Drug Metabolism and Disposition: 19 (2)

March 01, 1991; Volume 19,Issue 2

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Purification and aminopyrine monooxygenase activity of liver microsomal cytochrome P-450 from alloxan-induced diabetic rats.
H Shimeno, A Toda, S Ogata and A Nagamatsu

Drug Metabolism and Disposition March 1991, 19 (2) 291-297;
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Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1.
M J Olson, S G Kim, C A Reidy, J T Johnson and R F Novak

Drug Metabolism and Disposition March 1991, 19 (2) 298-303;
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Stereoselective (S)- and (R)-naproxen glucuronosyl transferases of rat liver.
M el Mouelhi and K W Bock

Drug Metabolism and Disposition March 1991, 19 (2) 304-308;
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The pharmacokinetics of albumin conjugates of D-penicillamine in humans.
D A Joyce, R O Day and B R Murphy

Drug Metabolism and Disposition March 1991, 19 (2) 309-311;
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Effect of H2 antagonists on the differential secretion of triamterene and its sulfate conjugate metabolite by the isolated perfused rat kidney.
M R Muirhead and A A Somogyi

Drug Metabolism and Disposition March 1991, 19 (2) 312-316;
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Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.
J C Kraft, W Slikker, J R Bailey, L G Roberts, B Fischer, W Wittfoht and H Nau

Drug Metabolism and Disposition March 1991, 19 (2) 317-324;
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The detection of halocarbon-derived radical adducts in bile and liver of rats.
K T Knecht and R P Mason

Drug Metabolism and Disposition March 1991, 19 (2) 325-331;
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Conversion of retinol to retinal by rat liver microsomes.
T W Shih and D L Hill

Drug Metabolism and Disposition March 1991, 19 (2) 332-335;
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Conversion of retinoid ethers to alcohols by enzymatic activity present in rat liver microsomes.
T W Shih, Y F Shealy and D L Hill

Drug Metabolism and Disposition March 1991, 19 (2) 336-339;
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Intestinal biotransformation of harmol and 1-naphthol in the rat. Further evidence of dose-dependent phase-II conjugation in situ.
D Goon and C D Klaassen

Drug Metabolism and Disposition March 1991, 19 (2) 340-347;
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Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2.
C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery

Drug Metabolism and Disposition March 1991, 19 (2) 348-353;
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Oxidation of propylthiouracil to reactive metabolites by activated neutrophils. Implications for agranulocytosis.
L Waldhauser and J Uetrecht

Drug Metabolism and Disposition March 1991, 19 (2) 354-359;
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Model systems for metabolism studies. Biomimetic oxidation of acetaminophen and ellipticine derivatives with water-soluble metalloporphyrins associated to potassium monopersulfate.
J Bernadou, M Bonnafous, G Labat, P Loiseau and B Meunier

Drug Metabolism and Disposition March 1991, 19 (2) 360-365;
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Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey.
W J Ehlhardt and J J Howbert

Drug Metabolism and Disposition March 1991, 19 (2) 366-369;
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Metabolism and disposition of the anticancer agent sulofenur in mouse, rat, monkey, and human.
W J Ehlhardt

Drug Metabolism and Disposition March 1991, 19 (2) 370-375;
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Stereoselective glucuronidation of ofloxacin in rat liver microsomes.
O Okazaki, T Kurata, H Hakusui and H Tachizawa

Drug Metabolism and Disposition March 1991, 19 (2) 376-380;
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The metabolism of [14C]rimantadine hydrochloride in rats and dogs.
A C Loh, A J Szuna, T H Williams, G J Sasso and F J Leinweber

Drug Metabolism and Disposition March 1991, 19 (2) 381-387;
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Studies on inhibition and induction of metabolism of ethyl carbamate by acetone and related compounds. Evidence for metabolism by cytochromes P-450.
N Kurata, H E Hurst, F W Benz, R A Kemper and W J Waddell

Drug Metabolism and Disposition March 1991, 19 (2) 388-393;
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Metabolism of the antipsychotic drug tiospirone in humans.
R F Mayol, H K Jajoo, L J Klunk and I A Blair

Drug Metabolism and Disposition March 1991, 19 (2) 394-399;
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Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects.
S Knapp, M L Wardlow, K Albert, D Waters and L J Thal

Drug Metabolism and Disposition March 1991, 19 (2) 400-404;
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Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
S M Sanins, W J Adams, D G Kaiser, G W Halstead, J Hosley, H Barnes and T A Baillie

Drug Metabolism and Disposition March 1991, 19 (2) 405-410;
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Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice.
N A Mahmood, D Overstreet and L T Burka

Drug Metabolism and Disposition March 1991, 19 (2) 411-418;
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Urinary and biliary excretion of metabolites of halothane in dogs.
T Sakai, H Yoshida, A Fukui and M Takaori

Drug Metabolism and Disposition March 1991, 19 (2) 419-422;
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Phenacetin and acetaminophen metabolism in the isolated perfused rat liver. Precursor concentration influences the selection of kinetic parameters to assess hypoxic impairment.
S D Studenberg and K L Brouwer

