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Drug Metabolism & Disposition

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  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
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Index by author

May 01, 1991; Volume 19,Issue 3
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

A

  1. Adams, L E

    1. You have access
      Determination of metabolically derived nitroprocainamide in the urine of procainamide-dosed humans and rats by liquid chromatography with electrochemical detection.
      J F Wheeler, L E Adams, A B Mongey, S M Roberts, W R Heineman and E V Hess
      Drug Metabolism and Disposition May 1991, 19 (3) 691-695;
  2. Agarwal, R

    1. You have access
      Nordihydroguaiaretic acid, an inhibitor of lipoxygenase, also inhibits cytochrome P-450-mediated monooxygenase activity in rat epidermal and hepatic microsomes.
      R Agarwal, Z Y Wang, D P Bik and H Mukhtar
      Drug Metabolism and Disposition May 1991, 19 (3) 620-624;
  3. Amato, R

    1. You have access
      Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion.
      D H Ho, N Brown, J R Lin, W Covington, R A Newman, M Raber, R Amato, S Schmidt and I H Krakoff
      Drug Metabolism and Disposition May 1991, 19 (3) 643-647;
  4. Anders, M W

    1. You have access
      Intestinal absorption of S-(pentachlorobutadienyl)glutathione and S-(pentachlorobutadienyl)-L-cysteine, the glutathione and cysteine S-conjugates of hexachlorobuta-1,3-diene.
      Y Gietl, S Vamvakas and M W Anders
      Drug Metabolism and Disposition May 1991, 19 (3) 703-707;

B

  1. Barr, J

    1. You have access
      The N-acetylation of sulfamethazine and p-aminobenzoic acid by human liver slices in dynamic organ culture.
      L Gunawardhana, J Barr, A J Weir, K Brendel and I G Sipes
      Drug Metabolism and Disposition May 1991, 19 (3) 648-654;
  2. Bartlett, M G

    1. You have access
      Degradation of peptide drugs by immobilized digestive proteases.
      R B Van Breemen, M G Bartlett, Y H Tsou, C Culver, H Swaisgood and S E Unger
      Drug Metabolism and Disposition May 1991, 19 (3) 683-690;
  3. Beaune, P

    1. You have access
      Evidence for the involvement of several cytochromes P-450 in the first steps of caffeine metabolism by human liver microsomes.
      F Berthou, J P Flinois, D Ratanasavanh, P Beaune, C Riche and A Guillouzo
      Drug Metabolism and Disposition May 1991, 19 (3) 561-567;
  4. Benet, L Z

    1. You have access
      Stereoselective disposition of ketoprofen in rats.
      S Iwakawa, X W He, S Hashimoto, C Volland, L Z Benet and E T Lin
      Drug Metabolism and Disposition May 1991, 19 (3) 717-718;
  5. Benowitz, N L

    1. You have access
      Disposition kinetics and metabolism of nicotine-1'-N-oxide in rabbits.
      M J Duan, L Yu, C Savanapridi, P Jacob and N L Benowitz
      Drug Metabolism and Disposition May 1991, 19 (3) 667-672;
  6. Berthou, F

    1. You have access
      Evidence for the involvement of several cytochromes P-450 in the first steps of caffeine metabolism by human liver microsomes.
      F Berthou, J P Flinois, D Ratanasavanh, P Beaune, C Riche and A Guillouzo
      Drug Metabolism and Disposition May 1991, 19 (3) 561-567;
  7. Bik, D P

    1. You have access
      Nordihydroguaiaretic acid, an inhibitor of lipoxygenase, also inhibits cytochrome P-450-mediated monooxygenase activity in rat epidermal and hepatic microsomes.
      R Agarwal, Z Y Wang, D P Bik and H Mukhtar
      Drug Metabolism and Disposition May 1991, 19 (3) 620-624;
  8. Bjorge, S M

    1. You have access
      Metabolism of the acyl-CoA:cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide in rat and monkey. Omega-/beta-oxidation pathway.
      T F Woolf, S M Bjorge, A E Black, A Holmes and T Chang
      Drug Metabolism and Disposition May 1991, 19 (3) 696-702;
  9. Black, A E

    1. You have access
      Metabolism of the acyl-CoA:cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide in rat and monkey. Omega-/beta-oxidation pathway.
      T F Woolf, S M Bjorge, A E Black, A Holmes and T Chang
      Drug Metabolism and Disposition May 1991, 19 (3) 696-702;
  10. Blair, I A

