Drug Metabolism and Disposition: 18 (6)

November 01, 1990; Volume 18,Issue 6

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The 1988 Bernard B. Brodie Award lecture. Functional diversity of hepatic cytochromes P-450.
W Levin

Drug Metabolism and Disposition November 1990, 18 (6) 824-830;
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Pharmacokinetics and tissue distribution of the renin inhibitor N-(2-(R)-benzyl-3-tert-butyl-sulfonyl-propionyl)-His-ChacVal-n-butylami ne in marmosets.
F Cumin, C Schnell, P Richert, F Raschdorf, A Probst, K Schmid, J M Wood and M de Gasparo

Drug Metabolism and Disposition November 1990, 18 (6) 831-835;
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Dose-dependent pharmacokinetics of MK-417, a potent carbonic anhydrase inhibitor, in rabbits following single and multiple doses.
J H Lin, I W Chen, E H Ulm, J R Gehret and D E Duggan

Drug Metabolism and Disposition November 1990, 18 (6) 836-841;
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Disposition and metabolism of carbovir in mice dosed intravenously or orally.
S M el Dareer, K F Tillery, L M Rose, R F Struck and D L Hill

Drug Metabolism and Disposition November 1990, 18 (6) 842-845;
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Disposition of amiodarone and its proximate metabolite, desethylamiodarone, in the dog for oral administration of single-dose and short-term drug regimens.
J F Brien, S Jimmo, F J Brennan, P W Armstrong and H Abdollah

Drug Metabolism and Disposition November 1990, 18 (6) 846-851;
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Pharmacokinetics, N1-glucuronidation, and N4-acetylation of sulfa-6-monomethoxine in humans.
T B Vree, E W Beneken Kolmer, Y A Hekster, M Shimoda, M Ono and T Miura

Drug Metabolism and Disposition November 1990, 18 (6) 852-858;
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Progesterone metabolism in hepatic microsomes. Effect of the cytochrome P-450 inhibitor, ketoconazole, and the NADPH 5 alpha-reductase inhibitor, 4-MA, upon the metabolic profile in human, monkey, dog, and rat.
D C Swinney

Drug Metabolism and Disposition November 1990, 18 (6) 859-865;
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Metabolism of citral, an alpha,beta-unsaturated aldehyde, in male F344 rats.
J J Diliberto, P Srinivas, D Overstreet, G Usha, L T Burka and L S Birnbaum

Drug Metabolism and Disposition November 1990, 18 (6) 866-875;
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Metabolism of diphenyl sulfoxide in perfused guinea pig liver. Involvement of aldehyde oxidase as a sulfoxide reductase.
S Yoshihara and K Tatsumi

Drug Metabolism and Disposition November 1990, 18 (6) 876-881;
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Life span profiles of glutathione and acetaminophen detoxification.
T S Chen, J P Richie and C A Lang

Drug Metabolism and Disposition November 1990, 18 (6) 882-887;
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Metabolism of the anticonvulsant agent zonisamide in the rat.
D D Stiff and M A Zemaitis

Drug Metabolism and Disposition November 1990, 18 (6) 888-894;
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Taxol metabolism. Isolation and identification of three major metabolites of taxol in rat bile.
B Monsarrat, E Mariel, S Cros, M Garès, D Guénard, F Guéritte-Voegelein and M Wright

Drug Metabolism and Disposition November 1990, 18 (6) 895-901;
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Physiological pharmacokinetics of a new muscle-relaxant, inaperisone, combined with its pharmacological effect on blood flow rate.
O Nagata, M Murata, H Kato, T Terasaki, H Sato and A Tsuji

Drug Metabolism and Disposition November 1990, 18 (6) 902-910;
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Metabolism of hexafluoropropene. Evidence for bioactivation by glutathione conjugate formation in the kidney.
M Koob and W Dekant

Drug Metabolism and Disposition November 1990, 18 (6) 911-916;
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In vivo metabolites of S-(2-benzothiazolyl)-L-cysteine as markers of in vivo cysteine conjugate beta-lyase and thiol glucuronosyl transferase activities.
A A Elfarra and I Y Hwang

