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Drug Metabolism & Disposition

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  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
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Index by author

September 01, 1991; Volume 19,Issue 5
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

A

  1. Anderson, B D

    1. You have access
      Dose dependence in the plasma pharmacokinetics and uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats.
      B L Hoesterey, R E Galinsky and B D Anderson
      Drug Metabolism and Disposition September 1991, 19 (5) 907-912;
  2. Aoki, K

    1. You have access
      Metabolism of cinobufagin in rat liver microsomes. Identification of epimerized and deacetylated metabolites by liquid chromatography/mass spectrometry.
      L S Zhang, T Yoshida, K Aoki and Y Kuroiwa
      Drug Metabolism and Disposition September 1991, 19 (5) 917-919;
  3. Appleton, M L

    1. You have access
      Metabolism of 3-methylindole in human tissues.
      W Ruangyuttikarn, M L Appleton and G S Yost
      Drug Metabolism and Disposition September 1991, 19 (5) 977-984;
  4. Asaad, W W

    1. You have access
      Excretion and tissue distribution of selenium following treatment of male F344 rats with benzylselenocyanate or sodium selenite.
      O S Sohn, L Blackwell, J Mathis, W W Asaad, B S Reddy and K el-Bayoumy
      Drug Metabolism and Disposition September 1991, 19 (5) 865-870;

B

  1. Bäärnhielm, C

    1. You have access
      Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human.
      U G Eriksson, J Lundahl, C Bäärnhielm and C G Regårdh
      Drug Metabolism and Disposition September 1991, 19 (5) 889-894;
  2. Backhus, S

    1. You have access
      Identification of the major metabolites of the prostaglandin E2-analogue sulprostone in human plasma, and isolation from urine (in vivo) and liver perfusate (in vitro) of female guinea-pigs.
      W Kuhnz, G A Hoyer, S Backhus and U Jakobs
      Drug Metabolism and Disposition September 1991, 19 (5) 920-925;
  3. Ballantyne, B

    1. You have access
      Pharmacokinetics of 2-ethyl-1,3-hexanediol. I. Systemic disposition following single intravenous doses in male Fischer 344 rats.
      S W Frantz, C M Grosse, M J Tallant and B Ballantyne
      Drug Metabolism and Disposition September 1991, 19 (5) 881-888;
  4. Basileo, G

    1. You have access
      Pharmacokinetics of iododoxorubicin in the rat, dog, and monkey.
      D M Edwards, P Marrari, C Efthymiopoulos, G Basileo, D Fraier, E Pianezzola and M Strolin-Benedetti
      Drug Metabolism and Disposition September 1991, 19 (5) 938-945;
  5. Benet, L Z

    1. You have access
      Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats.
      S Iwakawa, H Spahn, L Z Benet and E T Lin
      Drug Metabolism and Disposition September 1991, 19 (5) 853-857;
  6. Benfenati, E

    1. You have access
      Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent.
      E Benfenati, R Fanelli, E Bosone, C Biffi, R Caponi, M Cianetti and P Farina
      Drug Metabolism and Disposition September 1991, 19 (5) 913-916;
  7. Biffi, C

    1. You have access
      Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent.
      E Benfenati, R Fanelli, E Bosone, C Biffi, R Caponi, M Cianetti and P Farina
      Drug Metabolism and Disposition September 1991, 19 (5) 913-916;
  8. Blackwell, L

    1. You have access
      Excretion and tissue distribution of selenium following treatment of male F344 rats with benzylselenocyanate or sodium selenite.
      O S Sohn, L Blackwell, J Mathis, W W Asaad, B S Reddy and K el-Bayoumy
      Drug Metabolism and Disposition September 1991, 19 (5) 865-870;
  9. Blanz, J

    1. You have access
      Evidence for oxidative activation of mitoxantrone in human, pig, and rat.
      J Blanz, K Mewes, G Ehninger, B Proksch, D Waidelich, B Greger and K P Zeller
      Drug Metabolism and Disposition September 1991, 19 (5) 871-880;
  10. Bosone, E

    1. You have access
      Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent.
      E Benfenati, R Fanelli, E Bosone, C Biffi, R Caponi, M Cianetti and P Farina
      Drug Metabolism and Disposition September 1991, 19 (5) 913-916;
  11. Bucher, K D