    1. You have access
      Geometric isomerization of doxepin during its N-demethylation in humans.
      H Ghabrial, C Prakash, U G Tacke, I A Blair and G R Wilkinson
      Drug Metabolism and Disposition May 1991, 19 (3) 596-599;
  11. Brendel, K

    1. You have access
      The N-acetylation of sulfamethazine and p-aminobenzoic acid by human liver slices in dynamic organ culture.
      L Gunawardhana, J Barr, A J Weir, K Brendel and I G Sipes
      Drug Metabolism and Disposition May 1991, 19 (3) 648-654;
  12. Brown, N

    1. You have access
      Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion.
      D H Ho, N Brown, J R Lin, W Covington, R A Newman, M Raber, R Amato, S Schmidt and I H Krakoff
      Drug Metabolism and Disposition May 1991, 19 (3) 643-647;
  13. Brown, N K

    1. You have access
      In vitro metabolism of the equatorial C11-methyl isomer of hexahydrocannabinol in several mammalian species.
      D J Harvey and N K Brown
      Drug Metabolism and Disposition May 1991, 19 (3) 714-716;
  14. Brundrett, R B

    1. You have access
      Glutathione conjugation with phosphoramide mustard and cyclophosphamide. A mechanistic study using tandem mass spectrometry.
      Z M Yuan, P B Smith, R B Brundrett, M Colvin and C Fenselau
      Drug Metabolism and Disposition May 1991, 19 (3) 625-629;

C

  1. Carpenter, H M

    1. You have access
      Low dose chlordecone pretreatment altered cholesterol disposition without induction of cytochrome P-450.
      H M Carpenter and L R Curtis
      Drug Metabolism and Disposition May 1991, 19 (3) 673-678;
  2. Chan, K K

    1. You have access
      Enzymatic detoxification of phosphoramide mustard by soluble fractions from rat organ tissues.
      P S Hong and K K Chan
      Drug Metabolism and Disposition May 1991, 19 (3) 568-573;
  3. Chang, T

    1. You have access
      Metabolism of the acyl-CoA:cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide in rat and monkey. Omega-/beta-oxidation pathway.
      T F Woolf, S M Bjorge, A E Black, A Holmes and T Chang
      Drug Metabolism and Disposition May 1991, 19 (3) 696-702;
  4. Chiou, C M

    1. You have access
      Biotransformation of territrems by S9 fraction from rat liver.
      K H Ling, C M Chiou and Y L Tseng
      Drug Metabolism and Disposition May 1991, 19 (3) 587-595;
  5. Colby, H D

    1. You have access
      Mechanisms responsible for the thermal sensitivity of adrenal microsomal monooxygenases.
      H D Colby, P B Johnson and M R Pope
      Drug Metabolism and Disposition May 1991, 19 (3) 679-682;
  6. Colvin, M

    1. You have access
      Glutathione conjugation with phosphoramide mustard and cyclophosphamide. A mechanistic study using tandem mass spectrometry.
      Z M Yuan, P B Smith, R B Brundrett, M Colvin and C Fenselau
      Drug Metabolism and Disposition May 1991, 19 (3) 625-629;
  7. Covington, W

    1. You have access
      Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion.
      D H Ho, N Brown, J R Lin, W Covington, R A Newman, M Raber, R Amato, S Schmidt and I H Krakoff
      Drug Metabolism and Disposition May 1991, 19 (3) 643-647;
  8. Crouch, R C

    1. You have access
      The disposition and metabolism of [14C]piritrexim in rats after intravenous and oral administration.
      J L Woolley, D V Deangelis, R C Crouch, J P Shockcor and C W Sigel
      Drug Metabolism and Disposition May 1991, 19 (3) 600-608;
  9. Culver, C

    1. You have access
      Degradation of peptide drugs by immobilized digestive proteases.
      R B Van Breemen, M G Bartlett, Y H Tsou, C Culver, H Swaisgood and S E Unger
      Drug Metabolism and Disposition May 1991, 19 (3) 683-690;
  10. Curtis, L R

    1. You have access
      Low dose chlordecone pretreatment altered cholesterol disposition without induction of cytochrome P-450.
      H M Carpenter and L R Curtis
      Drug Metabolism and Disposition May 1991, 19 (3) 673-678;

