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Drug Metabolism & Disposition

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Table of Contents

March 01, 1991; Volume 19,Issue 2
  • You have access
    Purification and aminopyrine monooxygenase activity of liver microsomal cytochrome P-450 from alloxan-induced diabetic rats.
    H Shimeno, A Toda, S Ogata and A Nagamatsu
    Drug Metabolism and Disposition March 1991, 19 (2) 291-297;
  • You have access
    Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1.
    M J Olson, S G Kim, C A Reidy, J T Johnson and R F Novak
    Drug Metabolism and Disposition March 1991, 19 (2) 298-303;
  • You have access
    Stereoselective (S)- and (R)-naproxen glucuronosyl transferases of rat liver.
    M el Mouelhi and K W Bock
    Drug Metabolism and Disposition March 1991, 19 (2) 304-308;
  • You have access
    The pharmacokinetics of albumin conjugates of D-penicillamine in humans.
    D A Joyce, R O Day and B R Murphy
    Drug Metabolism and Disposition March 1991, 19 (2) 309-311;
  • You have access
    Effect of H2 antagonists on the differential secretion of triamterene and its sulfate conjugate metabolite by the isolated perfused rat kidney.
    M R Muirhead and A A Somogyi
    Drug Metabolism and Disposition March 1991, 19 (2) 312-316;
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    Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.
    J C Kraft, W Slikker, J R Bailey, L G Roberts, B Fischer, W Wittfoht and H Nau
    Drug Metabolism and Disposition March 1991, 19 (2) 317-324;
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    The detection of halocarbon-derived radical adducts in bile and liver of rats.
    K T Knecht and R P Mason
    Drug Metabolism and Disposition March 1991, 19 (2) 325-331;
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    Conversion of retinol to retinal by rat liver microsomes.
    T W Shih and D L Hill
    Drug Metabolism and Disposition March 1991, 19 (2) 332-335;
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    Conversion of retinoid ethers to alcohols by enzymatic activity present in rat liver microsomes.
    T W Shih, Y F Shealy and D L Hill
    Drug Metabolism and Disposition March 1991, 19 (2) 336-339;
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    Intestinal biotransformation of harmol and 1-naphthol in the rat. Further evidence of dose-dependent phase-II conjugation in situ.
    D Goon and C D Klaassen
    Drug Metabolism and Disposition March 1991, 19 (2) 340-347;
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    Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2.
    C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
    Drug Metabolism and Disposition March 1991, 19 (2) 348-353;
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    Oxidation of propylthiouracil to reactive metabolites by activated neutrophils. Implications for agranulocytosis.
    L Waldhauser and J Uetrecht
    Drug Metabolism and Disposition March 1991, 19 (2) 354-359;
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    Model systems for metabolism studies. Biomimetic oxidation of acetaminophen and ellipticine derivatives with water-soluble metalloporphyrins associated to potassium monopersulfate.
    J Bernadou, M Bonnafous, G Labat, P Loiseau and B Meunier
    Drug Metabolism and Disposition March 1991, 19 (2) 360-365;
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    Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey.
    W J Ehlhardt and J J Howbert
    Drug Metabolism and Disposition March 1991, 19 (2) 366-369;
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    Metabolism and disposition of the anticancer agent sulofenur in mouse, rat, monkey, and human.
    W J Ehlhardt
    Drug Metabolism and Disposition March 1991, 19 (2) 370-375;
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    Stereoselective glucuronidation of ofloxacin in rat liver microsomes.
    O Okazaki, T Kurata, H Hakusui and H Tachizawa
    Drug Metabolism and Disposition March 1991, 19 (2) 376-380;
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    The metabolism of [14C]rimantadine hydrochloride in rats and dogs.
    A C Loh, A J Szuna, T H Williams, G J Sasso and F J Leinweber
    Drug Metabolism and Disposition March 1991, 19 (2) 381-387;
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    Studies on inhibition and induction of metabolism of ethyl carbamate by acetone and related compounds. Evidence for metabolism by cytochromes P-450.
    N Kurata, H E Hurst, F W Benz, R A Kemper and W J Waddell
    Drug Metabolism and Disposition March 1991, 19 (2) 388-393;
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    Metabolism of the antipsychotic drug tiospirone in humans.
    R F Mayol, H K Jajoo, L J Klunk and I A Blair
    Drug Metabolism and Disposition March 1991, 19 (2) 394-399;
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    Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects.
    S Knapp, M L Wardlow, K Albert, D Waters and L J Thal
    Drug Metabolism and Disposition March 1991, 19 (2) 400-404;
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    Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
    S M Sanins, W J Adams, D G Kaiser, G W Halstead, J Hosley, H Barnes and T A Baillie
    Drug Metabolism and Disposition March 1991, 19 (2) 405-410;
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    Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice.
    N A Mahmood, D Overstreet and L T Burka
    Drug Metabolism and Disposition March 1991, 19 (2) 411-418;
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    Urinary and biliary excretion of metabolites of halothane in dogs.
    T Sakai, H Yoshida, A Fukui and M Takaori
    Drug Metabolism and Disposition March 1991, 19 (2) 419-422;
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    Phenacetin and acetaminophen metabolism in the isolated perfused rat liver. Precursor concentration influences the selection of kinetic parameters to assess hypoxic impairment.
    S D Studenberg and K L Brouwer