    1. You have access
      Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver.
      D W Hein, T D Rustan, K D Bucher, W J Martin and E J Furman
      Drug Metabolism and Disposition September 1991, 19 (5) 933-937;

C

  1. Caponi, R

    1. You have access
      Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent.
      E Benfenati, R Fanelli, E Bosone, C Biffi, R Caponi, M Cianetti and P Farina
      Drug Metabolism and Disposition September 1991, 19 (5) 913-916;
  2. Chan, R L

    1. You have access
      Disposition of RS-26306, a potent luteinizing hormone-releasing hormone antagonist, in monkeys and rats after single intravenous and subcutaneous administration.
      R L Chan, S C Hsieh, P E Haroldsen, W Ho and J J Nestor
      Drug Metabolism and Disposition September 1991, 19 (5) 858-864;
  3. Chen, I W

    1. You have access
      Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals.
      J H Lin, D E Duggan, I W Chen and R L Ellsworth
      Drug Metabolism and Disposition September 1991, 19 (5) 926-932;
  4. Cianetti, M

    1. You have access
      Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent.
      E Benfenati, R Fanelli, E Bosone, C Biffi, R Caponi, M Cianetti and P Farina
      Drug Metabolism and Disposition September 1991, 19 (5) 913-916;
  5. Cribb, A E

    1. You have access
      Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.
      A E Cribb, M Miller, J S Leeder, J Hill and S P Spielberg
      Drug Metabolism and Disposition September 1991, 19 (5) 900-906;

D

  1. Douglas, F L

    1. You have access
      Determination of in vivo hepatic extraction ratio from in vitro metabolism by rat hepatocytes.
      K Singh, S L Tripp, A W Dunton, F L Douglas and A Rakhit
      Drug Metabolism and Disposition September 1991, 19 (5) 990-996;
  2. Duggan, D E

    1. You have access
      Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals.
      J H Lin, D E Duggan, I W Chen and R L Ellsworth
      Drug Metabolism and Disposition September 1991, 19 (5) 926-932;
  3. Dunton, A W

    1. You have access
      Determination of in vivo hepatic extraction ratio from in vitro metabolism by rat hepatocytes.
      K Singh, S L Tripp, A W Dunton, F L Douglas and A Rakhit
      Drug Metabolism and Disposition September 1991, 19 (5) 990-996;
  4. du Souich, P

    1. You have access
      Effect of congestive heart failure on the intrinsic metabolic capacity of the liver in the dog.
      C Lambert, J R Halpert, J Rouleau, L Jutras, V Leroyer and P du Souich
      Drug Metabolism and Disposition September 1991, 19 (5) 985-989;

E

  1. Ebner, T

    1. You have access
      A nuclear magnetic resonance study of sparteine delta metabolite structure.
      T Ebner, C O Meese, P Fischer and M Eichelbaum
      Drug Metabolism and Disposition September 1991, 19 (5) 955-959;
  2. Edwards, D M

    1. You have access
      Pharmacokinetics of iododoxorubicin in the rat, dog, and monkey.
      D M Edwards, P Marrari, C Efthymiopoulos, G Basileo, D Fraier, E Pianezzola and M Strolin-Benedetti
      Drug Metabolism and Disposition September 1991, 19 (5) 938-945;
  3. Efthymiopoulos, C

    1. You have access
      Pharmacokinetics of iododoxorubicin in the rat, dog, and monkey.
      D M Edwards, P Marrari, C Efthymiopoulos, G Basileo, D Fraier, E Pianezzola and M Strolin-Benedetti
      Drug Metabolism and Disposition September 1991, 19 (5) 938-945;
  4. Ehninger, G

    1. You have access
      Evidence for oxidative activation of mitoxantrone in human, pig, and rat.
      J Blanz, K Mewes, G Ehninger, B Proksch, D Waidelich, B Greger and K P Zeller
      Drug Metabolism and Disposition September 1991, 19 (5) 871-880;
  5. Eichelbaum, M

    1. You have access
      A nuclear magnetic resonance study of sparteine delta metabolite structure.
      T Ebner, C O Meese, P Fischer and M Eichelbaum
      Drug Metabolism and Disposition September 1991, 19 (5) 955-959;
  6. el-Bayoumy, K

