Drug Metabolism and Disposition: 19 (1)

January 01, 1991; Volume 19,Issue 1

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Pharmacokinetics of 4-hydroxycyclophosphamide and metabolites in the rat.
P S Hong, A Srigritsanapol and K K Chan

Drug Metabolism and Disposition January 1991, 19 (1) 1-7;
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Kinetics of distribution and adipose tissue storage as a function of lipophilicity and chemical structure. I. Barbiturates.
S H Steiner, M J Moor and M H Bickel

Drug Metabolism and Disposition January 1991, 19 (1) 8-14;
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Kinetics of distribution and adipose tissue storage as a function of lipophilicity and chemical structure. II. Benzodiazepines.
X Xie, S H Steiner and M H Bickel

Drug Metabolism and Disposition January 1991, 19 (1) 15-19;
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Glucuronidation of labetalol at the two hydroxy positions by bovine liver microsomes. Isolation, purification, and structure elucidation of the glucuronides of labetalol.
N R Niemeijer, T K Gerding and R A De Zeeuw

Drug Metabolism and Disposition January 1991, 19 (1) 20-23;
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Redistribution of tricyclic antidepressants in rats using a drug-specific monoclonal antibody: dose-response relationship.
P R Pentel, D E Keyler, G J Brunn, J M Milavetz, D G Gilbertson, S G Matta and S M Pond

Drug Metabolism and Disposition January 1991, 19 (1) 24-28;
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Comparative pharmacokinetics of abecarnil in rat following single and multiple intragastric treatment and continuous administration via the diet.
W Krause, F Reissmann, W Schunack and C Schöbel

Drug Metabolism and Disposition January 1991, 19 (1) 29-35;
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Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient.
S P Robinson, S M Langan-Fahey, D A Johnson and V C Jordan

Drug Metabolism and Disposition January 1991, 19 (1) 36-43;
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In vitro and in vivo murine metabolism of spirogermanium.
D Garteiz, Z H Siddik and R A Newman

Drug Metabolism and Disposition January 1991, 19 (1) 44-47;
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Genetic polymorphism of cytochrome P-450-dependent phencyclidine hydroxylation in mice. Comparison of phencyclidine hydroxylation in humans.
E J Holsztynska, W W Weber and E F Domino

Drug Metabolism and Disposition January 1991, 19 (1) 48-53;
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Observations on the absorption, distribution, metabolism, and excretion of the dopamine (D2) agonist, quinelorane, in rats, mice, dogs, and monkeys.
B M Manzione, J R Bernstein and R B Franklin

Drug Metabolism and Disposition January 1991, 19 (1) 54-60;
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Effects of age and dose on the pharmacokinetics of ibuprofen in the rat.
J H Satterwhite and F D Boudinot

Drug Metabolism and Disposition January 1991, 19 (1) 61-67;
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Disposition of the cephalosporin cefepime in normal and renally impaired subjects.
R H Barbhaiya, C A Knupp, S T Forgue, G R Matzke, C E Halstenson, J A Opsahl and K A Pittman

Drug Metabolism and Disposition January 1991, 19 (1) 68-73;
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The enzymatic hydrolysis-activation of the adriamycin cardioprotective agent (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane.
B B Hasinoff, F X Reinders and V Clark

Drug Metabolism and Disposition January 1991, 19 (1) 74-80;
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The metabolism of 3,7-dimethyl-2,6-octadienal (citral) in rat hepatic mitochondrial and cytosolic fractions. Interactions with aldehyde and alcohol dehydrogenases.
C S Boyer and D R Petersen

Drug Metabolism and Disposition January 1991, 19 (1) 81-86;
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Prednisolone and prednisone exhibit linear extraction in the perfused rabbit liver.
V G Hale and L Z Benet

Drug Metabolism and Disposition January 1991, 19 (1) 87-93;
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Biodistribution and metabolism in rats and mice of bucromarone.
J C Maurizis, C Nicolas, M Verny, M Ollier, M Faurie, M Payard and A Veyre

Drug Metabolism and Disposition January 1991, 19 (1) 94-99;
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Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities.
K N Gan, A Smolen, H W Eckerson and B N La Du

Drug Metabolism and Disposition January 1991, 19 (1) 100-106;
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Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase.
A Smolen, H W Eckerson, K N Gan, N Hailat and B N La Du

