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Index by author

March 01, 1991; Volume 19,Issue 2

A

  1. Abbott, F

    1. Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.
      K Kassahun, K Farrell and F Abbott
      Drug Metabolism and Disposition March 1991, 19 (2) 525-535;

  2. Adams, W J

    1. Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
      S M Sanins, W J Adams, D G Kaiser, G W Halstead, J Hosley, H Barnes and T A Baillie
      Drug Metabolism and Disposition March 1991, 19 (2) 405-410;

  3. Albert, K

    1. Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects.
      S Knapp, M L Wardlow, K Albert, D Waters and L J Thal
      Drug Metabolism and Disposition March 1991, 19 (2) 400-404;

B

  1. Bailey, J R

    1. Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.
      J C Kraft, W Slikker, J R Bailey, L G Roberts, B Fischer, W Wittfoht and H Nau
      Drug Metabolism and Disposition March 1991, 19 (2) 317-324;

  2. Baillie, T A

    1. Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
      S M Sanins, W J Adams, D G Kaiser, G W Halstead, J Hosley, H Barnes and T A Baillie
      Drug Metabolism and Disposition March 1991, 19 (2) 405-410;

  3. Barnes, H

    1. Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
      S M Sanins, W J Adams, D G Kaiser, G W Halstead, J Hosley, H Barnes and T A Baillie
      Drug Metabolism and Disposition March 1991, 19 (2) 405-410;

  4. Barron, M G

    1. Rapid, dose-dependent elimination of phenol across the gills, and slow elimination of phenyl sulfate in the urine of phenol-dosed lobsters, Homarus americanus.
      M O James, J D Schell, M G Barron and C L Li
      Drug Metabolism and Disposition March 1991, 19 (2) 536-542;

  5. Barzago, M M

    1. Pharmacokinetics of theophylline in the newborn and adult rabbit. In vivo and isolated perfused liver approaches.
      A Bortolotti, M Corada, M M Barzago, A Celardo, A Guaitani and M Bonati
      Drug Metabolism and Disposition March 1991, 19 (2) 430-435;

  6. Bélanger, P M

    1. Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation.
      O Grech-Bélanger, J Turgeon, M Lalande and P M Bélanger
      Drug Metabolism and Disposition March 1991, 19 (2) 458-461;

  7. Benz, F W

    1. Studies on inhibition and induction of metabolism of ethyl carbamate by acetone and related compounds. Evidence for metabolism by cytochromes P-450.
      N Kurata, H E Hurst, F W Benz, R A Kemper and W J Waddell
      Drug Metabolism and Disposition March 1991, 19 (2) 388-393;

  8. Bernadou, J

    1. Model systems for metabolism studies. Biomimetic oxidation of acetaminophen and ellipticine derivatives with water-soluble metalloporphyrins associated to potassium monopersulfate.
      J Bernadou, M Bonnafous, G Labat, P Loiseau and B Meunier
      Drug Metabolism and Disposition March 1991, 19 (2) 360-365;

  9. Biglino, G

    1. Metabolism of 7-(1,3-dithiolan-2-ylmethyl)-1,3-dimethylxanthine by rat liver microsomes. Diastereoselective metabolism of the 1,3-dithiolane ring.
      G Grosa, O Caputo, M Ceruti, G Biglino, J S Franzone and C Cravanzola
      Drug Metabolism and Disposition March 1991, 19 (2) 454-457;

  10. Blair, I A

    1. Metabolism of the antipsychotic drug tiospirone in humans.
      R F Mayol, H K Jajoo, L J Klunk and I A Blair
      Drug Metabolism and Disposition March 1991, 19 (2) 394-399;

  11. Bock, K W

    1. Stereoselective (S)- and (R)-naproxen glucuronosyl transferases of rat liver.
      M el Mouelhi and K W Bock
      Drug Metabolism and Disposition March 1991, 19 (2) 304-308;

  12. Bolton, J L

    1. Oxidation of butylated hydroxytoluene to toxic metabolites. Factors influencing hydroxylation and quinone methide formation by hepatic and pulmonary microsomes.
      J L Bolton and J A Thompson
      Drug Metabolism and Disposition March 1991, 19 (2) 467-472;

  13. Bonati, M

    1. Pharmacokinetics of theophylline in the newborn and adult rabbit. In vivo and isolated perfused liver approaches.
      A Bortolotti, M Corada, M M Barzago, A Celardo, A Guaitani and M Bonati
      Drug Metabolism and Disposition March 1991, 19 (2) 430-435;

  14. Bonnafous, M

    1. Model systems for metabolism studies. Biomimetic oxidation of acetaminophen and ellipticine derivatives with water-soluble metalloporphyrins associated to potassium monopersulfate.
      J Bernadou, M Bonnafous, G Labat, P Loiseau and B Meunier
      Drug Metabolism and Disposition March 1991, 19 (2) 360-365;

  15. Bortolotti, A

    1. Pharmacokinetics of theophylline in the newborn and adult rabbit. In vivo and isolated perfused liver approaches.
      A Bortolotti, M Corada, M M Barzago, A Celardo, A Guaitani and M Bonati
      Drug Metabolism and Disposition March 1991, 19 (2) 430-435;

  16. Bozigian, H

    1. Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat.
      S P Khor, H Bozigian and M Mayersohn
      Drug Metabolism and Disposition March 1991, 19 (2) 486-490;