    1. You have access
      Excretion and tissue distribution of selenium following treatment of male F344 rats with benzylselenocyanate or sodium selenite.
      O S Sohn, L Blackwell, J Mathis, W W Asaad, B S Reddy and K el-Bayoumy
      Drug Metabolism and Disposition September 1991, 19 (5) 865-870;
  7. Ellsworth, R L

    1. You have access
      Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals.
      J H Lin, D E Duggan, I W Chen and R L Ellsworth
      Drug Metabolism and Disposition September 1991, 19 (5) 926-932;
  8. Endo, H

    1. You have access
      First pass metabolism and in vitro metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine in dogs.
      M Yoshikawa, S Nishiyama, H Endo, Y Togo and O Takaiti
      Drug Metabolism and Disposition September 1991, 19 (5) 960-965;
  9. Eriksson, U G

    1. You have access
      Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human.
      U G Eriksson, J Lundahl, C Bäärnhielm and C G Regårdh
      Drug Metabolism and Disposition September 1991, 19 (5) 889-894;

F

  1. Fanelli, R

    1. You have access
      Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent.
      E Benfenati, R Fanelli, E Bosone, C Biffi, R Caponi, M Cianetti and P Farina
      Drug Metabolism and Disposition September 1991, 19 (5) 913-916;
  2. Farina, P

    1. You have access
      Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent.
      E Benfenati, R Fanelli, E Bosone, C Biffi, R Caponi, M Cianetti and P Farina
      Drug Metabolism and Disposition September 1991, 19 (5) 913-916;
  3. Fischer, P

    1. You have access
      A nuclear magnetic resonance study of sparteine delta metabolite structure.
      T Ebner, C O Meese, P Fischer and M Eichelbaum
      Drug Metabolism and Disposition September 1991, 19 (5) 955-959;
  4. Fraier, D

    1. You have access
      Pharmacokinetics of iododoxorubicin in the rat, dog, and monkey.
      D M Edwards, P Marrari, C Efthymiopoulos, G Basileo, D Fraier, E Pianezzola and M Strolin-Benedetti
      Drug Metabolism and Disposition September 1991, 19 (5) 938-945;
  5. Frantz, S W

    1. You have access
      Pharmacokinetics of 2-ethyl-1,3-hexanediol. I. Systemic disposition following single intravenous doses in male Fischer 344 rats.
      S W Frantz, C M Grosse, M J Tallant and B Ballantyne
      Drug Metabolism and Disposition September 1991, 19 (5) 881-888;
  6. Furman, E J

    1. You have access
      Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver.
      D W Hein, T D Rustan, K D Bucher, W J Martin and E J Furman
      Drug Metabolism and Disposition September 1991, 19 (5) 933-937;

G

  1. Galinsky, R E

    1. You have access
      Dose dependence in the plasma pharmacokinetics and uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats.
      B L Hoesterey, R E Galinsky and B D Anderson
      Drug Metabolism and Disposition September 1991, 19 (5) 907-912;
  2. Greger, B

    1. You have access
      Evidence for oxidative activation of mitoxantrone in human, pig, and rat.
      J Blanz, K Mewes, G Ehninger, B Proksch, D Waidelich, B Greger and K P Zeller
      Drug Metabolism and Disposition September 1991, 19 (5) 871-880;
  3. Grosse, C M

    1. You have access
      Pharmacokinetics of 2-ethyl-1,3-hexanediol. I. Systemic disposition following single intravenous doses in male Fischer 344 rats.
      S W Frantz, C M Grosse, M J Tallant and B Ballantyne
      Drug Metabolism and Disposition September 1991, 19 (5) 881-888;

H

  1. Halpert, J R

    1. You have access
      Effect of congestive heart failure on the intrinsic metabolic capacity of the liver in the dog.
      C Lambert, J R Halpert, J Rouleau, L Jutras, V Leroyer and P du Souich
      Drug Metabolism and Disposition September 1991, 19 (5) 985-989;
  2. Hanano, M

    1. You have access
      Pharmacokinetic analysis of the disposition of valproate in pregnant rats.
      S Kobayashi, K Takai, T Iga and M Hanano
      Drug Metabolism and Disposition September 1991, 19 (5) 972-976;
  3. Haroldsen, P E

    1. You have access
      Disposition of RS-26306, a potent luteinizing hormone-releasing hormone antagonist, in monkeys and rats after single intravenous and subcutaneous administration.
      R L Chan, S C Hsieh, P E Haroldsen, W Ho and J J Nestor
      Drug Metabolism and Disposition September 1991, 19 (5) 858-864;
  4. Hein, D W