Drug Metabolism and Disposition January 1991, 19 (1) 107-112;
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Immunohistochemical localization of cytochrome P-450IA1 induced by 3,3',4,4'-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzoafuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (scup).
R M Smolowitz, M E Hahn and J J Stegeman

Drug Metabolism and Disposition January 1991, 19 (1) 113-123;
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Metabolism of dibasic esters by rat nasal mucosal carboxylesterase.
M S Bogdanffy, C R Kee, C A Hinchman and B A Trela

Drug Metabolism and Disposition January 1991, 19 (1) 124-129;
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Chronic stress impairs oxidative metabolism and hepatic excretion of model xenobiotic substrates in the rat.
G M Pollack, J L Browne, J Marton and L J Haberer

Drug Metabolism and Disposition January 1991, 19 (1) 130-134;
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[14C]monocrotaline kinetics and metabolism in the rat.
J E Estep, M W Lamé, D Morin, A D Jones, D W Wilson and H J Segall

Drug Metabolism and Disposition January 1991, 19 (1) 135-139;
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Evidence for glucuronidation and sulfation of zeranol and metabolites (taleranol and zearalanone) by rat and pig hepatic subfractions.
G F Bories, E F Perdu-Durand, J F Sutra and J E Tulliez

Drug Metabolism and Disposition January 1991, 19 (1) 140-143;
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Gastrointestinal absorption of xenobiotics in physiologically based pharmacokinetic models. A two-compartment description.
D A Staats, J W Fisher and R B Connolly

Drug Metabolism and Disposition January 1991, 19 (1) 144-148;
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Isolation and characterization of a novel quaternary ammonium-linked glucuronide of lamotrigine.
M W Sinz and R P Remmel

Drug Metabolism and Disposition January 1991, 19 (1) 149-153;
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Cis-flupentixol metabolites in rat plasma and bile. The first proof of glutathione conjugation at the exocyclic double bond.
Y Z Shu, J W Hubbard, G McKay, E M Hawes and K K Midha

Drug Metabolism and Disposition January 1991, 19 (1) 154-162;
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Pharmacokinetics and metabolism of triclopyr in the crayfish (Procambarus clarki).
M G Barron, S C Hansen and T Ball

Drug Metabolism and Disposition January 1991, 19 (1) 163-167;
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Study of the placental transfer of cisapride in sheep. Plasma levels in the pregnant ewe, the fetus, and the lamb.
G Veereman-Wauters, J Monbaliu, W Meuldermans, R Woestenborghs, M Verlinden, J Heykants and C D Rudolph

Drug Metabolism and Disposition January 1991, 19 (1) 168-172;
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Glucuronidation of monohydroxylated short chain bile acids by human liver microsomes and purified human liver UDP-glucuronosyltransferases.
Y M Irshaid, A Radominska, P Zimniak, A Zimniak, R Lester and T R Tephly

Drug Metabolism and Disposition January 1991, 19 (1) 173-177;
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Identification of major metabolites of the catechol-O-methyltransferase-inhibitor nitecapone in human urine.
J Taskinen, T Wikberg, P Ottoila, L Kanner, T Lotta, A Pippuri and R Bäckström

Drug Metabolism and Disposition January 1991, 19 (1) 178-183;
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Mechanism of acetaminophen-stimulated NADPH oxidation catalyzed by the peroxidase-H2O2 system.
R J Keller and J A Hinson

Drug Metabolism and Disposition January 1991, 19 (1) 184-187;
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Identification of phase-I and phase-II metabolites of fluphenazine in rat bile. Intact glucuronide and sulfate conjugates.
C J Jackson, J W Hubbard, G McKay, J K Cooper, E M Hawes and K K Midha

Drug Metabolism and Disposition January 1991, 19 (1) 188-193;
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Role of the endopeptidase 24.11 in the disposition and metabolism of endogenous atrial natriuretic factor in the rabbit.
S Marleau, T T Nguyen, P Du Souich, M Bellemare, A De Lean and H Ong

Drug Metabolism and Disposition January 1991, 19 (1) 194-199;
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Pharmacokinetics of recombinant human granulocyte colony-stimulating factor in the rat. Single and multiple dosing studies.
H Tanaka and T Kaneko

Drug Metabolism and Disposition January 1991, 19 (1) 200-204;
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Metabolism and disposition of sulfluramid, a unique polyfluorinated insecticide, in the rat.
R O Manning, J V Bruckner, M E Mispagel and J M Bowen