  17. Brouwer, K L

    1. Phenacetin and acetaminophen metabolism in the isolated perfused rat liver. Precursor concentration influences the selection of kinetic parameters to assess hypoxic impairment.
      S D Studenberg and K L Brouwer
      Drug Metabolism and Disposition March 1991, 19 (2) 423-429;

  18. Brouwer, K R

    1. (-)-6-Aminocarbovir pharmacokinetics and relative carbovir exposure in rats.
      R L Yeager, K R Brouwer and G T Miwa
      Drug Metabolism and Disposition March 1991, 19 (2) 462-466;

  19. Burka, L T

    1. Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice.
      N A Mahmood, D Overstreet and L T Burka
      Drug Metabolism and Disposition March 1991, 19 (2) 411-418;
    2. Metabolism of tris(2-chloroethyl) phosphate in rats and mice.
      L T Burka, J M Sanders, D W Herr and H B Matthews
      Drug Metabolism and Disposition March 1991, 19 (2) 443-447;

C

  1. Caputo, O

    1. Metabolism of 7-(1,3-dithiolan-2-ylmethyl)-1,3-dimethylxanthine by rat liver microsomes. Diastereoselective metabolism of the 1,3-dithiolane ring.
      G Grosa, O Caputo, M Ceruti, G Biglino, J S Franzone and C Cravanzola
      Drug Metabolism and Disposition March 1991, 19 (2) 454-457;

  2. Catto, B A

    1. Formation of N-(5-nitro-2-thiazolyl)-N'-carboxymethylurea from 5-hydroxyniridazole. Role of aldehyde dehydrogenase in the oxidative metabolism of niridazole.
      J W Tracy, B A Catto and L T Webster
      Drug Metabolism and Disposition March 1991, 19 (2) 508-515;

  3. Celardo, A

    1. Pharmacokinetics of theophylline in the newborn and adult rabbit. In vivo and isolated perfused liver approaches.
      A Bortolotti, M Corada, M M Barzago, A Celardo, A Guaitani and M Bonati
      Drug Metabolism and Disposition March 1991, 19 (2) 430-435;

  4. Ceruti, M

    1. Metabolism of 7-(1,3-dithiolan-2-ylmethyl)-1,3-dimethylxanthine by rat liver microsomes. Diastereoselective metabolism of the 1,3-dithiolane ring.
      G Grosa, O Caputo, M Ceruti, G Biglino, J S Franzone and C Cravanzola
      Drug Metabolism and Disposition March 1991, 19 (2) 454-457;

  5. Chanoine, F

    1. Pharmacokinetics of butixocort 21-propionate, budesonide, and beclomethasone dipropionate in the rat after intratracheal, intravenous, and oral treatments.
      F Chanoine, C Grenot, P Heidmann and J L Junien
      Drug Metabolism and Disposition March 1991, 19 (2) 546-553;

  6. Corada, M

    1. Pharmacokinetics of theophylline in the newborn and adult rabbit. In vivo and isolated perfused liver approaches.
      A Bortolotti, M Corada, M M Barzago, A Celardo, A Guaitani and M Bonati
      Drug Metabolism and Disposition March 1991, 19 (2) 430-435;

  7. Cravanzola, C

    1. Metabolism of 7-(1,3-dithiolan-2-ylmethyl)-1,3-dimethylxanthine by rat liver microsomes. Diastereoselective metabolism of the 1,3-dithiolane ring.
      G Grosa, O Caputo, M Ceruti, G Biglino, J S Franzone and C Cravanzola
      Drug Metabolism and Disposition March 1991, 19 (2) 454-457;

D

  1. Day, R O

    1. The pharmacokinetics of albumin conjugates of D-penicillamine in humans.
      D A Joyce, R O Day and B R Murphy
      Drug Metabolism and Disposition March 1991, 19 (2) 309-311;

  2. Duffel, M W

    1. Inhibition of aryl sulfotransferase by carboxylic acids.
      S I Rao and M W Duffel
      Drug Metabolism and Disposition March 1991, 19 (2) 543-545;

E

  1. Ehlhardt, W J

    1. Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey.
      W J Ehlhardt and J J Howbert
      Drug Metabolism and Disposition March 1991, 19 (2) 366-369;
    2. Metabolism and disposition of the anticancer agent sulofenur in mouse, rat, monkey, and human.
      W J Ehlhardt
      Drug Metabolism and Disposition March 1991, 19 (2) 370-375;

  2. el Mouelhi, M

    1. Stereoselective (S)- and (R)-naproxen glucuronosyl transferases of rat liver.
      M el Mouelhi and K W Bock
      Drug Metabolism and Disposition March 1991, 19 (2) 304-308;

F

  1. Farrell, K

    1. Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.
      K Kassahun, K Farrell and F Abbott
      Drug Metabolism and Disposition March 1991, 19 (2) 525-535;

  2. Fischer, B

    1. Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.
      J C Kraft, W Slikker, J R Bailey, L G Roberts, B Fischer, W Wittfoht and H Nau
      Drug Metabolism and Disposition March 1991, 19 (2) 317-324;