    1. You have access
      Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver.
      D W Hein, T D Rustan, K D Bucher, W J Martin and E J Furman
      Drug Metabolism and Disposition September 1991, 19 (5) 933-937;
  5. Hill, J

    1. You have access
      Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.
      A E Cribb, M Miller, J S Leeder, J Hill and S P Spielberg
      Drug Metabolism and Disposition September 1991, 19 (5) 900-906;
  6. Ho, W

    1. You have access
      Disposition of RS-26306, a potent luteinizing hormone-releasing hormone antagonist, in monkeys and rats after single intravenous and subcutaneous administration.
      R L Chan, S C Hsieh, P E Haroldsen, W Ho and J J Nestor
      Drug Metabolism and Disposition September 1991, 19 (5) 858-864;
  7. Hoesterey, B L

    1. You have access
      Dose dependence in the plasma pharmacokinetics and uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats.
      B L Hoesterey, R E Galinsky and B D Anderson
      Drug Metabolism and Disposition September 1991, 19 (5) 907-912;
  8. Hoyer, G A

    1. You have access
      Identification of the major metabolites of the prostaglandin E2-analogue sulprostone in human plasma, and isolation from urine (in vivo) and liver perfusate (in vitro) of female guinea-pigs.
      W Kuhnz, G A Hoyer, S Backhus and U Jakobs
      Drug Metabolism and Disposition September 1991, 19 (5) 920-925;
  9. Hsieh, S C

    1. You have access
      Disposition of RS-26306, a potent luteinizing hormone-releasing hormone antagonist, in monkeys and rats after single intravenous and subcutaneous administration.
      R L Chan, S C Hsieh, P E Haroldsen, W Ho and J J Nestor
      Drug Metabolism and Disposition September 1991, 19 (5) 858-864;

I

  1. Iga, T

    1. You have access
      Pharmacokinetic analysis of the disposition of valproate in pregnant rats.
      S Kobayashi, K Takai, T Iga and M Hanano
      Drug Metabolism and Disposition September 1991, 19 (5) 972-976;
  2. Ishida, T

    1. You have access
      In vivo formation of codeinone and morphinone from codeine. Isolation and identification from guinea pig bile.
      T Ishida, M Yano and S Toki
      Drug Metabolism and Disposition September 1991, 19 (5) 895-899;
  3. Iwakawa, S

    1. You have access
      Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats.
      S Iwakawa, H Spahn, L Z Benet and E T Lin
      Drug Metabolism and Disposition September 1991, 19 (5) 853-857;

J

  1. Jakobs, U

    1. You have access
      Identification of the major metabolites of the prostaglandin E2-analogue sulprostone in human plasma, and isolation from urine (in vivo) and liver perfusate (in vitro) of female guinea-pigs.
      W Kuhnz, G A Hoyer, S Backhus and U Jakobs
      Drug Metabolism and Disposition September 1991, 19 (5) 920-925;
  2. Jeszenka, E V

    1. You have access
      Nicotine metabolism in stumptailed macaques, Macaca arctoides.
      M Seaton, G A Kyerematen, M Morgan, E V Jeszenka and E S Vesell
      Drug Metabolism and Disposition September 1991, 19 (5) 946-954;
  3. Johnson, J T

    1. You have access
      Metabolism in vivo and in vitro of the refrigerant substitute 1,1,1,2-tetrafluoro-2-chloroethane.
      M J Olson, J T Johnson, J F O'Gara and S E Surbrook
      Drug Metabolism and Disposition September 1991, 19 (5) 1004-1011;
  4. Jutras, L

    1. You have access
      Effect of congestive heart failure on the intrinsic metabolic capacity of the liver in the dog.
      C Lambert, J R Halpert, J Rouleau, L Jutras, V Leroyer and P du Souich
      Drug Metabolism and Disposition September 1991, 19 (5) 985-989;

K

  1. Kalhorn, T F

    1. You have access
      Activation of acetaminophen-reactive metabolite formation by methylxanthines and known cytochrome P-450 activators.
      C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
      Drug Metabolism and Disposition September 1991, 19 (5) 966-971;
  2. Kobayashi, S