D

  1. Deangelis, D V

    1. You have access
      The disposition and metabolism of [14C]piritrexim in rats after intravenous and oral administration.
      J L Woolley, D V Deangelis, R C Crouch, J P Shockcor and C W Sigel
      Drug Metabolism and Disposition May 1991, 19 (3) 600-608;
  2. Duan, M J

    1. You have access
      Disposition kinetics and metabolism of nicotine-1'-N-oxide in rabbits.
      M J Duan, L Yu, C Savanapridi, P Jacob and N L Benowitz
      Drug Metabolism and Disposition May 1991, 19 (3) 667-672;
  3. Durand, A

    1. You have access
      The disposition and pharmacokinetics of alpidem, a new anxiolytic, in the rat.
      D Garrigou-Gadenne, A Durand, J P Thenot and P L Morselli
      Drug Metabolism and Disposition May 1991, 19 (3) 574-579;

E

  1. Eldadah, M K

    1. You have access
      The pharmacokinetics of dobutamine in pediatric intensive care unit patients.
      P H Schwartz, M K Eldadah and C J Newth
      Drug Metabolism and Disposition May 1991, 19 (3) 614-619;

F

  1. Fenselau, C

    1. You have access
      Glutathione conjugation with phosphoramide mustard and cyclophosphamide. A mechanistic study using tandem mass spectrometry.
      Z M Yuan, P B Smith, R B Brundrett, M Colvin and C Fenselau
      Drug Metabolism and Disposition May 1991, 19 (3) 625-629;
  2. Flinois, J P

    1. You have access
      Evidence for the involvement of several cytochromes P-450 in the first steps of caffeine metabolism by human liver microsomes.
      F Berthou, J P Flinois, D Ratanasavanh, P Beaune, C Riche and A Guillouzo
      Drug Metabolism and Disposition May 1991, 19 (3) 561-567;

G

  1. Garrigou-Gadenne, D

    1. You have access
      The disposition and pharmacokinetics of alpidem, a new anxiolytic, in the rat.
      D Garrigou-Gadenne, A Durand, J P Thenot and P L Morselli
      Drug Metabolism and Disposition May 1991, 19 (3) 574-579;
  2. Gek Forkert, P

    1. You have access
      1,1-Dichloroethylene elicits dose-dependent alterations in covalent binding and glutathione in murine liver.
      P Gek Forkert and M Moussa
      Drug Metabolism and Disposition May 1991, 19 (3) 580-586;
  3. Ghabrial, H

    1. You have access
      Geometric isomerization of doxepin during its N-demethylation in humans.
      H Ghabrial, C Prakash, U G Tacke, I A Blair and G R Wilkinson
      Drug Metabolism and Disposition May 1991, 19 (3) 596-599;
  4. Gietl, Y

    1. You have access
      Intestinal absorption of S-(pentachlorobutadienyl)glutathione and S-(pentachlorobutadienyl)-L-cysteine, the glutathione and cysteine S-conjugates of hexachlorobuta-1,3-diene.
      Y Gietl, S Vamvakas and M W Anders
      Drug Metabolism and Disposition May 1991, 19 (3) 703-707;
  5. Guengerich, F P

    1. You have access
      Enantioselective hydrolysis of lorazepam 3-acetate by esterases in human and rat liver microsomes and rat brain S9 fraction.
      K Liu, F P Guengerich and S K Yang
      Drug Metabolism and Disposition May 1991, 19 (3) 609-613;
    2. You have access
      Stereoselective metabolism of prazepam and halazepam by human liver microsomes.
      X L Lu, F P Guengerich and S K Yang
      Drug Metabolism and Disposition May 1991, 19 (3) 637-642;
  6. Guillouzo, A

    1. You have access
      Evidence for the involvement of several cytochromes P-450 in the first steps of caffeine metabolism by human liver microsomes.
      F Berthou, J P Flinois, D Ratanasavanh, P Beaune, C Riche and A Guillouzo
      Drug Metabolism and Disposition May 1991, 19 (3) 561-567;
  7. Gunawardhana, L

    1. You have access
      The N-acetylation of sulfamethazine and p-aminobenzoic acid by human liver slices in dynamic organ culture.
      L Gunawardhana, J Barr, A J Weir, K Brendel and I G Sipes
      Drug Metabolism and Disposition May 1991, 19 (3) 648-654;
  8. Gupta, S K