  3. Franklin, M R

    1. Drug metabolizing enzyme changes after chronic buthionine sulfoximine exposure modify acetaminophen disposition in rats.
      B W Manning, M R Franklin and R E Galinsky
      Drug Metabolism and Disposition March 1991, 19 (2) 498-502;

  4. Franzone, J S

    1. Metabolism of 7-(1,3-dithiolan-2-ylmethyl)-1,3-dimethylxanthine by rat liver microsomes. Diastereoselective metabolism of the 1,3-dithiolane ring.
      G Grosa, O Caputo, M Ceruti, G Biglino, J S Franzone and C Cravanzola
      Drug Metabolism and Disposition March 1991, 19 (2) 454-457;

  5. Fukui, A

    1. Urinary and biliary excretion of metabolites of halothane in dogs.
      T Sakai, H Yoshida, A Fukui and M Takaori
      Drug Metabolism and Disposition March 1991, 19 (2) 419-422;

G

  1. Galinsky, R E

    1. Drug metabolizing enzyme changes after chronic buthionine sulfoximine exposure modify acetaminophen disposition in rats.
      B W Manning, M R Franklin and R E Galinsky
      Drug Metabolism and Disposition March 1991, 19 (2) 498-502;

  2. Goon, D

    1. Intestinal biotransformation of harmol and 1-naphthol in the rat. Further evidence of dose-dependent phase-II conjugation in situ.
      D Goon and C D Klaassen
      Drug Metabolism and Disposition March 1991, 19 (2) 340-347;

  3. Grech-Bélanger, O

    1. Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation.
      O Grech-Bélanger, J Turgeon, M Lalande and P M Bélanger
      Drug Metabolism and Disposition March 1991, 19 (2) 458-461;

  4. Grenot, C

    1. Pharmacokinetics of butixocort 21-propionate, budesonide, and beclomethasone dipropionate in the rat after intratracheal, intravenous, and oral treatments.
      F Chanoine, C Grenot, P Heidmann and J L Junien
      Drug Metabolism and Disposition March 1991, 19 (2) 546-553;

  5. Grosa, G

    1. Metabolism of 7-(1,3-dithiolan-2-ylmethyl)-1,3-dimethylxanthine by rat liver microsomes. Diastereoselective metabolism of the 1,3-dithiolane ring.
      G Grosa, O Caputo, M Ceruti, G Biglino, J S Franzone and C Cravanzola
      Drug Metabolism and Disposition March 1991, 19 (2) 454-457;

  6. Guaitani, A

    1. Pharmacokinetics of theophylline in the newborn and adult rabbit. In vivo and isolated perfused liver approaches.
      A Bortolotti, M Corada, M M Barzago, A Celardo, A Guaitani and M Bonati
      Drug Metabolism and Disposition March 1991, 19 (2) 430-435;

H

  1. Hakusui, H

    1. Stereoselective glucuronidation of ofloxacin in rat liver microsomes.
      O Okazaki, T Kurata, H Hakusui and H Tachizawa
      Drug Metabolism and Disposition March 1991, 19 (2) 376-380;

  2. Halstead, G W

    1. Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
      S M Sanins, W J Adams, D G Kaiser, G W Halstead, J Hosley, H Barnes and T A Baillie
      Drug Metabolism and Disposition March 1991, 19 (2) 405-410;

  3. Heidmann, P

    1. Pharmacokinetics of butixocort 21-propionate, budesonide, and beclomethasone dipropionate in the rat after intratracheal, intravenous, and oral treatments.
      F Chanoine, C Grenot, P Heidmann and J L Junien
      Drug Metabolism and Disposition March 1991, 19 (2) 546-553;

  4. Herr, D W

    1. Brain distribution and fate of tris(2-chloroethyl) phosphate in Fischer 344 rats.
      D W Herr, J M Sanders and H B Matthews
      Drug Metabolism and Disposition March 1991, 19 (2) 436-442;
    2. Metabolism of tris(2-chloroethyl) phosphate in rats and mice.
      L T Burka, J M Sanders, D W Herr and H B Matthews
      Drug Metabolism and Disposition March 1991, 19 (2) 443-447;

  5. Hill, D L

    1. Conversion of retinol to retinal by rat liver microsomes.
      T W Shih and D L Hill
      Drug Metabolism and Disposition March 1991, 19 (2) 332-335;
    2. Conversion of retinoid ethers to alcohols by enzymatic activity present in rat liver microsomes.
      T W Shih, Y F Shealy and D L Hill
      Drug Metabolism and Disposition March 1991, 19 (2) 336-339;

  6. Hosley, J

    1. Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
      S M Sanins, W J Adams, D G Kaiser, G W Halstead, J Hosley, H Barnes and T A Baillie
      Drug Metabolism and Disposition March 1991, 19 (2) 405-410;

  7. Howbert, J J

    1. Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey.
      W J Ehlhardt and J J Howbert
      Drug Metabolism and Disposition March 1991, 19 (2) 366-369;

  8. Hurst, H E

    1. Studies on inhibition and induction of metabolism of ethyl carbamate by acetone and related compounds. Evidence for metabolism by cytochromes P-450.
      N Kurata, H E Hurst, F W Benz, R A Kemper and W J Waddell
      Drug Metabolism and Disposition March 1991, 19 (2) 388-393;

