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Drug Metabolism & Disposition

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Table of Contents

September 01, 1990; Volume 18,Issue 5
  • You have access
    Expressing the specificity and the potency of cytochrome P-450 inducers toward 7-ethoxyresorufin.
    M Paolini, G C Forti and C Bauer
    Drug Metabolism and Disposition September 1990, 18 (5) 551;
  • You have access
    Bioavailability, metabolism, and renal excretion of benzoic acid in the channel catfish (Ictalurus punctatus).
    S M Plakas and M O James
    Drug Metabolism and Disposition September 1990, 18 (5) 552-556;
  • You have access
    Isozymes of cytochrome P-450 that metabolize naphthalene in liver and lung of untreated mice.
    K Nagata, B M Martin, J R Gillette and H A Sasame
    Drug Metabolism and Disposition September 1990, 18 (5) 557-564;
  • You have access
    Effect of diabetes on disposition and renal handling of cefazolin in rats.
    M Nadai, H Yoshizumi, T Kuzuya, T Hasegawa, I Johno and S Kitazawa
    Drug Metabolism and Disposition September 1990, 18 (5) 565-570;
  • You have access
    Identification of urinary metabolites of cannabidiol in the dog.
    E Samara, M Bialer and D J Harvey
    Drug Metabolism and Disposition September 1990, 18 (5) 571-579;
  • You have access
    First-pass metabolism of gentisamide: influence of intestinal metabolism on hepatic formation of conjugates. Studies in the once-through vascularly perfused rat intestine-liver preparation.
    H Hirayama and K S Pang
    Drug Metabolism and Disposition September 1990, 18 (5) 580-587;
  • You have access
    Estimations of intestinal and liver first-pass metabolism in vivo. Studies on gentisamide conjugation in the rat.
    H Hirayama, J Morgado, I Gasinska and K S Pang
    Drug Metabolism and Disposition September 1990, 18 (5) 588-594;
  • You have access
    Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.
    L Pichard, I Fabre, G Fabre, J Domergue, B Saint Aubert, G Mourad and P Maurel
    Drug Metabolism and Disposition September 1990, 18 (5) 595-606;
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    In vitro metabolism of the novel antiinflammatory agent 6-(4'-fluorophenyl)-5-(4'-pyridyl)-2,3-dihydroimidazo-[2,1-b]-thiazole.
    M O Howard, J F Newton, D J Keohane, L P Yodis, C M Saverino, C W Qualls and L W Schwartz
    Drug Metabolism and Disposition September 1990, 18 (5) 607-612;
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    The disposition of 2-cyano-1-methyl 3-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)phenyl)guanidine in animals.
    D G Walker, M Hutchison, T A Shepard, P M Osborne, S M Allenby, A J Webb, N J Viney, M A Pue, R J Chenery and P J Wood
    Drug Metabolism and Disposition September 1990, 18 (5) 613-620;
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    Absorption of a novel prodrug of L-dopa, L-3-(3-hydroxy-4-pivaloyloxyphenyl)alanine (NB-355). In vitro and in situ studies.
    A Hisaka, S Kasamatsu, N Takenaga and M Ohtawa
    Drug Metabolism and Disposition September 1990, 18 (5) 621-625;
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    The formation, disposition, and hepatic metabolism of dimethylnitrosamine in the pig.
    G W Harrington, P N Magee, H M Pylypiw, R Kozeniauskas, R F Bevill, D R Nelson and J C Thurmon
    Drug Metabolism and Disposition September 1990, 18 (5) 626-631;
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    Thiopurine methyltransferase isozymes in human renal tissue.
    J A Van Loon and R M Weinshilboum
    Drug Metabolism and Disposition September 1990, 18 (5) 632-638;
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    Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism.
    P C Smith, L Z Benet and A F McDonagh
    Drug Metabolism and Disposition September 1990, 18 (5) 639-644;
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    Identification and distribution in the rat of acidic metabolites of tamoxifen.
    P C Ruenitz and N T Nanavati
    Drug Metabolism and Disposition September 1990, 18 (5) 645-648;
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    Pretranslational suppression of cytochrome P-450h (IIC11) gene expression in rat liver after administration of interferon inducers.
    E T Morgan and C A Norman
    Drug Metabolism and Disposition September 1990, 18 (5) 649-653;
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    Pharmacokinetics of the anti-AIDS drug 2',3'-dideoxyinosine in the rat.