    1. You have access
      Pharmacokinetic analysis of the disposition of valproate in pregnant rats.
      S Kobayashi, K Takai, T Iga and M Hanano
      Drug Metabolism and Disposition September 1991, 19 (5) 972-976;
  3. Kuhnz, W

    1. You have access
      Identification of the major metabolites of the prostaglandin E2-analogue sulprostone in human plasma, and isolation from urine (in vivo) and liver perfusate (in vitro) of female guinea-pigs.
      W Kuhnz, G A Hoyer, S Backhus and U Jakobs
      Drug Metabolism and Disposition September 1991, 19 (5) 920-925;
  4. Kuroiwa, Y

    1. You have access
      Metabolism of cinobufagin in rat liver microsomes. Identification of epimerized and deacetylated metabolites by liquid chromatography/mass spectrometry.
      L S Zhang, T Yoshida, K Aoki and Y Kuroiwa
      Drug Metabolism and Disposition September 1991, 19 (5) 917-919;
  5. Kyerematen, G A

    1. You have access
      Nicotine metabolism in stumptailed macaques, Macaca arctoides.
      M Seaton, G A Kyerematen, M Morgan, E V Jeszenka and E S Vesell
      Drug Metabolism and Disposition September 1991, 19 (5) 946-954;

L

  1. Lambert, C

    1. You have access
      Effect of congestive heart failure on the intrinsic metabolic capacity of the liver in the dog.
      C Lambert, J R Halpert, J Rouleau, L Jutras, V Leroyer and P du Souich
      Drug Metabolism and Disposition September 1991, 19 (5) 985-989;
  2. Lee, C A

    1. You have access
      Activation of acetaminophen-reactive metabolite formation by methylxanthines and known cytochrome P-450 activators.
      C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
      Drug Metabolism and Disposition September 1991, 19 (5) 966-971;
  3. Leeder, J S

    1. You have access
      Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.
      A E Cribb, M Miller, J S Leeder, J Hill and S P Spielberg
      Drug Metabolism and Disposition September 1991, 19 (5) 900-906;
  4. Leroyer, V

    1. You have access
      Effect of congestive heart failure on the intrinsic metabolic capacity of the liver in the dog.
      C Lambert, J R Halpert, J Rouleau, L Jutras, V Leroyer and P du Souich
      Drug Metabolism and Disposition September 1991, 19 (5) 985-989;
  5. Lin, E T

    1. You have access
      Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats.
      S Iwakawa, H Spahn, L Z Benet and E T Lin
      Drug Metabolism and Disposition September 1991, 19 (5) 853-857;
  6. Lin, J H

    1. You have access
      Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals.
      J H Lin, D E Duggan, I W Chen and R L Ellsworth
      Drug Metabolism and Disposition September 1991, 19 (5) 926-932;
  7. Lundahl, J

    1. You have access
      Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human.
      U G Eriksson, J Lundahl, C Bäärnhielm and C G Regårdh
      Drug Metabolism and Disposition September 1991, 19 (5) 889-894;

M

  1. Marrari, P

    1. You have access
      Pharmacokinetics of iododoxorubicin in the rat, dog, and monkey.
      D M Edwards, P Marrari, C Efthymiopoulos, G Basileo, D Fraier, E Pianezzola and M Strolin-Benedetti
      Drug Metabolism and Disposition September 1991, 19 (5) 938-945;
  2. Martin, W J

    1. You have access
      Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver.
      D W Hein, T D Rustan, K D Bucher, W J Martin and E J Furman
      Drug Metabolism and Disposition September 1991, 19 (5) 933-937;
  3. Mathis, J

    1. You have access
      Excretion and tissue distribution of selenium following treatment of male F344 rats with benzylselenocyanate or sodium selenite.
      O S Sohn, L Blackwell, J Mathis, W W Asaad, B S Reddy and K el-Bayoumy
      Drug Metabolism and Disposition September 1991, 19 (5) 865-870;
  4. Meese, C O

    1. You have access
      A nuclear magnetic resonance study of sparteine delta metabolite structure.
      T Ebner, C O Meese, P Fischer and M Eichelbaum
      Drug Metabolism and Disposition September 1991, 19 (5) 955-959;
  5. Mewes, K

    1. You have access
      Evidence for oxidative activation of mitoxantrone in human, pig, and rat.
      J Blanz, K Mewes, G Ehninger, B Proksch, D Waidelich, B Greger and K P Zeller
      Drug Metabolism and Disposition September 1991, 19 (5) 871-880;
  6. Miller, M

