Drug Metabolism and Disposition: 18 (4)

July 01, 1990; Volume 18,Issue 4

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Comment: Pharmaceutics of acetaminophen, vancomycin, and antipyrine on the Hanford miniature swine.
J Mordenti

Drug Metabolism and Disposition July 1990, 18 (4) 387;
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Interspecies differences in stereoselective protein binding and clearance of MK-571.
D J Tocco, F A deLuna, A E Duncan, J H Hsieh and J H Lin

Drug Metabolism and Disposition July 1990, 18 (4) 388-392;
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Comparison of the interaction of pyrazole and its metabolite 4-hydroxypyrazole with rat liver microsomes.
L A Clejan and A I Cederbaum

Drug Metabolism and Disposition July 1990, 18 (4) 393-397;
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Tissue, species, and substrate concentration differences in the position-selective hydroxylation of N-nitrosodibutylamine. Relationship to the distribution of cytochrome P-450 isozymes 2 (IIB) and 5 (IVB).
J Schulze, E Richter and R M Philpot

Drug Metabolism and Disposition July 1990, 18 (4) 398-402;
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Effects of thyroid dysfunction on prednisolone and prednisone interconversion and disposition in the rat.
R Murata, D B Haughey and W J Jusko

Drug Metabolism and Disposition July 1990, 18 (4) 403-408;
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Metabolic fate of alclometasone dipropionate in rats, rabbits, and mice. Metabolic products and pathway following subcutaneous administration.
S Aoyama and K Kamata

Drug Metabolism and Disposition July 1990, 18 (4) 409-417;
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The role of cytochromes P-450 and flavin-containing monooxygenase in the metabolism of (S)-nicotine by rabbit lung.
D E Williams, M K Shigenaga and N Castagnoli

Drug Metabolism and Disposition July 1990, 18 (4) 418-428;
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A pharmacokinetic model for isosorbidedinitrate, isosorbide-2-mononitrate, and isosorbide-5-mononitrate.
D Smith, W Aldrich, M Dey, R Enever, R Warner and R Weierstall

Drug Metabolism and Disposition July 1990, 18 (4) 429-434;
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Interspecies comparison of the pharmacokinetics of aldose reductase inhibitors.
R K Brazzell, Y H Park, C B Wooldridge, B McCue, R Barker, R Couch and B York

Drug Metabolism and Disposition July 1990, 18 (4) 435-440;
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Metabolism and disposition of clarithromycin in man.
J L Ferrero, B A Bopp, K C Marsh, S C Quigley, M J Johnson, D J Anderson, J E Lamm, K G Tolman, S W Sanders and J H Cavanaugh

Drug Metabolism and Disposition July 1990, 18 (4) 441-446;
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Deuterium isotope effect on the toxicokinetics of monomethylamine in the rat.
A J Streeter, R W Nims, P R Sheffels, J A Hrabie, L Ohannesian, Y H Heur, B A Mico and L K Keefer

Drug Metabolism and Disposition July 1990, 18 (4) 447-452;
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N-depyridination and N-dedimethylaminoethylation of tripelennamine and pyrilamine in the rat. New metabolic pathways.
S Y Yeh

Drug Metabolism and Disposition July 1990, 18 (4) 453-461;
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Stimulation mechanism of guinea pig liver-mediated reduction of naloxone by morphine.
Y Kumagai, T Todaka, S Yamano and S Toki

Drug Metabolism and Disposition July 1990, 18 (4) 462-466;
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Effect of recombinant human interleukin-1 beta and tumor necrosis factor alpha on liver cytochrome P-450 and serum alpha-1-acid glycoprotein concentrations in the rat.
C Poüs, J P Giroud, C Damais, D Raichvarg and L Chauvelot-Moachon

Drug Metabolism and Disposition July 1990, 18 (4) 467-470;
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The pharmacokinetics of etodolac enantiomers in the rat. Lack of pharmacokinetic interaction between enantiomers.
D R Brocks and F Jamali

Drug Metabolism and Disposition July 1990, 18 (4) 471-475;
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In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase.
S Vickers, C A Duncan, K P Vyas, P H Kari, B Arison, S R Prakash, H G Ramjit, S M Pitzenberger, G Stokker and D E Duggan

Drug Metabolism and Disposition July 1990, 18 (4) 476-483;
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Species-dependent enantioselective plasma protein binding of MK-571, a potent leukotriene D4 antagonist.
J H Lin, F A deLuna, E H Ulm and D J Tocco

Drug Metabolism and Disposition July 1990, 18 (4) 484-487;
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Structural determination of the conjugated metabolites of ritodrine.
W T Brashear, B R Kuhnert and R Wei

Drug Metabolism and Disposition July 1990, 18 (4) 488-493;
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Effects of age and dose on disposition and metabolism of salicylic acid in male Fischer 344 rats.
T F McMahon, J J Diliberto and L S Birnbaum

Drug Metabolism and Disposition July 1990, 18 (4) 494-503;
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Inhibition of the metabolism of ethyl carbamate by acetaldehyde.
N Kurata, R Kemper, H E Hurst and W J Waddell

Drug Metabolism and Disposition July 1990, 18 (4) 504-507;
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Radioimmunoassay of nicotine-delta 1'(5')-iminium ion, an intermediate formed during the metabolism of nicotine to cotinine.
R S Obach and H van Vunakis

Drug Metabolism and Disposition July 1990, 18 (4) 508-513;
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Biotransformation of halothane in guinea pig liver slices.
H N Ghantous, J Fernando, A J Gandolfi and K Brendel

Drug Metabolism and Disposition July 1990, 18 (4) 514-518;
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Effects of vanadate on hepatic cytochrome P-450 expression in streptozotocin-diabetic rats.
B S Donahue and E T Morgan

Drug Metabolism and Disposition July 1990, 18 (4) 519-526;
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Studies on the metabolism and chiral inversion of ibuprofen in isolated rat hepatocytes.
S M Sanins, W J Adams, D G Kaiser, G W Halstead and T A Baillie

Drug Metabolism and Disposition July 1990, 18 (4) 527-533;
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Morphologic changes and covalent binding of 1,1-dichloroethylene in Clara and alveolar type II cells isolated from lungs of mice following in vivo administration.
P G Forkert, B A Geddes, D W Birch and T E Massey

Drug Metabolism and Disposition July 1990, 18 (4) 534-539;
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Unsubstituted amides: new class of potent inhibitors of human microsomal epoxide hydrolase.
B M Kerr and R H Levy

Drug Metabolism and Disposition July 1990, 18 (4) 540-542;
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Effects of carbon tetrachloride administration to guinea pigs on cytochromes P-450 and antioxidant levels in the inner and outer zones of the adrenal cortex.
D A Staats, D P Lohr and H D Colby

Drug Metabolism and Disposition July 1990, 18 (4) 543-545;
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Isolation and characterization of an unusual glucuronide conjugate of rimantadine.
S Y Brown, W A Garland and E K Fukuda

Drug Metabolism and Disposition July 1990, 18 (4) 546-547;
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Microsomal metabolism of the 1",1"-dimethylheptyl analogue of cannabidiol: relative percentage of monohydroxy metabolites in four species.
E Samara, N K Brown and D J Harvey

Drug Metabolism and Disposition July 1990, 18 (4) 548-549;

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