    1. You have access
      Physiological pharmacokinetic and pharmacodynamic model of physostigmine in the rat.
      S M Somani, S K Gupta, A Khalique and L K Unni
      Drug Metabolism and Disposition May 1991, 19 (3) 655-660;

H

  1. Harvey, D J

    1. You have access
      In vitro metabolism of the equatorial C11-methyl isomer of hexahydrocannabinol in several mammalian species.
      D J Harvey and N K Brown
      Drug Metabolism and Disposition May 1991, 19 (3) 714-716;
  2. Hashimoto, S

    1. You have access
      Stereoselective disposition of ketoprofen in rats.
      S Iwakawa, X W He, S Hashimoto, C Volland, L Z Benet and E T Lin
      Drug Metabolism and Disposition May 1991, 19 (3) 717-718;
  3. Hawes, E M

    1. You have access
      The quaternary ammonium-linked glucuronide of doxepin: a major metabolite in depressed patients treated with doxepin.
      H Luo, E M Hawes, G McKay, E D Korchinski and K K Midha
      Drug Metabolism and Disposition May 1991, 19 (3) 722-724;
  4. He, X W

    1. You have access
      Stereoselective disposition of ketoprofen in rats.
      S Iwakawa, X W He, S Hashimoto, C Volland, L Z Benet and E T Lin
      Drug Metabolism and Disposition May 1991, 19 (3) 717-718;
  5. Heineman, W R

    1. You have access
      Determination of metabolically derived nitroprocainamide in the urine of procainamide-dosed humans and rats by liquid chromatography with electrochemical detection.
      J F Wheeler, L E Adams, A B Mongey, S M Roberts, W R Heineman and E V Hess
      Drug Metabolism and Disposition May 1991, 19 (3) 691-695;
  6. Hess, E V

    1. You have access
      Determination of metabolically derived nitroprocainamide in the urine of procainamide-dosed humans and rats by liquid chromatography with electrochemical detection.
      J F Wheeler, L E Adams, A B Mongey, S M Roberts, W R Heineman and E V Hess
      Drug Metabolism and Disposition May 1991, 19 (3) 691-695;
  7. Ho, D H

    1. You have access
      Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion.
      D H Ho, N Brown, J R Lin, W Covington, R A Newman, M Raber, R Amato, S Schmidt and I H Krakoff
      Drug Metabolism and Disposition May 1991, 19 (3) 643-647;
  8. Holmes, A

    1. You have access
      Metabolism of the acyl-CoA:cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide in rat and monkey. Omega-/beta-oxidation pathway.
      T F Woolf, S M Bjorge, A E Black, A Holmes and T Chang
      Drug Metabolism and Disposition May 1991, 19 (3) 696-702;
  9. Hong, P S

    1. You have access
      Enzymatic detoxification of phosphoramide mustard by soluble fractions from rat organ tissues.
      P S Hong and K K Chan
      Drug Metabolism and Disposition May 1991, 19 (3) 568-573;

I

  1. Iwakawa, S

    1. You have access
      Stereoselective disposition of ketoprofen in rats.
      S Iwakawa, X W He, S Hashimoto, C Volland, L Z Benet and E T Lin
      Drug Metabolism and Disposition May 1991, 19 (3) 717-718;

J

  1. Jacob, P

    1. You have access
      Disposition kinetics and metabolism of nicotine-1'-N-oxide in rabbits.
      M J Duan, L Yu, C Savanapridi, P Jacob and N L Benowitz
      Drug Metabolism and Disposition May 1991, 19 (3) 667-672;
  2. Johnson, P B

    1. You have access
      Mechanisms responsible for the thermal sensitivity of adrenal microsomal monooxygenases.
      H D Colby, P B Johnson and M R Pope
      Drug Metabolism and Disposition May 1991, 19 (3) 679-682;

K

  1. Khalique, A

    1. You have access
      Physiological pharmacokinetic and pharmacodynamic model of physostigmine in the rat.
      S M Somani, S K Gupta, A Khalique and L K Unni
      Drug Metabolism and Disposition May 1991, 19 (3) 655-660;
  2. Korchinski, E D

    1. You have access
      The quaternary ammonium-linked glucuronide of doxepin: a major metabolite in depressed patients treated with doxepin.
      H Luo, E M Hawes, G McKay, E D Korchinski and K K Midha
      Drug Metabolism and Disposition May 1991, 19 (3) 722-724;
  3. Krakoff, I H

