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Drug Metabolism & Disposition

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Table of Contents

May 01, 1992; Volume 20,Issue 3
  • You have access
    Caffeine demethylase activity in human and Dark Agouti rat liver microsomes. Comparison with aminopyrine N-demethylase activity.
    J A Agúndez, A Luengo and J Benítez
    Drug Metabolism and Disposition May 1992, 20 (3) 343-349;
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    Stereoselective disposition of S-8666, a novel uricosuric antihypertensive diuretic, and its N-monodemethylated metabolite in a perfused rat liver preparation. Effect of protein binding on the kinetics of S-8666.
    K Higaki and M Nakano
    Drug Metabolism and Disposition May 1992, 20 (3) 350-355;
  • You have access
    Diphenyl ether cleavage of 3-phenoxybenzoic acid by chicken kidney microsomal preparations.
    M H Akhtar and S Mahadevan
    Drug Metabolism and Disposition May 1992, 20 (3) 356-359;
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    Differential expression of basal and hydrocarbon-induced cytochrome P-450 monooxygenase and quinone reductase activities in subpopulations of murine epidermal cells differing in their stages of differentiation.
    J J Reiners, A R Cantu, G Thai and A Schöller
    Drug Metabolism and Disposition May 1992, 20 (3) 360-366;
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    Purification and characterization of a cytochrome P-450 isozyme catalyzing bunitrolol 4-hydroxylation in liver microsomes of male rats.
    T Suzuki, S Narimatsu, S Fujita, Y Masubuchi, S Umeda, S Imaoka and Y Funae
    Drug Metabolism and Disposition May 1992, 20 (3) 367-373;
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    Homeostasis of sulfate and 3'-phosphoadenosine 5'-phosphosulfate in rats with deficient dietary intake of sulfur.
    P Rozman, H J Kim, C Madhu, Z Gregus and C D Klaassen
    Drug Metabolism and Disposition May 1992, 20 (3) 374-378;
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    Inhibition of debrisoquin clearance in perfused rat livers and inhibition of dextromethorphan metabolism in human liver microsomes by 4-hydroxydebrisoquin or other metabolites of debrisoquin.
    S Jaruratanasirikul, A D Cooper and T F Blaschke
    Drug Metabolism and Disposition May 1992, 20 (3) 379-382;
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    In vitro and in vivo biotransformations of the potent leukotriene D4 antagonist verlukast in the rat.
    D Nicoll-Griffith, J Yergey, L Trimble, H Williams, R Rasori and R Zamboni
    Drug Metabolism and Disposition May 1992, 20 (3) 383-389;
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    Physiological disposition and metabolism of L-365,260, a potent antagonist of brain cholecystokinin receptor, in laboratory animals.
    I W Chen, J M Dorley, H G Ramjit, S M Pitzenberger and J H Lin
    Drug Metabolism and Disposition May 1992, 20 (3) 390-395;
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    Pharmacokinetic evaluation of drug interactions with anti-human immunodeficiency virus drugs. V. Effect of soluble CD4 on 2',3'-dideoxycytidine kinetics in monkeys.
    M Qian, A R Swagler, K L Fong, C S Crysler, M Mehta and J M Gallo
    Drug Metabolism and Disposition May 1992, 20 (3) 396-401;
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    Obesity as a risk factor in drug-induced organ injury. V. Toxicokinetics of gentamicin in the obese overfed rat.
    D E Salazar, J J Schentag and G B Corcoran
    Drug Metabolism and Disposition May 1992, 20 (3) 402-406;
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    Differential effects of human recombinant interleukin-1 beta on cytochrome P-450-dependent activities in cultured fetal rat hepatocytes.
    L Ferrari, P Kremers, A M Batt, J E Gielen and G Siest
    Drug Metabolism and Disposition May 1992, 20 (3) 407-412;
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    Sulfation of estrone and 17 beta-estradiol in human liver. Catalysis by thermostable phenol sulfotransferase and by dehydroepiandrosterone sulfotransferase.
    J S Hernández, R W Watson, T C Wood and R M Weinshilboum
    Drug Metabolism and Disposition May 1992, 20 (3) 413-422;
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    Tissue concentrations of coenzyme Q10 in the rat following its oral and intraperitoneal administration.
    S Reahal and J Wrigglesworth
    Drug Metabolism and Disposition May 1992, 20 (3) 423-427;
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    Physiological disposition of aerosolized MK-679 in rats.
    D J Tocco, F A deluna, E Vadas and J H Lin
    Drug Metabolism and Disposition May 1992, 20 (3) 428-431;
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    Disposition kinetics of amphotericin B in rats. The influence of dose.
    H H Chow, Y Cai and M Mayersohn
    Drug Metabolism and Disposition May 1992, 20 (3) 432-435;
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    Effect of dose on the percutaneous absorption of 2- and 4-chloronitrobenzene in rats.
    A A Nomeir, P M Markham, A L Mongan, D M Silveira and M Chadwick
    Drug Metabolism and Disposition May 1992, 20 (3) 436-439;
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    Hydrolysis of the 2',3'-allylic epoxides of allylbenzene, estragole, eugenol, and safrole by both microsomal and cytosolic epoxide hydrolases.
    G Luo, M K Qato and T M Guenthner
    Drug Metabolism and Disposition May 1992, 20 (3) 440-445;
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    Cytochrome P-450 in the brain. Potential evolutionary and therapeutic relevance of localization of drug-metabolizing enzymes.
    M R Britto and P J Wedlund
    Drug Metabolism and Disposition May 1992, 20 (3) 446-450;
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    Isolation and characterization of carbinolamide and phenolic glucuronide conjugates of (+-)-N-methyl-N-(1-methyl-3,3-diphenylpropyl) formamide and N-formylmethamphetamine by FAB/MS, LC/MS/MS, and NMR.
    A E Mutlib and F S Abbott
    Drug Metabolism and Disposition May 1992, 20 (3) 451-460;
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    Influence of dibutyryl-cAMP on ibuprofen-induced alterations of sulfate renal clearance in rats.
    L J Benincosa and M E Morris
    Drug Metabolism and Disposition May 1992, 20 (3) 461-464;
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    Carbonyl (phenone) reductase in human liver: structure-activity relationship among substrates.
    J M Wong, W A Mahon, W Kalow and T Inaba
    Drug Metabolism and Disposition May 1992, 20 (3) 465-466;
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    Distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in splenic tissue of C57BL/6J mice.
    C M Neumann, L B Steppan and N I Kerkvliet
    Drug Metabolism and Disposition May 1992, 20 (3) 467-469;
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    Glucosidation as a new conjugation pathway for metabolites of bis(2-ethylhexyl) phthalate.
    B Egestad and P Sjöberg
    Drug Metabolism and Disposition May 1992, 20 (3) 470-472;
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In this issue

Drug Metabolism and Disposition
Vol. 20, Issue 3
1 May 1992
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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