    G F Ray, W D Mason and M Z Badr
    Drug Metabolism and Disposition September 1990, 18 (5) 654-658;
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    Metabolism and cytotoxicity of acetaminophen in hepatocyte cultures from rat, rabbit, dog, and monkey.
    T A Smolarek, C V Higgins and D E Amacher
    Drug Metabolism and Disposition September 1990, 18 (5) 659-663;
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    Metabolism of the carcinogen 3-methylcholanthrene in human bone marrow preparations.
    S R Myers and J W Flesher
    Drug Metabolism and Disposition September 1990, 18 (5) 664-669;
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    Pharmacokinetics of codeine after parenteral and oral dosing in the rat.
    J Shah and W D Mason
    Drug Metabolism and Disposition September 1990, 18 (5) 670-673;
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    Pharmacokinetics of a novel butylated hydroxytoluene-thiazolidinone CNS antiischemic agent LY256548 in rats, mice, dogs, and monkeys.
    K J Ruterbories and T D Lindstrom
    Drug Metabolism and Disposition September 1990, 18 (5) 674-679;
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    Acetylator genotype-dependent expression of arylamine N-acetyltransferase and N-hydroxyarylamine O-acetyltransferase in Syrian inbred hamster intestine and colon. Identity with the hepatic acetylation polymorphism.
    F Ogolla, R J Ferguson, W G Kirlin, A Trinidad, A F Andrews, M Mpezo and D W Hein
    Drug Metabolism and Disposition September 1990, 18 (5) 680-685;
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    Stereochemical differences in the metabolism of 3,4-methylenedioxymethamphetamine in vivo and in vitro: a pharmacokinetic analysis.
    A K Cho, M Hiramatsu, E W Distefano, A S Chang and D J Jenden
    Drug Metabolism and Disposition September 1990, 18 (5) 686-691;
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    Glucuronidation of 2-arylpropionic acids pirprofen, flurbiprofen, and ibuprofen by liver microsomes.
    J Magdalou, V Chajes, C Lafaurie and G Siest
    Drug Metabolism and Disposition September 1990, 18 (5) 692-697;
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    Identification of DP-1904 and its ester glucuronide in human urine and determination of their enantiomeric compositions by high-performance liquid chromatography with optical activity and ultraviolet detection.
    M Tanaka, K Ono, H Hakusui, T Takegoshi, Y Watanabe and M Kanao
    Drug Metabolism and Disposition September 1990, 18 (5) 698-703;
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    Biotransformation of sufentanil in liver microsomes of rats, dogs, and humans.
    K Lavrijsen, J Van Houdt, D Van Dyck, J Hendrickx, W Lauwers, R Hurkmans, M Bockx, C Janssen, W Meuldermans and J Heykants
    Drug Metabolism and Disposition September 1990, 18 (5) 704-710;
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    Identification of the rabbit and human cytochromes P-450IIIA as the major enzymes involved in the N-demethylation of diltiazem.
    L Pichard, G Gillet, I Fabre, I Dalet-Beluche, C Bonfils, J P Thenot and P Maurel
    Drug Metabolism and Disposition September 1990, 18 (5) 711-719;
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    Metabolism of benzene in rat hepatocytes. Influence of inducers on phenol glucuronidation.
    D Schrenk and K W Bock
    Drug Metabolism and Disposition September 1990, 18 (5) 720-725;
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    Distribution and disposition of trospectomycin sulfate in the in vivo rat, perfused rat liver, and cultured rat hepatocytes.
    J W Cox, L G Dring, L C Ginsberg, P G Larson, D A Constable and R G Ulrich
    Drug Metabolism and Disposition September 1990, 18 (5) 726-731;
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    Influence of a single dose of ethanol on the kinetics of valproic acid in rats.
    I G Alonso, J M Lanao, M I Martin, A Mateos, A Dominguez-Gil Hurlé and J Fermoso
    Drug Metabolism and Disposition September 1990, 18 (5) 732-734;
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    The identification of urinary metabolites of doxepin in patients.
    Y Z Shu, J W Hubbard, J K Cooper, G McKay, E D Korchinski, R Kumar and K K Midha
    Drug Metabolism and Disposition September 1990, 18 (5) 735-741;
  • You have access
    Induction of cytochrome P-450 isozyme 3a (P-450IIE1) in rabbit olfactory mucosa by ethanol and acetone.