    1. You have access
      Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion.
      D H Ho, N Brown, J R Lin, W Covington, R A Newman, M Raber, R Amato, S Schmidt and I H Krakoff
      Drug Metabolism and Disposition May 1991, 19 (3) 643-647;

L

  1. Lin, E T

    1. You have access
      Stereoselective disposition of ketoprofen in rats.
      S Iwakawa, X W He, S Hashimoto, C Volland, L Z Benet and E T Lin
      Drug Metabolism and Disposition May 1991, 19 (3) 717-718;
  2. Lin, J R

    1. You have access
      Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion.
      D H Ho, N Brown, J R Lin, W Covington, R A Newman, M Raber, R Amato, S Schmidt and I H Krakoff
      Drug Metabolism and Disposition May 1991, 19 (3) 643-647;
  3. Ling, K H

    1. You have access
      Biotransformation of territrems by S9 fraction from rat liver.
      K H Ling, C M Chiou and Y L Tseng
      Drug Metabolism and Disposition May 1991, 19 (3) 587-595;
  4. Liu, K

    1. You have access
      Enantioselective hydrolysis of lorazepam 3-acetate by esterases in human and rat liver microsomes and rat brain S9 fraction.
      K Liu, F P Guengerich and S K Yang
      Drug Metabolism and Disposition May 1991, 19 (3) 609-613;
  5. Lu, X L

    1. You have access
      Stereoselective metabolism of prazepam and halazepam by human liver microsomes.
      X L Lu, F P Guengerich and S K Yang
      Drug Metabolism and Disposition May 1991, 19 (3) 637-642;
  6. Luo, H

    1. You have access
      The quaternary ammonium-linked glucuronide of doxepin: a major metabolite in depressed patients treated with doxepin.
      H Luo, E M Hawes, G McKay, E D Korchinski and K K Midha
      Drug Metabolism and Disposition May 1991, 19 (3) 722-724;

M

  1. McEuen, S F

    1. You have access
      Metabolism and pharmacokinetics of 1,3-dinitrobenzene in the rat and the hamster.
      S F McEuen and M G Miller
      Drug Metabolism and Disposition May 1991, 19 (3) 661-666;
  2. McKay, G

    1. You have access
      The quaternary ammonium-linked glucuronide of doxepin: a major metabolite in depressed patients treated with doxepin.
      H Luo, E M Hawes, G McKay, E D Korchinski and K K Midha
      Drug Metabolism and Disposition May 1991, 19 (3) 722-724;
  3. Midha, K K

    1. You have access
      The quaternary ammonium-linked glucuronide of doxepin: a major metabolite in depressed patients treated with doxepin.
      H Luo, E M Hawes, G McKay, E D Korchinski and K K Midha
      Drug Metabolism and Disposition May 1991, 19 (3) 722-724;
  4. Miller, M G

    1. You have access
      Metabolism and pharmacokinetics of 1,3-dinitrobenzene in the rat and the hamster.
      S F McEuen and M G Miller
      Drug Metabolism and Disposition May 1991, 19 (3) 661-666;
  5. Mongey, A B

    1. You have access
      Determination of metabolically derived nitroprocainamide in the urine of procainamide-dosed humans and rats by liquid chromatography with electrochemical detection.
      J F Wheeler, L E Adams, A B Mongey, S M Roberts, W R Heineman and E V Hess
      Drug Metabolism and Disposition May 1991, 19 (3) 691-695;
  6. Morselli, P L

    1. You have access
      The disposition and pharmacokinetics of alpidem, a new anxiolytic, in the rat.
      D Garrigou-Gadenne, A Durand, J P Thenot and P L Morselli
      Drug Metabolism and Disposition May 1991, 19 (3) 574-579;
  7. Moussa, M

    1. You have access
      1,1-Dichloroethylene elicits dose-dependent alterations in covalent binding and glutathione in murine liver.
      P Gek Forkert and M Moussa
      Drug Metabolism and Disposition May 1991, 19 (3) 580-586;
  8. Mukhtar, H

    1. You have access
      Nordihydroguaiaretic acid, an inhibitor of lipoxygenase, also inhibits cytochrome P-450-mediated monooxygenase activity in rat epidermal and hepatic microsomes.
      R Agarwal, Z Y Wang, D P Bik and H Mukhtar
      Drug Metabolism and Disposition May 1991, 19 (3) 620-624;