J

  1. Jajoo, H K

    1. Metabolism of the antipsychotic drug tiospirone in humans.
      R F Mayol, H K Jajoo, L J Klunk and I A Blair
      Drug Metabolism and Disposition March 1991, 19 (2) 394-399;

  2. James, M O

    1. Rapid, dose-dependent elimination of phenol across the gills, and slow elimination of phenyl sulfate in the urine of phenol-dosed lobsters, Homarus americanus.
      M O James, J D Schell, M G Barron and C L Li
      Drug Metabolism and Disposition March 1991, 19 (2) 536-542;

  3. Johnson, J T

    1. Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1.
      M J Olson, S G Kim, C A Reidy, J T Johnson and R F Novak
      Drug Metabolism and Disposition March 1991, 19 (2) 298-303;

  4. Johnson, R L

    1. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.
      D K Patel, J L Woolley, J P Shcokcor, R L Johnson, L C Taylor and C W Sigel
      Drug Metabolism and Disposition March 1991, 19 (2) 491-497;

  5. Jones, A D

    1. Metabolism of [14C]monocrotaline by isolated perfused rat liver.
      M W Lamé, A D Jones, D Morin and H J Segall
      Drug Metabolism and Disposition March 1991, 19 (2) 516-524;

  6. Joyce, D A

    1. The pharmacokinetics of albumin conjugates of D-penicillamine in humans.
      D A Joyce, R O Day and B R Murphy
      Drug Metabolism and Disposition March 1991, 19 (2) 309-311;

  7. Junien, J L

    1. Pharmacokinetics of butixocort 21-propionate, budesonide, and beclomethasone dipropionate in the rat after intratracheal, intravenous, and oral treatments.
      F Chanoine, C Grenot, P Heidmann and J L Junien
      Drug Metabolism and Disposition March 1991, 19 (2) 546-553;

K

  1. Kaiser, D G

    1. Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
      S M Sanins, W J Adams, D G Kaiser, G W Halstead, J Hosley, H Barnes and T A Baillie
      Drug Metabolism and Disposition March 1991, 19 (2) 405-410;

  2. Kalhorn, T F

    1. Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2.
      C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
      Drug Metabolism and Disposition March 1991, 19 (2) 348-353;
    2. Mechanisms by which acetaminophen administration diminishes ethanol clearance.
      J T Slattery, T F Kalhorn and K E Thummel
      Drug Metabolism and Disposition March 1991, 19 (2) 558-560;

  3. Kassahun, K

    1. Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.
      K Kassahun, K Farrell and F Abbott
      Drug Metabolism and Disposition March 1991, 19 (2) 525-535;

  4. Kemper, R A

    1. Studies on inhibition and induction of metabolism of ethyl carbamate by acetone and related compounds. Evidence for metabolism by cytochromes P-450.
      N Kurata, H E Hurst, F W Benz, R A Kemper and W J Waddell
      Drug Metabolism and Disposition March 1991, 19 (2) 388-393;

  5. Khor, S P

    1. Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. I. Theoretical considerations.
      S P Khor and M Mayersohn
      Drug Metabolism and Disposition March 1991, 19 (2) 478-485;
    2. Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat.
      S P Khor, H Bozigian and M Mayersohn
      Drug Metabolism and Disposition March 1991, 19 (2) 486-490;

  6. Kilbane, A J

    1. Kinetics of acetyl CoA: arylamine N-acetyltransferase from rapid and slow acetylator human liver.
      A J Kilbane, T Petroff and W W Weber
      Drug Metabolism and Disposition March 1991, 19 (2) 503-507;

  7. Kim, S G

    1. Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1.
      M J Olson, S G Kim, C A Reidy, J T Johnson and R F Novak
      Drug Metabolism and Disposition March 1991, 19 (2) 298-303;

  8. Klaassen, C D

    1. Intestinal biotransformation of harmol and 1-naphthol in the rat. Further evidence of dose-dependent phase-II conjugation in situ.
      D Goon and C D Klaassen
      Drug Metabolism and Disposition March 1991, 19 (2) 340-347;

  9. Klunk, L J

    1. Metabolism of the antipsychotic drug tiospirone in humans.
      R F Mayol, H K Jajoo, L J Klunk and I A Blair
      Drug Metabolism and Disposition March 1991, 19 (2) 394-399;

  10. Knapp, S

    1. Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects.
      S Knapp, M L Wardlow, K Albert, D Waters and L J Thal
      Drug Metabolism and Disposition March 1991, 19 (2) 400-404;

  11. Knecht, K T

    1. The detection of halocarbon-derived radical adducts in bile and liver of rats.
      K T Knecht and R P Mason
      Drug Metabolism and Disposition March 1991, 19 (2) 325-331;

  12. Kraft, J C

    1. Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.
      J C Kraft, W Slikker, J R Bailey, L G Roberts, B Fischer, W Wittfoht and H Nau
      Drug Metabolism and Disposition March 1991, 19 (2) 317-324;

  13. Kurata, N

    1. Studies on inhibition and induction of metabolism of ethyl carbamate by acetone and related compounds. Evidence for metabolism by cytochromes P-450.
      N Kurata, H E Hurst, F W Benz, R A Kemper and W J Waddell
      Drug Metabolism and Disposition March 1991, 19 (2) 388-393;

