Drug Metabolism and Disposition: 19 (5)

September 01, 1991; Volume 19,Issue 5

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The 1990 Bernard B. Brodie Award Lecture. Unique properties of the enzymes of detoxication.
D M Ziegler

Drug Metabolism and Disposition September 1991, 19 (5) 847-852;
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Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats.
S Iwakawa, H Spahn, L Z Benet and E T Lin

Drug Metabolism and Disposition September 1991, 19 (5) 853-857;
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Disposition of RS-26306, a potent luteinizing hormone-releasing hormone antagonist, in monkeys and rats after single intravenous and subcutaneous administration.
R L Chan, S C Hsieh, P E Haroldsen, W Ho and J J Nestor

Drug Metabolism and Disposition September 1991, 19 (5) 858-864;
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Excretion and tissue distribution of selenium following treatment of male F344 rats with benzylselenocyanate or sodium selenite.
O S Sohn, L Blackwell, J Mathis, W W Asaad, B S Reddy and K el-Bayoumy

Drug Metabolism and Disposition September 1991, 19 (5) 865-870;
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Evidence for oxidative activation of mitoxantrone in human, pig, and rat.
J Blanz, K Mewes, G Ehninger, B Proksch, D Waidelich, B Greger and K P Zeller

Drug Metabolism and Disposition September 1991, 19 (5) 871-880;
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Pharmacokinetics of 2-ethyl-1,3-hexanediol. I. Systemic disposition following single intravenous doses in male Fischer 344 rats.
S W Frantz, C M Grosse, M J Tallant and B Ballantyne

Drug Metabolism and Disposition September 1991, 19 (5) 881-888;
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Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human.
U G Eriksson, J Lundahl, C Bäärnhielm and C G Regårdh

Drug Metabolism and Disposition September 1991, 19 (5) 889-894;
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In vivo formation of codeinone and morphinone from codeine. Isolation and identification from guinea pig bile.
T Ishida, M Yano and S Toki

Drug Metabolism and Disposition September 1991, 19 (5) 895-899;
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Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.
A E Cribb, M Miller, J S Leeder, J Hill and S P Spielberg

Drug Metabolism and Disposition September 1991, 19 (5) 900-906;
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Dose dependence in the plasma pharmacokinetics and uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats.
B L Hoesterey, R E Galinsky and B D Anderson

Drug Metabolism and Disposition September 1991, 19 (5) 907-912;
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Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent.
E Benfenati, R Fanelli, E Bosone, C Biffi, R Caponi, M Cianetti and P Farina

Drug Metabolism and Disposition September 1991, 19 (5) 913-916;
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Metabolism of cinobufagin in rat liver microsomes. Identification of epimerized and deacetylated metabolites by liquid chromatography/mass spectrometry.
L S Zhang, T Yoshida, K Aoki and Y Kuroiwa

Drug Metabolism and Disposition September 1991, 19 (5) 917-919;
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Identification of the major metabolites of the prostaglandin E2-analogue sulprostone in human plasma, and isolation from urine (in vivo) and liver perfusate (in vitro) of female guinea-pigs.
W Kuhnz, G A Hoyer, S Backhus and U Jakobs

Drug Metabolism and Disposition September 1991, 19 (5) 920-925;
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Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals.
J H Lin, D E Duggan, I W Chen and R L Ellsworth

Drug Metabolism and Disposition September 1991, 19 (5) 926-932;
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Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver.
D W Hein, T D Rustan, K D Bucher, W J Martin and E J Furman

Drug Metabolism and Disposition September 1991, 19 (5) 933-937;
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Pharmacokinetics of iododoxorubicin in the rat, dog, and monkey.
D M Edwards, P Marrari, C Efthymiopoulos, G Basileo, D Fraier, E Pianezzola and M Strolin-Benedetti

Drug Metabolism and Disposition September 1991, 19 (5) 938-945;
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Nicotine metabolism in stumptailed macaques, Macaca arctoides.
M Seaton, G A Kyerematen, M Morgan, E V Jeszenka and E S Vesell

Drug Metabolism and Disposition September 1991, 19 (5) 946-954;
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A nuclear magnetic resonance study of sparteine delta metabolite structure.
T Ebner, C O Meese, P Fischer and M Eichelbaum

Drug Metabolism and Disposition September 1991, 19 (5) 955-959;
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First pass metabolism and in vitro metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine in dogs.
M Yoshikawa, S Nishiyama, H Endo, Y Togo and O Takaiti

Drug Metabolism and Disposition September 1991, 19 (5) 960-965;
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Activation of acetaminophen-reactive metabolite formation by methylxanthines and known cytochrome P-450 activators.
C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery

Drug Metabolism and Disposition September 1991, 19 (5) 966-971;
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Pharmacokinetic analysis of the disposition of valproate in pregnant rats.
S Kobayashi, K Takai, T Iga and M Hanano

Drug Metabolism and Disposition September 1991, 19 (5) 972-976;
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Metabolism of 3-methylindole in human tissues.
W Ruangyuttikarn, M L Appleton and G S Yost

Drug Metabolism and Disposition September 1991, 19 (5) 977-984;
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Effect of congestive heart failure on the intrinsic metabolic capacity of the liver in the dog.
C Lambert, J R Halpert, J Rouleau, L Jutras, V Leroyer and P du Souich

Drug Metabolism and Disposition September 1991, 19 (5) 985-989;
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Determination of in vivo hepatic extraction ratio from in vitro metabolism by rat hepatocytes.
K Singh, S L Tripp, A W Dunton, F L Douglas and A Rakhit

Drug Metabolism and Disposition September 1991, 19 (5) 990-996;
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Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates.
D Thomassen, P G Pearson, J T Slattery and S D Nelson

Drug Metabolism and Disposition September 1991, 19 (5) 997-1003;
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Metabolism in vivo and in vitro of the refrigerant substitute 1,1,1,2-tetrafluoro-2-chloroethane.
M J Olson, J T Johnson, J F O'Gara and S E Surbrook

Drug Metabolism and Disposition September 1991, 19 (5) 1004-1011;
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Product enantioselectivity in the N-glucosylation of amobarbital by cats.
S E Mongrain and W H Soine

Drug Metabolism and Disposition September 1991, 19 (5) 1012-1013;

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