N

  1. Newman, R A

    1. You have access
      Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion.
      D H Ho, N Brown, J R Lin, W Covington, R A Newman, M Raber, R Amato, S Schmidt and I H Krakoff
      Drug Metabolism and Disposition May 1991, 19 (3) 643-647;
  2. Newth, C J

    1. You have access
      The pharmacokinetics of dobutamine in pediatric intensive care unit patients.
      P H Schwartz, M K Eldadah and C J Newth
      Drug Metabolism and Disposition May 1991, 19 (3) 614-619;

O

  1. Owens, S M

    1. You have access
      Chronic administration of phencyclidine: pharmacokinetic comparison of intravenous and subcutaneous infusions in Sprague-Dawley rats.
      W D Wessinger and S M Owens
      Drug Metabolism and Disposition May 1991, 19 (3) 719-721;

P

  1. Pope, M R

    1. You have access
      Mechanisms responsible for the thermal sensitivity of adrenal microsomal monooxygenases.
      H D Colby, P B Johnson and M R Pope
      Drug Metabolism and Disposition May 1991, 19 (3) 679-682;
  2. Prakash, C

    1. You have access
      Geometric isomerization of doxepin during its N-demethylation in humans.
      H Ghabrial, C Prakash, U G Tacke, I A Blair and G R Wilkinson
      Drug Metabolism and Disposition May 1991, 19 (3) 596-599;

R

  1. Raber, M

    1. You have access
      Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion.
      D H Ho, N Brown, J R Lin, W Covington, R A Newman, M Raber, R Amato, S Schmidt and I H Krakoff
      Drug Metabolism and Disposition May 1991, 19 (3) 643-647;
  2. Ratanasavanh, D

    1. You have access
      Evidence for the involvement of several cytochromes P-450 in the first steps of caffeine metabolism by human liver microsomes.
      F Berthou, J P Flinois, D Ratanasavanh, P Beaune, C Riche and A Guillouzo
      Drug Metabolism and Disposition May 1991, 19 (3) 561-567;
  3. Remmel, R P

    1. You have access
      A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs. In vitro and in vivo studies.
      R P Remmel and M W Sinz
      Drug Metabolism and Disposition May 1991, 19 (3) 630-636;
  4. Riche, C

    1. You have access
      Evidence for the involvement of several cytochromes P-450 in the first steps of caffeine metabolism by human liver microsomes.
      F Berthou, J P Flinois, D Ratanasavanh, P Beaune, C Riche and A Guillouzo
      Drug Metabolism and Disposition May 1991, 19 (3) 561-567;
  5. Roberts, S M

    1. You have access
      Determination of metabolically derived nitroprocainamide in the urine of procainamide-dosed humans and rats by liquid chromatography with electrochemical detection.
      J F Wheeler, L E Adams, A B Mongey, S M Roberts, W R Heineman and E V Hess
      Drug Metabolism and Disposition May 1991, 19 (3) 691-695;

S

  1. Sanders, R A

    1. You have access
      Comparative study of phase II biotransformation in rabbit ocular tissues.
      J B Watkins, D P Wirthwein and R A Sanders
      Drug Metabolism and Disposition May 1991, 19 (3) 708-713;
  2. Savanapridi, C

    1. You have access
      Disposition kinetics and metabolism of nicotine-1'-N-oxide in rabbits.
      M J Duan, L Yu, C Savanapridi, P Jacob and N L Benowitz
      Drug Metabolism and Disposition May 1991, 19 (3) 667-672;
  3. Schmidt, S

    1. You have access
      Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion.
      D H Ho, N Brown, J R Lin, W Covington, R A Newman, M Raber, R Amato, S Schmidt and I H Krakoff
      Drug Metabolism and Disposition May 1991, 19 (3) 643-647;
  4. Schwartz, P H

    1. You have access
      The pharmacokinetics of dobutamine in pediatric intensive care unit patients.
      P H Schwartz, M K Eldadah and C J Newth
      Drug Metabolism and Disposition May 1991, 19 (3) 614-619;
  5. Shockcor, J P

    1. You have access
      The disposition and metabolism of [14C]piritrexim in rats after intravenous and oral administration.
      J L Woolley, D V Deangelis, R C Crouch, J P Shockcor and C W Sigel
      Drug Metabolism and Disposition May 1991, 19 (3) 600-608;
  6. Sigel, C W