  14. Kurata, T

    1. Stereoselective glucuronidation of ofloxacin in rat liver microsomes.
      O Okazaki, T Kurata, H Hakusui and H Tachizawa
      Drug Metabolism and Disposition March 1991, 19 (2) 376-380;

L

  1. Labat, G

    1. Model systems for metabolism studies. Biomimetic oxidation of acetaminophen and ellipticine derivatives with water-soluble metalloporphyrins associated to potassium monopersulfate.
      J Bernadou, M Bonnafous, G Labat, P Loiseau and B Meunier
      Drug Metabolism and Disposition March 1991, 19 (2) 360-365;

  2. Lalande, M

    1. Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation.
      O Grech-Bélanger, J Turgeon, M Lalande and P M Bélanger
      Drug Metabolism and Disposition March 1991, 19 (2) 458-461;

  3. Lamé, M W

    1. Metabolism of [14C]monocrotaline by isolated perfused rat liver.
      M W Lamé, A D Jones, D Morin and H J Segall
      Drug Metabolism and Disposition March 1991, 19 (2) 516-524;

  4. Lee, C A

    1. Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2.
      C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
      Drug Metabolism and Disposition March 1991, 19 (2) 348-353;

  5. Leinweber, F J

    1. The metabolism of [14C]rimantadine hydrochloride in rats and dogs.
      A C Loh, A J Szuna, T H Williams, G J Sasso and F J Leinweber
      Drug Metabolism and Disposition March 1991, 19 (2) 381-387;

  6. Li, C L

    1. Rapid, dose-dependent elimination of phenol across the gills, and slow elimination of phenyl sulfate in the urine of phenol-dosed lobsters, Homarus americanus.
      M O James, J D Schell, M G Barron and C L Li
      Drug Metabolism and Disposition March 1991, 19 (2) 536-542;

  7. Loh, A C

    1. The metabolism of [14C]rimantadine hydrochloride in rats and dogs.
      A C Loh, A J Szuna, T H Williams, G J Sasso and F J Leinweber
      Drug Metabolism and Disposition March 1991, 19 (2) 381-387;

  8. Loiseau, P

    1. Model systems for metabolism studies. Biomimetic oxidation of acetaminophen and ellipticine derivatives with water-soluble metalloporphyrins associated to potassium monopersulfate.
      J Bernadou, M Bonnafous, G Labat, P Loiseau and B Meunier
      Drug Metabolism and Disposition March 1991, 19 (2) 360-365;

M

  1. Mahmood, N A

    1. Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice.
      N A Mahmood, D Overstreet and L T Burka
      Drug Metabolism and Disposition March 1991, 19 (2) 411-418;

  2. Manning, B W

    1. Drug metabolizing enzyme changes after chronic buthionine sulfoximine exposure modify acetaminophen disposition in rats.
      B W Manning, M R Franklin and R E Galinsky
      Drug Metabolism and Disposition March 1991, 19 (2) 498-502;

  3. Mason, R P

    1. The detection of halocarbon-derived radical adducts in bile and liver of rats.
      K T Knecht and R P Mason
      Drug Metabolism and Disposition March 1991, 19 (2) 325-331;

  4. Matthews, H B

    1. Brain distribution and fate of tris(2-chloroethyl) phosphate in Fischer 344 rats.
      D W Herr, J M Sanders and H B Matthews
      Drug Metabolism and Disposition March 1991, 19 (2) 436-442;
    2. Metabolism of tris(2-chloroethyl) phosphate in rats and mice.
      L T Burka, J M Sanders, D W Herr and H B Matthews
      Drug Metabolism and Disposition March 1991, 19 (2) 443-447;

  5. Mayersohn, M

    1. Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. I. Theoretical considerations.
      S P Khor and M Mayersohn
      Drug Metabolism and Disposition March 1991, 19 (2) 478-485;
    2. Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat.
      S P Khor, H Bozigian and M Mayersohn
      Drug Metabolism and Disposition March 1991, 19 (2) 486-490;

  6. Mayol, R F

    1. Metabolism of the antipsychotic drug tiospirone in humans.
      R F Mayol, H K Jajoo, L J Klunk and I A Blair
      Drug Metabolism and Disposition March 1991, 19 (2) 394-399;

  7. Meunier, B

    1. Model systems for metabolism studies. Biomimetic oxidation of acetaminophen and ellipticine derivatives with water-soluble metalloporphyrins associated to potassium monopersulfate.
      J Bernadou, M Bonnafous, G Labat, P Loiseau and B Meunier
      Drug Metabolism and Disposition March 1991, 19 (2) 360-365;

  8. Miwa, G T

    1. (-)-6-Aminocarbovir pharmacokinetics and relative carbovir exposure in rats.
      R L Yeager, K R Brouwer and G T Miwa
      Drug Metabolism and Disposition March 1991, 19 (2) 462-466;

  9. Morin, D

    1. Metabolism of [14C]monocrotaline by isolated perfused rat liver.
      M W Lamé, A D Jones, D Morin and H J Segall
      Drug Metabolism and Disposition March 1991, 19 (2) 516-524;

  10. Muirhead, M R

    1. Effect of H2 antagonists on the differential secretion of triamterene and its sulfate conjugate metabolite by the isolated perfused rat kidney.
      M R Muirhead and A A Somogyi
      Drug Metabolism and Disposition March 1991, 19 (2) 312-316;