Drug Metabolism and Disposition January 1991, 19 (1) 205-211;
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Disposition and metabolism of the angiotensin-converting enzyme inhibitor [4S-[4 alpha, 7 alpha, (R*), 12b beta]]-7-[S-(1-ethoxycarbonyl-3- phenylpropyl)amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxo- pyrido[2,1-a][2]benzazepine-4-carboxylic acid in monkeys and dogs.
H Cheng, J D Stuhler, B R Dorrbecker and W P Gordon

Drug Metabolism and Disposition January 1991, 19 (1) 212-217;
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Mouse hepatic microsomal enzyme that catalyzes oxidation of 11-oxo-delta 8-tetrahydrocannabinol to delta 8-tetrahydrocannabinol-11-oic acid.
K Watanabe, N Hirahashi, S Narimatsu, I Yamamoto and H Yoshimura

Drug Metabolism and Disposition January 1991, 19 (1) 218-221;
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Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine.
U Hofmann, M Eichelbaum, S Seefried and C O Meese

Drug Metabolism and Disposition January 1991, 19 (1) 222-226;
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Xenobiotic metabolizing enzyme activities in rat, mouse, monkey, and human testes.
K W DiBiasio, M H Silva, L R Shull, J W Overstreet, B D Hammock and M G Miller

Drug Metabolism and Disposition January 1991, 19 (1) 227-232;
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Dose-dependent stereopharmacokinetics of 5,6-dihydro-4H-4(isobutylamino)thieno(2,3-B)thiopyran-2-sulfonamide-7,7 -dioxide , a potent carbonic anhydrase inhibitor, in rats.
J H Lin, E H Ulm and L E Los

Drug Metabolism and Disposition January 1991, 19 (1) 233-238;
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Studies on induction of metabolism of ethyl carbamate in mice by ethanol.
N Kurata, H E Hurst, R A Kemper and W J Waddell

Drug Metabolism and Disposition January 1991, 19 (1) 239-240;
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Temporal variations in microsomal lipid peroxidation and in glutathione concentration of rat liver.
P M Bélanger, M Desgagné and B Bruguerolle

Drug Metabolism and Disposition January 1991, 19 (1) 241-244;
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Dose-dependent and time-dependent pharmacokinetics in the dog after intravenous administration of dextrorphan.
P A Cleveland, S Teller, V Kachevsky, E Pinili, R Evans and M W Modi

Drug Metabolism and Disposition January 1991, 19 (1) 245-250;
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Stereoselective differences in propranolol disposition in female Sprague-Dawley and Dark Agouti rats.
R J Guttendorf, H B Kostenbauder and P J Wedlund

Drug Metabolism and Disposition January 1991, 19 (1) 251-256;
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Metabolism and penetration through blood-brain barrier of parkinsonism-related compounds. 1,2,3,4-Tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline.
K Kikuchi, Y Nagatsu, Y Makino, T Mashino, S Ohta and M Hirobe

Drug Metabolism and Disposition January 1991, 19 (1) 257-262;
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Characterization of the urinary metabolites of merbarone in cancer patients.
J G Supko and L Malspeis

Drug Metabolism and Disposition January 1991, 19 (1) 263-273;
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Biosynthesis and biliary excretion of S-conjugates of hexachlorobuta-1,3-diene in the perfused rat liver.
Y S Gietl and M W Anders

Drug Metabolism and Disposition January 1991, 19 (1) 274-277;
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Vitamin K epoxide reductase activity and its inhibition by warfarin in young and old rats.
H O Hallak and P J Wedlund

Drug Metabolism and Disposition January 1991, 19 (1) 278-279;
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Stereoselective hydrolysis of flurbiprofen conjugates.
M P Knadler and S D Hall

Drug Metabolism and Disposition January 1991, 19 (1) 280-282;
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MMB-4 pharmacokinetics in rabbits after intravenous and intramuscular administration.
C L Woodard and B J Lukey

Drug Metabolism and Disposition January 1991, 19 (1) 283-284;
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Circadian variation of fluoropyrimidine catabolic enzymes in rat liver: possible relevance to 5-fluorodeoxyuridine chemotherapy.
G C Daher, R W Zhang, S J Soong and R B Diasio

Drug Metabolism and Disposition January 1991, 19 (1) 285-287;

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