    X X Ding and M J Coon
    Drug Metabolism and Disposition September 1990, 18 (5) 742-745;
  • You have access
    Excretion and metabolism of recainam, a new anti-arrhythmic drug, in laboratory animals and humans.
    J A Scatina, D S Wells, H B Kimmel, C J Kemper and S F Sisenwine
    Drug Metabolism and Disposition September 1990, 18 (5) 746-752;
  • You have access
    Metabolism of 2-chloro-1,1-difluoroethene to glyoxylic and glycolic acid in rat hepatic microsomes.
    M T Baker, M T Vasquez, J N Bates and C K Chiang
    Drug Metabolism and Disposition September 1990, 18 (5) 753-758;
  • You have access
    Interaction of cotinine with rat hepatic microsomal P-450. Comparison with metyrapone and immunomodulation of cotinine and metyrapone binding by monoclonal anti-cotinine antibodies.
    R J Bjercke, D K Hammond, H W Strobel and J J Langone
    Drug Metabolism and Disposition September 1990, 18 (5) 759-764;
  • You have access
    Hepatic protein arylation, glutathione depletion, and metabolite profiles of acetaminophen and a non-hepatotoxic regioisomer, 3'-hydroxyacetanilide, in the mouse.
    M S Rashed, T G Myers and S D Nelson
    Drug Metabolism and Disposition September 1990, 18 (5) 765-770;
  • You have access
    Metabolism of 1,1-dichloro-cis-diphenylcyclopropane by rat liver microsomes.
    O Caputo, G Grosa, M Ceruti, F Rocco and G Biglino
    Drug Metabolism and Disposition September 1990, 18 (5) 771-778;
  • You have access
    Identification of the urinary metabolites of tacrine in the rat.
    R S Hsu, G M Shutske, E M Dileo, S M Chesson, A R Linville and R C Allen
    Drug Metabolism and Disposition September 1990, 18 (5) 779-783;
  • You have access
    Hepatic microsomal metabolism of sulfamethoxazole to the hydroxylamine.
    A E Cribb and S P Spielberg
    Drug Metabolism and Disposition September 1990, 18 (5) 784-787;
  • You have access
    Factors affecting the expression of trifluoroacetylated liver microsomal protein neoantigens in rats treated with halothane.
    J G Kenna, J L Martin, H Satoh and L R Pohl
    Drug Metabolism and Disposition September 1990, 18 (5) 788-793;
  • You have access
    The metabolic pathways of tianeptine, a new antidepressant, in healthy volunteers.
    L Grislain, P Gele, M Bertrand, W Luijten, N Bromet, C Salvadori and A Kamoun
    Drug Metabolism and Disposition September 1990, 18 (5) 804-808;
  • You have access
    Pharmacokinetics and protein binding of salicylate metabolites in rats.
    M E Morris
    Drug Metabolism and Disposition September 1990, 18 (5) 809-811;
  • You have access
    Age-associated alterations in diazepam metabolizing enzyme activities in male and female rats.
    S Fujita, J Tatsuno, K Kitani and T Suzuki
    Drug Metabolism and Disposition September 1990, 18 (5) 812-814;
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    Disposition and metabolism of oligodeoxynucleoside methylphosphonate following a single i.v. injection in mice.
    T L Chen, P S Miller, P O Ts'o, O M Colvin and T L Chem
    Drug Metabolism and Disposition September 1990, 18 (5) 815-818;
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    Influence of isoniazid, phenobarbital, phenytoin, pregnenolone 16-alpha carbonitrile, and beta-naphthoflavone on halothane metabolism and hepatotoxicity.
    M A Jenner, J L Plummer and M J Cousins
    Drug Metabolism and Disposition September 1990, 18 (5) 819-822;
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In this issue

Drug Metabolism and Disposition
Vol. 18, Issue 5
1 Sep 1990
  • Table of Contents
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  • PBPK Modeling for Clopidogrel and Its Active Metabolite
  • Physiology of the Neonatal Gastrointestinal System
  • Pharmacokinetics and Disposition of Biologics
  • Tissue Drug Concentrations: Beyond the Free Drug Hypothesis
  • Metabolism and Disposition of Volanesorsen across Species
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