    1. You have access
      Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.
      A E Cribb, M Miller, J S Leeder, J Hill and S P Spielberg
      Drug Metabolism and Disposition September 1991, 19 (5) 900-906;
  7. Mongrain, S E

    1. You have access
      Product enantioselectivity in the N-glucosylation of amobarbital by cats.
      S E Mongrain and W H Soine
      Drug Metabolism and Disposition September 1991, 19 (5) 1012-1013;
  8. Morgan, M

    1. You have access
      Nicotine metabolism in stumptailed macaques, Macaca arctoides.
      M Seaton, G A Kyerematen, M Morgan, E V Jeszenka and E S Vesell
      Drug Metabolism and Disposition September 1991, 19 (5) 946-954;

N

  1. Nelson, S D

    1. You have access
      Activation of acetaminophen-reactive metabolite formation by methylxanthines and known cytochrome P-450 activators.
      C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
      Drug Metabolism and Disposition September 1991, 19 (5) 966-971;
    2. You have access
      Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates.
      D Thomassen, P G Pearson, J T Slattery and S D Nelson
      Drug Metabolism and Disposition September 1991, 19 (5) 997-1003;
  2. Nestor, J J

    1. You have access
      Disposition of RS-26306, a potent luteinizing hormone-releasing hormone antagonist, in monkeys and rats after single intravenous and subcutaneous administration.
      R L Chan, S C Hsieh, P E Haroldsen, W Ho and J J Nestor
      Drug Metabolism and Disposition September 1991, 19 (5) 858-864;
  3. Nishiyama, S

    1. You have access
      First pass metabolism and in vitro metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine in dogs.
      M Yoshikawa, S Nishiyama, H Endo, Y Togo and O Takaiti
      Drug Metabolism and Disposition September 1991, 19 (5) 960-965;

O

  1. O'Gara, J F

    1. You have access
      Metabolism in vivo and in vitro of the refrigerant substitute 1,1,1,2-tetrafluoro-2-chloroethane.
      M J Olson, J T Johnson, J F O'Gara and S E Surbrook
      Drug Metabolism and Disposition September 1991, 19 (5) 1004-1011;
  2. Olson, M J

    1. You have access
      Metabolism in vivo and in vitro of the refrigerant substitute 1,1,1,2-tetrafluoro-2-chloroethane.
      M J Olson, J T Johnson, J F O'Gara and S E Surbrook
      Drug Metabolism and Disposition September 1991, 19 (5) 1004-1011;

P

  1. Pearson, P G

    1. You have access
      Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates.
      D Thomassen, P G Pearson, J T Slattery and S D Nelson
      Drug Metabolism and Disposition September 1991, 19 (5) 997-1003;
  2. Pianezzola, E

    1. You have access
      Pharmacokinetics of iododoxorubicin in the rat, dog, and monkey.
      D M Edwards, P Marrari, C Efthymiopoulos, G Basileo, D Fraier, E Pianezzola and M Strolin-Benedetti
      Drug Metabolism and Disposition September 1991, 19 (5) 938-945;
  3. Proksch, B

    1. You have access
      Evidence for oxidative activation of mitoxantrone in human, pig, and rat.
      J Blanz, K Mewes, G Ehninger, B Proksch, D Waidelich, B Greger and K P Zeller
      Drug Metabolism and Disposition September 1991, 19 (5) 871-880;

R

  1. Rakhit, A

    1. You have access
      Determination of in vivo hepatic extraction ratio from in vitro metabolism by rat hepatocytes.
      K Singh, S L Tripp, A W Dunton, F L Douglas and A Rakhit
      Drug Metabolism and Disposition September 1991, 19 (5) 990-996;
  2. Reddy, B S

    1. You have access
      Excretion and tissue distribution of selenium following treatment of male F344 rats with benzylselenocyanate or sodium selenite.
      O S Sohn, L Blackwell, J Mathis, W W Asaad, B S Reddy and K el-Bayoumy
      Drug Metabolism and Disposition September 1991, 19 (5) 865-870;
  3. Regårdh, C G

    1. You have access
      Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human.
      U G Eriksson, J Lundahl, C Bäärnhielm and C G Regårdh
      Drug Metabolism and Disposition September 1991, 19 (5) 889-894;
  4. Rouleau, J