    Drug Metabolism and Disposition March 1991, 19 (2) 423-429;
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    Pharmacokinetics of theophylline in the newborn and adult rabbit. In vivo and isolated perfused liver approaches.
    A Bortolotti, M Corada, M M Barzago, A Celardo, A Guaitani and M Bonati
    Drug Metabolism and Disposition March 1991, 19 (2) 430-435;
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    Brain distribution and fate of tris(2-chloroethyl) phosphate in Fischer 344 rats.
    D W Herr, J M Sanders and H B Matthews
    Drug Metabolism and Disposition March 1991, 19 (2) 436-442;
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    Metabolism of tris(2-chloroethyl) phosphate in rats and mice.
    L T Burka, J M Sanders, D W Herr and H B Matthews
    Drug Metabolism and Disposition March 1991, 19 (2) 443-447;
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    Stereoselective sulfate conjugation of racemic 4-hydroxypropranolol by human and rat liver cytosol.
    T Walle and U K Walle
    Drug Metabolism and Disposition March 1991, 19 (2) 448-453;
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    Metabolism of 7-(1,3-dithiolan-2-ylmethyl)-1,3-dimethylxanthine by rat liver microsomes. Diastereoselective metabolism of the 1,3-dithiolane ring.
    G Grosa, O Caputo, M Ceruti, G Biglino, J S Franzone and C Cravanzola
    Drug Metabolism and Disposition March 1991, 19 (2) 454-457;
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    Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation.
    O Grech-Bélanger, J Turgeon, M Lalande and P M Bélanger
    Drug Metabolism and Disposition March 1991, 19 (2) 458-461;
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    (-)-6-Aminocarbovir pharmacokinetics and relative carbovir exposure in rats.
    R L Yeager, K R Brouwer and G T Miwa
    Drug Metabolism and Disposition March 1991, 19 (2) 462-466;
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    Oxidation of butylated hydroxytoluene to toxic metabolites. Factors influencing hydroxylation and quinone methide formation by hepatic and pulmonary microsomes.
    J L Bolton and J A Thompson
    Drug Metabolism and Disposition March 1991, 19 (2) 467-472;
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    Biotransformation of the organophosphorus insecticides parathion and methyl parathion in male and female rat livers perfused in situ.
    H X Zhang and L G Sultatos
    Drug Metabolism and Disposition March 1991, 19 (2) 473-477;
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    Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. I. Theoretical considerations.
    S P Khor and M Mayersohn
    Drug Metabolism and Disposition March 1991, 19 (2) 478-485;
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    Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat.
    S P Khor, H Bozigian and M Mayersohn
    Drug Metabolism and Disposition March 1991, 19 (2) 486-490;
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    Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.
    D K Patel, J L Woolley, J P Shcokcor, R L Johnson, L C Taylor and C W Sigel
    Drug Metabolism and Disposition March 1991, 19 (2) 491-497;
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    Drug metabolizing enzyme changes after chronic buthionine sulfoximine exposure modify acetaminophen disposition in rats.
    B W Manning, M R Franklin and R E Galinsky
    Drug Metabolism and Disposition March 1991, 19 (2) 498-502;
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    Kinetics of acetyl CoA: arylamine N-acetyltransferase from rapid and slow acetylator human liver.
    A J Kilbane, T Petroff and W W Weber
    Drug Metabolism and Disposition March 1991, 19 (2) 503-507;
  • You have access
    Formation of N-(5-nitro-2-thiazolyl)-N'-carboxymethylurea from 5-hydroxyniridazole. Role of aldehyde dehydrogenase in the oxidative metabolism of niridazole.
    J W Tracy, B A Catto and L T Webster
    Drug Metabolism and Disposition March 1991, 19 (2) 508-515;
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    Metabolism of [14C]monocrotaline by isolated perfused rat liver.
    M W Lamé, A D Jones, D Morin and H J Segall
    Drug Metabolism and Disposition March 1991, 19 (2) 516-524;
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    Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.
    K Kassahun, K Farrell and F Abbott
    Drug Metabolism and Disposition March 1991, 19 (2) 525-535;
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    Rapid, dose-dependent elimination of phenol across the gills, and slow elimination of phenyl sulfate in the urine of phenol-dosed lobsters, Homarus americanus.
    M O James, J D Schell, M G Barron and C L Li
    Drug Metabolism and Disposition March 1991, 19 (2) 536-542;
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    Inhibition of aryl sulfotransferase by carboxylic acids.
    S I Rao and M W Duffel
    Drug Metabolism and Disposition March 1991, 19 (2) 543-545;
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    Pharmacokinetics of butixocort 21-propionate, budesonide, and beclomethasone dipropionate in the rat after intratracheal, intravenous, and oral treatments.
    F Chanoine, C Grenot, P Heidmann and J L Junien
    Drug Metabolism and Disposition March 1991, 19 (2) 546-553;
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    Binding interaction between enantiomers of disopyramide and mono-N-dealkyldisopyramide on plasma protein.
    H Takahashi, H Ogata and Y Seki
    Drug Metabolism and Disposition March 1991, 19 (2) 554-557;
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    Mechanisms by which acetaminophen administration diminishes ethanol clearance.
    J T Slattery, T F Kalhorn and K E Thummel
    Drug Metabolism and Disposition March 1991, 19 (2) 558-560;
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In this issue

Drug Metabolism and Disposition
Vol. 19, Issue 2
1 Mar 1991
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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