1990, 18 (2) 203-211;
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Disposition of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl) dopamine (TA-870) in humans.
M Yoshikawa, H Endo, K Komatsu, M Fujihara, O Takaiti, T Kagoshima, M Umehara and H Ishikawa

Drug Metabolism and Disposition March 1990, 18 (2) 212-217;
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Biotransformation of lovastatin. II. In vitro metabolism by rat and mouse liver microsomes and involvement of cytochrome P-450 in dehydrogenation of lovastatin.
K P Vyas, P H Kari, S R Prakash and D E Duggan

Drug Metabolism and Disposition March 1990, 18 (2) 218-222;
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The effect of aspartame on the activity of rat liver xenobiotic-metabolizing enzymes.
V A Tutelyan, L V Kravchenko and E E Kuzmina

Drug Metabolism and Disposition March 1990, 18 (2) 223-225;
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Pharmacokinetics and biotransformation of the cyclosporine metabolite M-17 in the rabbit.
K Copeland, M Lukowski, R Yatscoff, J Thliveris and N Honcharik

Drug Metabolism and Disposition March 1990, 18 (2) 226-230;
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Clearance of prednisone in isolated perfused livers of normal and uremic rats. Effects of acute and chronic cyclosporin A administration.
M Egfjord, H Daugaard and K Olgaard

Drug Metabolism and Disposition March 1990, 18 (2) 231-237;
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The disposition of valpromide in rats and the isolated perfused rat liver.
H Billig, E Ziv, H Bar-On and M Bialer

Drug Metabolism and Disposition March 1990, 18 (2) 238-244;
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Physiologically based pharmacokinetics of a new penem, SUN5555, for evaluation of in vivo efficacy.
A Tsuji, H Sato, I Tamai, H Adachi, T Nishihara, M Ishiguro, N Ohnuma and T Noguchi

Drug Metabolism and Disposition March 1990, 18 (2) 245-252;
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Relative contribution of the gut, liver, and lung to the first-pass hydrolysis (bioactivation) of orally administered 14C-fosinopril sodium in dogs. In vivo and in vitro studies.
R A Morrison, S M Singhvi, A E Peterson, D A Pocetti and B H Migdalof

Drug Metabolism and Disposition March 1990, 18 (2) 253-257;
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Effect of fat tissue volume on the distribution kinetics of biperiden as a function of age in rats.
K Yokogawa, E Nakashima and F Ichimura

Drug Metabolism and Disposition March 1990, 18 (2) 258-263;
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Enzymatic reduction of an epoxysuccinic acid derivative by rat cecal microflora.
K Fukushima, M Arai, T Suwa and T Satoh

Drug Metabolism and Disposition March 1990, 18 (2) 264-266;

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