  11. Murphy, B R

    1. The pharmacokinetics of albumin conjugates of D-penicillamine in humans.
      D A Joyce, R O Day and B R Murphy
      Drug Metabolism and Disposition March 1991, 19 (2) 309-311;

N

  1. Nagamatsu, A

    1. Purification and aminopyrine monooxygenase activity of liver microsomal cytochrome P-450 from alloxan-induced diabetic rats.
      H Shimeno, A Toda, S Ogata and A Nagamatsu
      Drug Metabolism and Disposition March 1991, 19 (2) 291-297;

  2. Nau, H

    1. Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.
      J C Kraft, W Slikker, J R Bailey, L G Roberts, B Fischer, W Wittfoht and H Nau
      Drug Metabolism and Disposition March 1991, 19 (2) 317-324;

  3. Nelson, S D

    1. Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2.
      C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
      Drug Metabolism and Disposition March 1991, 19 (2) 348-353;

  4. Novak, R F

    1. Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1.
      M J Olson, S G Kim, C A Reidy, J T Johnson and R F Novak
      Drug Metabolism and Disposition March 1991, 19 (2) 298-303;

O

  1. Ogata, H

    1. Binding interaction between enantiomers of disopyramide and mono-N-dealkyldisopyramide on plasma protein.
      H Takahashi, H Ogata and Y Seki
      Drug Metabolism and Disposition March 1991, 19 (2) 554-557;

  2. Ogata, S

    1. Purification and aminopyrine monooxygenase activity of liver microsomal cytochrome P-450 from alloxan-induced diabetic rats.
      H Shimeno, A Toda, S Ogata and A Nagamatsu
      Drug Metabolism and Disposition March 1991, 19 (2) 291-297;

  3. Okazaki, O

    1. Stereoselective glucuronidation of ofloxacin in rat liver microsomes.
      O Okazaki, T Kurata, H Hakusui and H Tachizawa
      Drug Metabolism and Disposition March 1991, 19 (2) 376-380;

  4. Olson, M J

    1. Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1.
      M J Olson, S G Kim, C A Reidy, J T Johnson and R F Novak
      Drug Metabolism and Disposition March 1991, 19 (2) 298-303;

  5. Overstreet, D

    1. Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice.
      N A Mahmood, D Overstreet and L T Burka
      Drug Metabolism and Disposition March 1991, 19 (2) 411-418;

P

  1. Patel, D K

    1. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.
      D K Patel, J L Woolley, J P Shcokcor, R L Johnson, L C Taylor and C W Sigel
      Drug Metabolism and Disposition March 1991, 19 (2) 491-497;

  2. Petroff, T

    1. Kinetics of acetyl CoA: arylamine N-acetyltransferase from rapid and slow acetylator human liver.
      A J Kilbane, T Petroff and W W Weber
      Drug Metabolism and Disposition March 1991, 19 (2) 503-507;

R

  1. Rao, S I

    1. Inhibition of aryl sulfotransferase by carboxylic acids.
      S I Rao and M W Duffel
      Drug Metabolism and Disposition March 1991, 19 (2) 543-545;

  2. Reidy, C A

    1. Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1.
      M J Olson, S G Kim, C A Reidy, J T Johnson and R F Novak
      Drug Metabolism and Disposition March 1991, 19 (2) 298-303;

  3. Roberts, L G

    1. Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.
      J C Kraft, W Slikker, J R Bailey, L G Roberts, B Fischer, W Wittfoht and H Nau
      Drug Metabolism and Disposition March 1991, 19 (2) 317-324;

S

  1. Sakai, T

    1. Urinary and biliary excretion of metabolites of halothane in dogs.
      T Sakai, H Yoshida, A Fukui and M Takaori
      Drug Metabolism and Disposition March 1991, 19 (2) 419-422;

  2. Sanders, J M

    1. Brain distribution and fate of tris(2-chloroethyl) phosphate in Fischer 344 rats.
      D W Herr, J M Sanders and H B Matthews
      Drug Metabolism and Disposition March 1991, 19 (2) 436-442;
    2. Metabolism of tris(2-chloroethyl) phosphate in rats and mice.
      L T Burka, J M Sanders, D W Herr and H B Matthews
      Drug Metabolism and Disposition March 1991, 19 (2) 443-447;

  3. Sanins, S M

    1. Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
      S M Sanins, W J Adams, D G Kaiser, G W Halstead, J Hosley, H Barnes and T A Baillie
      Drug Metabolism and Disposition March 1991, 19 (2) 405-410;

  4. Sasso, G J

    1. The metabolism of [14C]rimantadine hydrochloride in rats and dogs.
      A C Loh, A J Szuna, T H Williams, G J Sasso and F J Leinweber
      Drug Metabolism and Disposition March 1991, 19 (2) 381-387;

  5. Schell, J D

    1. Rapid, dose-dependent elimination of phenol across the gills, and slow elimination of phenyl sulfate in the urine of phenol-dosed lobsters, Homarus americanus.
      M O James, J D Schell, M G Barron and C L Li
      Drug Metabolism and Disposition March 1991, 19 (2) 536-542;

  6. Segall, H J

    1. Metabolism of [14C]monocrotaline by isolated perfused rat liver.
      M W Lamé, A D Jones, D Morin and H J Segall
      Drug Metabolism and Disposition March 1991, 19 (2) 516-524;