Drug Metabolism and Disposition March 1991, 19 (2) 423-429;
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Pharmacokinetics of theophylline in the newborn and adult rabbit. In vivo and isolated perfused liver approaches.
A Bortolotti, M Corada, M M Barzago, A Celardo, A Guaitani and M Bonati

Drug Metabolism and Disposition March 1991, 19 (2) 430-435;
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Brain distribution and fate of tris(2-chloroethyl) phosphate in Fischer 344 rats.
D W Herr, J M Sanders and H B Matthews

Drug Metabolism and Disposition March 1991, 19 (2) 436-442;
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Metabolism of tris(2-chloroethyl) phosphate in rats and mice.
L T Burka, J M Sanders, D W Herr and H B Matthews

Drug Metabolism and Disposition March 1991, 19 (2) 443-447;
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Stereoselective sulfate conjugation of racemic 4-hydroxypropranolol by human and rat liver cytosol.
T Walle and U K Walle

Drug Metabolism and Disposition March 1991, 19 (2) 448-453;
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Metabolism of 7-(1,3-dithiolan-2-ylmethyl)-1,3-dimethylxanthine by rat liver microsomes. Diastereoselective metabolism of the 1,3-dithiolane ring.
G Grosa, O Caputo, M Ceruti, G Biglino, J S Franzone and C Cravanzola

Drug Metabolism and Disposition March 1991, 19 (2) 454-457;
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Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation.
O Grech-Bélanger, J Turgeon, M Lalande and P M Bélanger

Drug Metabolism and Disposition March 1991, 19 (2) 458-461;
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(-)-6-Aminocarbovir pharmacokinetics and relative carbovir exposure in rats.
R L Yeager, K R Brouwer and G T Miwa

Drug Metabolism and Disposition March 1991, 19 (2) 462-466;
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Oxidation of butylated hydroxytoluene to toxic metabolites. Factors influencing hydroxylation and quinone methide formation by hepatic and pulmonary microsomes.
J L Bolton and J A Thompson

Drug Metabolism and Disposition March 1991, 19 (2) 467-472;
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Biotransformation of the organophosphorus insecticides parathion and methyl parathion in male and female rat livers perfused in situ.
H X Zhang and L G Sultatos

Drug Metabolism and Disposition March 1991, 19 (2) 473-477;
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Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. I. Theoretical considerations.
S P Khor and M Mayersohn

Drug Metabolism and Disposition March 1991, 19 (2) 478-485;
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Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat.
S P Khor, H Bozigian and M Mayersohn

Drug Metabolism and Disposition March 1991, 19 (2) 486-490;
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Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.
D K Patel, J L Woolley, J P Shcokcor, R L Johnson, L C Taylor and C W Sigel

Drug Metabolism and Disposition March 1991, 19 (2) 491-497;
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Drug metabolizing enzyme changes after chronic buthionine sulfoximine exposure modify acetaminophen disposition in rats.
B W Manning, M R Franklin and R E Galinsky

Drug Metabolism and Disposition March 1991, 19 (2) 498-502;
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Kinetics of acetyl CoA: arylamine N-acetyltransferase from rapid and slow acetylator human liver.
A J Kilbane, T Petroff and W W Weber

Drug Metabolism and Disposition March 1991, 19 (2) 503-507;
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Formation of N-(5-nitro-2-thiazolyl)-N'-carboxymethylurea from 5-hydroxyniridazole. Role of aldehyde dehydrogenase in the oxidative metabolism of niridazole.
J W Tracy, B A Catto and L T Webster

Drug Metabolism and Disposition March 1991, 19 (2) 508-515;
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Metabolism of [14C]monocrotaline by isolated perfused rat liver.
M W Lamé, A D Jones, D Morin and H J Segall

Drug Metabolism and Disposition March 1991, 19 (2) 516-524;
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Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.
K Kassahun, K Farrell and F Abbott

Drug Metabolism and Disposition March 1991, 19 (2) 525-535;
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Rapid, dose-dependent elimination of phenol across the gills, and slow elimination of phenyl sulfate in the urine of phenol-dosed lobsters, Homarus americanus.
M O James, J D Schell, M G Barron and C L Li

Drug Metabolism and Disposition March 1991, 19 (2) 536-542;
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Inhibition of aryl sulfotransferase by carboxylic acids.
S I Rao and M W Duffel

Drug Metabolism and Disposition March 1991, 19 (2) 543-545;
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Pharmacokinetics of butixocort 21-propionate, budesonide, and beclomethasone dipropionate in the rat after intratracheal, intravenous, and oral treatments.
F Chanoine, C Grenot, P Heidmann and J L Junien

Drug Metabolism and Disposition March 1991, 19 (2) 546-553;
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Binding interaction between enantiomers of disopyramide and mono-N-dealkyldisopyramide on plasma protein.
H Takahashi, H Ogata and Y Seki

Drug Metabolism and Disposition March 1991, 19 (2) 554-557;
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Mechanisms by which acetaminophen administration diminishes ethanol clearance.
J T Slattery, T F Kalhorn and K E Thummel

Drug Metabolism and Disposition March 1991, 19 (2) 558-560;

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