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Drug Metabolism & Disposition

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Table of Contents

July 01, 1990; Volume 18,Issue 4
  • You have access
    Comment: Pharmaceutics of acetaminophen, vancomycin, and antipyrine on the Hanford miniature swine.
    J Mordenti
    Drug Metabolism and Disposition July 1990, 18 (4) 387;
  • You have access
    Interspecies differences in stereoselective protein binding and clearance of MK-571.
    D J Tocco, F A deLuna, A E Duncan, J H Hsieh and J H Lin
    Drug Metabolism and Disposition July 1990, 18 (4) 388-392;
  • You have access
    Comparison of the interaction of pyrazole and its metabolite 4-hydroxypyrazole with rat liver microsomes.
    L A Clejan and A I Cederbaum
    Drug Metabolism and Disposition July 1990, 18 (4) 393-397;
  • You have access
    Tissue, species, and substrate concentration differences in the position-selective hydroxylation of N-nitrosodibutylamine. Relationship to the distribution of cytochrome P-450 isozymes 2 (IIB) and 5 (IVB).
    J Schulze, E Richter and R M Philpot
    Drug Metabolism and Disposition July 1990, 18 (4) 398-402;
  • You have access
    Effects of thyroid dysfunction on prednisolone and prednisone interconversion and disposition in the rat.
    R Murata, D B Haughey and W J Jusko
    Drug Metabolism and Disposition July 1990, 18 (4) 403-408;
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    Metabolic fate of alclometasone dipropionate in rats, rabbits, and mice. Metabolic products and pathway following subcutaneous administration.
    S Aoyama and K Kamata
    Drug Metabolism and Disposition July 1990, 18 (4) 409-417;
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    The role of cytochromes P-450 and flavin-containing monooxygenase in the metabolism of (S)-nicotine by rabbit lung.
    D E Williams, M K Shigenaga and N Castagnoli
    Drug Metabolism and Disposition July 1990, 18 (4) 418-428;
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    A pharmacokinetic model for isosorbidedinitrate, isosorbide-2-mononitrate, and isosorbide-5-mononitrate.
    D Smith, W Aldrich, M Dey, R Enever, R Warner and R Weierstall
    Drug Metabolism and Disposition July 1990, 18 (4) 429-434;
  • You have access
    Interspecies comparison of the pharmacokinetics of aldose reductase inhibitors.
    R K Brazzell, Y H Park, C B Wooldridge, B McCue, R Barker, R Couch and B York
    Drug Metabolism and Disposition July 1990, 18 (4) 435-440;
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    Metabolism and disposition of clarithromycin in man.
    J L Ferrero, B A Bopp, K C Marsh, S C Quigley, M J Johnson, D J Anderson, J E Lamm, K G Tolman, S W Sanders and J H Cavanaugh
    Drug Metabolism and Disposition July 1990, 18 (4) 441-446;
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    Deuterium isotope effect on the toxicokinetics of monomethylamine in the rat.
    A J Streeter, R W Nims, P R Sheffels, J A Hrabie, L Ohannesian, Y H Heur, B A Mico and L K Keefer
    Drug Metabolism and Disposition July 1990, 18 (4) 447-452;
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    N-depyridination and N-dedimethylaminoethylation of tripelennamine and pyrilamine in the rat. New metabolic pathways.
    S Y Yeh
    Drug Metabolism and Disposition July 1990, 18 (4) 453-461;
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    Stimulation mechanism of guinea pig liver-mediated reduction of naloxone by morphine.
    Y Kumagai, T Todaka, S Yamano and S Toki
    Drug Metabolism and Disposition July 1990, 18 (4) 462-466;
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    Effect of recombinant human interleukin-1 beta and tumor necrosis factor alpha on liver cytochrome P-450 and serum alpha-1-acid glycoprotein concentrations in the rat.
    C Poüs, J P Giroud, C Damais, D Raichvarg and L Chauvelot-Moachon
    Drug Metabolism and Disposition July 1990, 18 (4) 467-470;
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    The pharmacokinetics of etodolac enantiomers in the rat. Lack of pharmacokinetic interaction between enantiomers.