    1. You have access
      Effect of congestive heart failure on the intrinsic metabolic capacity of the liver in the dog.
      C Lambert, J R Halpert, J Rouleau, L Jutras, V Leroyer and P du Souich
      Drug Metabolism and Disposition September 1991, 19 (5) 985-989;
  5. Ruangyuttikarn, W

    1. You have access
      Metabolism of 3-methylindole in human tissues.
      W Ruangyuttikarn, M L Appleton and G S Yost
      Drug Metabolism and Disposition September 1991, 19 (5) 977-984;
  6. Rustan, T D

    1. You have access
      Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver.
      D W Hein, T D Rustan, K D Bucher, W J Martin and E J Furman
      Drug Metabolism and Disposition September 1991, 19 (5) 933-937;

S

  1. Seaton, M

    1. You have access
      Nicotine metabolism in stumptailed macaques, Macaca arctoides.
      M Seaton, G A Kyerematen, M Morgan, E V Jeszenka and E S Vesell
      Drug Metabolism and Disposition September 1991, 19 (5) 946-954;
  2. Singh, K

    1. You have access
      Determination of in vivo hepatic extraction ratio from in vitro metabolism by rat hepatocytes.
      K Singh, S L Tripp, A W Dunton, F L Douglas and A Rakhit
      Drug Metabolism and Disposition September 1991, 19 (5) 990-996;
  3. Slattery, J T

    1. You have access
      Activation of acetaminophen-reactive metabolite formation by methylxanthines and known cytochrome P-450 activators.
      C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
      Drug Metabolism and Disposition September 1991, 19 (5) 966-971;
    2. You have access
      Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates.
      D Thomassen, P G Pearson, J T Slattery and S D Nelson
      Drug Metabolism and Disposition September 1991, 19 (5) 997-1003;
  4. Sohn, O S

    1. You have access
      Excretion and tissue distribution of selenium following treatment of male F344 rats with benzylselenocyanate or sodium selenite.
      O S Sohn, L Blackwell, J Mathis, W W Asaad, B S Reddy and K el-Bayoumy
      Drug Metabolism and Disposition September 1991, 19 (5) 865-870;
  5. Soine, W H

    1. You have access
      Product enantioselectivity in the N-glucosylation of amobarbital by cats.
      S E Mongrain and W H Soine
      Drug Metabolism and Disposition September 1991, 19 (5) 1012-1013;
  6. Spahn, H

    1. You have access
      Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats.
      S Iwakawa, H Spahn, L Z Benet and E T Lin
      Drug Metabolism and Disposition September 1991, 19 (5) 853-857;
  7. Spielberg, S P

    1. You have access
      Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity.
      A E Cribb, M Miller, J S Leeder, J Hill and S P Spielberg
      Drug Metabolism and Disposition September 1991, 19 (5) 900-906;
  8. Strolin-Benedetti, M

    1. You have access
      Pharmacokinetics of iododoxorubicin in the rat, dog, and monkey.
      D M Edwards, P Marrari, C Efthymiopoulos, G Basileo, D Fraier, E Pianezzola and M Strolin-Benedetti
      Drug Metabolism and Disposition September 1991, 19 (5) 938-945;
  9. Surbrook, S E

    1. You have access
      Metabolism in vivo and in vitro of the refrigerant substitute 1,1,1,2-tetrafluoro-2-chloroethane.
      M J Olson, J T Johnson, J F O'Gara and S E Surbrook
      Drug Metabolism and Disposition September 1991, 19 (5) 1004-1011;

T

  1. Takai, K

    1. You have access
      Pharmacokinetic analysis of the disposition of valproate in pregnant rats.
      S Kobayashi, K Takai, T Iga and M Hanano
      Drug Metabolism and Disposition September 1991, 19 (5) 972-976;
  2. Takaiti, O

    1. You have access
      First pass metabolism and in vitro metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine in dogs.
      M Yoshikawa, S Nishiyama, H Endo, Y Togo and O Takaiti
      Drug Metabolism and Disposition September 1991, 19 (5) 960-965;
  3. Tallant, M J

    1. You have access
      Pharmacokinetics of 2-ethyl-1,3-hexanediol. I. Systemic disposition following single intravenous doses in male Fischer 344 rats.
      S W Frantz, C M Grosse, M J Tallant and B Ballantyne
      Drug Metabolism and Disposition September 1991, 19 (5) 881-888;
  4. Thomassen, D