Drug Metabolism and Disposition November 1990, 18 (6) 917-922;
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Metabolism and disposition of the dopamine agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin in conscious monkeys after subsequent i.v. oral, and ocular administration.
T K Gerding, B F Drenth, R A de Zeeuw, P G Tepper and A S Horn

Drug Metabolism and Disposition November 1990, 18 (6) 923-928;
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Metabolism and covalent binding of [14C]toluene by human and rat liver microsomal fractions and liver slices.
D E Chapman, T J Moore, S R Michener and G Powis

Drug Metabolism and Disposition November 1990, 18 (6) 929-936;
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Diflunisal disposition. Role of gastric absorption in the development of mucosal damage and anti-inflammatory potency in rodents.
B Nuernberg, I Szelenyi, H T Schneider and K Brune

Drug Metabolism and Disposition November 1990, 18 (6) 937-942;
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Cytochrome P-450 isozymes in metabolic activation of delta 9-tetrahydrocannabinol by rat liver microsomes.
S Narimatsu, K Watanabe, T Matsunaga, I Yamamoto, S Imaoka, Y Funae and H Yoshimura

Drug Metabolism and Disposition November 1990, 18 (6) 943-948;
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The metabolism of etintidine in rat, dog, and human.
F A Wong, J R Lloyd and D W Graden

Drug Metabolism and Disposition November 1990, 18 (6) 949-953;
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Ciprofloxacin does not impair the elimination of diazepam in humans.
W J Wijnands, J F Trooster, P C Teunissen, H A Cats and T B Vree

Drug Metabolism and Disposition November 1990, 18 (6) 954-957;
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Identification of N-acetyl-S-(2,5-dihydroxyphenyl)-L-cysteine as a urinary metabolite of benzene, phenol, and hydroquinone.
D E Nerland and W M Pierce

Drug Metabolism and Disposition November 1990, 18 (6) 958-961;
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Effects of sodium salicylate on elimination kinetics of indomethacin and bile production in dogs.
W S Beck, K Dietzel, G Geisslinger, H Engler, H Vergin and K Brune

Drug Metabolism and Disposition November 1990, 18 (6) 962-967;
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Disposition in humans of racemic picenadol, an opioid analgesic.
P M Franz, S L Anliker, J T Callaghan, K A DeSante, P H Dhahir, R L Nelson and A Rubin

Drug Metabolism and Disposition November 1990, 18 (6) 968-973;
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Isotope effect studies on the mechanism of the cytochrome P-450IIA1-catalyzed formation of delta 6-testosterone from testosterone.
K R Korzekwa, W F Trager, K Nagata, A Parkinson and J R Gillette

Drug Metabolism and Disposition November 1990, 18 (6) 974-979;
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Metabolic disposition of trimetrexate, a nonclassical dihydrofolate reductase inhibitor, in rat and dog.
B K Wong, T F Woolf, T Chang and L R Whitfield

Drug Metabolism and Disposition November 1990, 18 (6) 980-986;
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Pharmacokinetics of propafenone enantiomers in rats.
R Mehvar

Drug Metabolism and Disposition November 1990, 18 (6) 987-991;
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Oxidative defluorination of 1,1,1,2-tetrafluoroethane by rat liver microsomes.
M J Olson, C A Reidy, J T Johnson and T C Pederson

Drug Metabolism and Disposition November 1990, 18 (6) 992-998;
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The use of pig hepatocytes to study the biotransformation of beta-nortestosterone by pigs. Identification of glucuronidated 15 alpha-hydroxy-norandrostenedione as an important in vitro and in vivo metabolite.
L A Hoogenboom, M C Berghmans, A Van Veldhuizen and H A Kuiper

Drug Metabolism and Disposition November 1990, 18 (6) 999-1004;
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Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes.
U Fuhr, T Wolff, S Harder, P Schymanski and A H Staib

Drug Metabolism and Disposition November 1990, 18 (6) 1005-1010;
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Pulmonary elimination and metabolism of 5-fluoro-2'-deoxyuridine in isolated perfused rat lung and lung slices.
H Foth, J Hellkamp, E M Kunellis and G F Kahl