    1. You have access
      The disposition and metabolism of [14C]piritrexim in rats after intravenous and oral administration.
      J L Woolley, D V Deangelis, R C Crouch, J P Shockcor and C W Sigel
      Drug Metabolism and Disposition May 1991, 19 (3) 600-608;
  7. Sinz, M W

    1. You have access
      A quaternary ammonium glucuronide is the major metabolite of lamotrigine in guinea pigs. In vitro and in vivo studies.
      R P Remmel and M W Sinz
      Drug Metabolism and Disposition May 1991, 19 (3) 630-636;
  8. Sipes, I G

    1. You have access
      The N-acetylation of sulfamethazine and p-aminobenzoic acid by human liver slices in dynamic organ culture.
      L Gunawardhana, J Barr, A J Weir, K Brendel and I G Sipes
      Drug Metabolism and Disposition May 1991, 19 (3) 648-654;
  9. Smith, P B

    1. You have access
      Glutathione conjugation with phosphoramide mustard and cyclophosphamide. A mechanistic study using tandem mass spectrometry.
      Z M Yuan, P B Smith, R B Brundrett, M Colvin and C Fenselau
      Drug Metabolism and Disposition May 1991, 19 (3) 625-629;
  10. Somani, S M

    1. You have access
      Physiological pharmacokinetic and pharmacodynamic model of physostigmine in the rat.
      S M Somani, S K Gupta, A Khalique and L K Unni
      Drug Metabolism and Disposition May 1991, 19 (3) 655-660;
  11. Swaisgood, H

    1. You have access
      Degradation of peptide drugs by immobilized digestive proteases.
      R B Van Breemen, M G Bartlett, Y H Tsou, C Culver, H Swaisgood and S E Unger
      Drug Metabolism and Disposition May 1991, 19 (3) 683-690;

T

  1. Tacke, U G

    1. You have access
      Geometric isomerization of doxepin during its N-demethylation in humans.
      H Ghabrial, C Prakash, U G Tacke, I A Blair and G R Wilkinson
      Drug Metabolism and Disposition May 1991, 19 (3) 596-599;
  2. Thenot, J P

    1. You have access
      The disposition and pharmacokinetics of alpidem, a new anxiolytic, in the rat.
      D Garrigou-Gadenne, A Durand, J P Thenot and P L Morselli
      Drug Metabolism and Disposition May 1991, 19 (3) 574-579;
  3. Tseng, Y L

    1. You have access
      Biotransformation of territrems by S9 fraction from rat liver.
      K H Ling, C M Chiou and Y L Tseng
      Drug Metabolism and Disposition May 1991, 19 (3) 587-595;
  4. Tsou, Y H

    1. You have access
      Degradation of peptide drugs by immobilized digestive proteases.
      R B Van Breemen, M G Bartlett, Y H Tsou, C Culver, H Swaisgood and S E Unger
      Drug Metabolism and Disposition May 1991, 19 (3) 683-690;

U

  1. Unger, S E

    1. You have access
      Degradation of peptide drugs by immobilized digestive proteases.
      R B Van Breemen, M G Bartlett, Y H Tsou, C Culver, H Swaisgood and S E Unger
      Drug Metabolism and Disposition May 1991, 19 (3) 683-690;
  2. Unni, L K

    1. You have access
      Physiological pharmacokinetic and pharmacodynamic model of physostigmine in the rat.
      S M Somani, S K Gupta, A Khalique and L K Unni
      Drug Metabolism and Disposition May 1991, 19 (3) 655-660;

V

  1. Vamvakas, S

    1. You have access
      Intestinal absorption of S-(pentachlorobutadienyl)glutathione and S-(pentachlorobutadienyl)-L-cysteine, the glutathione and cysteine S-conjugates of hexachlorobuta-1,3-diene.
      Y Gietl, S Vamvakas and M W Anders
      Drug Metabolism and Disposition May 1991, 19 (3) 703-707;
  2. Van Breemen, R B

    1. You have access
      Degradation of peptide drugs by immobilized digestive proteases.
      R B Van Breemen, M G Bartlett, Y H Tsou, C Culver, H Swaisgood and S E Unger
      Drug Metabolism and Disposition May 1991, 19 (3) 683-690;
  3. Volland, C

