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Drug Metabolism & Disposition

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Table of Contents

July 01, 1991; Volume 19,Issue 4
  • You have access
    Changes in pharmacokinetics of cisplatin after hepatic resection in rats.
    K S Hall, B Lien, L Endresen, A Bergan and H E Rugstad
    Drug Metabolism and Disposition July 1991, 19 (4) 725-728;
  • You have access
    Effect of folinic acid on tissue residence and excretion of methotrexate in rats.
    Y L He, Y Tanigawara, M Yasuhara and R Hori
    Drug Metabolism and Disposition July 1991, 19 (4) 729-734;
  • You have access
    Disposition and tissue distribution of angiopeptin in the rat.
    S S Cathapermal, M L Foegh, C S Rau and P W Ramwell
    Drug Metabolism and Disposition July 1991, 19 (4) 735-739;
  • You have access
    Biotransformation of pravastatin sodium in humans.
    D W Everett, T J Chando, G C Didonato, S M Singhvi, H Y Pan and S H Weinstein
    Drug Metabolism and Disposition July 1991, 19 (4) 740-748;
  • You have access
    Stereoselective metabolism of carvedilol in the rat. Use of enantiomerically radiolabeled pseudoracemates.
    M Fujimaki, S Shintani and H Hakusui
    Drug Metabolism and Disposition July 1991, 19 (4) 749-753;
  • You have access
    Pharmacokinetics and pharmacodynamics of nifedipine in pregnant sheep.
    C E Nugent, M Hill, T Hursey and F P Abramson
    Drug Metabolism and Disposition July 1991, 19 (4) 754-757;
  • You have access
    Aldrin epoxidation. Catalytic potential of lipoxygenase coupled with linoleic acid oxidation.
    A K Naidu, A K Naidu and A P Kulkarni
    Drug Metabolism and Disposition July 1991, 19 (4) 758-763;
  • You have access
    The disposition and metabolism of [14C]fluconazole in humans.
    K W Brammer, A J Coakley, S G Jezequel and M H Tarbit
    Drug Metabolism and Disposition July 1991, 19 (4) 764-767;
  • You have access
    Application of chemical cytochrome P-450 model systems to studies on drug metabolism. IV. Mechanism of piperidine metabolism pathways via an iminium intermediate.
    H Masumoto, S Ohta and M Hirobe
    Drug Metabolism and Disposition July 1991, 19 (4) 768-780;
  • You have access
    Pharmacokinetics and fate of [3H]trospectomycin sulfate, a novel aminocyclitol antibiotic, in male and female dogs and rabbits. Allometric scaling with human.
    D J Nichols, M Burrows, A Bye, D A Constable, L G Dring and P Jeffrey
    Drug Metabolism and Disposition July 1991, 19 (4) 781-786;
  • You have access
    Inactivation mechanism of low-KM rat liver mitochondrial aldehyde dehydrogenase by cyanamide in vitro.
    J Pruñonosa, M L Sagristá and J Bozal
    Drug Metabolism and Disposition July 1991, 19 (4) 787-792;
  • You have access
    Metabolism of azoxy derivatives of procarbazine by aldehyde dehydrogenase and xanthine oxidase.
    D J Tweedie, D Fernandez, M E Spearman, R C Feldhoff and R A Prough
    Drug Metabolism and Disposition July 1991, 19 (4) 793-803;
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    Metabolism of nicotine by rat liver cytochromes P-450. Assessment utilizing monoclonal antibodies to nicotine and cotinine.
    D K Hammond, R J Bjercke, J J Langone and H W Strobel
    Drug Metabolism and Disposition July 1991, 19 (4) 804-808;
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    In vitro glucuronidation of 3'-azido-3'-deoxythymidine by human liver. Role of UDP-glucuronosyltransferase 2 form.
    J F Rajaonarison, B Lacarelle, G De Sousa, J Catalin and R Rahmani
    Drug Metabolism and Disposition July 1991, 19 (4) 809-815;
  • You have access
    Species-dependent stereopharmacokinetics of MK-927, a potent carbonic anhydrase inhibitor.
    J H Lin, I W Chen and T H Lin
    Drug Metabolism and Disposition July 1991, 19 (4) 816-822;
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    Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations.
    S M Bjorge and T A Baillie
    Drug Metabolism and Disposition July 1991, 19 (4) 823-829;
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    Enzymatic N-methylation of phenelzine catalyzed by methyltransferases from adrenal and other tissues.
    P H Yu, B A Davis and D A Durden
    Drug Metabolism and Disposition July 1991, 19 (4) 830-834;
  • You have access
    Blood levels of propylene oxide during propylene inhalation and effect on hepatic and nasal cytochrome P-450 concentrations.
    K R Maples and A R Dahl
    Drug Metabolism and Disposition July 1991, 19 (4) 835-837;
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    Stereoselective sulfate conjugation of 4-hydroxypropranolol in humans: comparison of platelet and hepatic activity.
    U K Walle and T Walle
    Drug Metabolism and Disposition July 1991, 19 (4) 838-840;
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    Species differences in the activation of mianserin to a cytotoxic metabolite.
    P Roberts, N R Kitteringham and B K Park
    Drug Metabolism and Disposition July 1991, 19 (4) 841-843;
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    Stereoselective glucuronidation of naproxen in isolated cells from liver, stomach, intestine, and colon of the guinea pig.
    M el Mouehli and M Schwenk
    Drug Metabolism and Disposition July 1991, 19 (4) 844-845;
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In this issue

Drug Metabolism and Disposition
Vol. 19, Issue 4
1 Jul 1991
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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