    1. You have access
      Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates.
      D Thomassen, P G Pearson, J T Slattery and S D Nelson
      Drug Metabolism and Disposition September 1991, 19 (5) 997-1003;
  5. Thummel, K E

    1. You have access
      Activation of acetaminophen-reactive metabolite formation by methylxanthines and known cytochrome P-450 activators.
      C A Lee, K E Thummel, T F Kalhorn, S D Nelson and J T Slattery
      Drug Metabolism and Disposition September 1991, 19 (5) 966-971;
  6. Togo, Y

    1. You have access
      First pass metabolism and in vitro metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine in dogs.
      M Yoshikawa, S Nishiyama, H Endo, Y Togo and O Takaiti
      Drug Metabolism and Disposition September 1991, 19 (5) 960-965;
  7. Toki, S

    1. You have access
      In vivo formation of codeinone and morphinone from codeine. Isolation and identification from guinea pig bile.
      T Ishida, M Yano and S Toki
      Drug Metabolism and Disposition September 1991, 19 (5) 895-899;
  8. Tripp, S L

    1. You have access
      Determination of in vivo hepatic extraction ratio from in vitro metabolism by rat hepatocytes.
      K Singh, S L Tripp, A W Dunton, F L Douglas and A Rakhit
      Drug Metabolism and Disposition September 1991, 19 (5) 990-996;

V

  1. Vesell, E S

    1. You have access
      Nicotine metabolism in stumptailed macaques, Macaca arctoides.
      M Seaton, G A Kyerematen, M Morgan, E V Jeszenka and E S Vesell
      Drug Metabolism and Disposition September 1991, 19 (5) 946-954;

W

  1. Waidelich, D

    1. You have access
      Evidence for oxidative activation of mitoxantrone in human, pig, and rat.
      J Blanz, K Mewes, G Ehninger, B Proksch, D Waidelich, B Greger and K P Zeller
      Drug Metabolism and Disposition September 1991, 19 (5) 871-880;

Y

  1. Yano, M

    1. You have access
      In vivo formation of codeinone and morphinone from codeine. Isolation and identification from guinea pig bile.
      T Ishida, M Yano and S Toki
      Drug Metabolism and Disposition September 1991, 19 (5) 895-899;
  2. Yoshida, T

    1. You have access
      Metabolism of cinobufagin in rat liver microsomes. Identification of epimerized and deacetylated metabolites by liquid chromatography/mass spectrometry.
      L S Zhang, T Yoshida, K Aoki and Y Kuroiwa
      Drug Metabolism and Disposition September 1991, 19 (5) 917-919;
  3. Yoshikawa, M

    1. You have access
      First pass metabolism and in vitro metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine in dogs.
      M Yoshikawa, S Nishiyama, H Endo, Y Togo and O Takaiti
      Drug Metabolism and Disposition September 1991, 19 (5) 960-965;
  4. Yost, G S

    1. You have access
      Metabolism of 3-methylindole in human tissues.
      W Ruangyuttikarn, M L Appleton and G S Yost
      Drug Metabolism and Disposition September 1991, 19 (5) 977-984;

Z

  1. Zeller, K P

    1. You have access
      Evidence for oxidative activation of mitoxantrone in human, pig, and rat.
      J Blanz, K Mewes, G Ehninger, B Proksch, D Waidelich, B Greger and K P Zeller
      Drug Metabolism and Disposition September 1991, 19 (5) 871-880;
  2. Zhang, L S

    1. You have access
      Metabolism of cinobufagin in rat liver microsomes. Identification of epimerized and deacetylated metabolites by liquid chromatography/mass spectrometry.
      L S Zhang, T Yoshida, K Aoki and Y Kuroiwa
      Drug Metabolism and Disposition September 1991, 19 (5) 917-919;
  3. Ziegler, D M

    1. You have access
      The 1990 Bernard B. Brodie Award Lecture. Unique properties of the enzymes of detoxication.
      D M Ziegler
      Drug Metabolism and Disposition September 1991, 19 (5) 847-852;
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In this issue

Drug Metabolism and Disposition
Vol. 19, Issue 5
1 Sep 1991
  • Table of Contents
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  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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