  7. Seki, Y

    1. Binding interaction between enantiomers of disopyramide and mono-N-dealkyldisopyramide on plasma protein.
      H Takahashi, H Ogata and Y Seki
      Drug Metabolism and Disposition March 1991, 19 (2) 554-557;

  8. Shcokcor, J P

    1. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.
      D K Patel, J L Woolley, J P Shcokcor, R L Johnson, L C Taylor and C W Sigel
      Drug Metabolism and Disposition March 1991, 19 (2) 491-497;

  9. Shealy, Y F

    1. Conversion of retinoid ethers to alcohols by enzymatic activity present in rat liver microsomes.
      T W Shih, Y F Shealy and D L Hill
      Drug Metabolism and Disposition March 1991, 19 (2) 336-339;

  10. Shih, T W

    1. Conversion of retinol to retinal by rat liver microsomes.
      T W Shih and D L Hill
      Drug Metabolism and Disposition March 1991, 19 (2) 332-335;
    2. Conversion of retinoid ethers to alcohols by enzymatic activity present in rat liver microsomes.
      T W Shih, Y F Shealy and D L Hill
      Drug Metabolism and Disposition March 1991, 19 (2) 336-339;

  11. Shimeno, H

    1. Purification and aminopyrine monooxygenase activity of liver microsomal cytochrome P-450 from alloxan-induced diabetic rats.
      H Shimeno, A Toda, S Ogata and A Nagamatsu
      Drug Metabolism and Disposition March 1991, 19 (2) 291-297;

  12. Sigel, C W

    1. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.
      D K Patel, J L Woolley, J P Shcokcor, R L Johnson, L C Taylor and C W Sigel
      Drug Metabolism and Disposition March 1991, 19 (2) 491-497;

  13. Slattery, J T

    1. Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2.
      C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
      Drug Metabolism and Disposition March 1991, 19 (2) 348-353;
    2. Mechanisms by which acetaminophen administration diminishes ethanol clearance.
      J T Slattery, T F Kalhorn and K E Thummel
      Drug Metabolism and Disposition March 1991, 19 (2) 558-560;

  14. Slikker, W

    1. Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.
      J C Kraft, W Slikker, J R Bailey, L G Roberts, B Fischer, W Wittfoht and H Nau
      Drug Metabolism and Disposition March 1991, 19 (2) 317-324;

  15. Somogyi, A A

    1. Effect of H2 antagonists on the differential secretion of triamterene and its sulfate conjugate metabolite by the isolated perfused rat kidney.
      M R Muirhead and A A Somogyi
      Drug Metabolism and Disposition March 1991, 19 (2) 312-316;

  16. Studenberg, S D

    1. Phenacetin and acetaminophen metabolism in the isolated perfused rat liver. Precursor concentration influences the selection of kinetic parameters to assess hypoxic impairment.
      S D Studenberg and K L Brouwer
      Drug Metabolism and Disposition March 1991, 19 (2) 423-429;

  17. Sultatos, L G

    1. Biotransformation of the organophosphorus insecticides parathion and methyl parathion in male and female rat livers perfused in situ.
      H X Zhang and L G Sultatos
      Drug Metabolism and Disposition March 1991, 19 (2) 473-477;

  18. Szuna, A J

    1. The metabolism of [14C]rimantadine hydrochloride in rats and dogs.
      A C Loh, A J Szuna, T H Williams, G J Sasso and F J Leinweber
      Drug Metabolism and Disposition March 1991, 19 (2) 381-387;

T

  1. Tachizawa, H

    1. Stereoselective glucuronidation of ofloxacin in rat liver microsomes.
      O Okazaki, T Kurata, H Hakusui and H Tachizawa
      Drug Metabolism and Disposition March 1991, 19 (2) 376-380;

  2. Takahashi, H

    1. Binding interaction between enantiomers of disopyramide and mono-N-dealkyldisopyramide on plasma protein.
      H Takahashi, H Ogata and Y Seki
      Drug Metabolism and Disposition March 1991, 19 (2) 554-557;

  3. Takaori, M

    1. Urinary and biliary excretion of metabolites of halothane in dogs.
      T Sakai, H Yoshida, A Fukui and M Takaori
      Drug Metabolism and Disposition March 1991, 19 (2) 419-422;

  4. Taylor, L C

    1. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.
      D K Patel, J L Woolley, J P Shcokcor, R L Johnson, L C Taylor and C W Sigel
      Drug Metabolism and Disposition March 1991, 19 (2) 491-497;

  5. Thal, L J

    1. Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects.
      S Knapp, M L Wardlow, K Albert, D Waters and L J Thal
      Drug Metabolism and Disposition March 1991, 19 (2) 400-404;

  6. Thompson, J A

    1. Oxidation of butylated hydroxytoluene to toxic metabolites. Factors influencing hydroxylation and quinone methide formation by hepatic and pulmonary microsomes.
      J L Bolton and J A Thompson
      Drug Metabolism and Disposition March 1991, 19 (2) 467-472;

  7. Thummel, K E

    1. Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2.
      C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
      Drug Metabolism and Disposition March 1991, 19 (2) 348-353;
    2. Mechanisms by which acetaminophen administration diminishes ethanol clearance.
      J T Slattery, T F Kalhorn and K E Thummel
      Drug Metabolism and Disposition March 1991, 19 (2) 558-560;