    D R Brocks and F Jamali
    Drug Metabolism and Disposition July 1990, 18 (4) 471-475;
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    In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase.
    S Vickers, C A Duncan, K P Vyas, P H Kari, B Arison, S R Prakash, H G Ramjit, S M Pitzenberger, G Stokker and D E Duggan
    Drug Metabolism and Disposition July 1990, 18 (4) 476-483;
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    Species-dependent enantioselective plasma protein binding of MK-571, a potent leukotriene D4 antagonist.
    J H Lin, F A deLuna, E H Ulm and D J Tocco
    Drug Metabolism and Disposition July 1990, 18 (4) 484-487;
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    Structural determination of the conjugated metabolites of ritodrine.
    W T Brashear, B R Kuhnert and R Wei
    Drug Metabolism and Disposition July 1990, 18 (4) 488-493;
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    Effects of age and dose on disposition and metabolism of salicylic acid in male Fischer 344 rats.
    T F McMahon, J J Diliberto and L S Birnbaum
    Drug Metabolism and Disposition July 1990, 18 (4) 494-503;
  • You have access
    Inhibition of the metabolism of ethyl carbamate by acetaldehyde.
    N Kurata, R Kemper, H E Hurst and W J Waddell
    Drug Metabolism and Disposition July 1990, 18 (4) 504-507;
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    Radioimmunoassay of nicotine-delta 1'(5')-iminium ion, an intermediate formed during the metabolism of nicotine to cotinine.
    R S Obach and H van Vunakis
    Drug Metabolism and Disposition July 1990, 18 (4) 508-513;
  • You have access
    Biotransformation of halothane in guinea pig liver slices.
    H N Ghantous, J Fernando, A J Gandolfi and K Brendel
    Drug Metabolism and Disposition July 1990, 18 (4) 514-518;
  • You have access
    Effects of vanadate on hepatic cytochrome P-450 expression in streptozotocin-diabetic rats.
    B S Donahue and E T Morgan
    Drug Metabolism and Disposition July 1990, 18 (4) 519-526;
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    Studies on the metabolism and chiral inversion of ibuprofen in isolated rat hepatocytes.
    S M Sanins, W J Adams, D G Kaiser, G W Halstead and T A Baillie
    Drug Metabolism and Disposition July 1990, 18 (4) 527-533;
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    Morphologic changes and covalent binding of 1,1-dichloroethylene in Clara and alveolar type II cells isolated from lungs of mice following in vivo administration.
    P G Forkert, B A Geddes, D W Birch and T E Massey
    Drug Metabolism and Disposition July 1990, 18 (4) 534-539;
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    Unsubstituted amides: new class of potent inhibitors of human microsomal epoxide hydrolase.
    B M Kerr and R H Levy
    Drug Metabolism and Disposition July 1990, 18 (4) 540-542;
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    Effects of carbon tetrachloride administration to guinea pigs on cytochromes P-450 and antioxidant levels in the inner and outer zones of the adrenal cortex.
    D A Staats, D P Lohr and H D Colby
    Drug Metabolism and Disposition July 1990, 18 (4) 543-545;
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    Isolation and characterization of an unusual glucuronide conjugate of rimantadine.
    S Y Brown, W A Garland and E K Fukuda
    Drug Metabolism and Disposition July 1990, 18 (4) 546-547;
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    Microsomal metabolism of the 1",1"-dimethylheptyl analogue of cannabidiol: relative percentage of monohydroxy metabolites in four species.
    E Samara, N K Brown and D J Harvey
    Drug Metabolism and Disposition July 1990, 18 (4) 548-549;
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In this issue

Drug Metabolism and Disposition
Vol. 18, Issue 4
1 Jul 1990
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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