    1. You have access
      Stereoselective disposition of ketoprofen in rats.
      S Iwakawa, X W He, S Hashimoto, C Volland, L Z Benet and E T Lin
      Drug Metabolism and Disposition May 1991, 19 (3) 717-718;

W

  1. Wang, Z Y

    1. You have access
      Nordihydroguaiaretic acid, an inhibitor of lipoxygenase, also inhibits cytochrome P-450-mediated monooxygenase activity in rat epidermal and hepatic microsomes.
      R Agarwal, Z Y Wang, D P Bik and H Mukhtar
      Drug Metabolism and Disposition May 1991, 19 (3) 620-624;
  2. Watkins, J B

    1. You have access
      Comparative study of phase II biotransformation in rabbit ocular tissues.
      J B Watkins, D P Wirthwein and R A Sanders
      Drug Metabolism and Disposition May 1991, 19 (3) 708-713;
  3. Weir, A J

    1. You have access
      The N-acetylation of sulfamethazine and p-aminobenzoic acid by human liver slices in dynamic organ culture.
      L Gunawardhana, J Barr, A J Weir, K Brendel and I G Sipes
      Drug Metabolism and Disposition May 1991, 19 (3) 648-654;
  4. Wessinger, W D

    1. You have access
      Chronic administration of phencyclidine: pharmacokinetic comparison of intravenous and subcutaneous infusions in Sprague-Dawley rats.
      W D Wessinger and S M Owens
      Drug Metabolism and Disposition May 1991, 19 (3) 719-721;
  5. Wheeler, J F

    1. You have access
      Determination of metabolically derived nitroprocainamide in the urine of procainamide-dosed humans and rats by liquid chromatography with electrochemical detection.
      J F Wheeler, L E Adams, A B Mongey, S M Roberts, W R Heineman and E V Hess
      Drug Metabolism and Disposition May 1991, 19 (3) 691-695;
  6. Wilkinson, G R

    1. You have access
      Geometric isomerization of doxepin during its N-demethylation in humans.
      H Ghabrial, C Prakash, U G Tacke, I A Blair and G R Wilkinson
      Drug Metabolism and Disposition May 1991, 19 (3) 596-599;
  7. Wirthwein, D P

    1. You have access
      Comparative study of phase II biotransformation in rabbit ocular tissues.
      J B Watkins, D P Wirthwein and R A Sanders
      Drug Metabolism and Disposition May 1991, 19 (3) 708-713;
  8. Woolf, T F

    1. You have access
      Metabolism of the acyl-CoA:cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide in rat and monkey. Omega-/beta-oxidation pathway.
      T F Woolf, S M Bjorge, A E Black, A Holmes and T Chang
      Drug Metabolism and Disposition May 1991, 19 (3) 696-702;
  9. Woolley, J L

    1. You have access
      The disposition and metabolism of [14C]piritrexim in rats after intravenous and oral administration.
      J L Woolley, D V Deangelis, R C Crouch, J P Shockcor and C W Sigel
      Drug Metabolism and Disposition May 1991, 19 (3) 600-608;

Y

  1. Yang, S K

    1. You have access
      Enantioselective hydrolysis of lorazepam 3-acetate by esterases in human and rat liver microsomes and rat brain S9 fraction.
      K Liu, F P Guengerich and S K Yang
      Drug Metabolism and Disposition May 1991, 19 (3) 609-613;
    2. You have access
      Stereoselective metabolism of prazepam and halazepam by human liver microsomes.
      X L Lu, F P Guengerich and S K Yang
      Drug Metabolism and Disposition May 1991, 19 (3) 637-642;
  2. Yu, L

    1. You have access
      Disposition kinetics and metabolism of nicotine-1'-N-oxide in rabbits.
      M J Duan, L Yu, C Savanapridi, P Jacob and N L Benowitz
      Drug Metabolism and Disposition May 1991, 19 (3) 667-672;
  3. Yuan, Z M

    1. You have access
      Glutathione conjugation with phosphoramide mustard and cyclophosphamide. A mechanistic study using tandem mass spectrometry.
      Z M Yuan, P B Smith, R B Brundrett, M Colvin and C Fenselau
      Drug Metabolism and Disposition May 1991, 19 (3) 625-629;
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In this issue

Drug Metabolism and Disposition
Vol. 19, Issue 3
1 May 1991
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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