Drug Metabolism and Disposition November 1990, 18 (6) 1011-1017;
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Plasma elimination and urinary excretion of methapyrilene in the rat.
D W Kelly, C L Holder, W A Korfmacher and W Slikker

Drug Metabolism and Disposition November 1990, 18 (6) 1018-1024;
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Metabolism of antiparkinson agent dopazinol by rat liver microsomes.
K P Vyas, P H Kari, H G Ramjit, S M Pitzenberger and M Hichens

Drug Metabolism and Disposition November 1990, 18 (6) 1025-1030;
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Three N-aralkylated derivatives of 1-aminobenzotriazole as potent and isozyme-selective, mechanism-based inhibitors of guinea pig pulmonary cytochrome P-450 in vitro.
K J Woodcroft, E W Szczepan, L C Knickle and J R Bend

Drug Metabolism and Disposition November 1990, 18 (6) 1031-1037;
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Formation and reversibility of S-linked conjugates of N-(1-methyl-3,3-diphenylpropyl)isocyanate, an in vivo metabolite of N-(1-methyl-3,3-diphenylpropyl)formamaide, in rats.
A E Mutlib, R E Talaat, J G Slatter and F S Abbott

Drug Metabolism and Disposition November 1990, 18 (6) 1038-1045;
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In vitro metabolism of (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl) phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol, a synthetic bicyclic cannabinoid analog.
B F Thomas and B R Martin

Drug Metabolism and Disposition November 1990, 18 (6) 1046-1054;
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Species comparison of pharmacokinetics and metabolism of diltiazem in humans, dogs, rabbits, and rats.
P K Yeung, S J Mosher, M A Quilliam and T J Montague

Drug Metabolism and Disposition November 1990, 18 (6) 1055-1059;
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Pharmacokinetics of flobufen and its main active metabolite in the rat.
R Lapka, S Smolík and V Rejholec

Drug Metabolism and Disposition November 1990, 18 (6) 1060-1064;
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In vitro metabolism of cannabichromene in seven common laboratory animals.
N K Brown and D J Harvey

Drug Metabolism and Disposition November 1990, 18 (6) 1065-1070;
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Systemic pharmacokinetics of acetylenic retinoids in rats.
S S Liu, R Sandri and D D Tang-Liu

Drug Metabolism and Disposition November 1990, 18 (6) 1071-1077;
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The pharmacokinetics of (-)-carbovir in rats. Evidence for nonlinear elimination.
K R Brouwer, R L St Claire, J Lagarde, J E Patanella, J S Walsh and G T Miwa

Drug Metabolism and Disposition November 1990, 18 (6) 1078-1083;
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The metabolism and excretion of carbovir, a carbocyclic nucleoside, in the rat.
J S Walsh, J E Patanella, S E Unger, K R Brouwer and G T Miwa

Drug Metabolism and Disposition November 1990, 18 (6) 1084-1091;
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Identification of a glucuronide conjugate of the carbocyclic nucleoside, carbovir, isolated from marmoset urine.
J E Patanella, J S Walsh, S E Unger, G T Miwa, P S Parry, M J Daniel and G L Evans

Drug Metabolism and Disposition November 1990, 18 (6) 1092-1095;
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Identification of phenolic doxepin glucuronides from patient urine and rat bile.
Y Z Shu, J W Hubbard, G McKay and K K Midha

Drug Metabolism and Disposition November 1990, 18 (6) 1096-1099;
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Characterization of a quaternary, N-glucuronide metabolite of the imidazole antifungal, tioconazole.
P V Macrae, M Kirrs, F S Pullen and M H Tarbit

Drug Metabolism and Disposition November 1990, 18 (6) 1100-1102;
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The metabolism of ofloxacin in humans.
F A Wong and S C Flor

Drug Metabolism and Disposition November 1990, 18 (6) 1103-1104;
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The metabolic fate of 13-cis-retinoic acid in mouse skin microsomal preparations.
N Oldfield

Drug Metabolism and Disposition November 1990, 18 (6) 1105-1107;

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