  8. Toda, A

    1. Purification and aminopyrine monooxygenase activity of liver microsomal cytochrome P-450 from alloxan-induced diabetic rats.
      H Shimeno, A Toda, S Ogata and A Nagamatsu
      Drug Metabolism and Disposition March 1991, 19 (2) 291-297;

  9. Tracy, J W

    1. Formation of N-(5-nitro-2-thiazolyl)-N'-carboxymethylurea from 5-hydroxyniridazole. Role of aldehyde dehydrogenase in the oxidative metabolism of niridazole.
      J W Tracy, B A Catto and L T Webster
      Drug Metabolism and Disposition March 1991, 19 (2) 508-515;

  10. Turgeon, J

    1. Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation.
      O Grech-Bélanger, J Turgeon, M Lalande and P M Bélanger
      Drug Metabolism and Disposition March 1991, 19 (2) 458-461;

U

  1. Uetrecht, J

    1. Oxidation of propylthiouracil to reactive metabolites by activated neutrophils. Implications for agranulocytosis.
      L Waldhauser and J Uetrecht
      Drug Metabolism and Disposition March 1991, 19 (2) 354-359;

W

  1. Waddell, W J

    1. Studies on inhibition and induction of metabolism of ethyl carbamate by acetone and related compounds. Evidence for metabolism by cytochromes P-450.
      N Kurata, H E Hurst, F W Benz, R A Kemper and W J Waddell
      Drug Metabolism and Disposition March 1991, 19 (2) 388-393;

  2. Waldhauser, L

    1. Oxidation of propylthiouracil to reactive metabolites by activated neutrophils. Implications for agranulocytosis.
      L Waldhauser and J Uetrecht
      Drug Metabolism and Disposition March 1991, 19 (2) 354-359;

  3. Walle, T

    1. Stereoselective sulfate conjugation of racemic 4-hydroxypropranolol by human and rat liver cytosol.
      T Walle and U K Walle
      Drug Metabolism and Disposition March 1991, 19 (2) 448-453;

  4. Walle, U K

    1. Stereoselective sulfate conjugation of racemic 4-hydroxypropranolol by human and rat liver cytosol.
      T Walle and U K Walle
      Drug Metabolism and Disposition March 1991, 19 (2) 448-453;

  5. Wardlow, M L

    1. Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects.
      S Knapp, M L Wardlow, K Albert, D Waters and L J Thal
      Drug Metabolism and Disposition March 1991, 19 (2) 400-404;

  6. Waters, D

    1. Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects.
      S Knapp, M L Wardlow, K Albert, D Waters and L J Thal
      Drug Metabolism and Disposition March 1991, 19 (2) 400-404;

  7. Weber, W W

    1. Kinetics of acetyl CoA: arylamine N-acetyltransferase from rapid and slow acetylator human liver.
      A J Kilbane, T Petroff and W W Weber
      Drug Metabolism and Disposition March 1991, 19 (2) 503-507;

  8. Webster, L T

    1. Formation of N-(5-nitro-2-thiazolyl)-N'-carboxymethylurea from 5-hydroxyniridazole. Role of aldehyde dehydrogenase in the oxidative metabolism of niridazole.
      J W Tracy, B A Catto and L T Webster
      Drug Metabolism and Disposition March 1991, 19 (2) 508-515;

  9. Williams, T H

    1. The metabolism of [14C]rimantadine hydrochloride in rats and dogs.
      A C Loh, A J Szuna, T H Williams, G J Sasso and F J Leinweber
      Drug Metabolism and Disposition March 1991, 19 (2) 381-387;

  10. Wittfoht, W

    1. Plasma pharmacokinetics and metabolism of 13-cis- and all-trans-retinoic acid in the cynomolgus monkey and the identification of 13-cis- and all-trans-retinoyl-beta-glucuronides. A comparison to one human case study with isotretinoin.
      J C Kraft, W Slikker, J R Bailey, L G Roberts, B Fischer, W Wittfoht and H Nau
      Drug Metabolism and Disposition March 1991, 19 (2) 317-324;

  11. Woolley, J L

    1. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.
      D K Patel, J L Woolley, J P Shcokcor, R L Johnson, L C Taylor and C W Sigel
      Drug Metabolism and Disposition March 1991, 19 (2) 491-497;

Y

  1. Yeager, R L

    1. (-)-6-Aminocarbovir pharmacokinetics and relative carbovir exposure in rats.
      R L Yeager, K R Brouwer and G T Miwa
      Drug Metabolism and Disposition March 1991, 19 (2) 462-466;

  2. Yoshida, H

    1. Urinary and biliary excretion of metabolites of halothane in dogs.
      T Sakai, H Yoshida, A Fukui and M Takaori
      Drug Metabolism and Disposition March 1991, 19 (2) 419-422;

Z

  1. Zhang, H X

    1. Biotransformation of the organophosphorus insecticides parathion and methyl parathion in male and female rat livers perfused in situ.
      H X Zhang and L G Sultatos
      Drug Metabolism and Disposition March 1991, 19 (2) 473-477;
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In this issue

Drug Metabolism and Disposition
Vol. 19, Issue 2
1 Mar 1991
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