Drug Metabolism and Disposition: 20 (4)

July 01, 1992; Volume 20,Issue 4

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Effects of dose, sex, and age on the disposition of alendronate, a potent antiosteolytic bisphosphonate, in rats.
J H Lin, I W Chen and D E Duggan

Drug Metabolism and Disposition July 1992, 20 (4) 473-478;
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Metabolism of the leukotriene receptor antagonist 5-(2-(8-phenyloctyl)phenyl)-4,6-dithianonanedioic acid (SK&F 102922) in the guinea pig. Rearrangement of the acyl glucuronide.
J F Newton, K M Straub, R H Dewey, C D Perchonock, M E McCarthy, J G Gleason and R K Lynn

Drug Metabolism and Disposition July 1992, 20 (4) 479-484;
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A physiologically based pharmacokinetic model for (-)-quinuclidinyl benzylate using nonlinear irreversible tissue binding parameters in rats.
J Ishizaki, E Nakashima, K Yokogawa, T Nagano, T Takayasu and F Ichimura

Drug Metabolism and Disposition July 1992, 20 (4) 485-489;
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Lack of effect of streptogramins on hepatic drug metabolism enzymes in the rat.
M R Martinet, Y Vedrine, V Piguet and A Frydman

Drug Metabolism and Disposition July 1992, 20 (4) 490-495;
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Probenecid-impaired biliary excretion of acetaminophen glucuronide and sulfate in the rat.
P M Savina and K L Brouwer

Drug Metabolism and Disposition July 1992, 20 (4) 496-501;
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Metabolism of simultaneously administered antipyrine and theophylline in male BN/BiRij rats before and after induction with 3-methylcholanthrene.
K Groen, D D Breimer and C F van Bezooijen

Drug Metabolism and Disposition July 1992, 20 (4) 502-506;
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Noninvasive in vivo 13C-NMR spectroscopy in the rat to study the pharmacokinetics of 13C-labeled xenobiotics.
H J Muller, D Lanens, T J de Cock Buning, F L van de Vyver, F C Alderweireldt, R Dommisse, M Spanoghe, G J Mulder and J Lugtenburg

Drug Metabolism and Disposition July 1992, 20 (4) 507-509;
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Effects of pregnancy and ethanol treatment on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by hamster liver and lung microsomes.
R Jorquera, A Castonguay and H M Schuller

Drug Metabolism and Disposition July 1992, 20 (4) 510-517;
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Dominant role of cytochrome P-450 2E1 in human hepatic microsomal oxidation of the CFC-substitute 1,1,1,2-tetrafluoroethane.
S E Surbrook and M J Olson

Drug Metabolism and Disposition July 1992, 20 (4) 518-524;
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Tissue distribution and lung localization of [14C]azelastine in guinea pigs.
K K Wong, J T Yang, N Kucharczyk and R D Sofia

Drug Metabolism and Disposition July 1992, 20 (4) 525-529;
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Pharmacokinetics of azelastine and its active metabolite, desmethylazelastine, in guinea pigs.
V E Adusumalli, K K Wong, N Kucharczyk and R D Sofia

Drug Metabolism and Disposition July 1992, 20 (4) 530-535;
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Metabolism of [14C]azelastine in guinea pigs.
J T Yang, K K Wong, N Kucharczyk and R D Sofia

Drug Metabolism and Disposition July 1992, 20 (4) 536-540;
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Total body and hepatic clearance in rats of recombinant tissue-type plasminogen activator expressed in mouse C127 and Chinese hamster ovary cells.
R Hori, Y L He, T Shima, K Inui, S Aoki, K Okumura and Y Tanigawara

Drug Metabolism and Disposition July 1992, 20 (4) 541-546;
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Effects of low-density lipoprotein and ethinyl estradiol on cyclosporine metabolism in isolated rat liver perfusions.
T Prueksaritanont, B A Hoener and L Z Benet

Drug Metabolism and Disposition July 1992, 20 (4) 547-552;
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Tissue disposition of glyceryl trinitrate, 1,2-glyceryl dinitrate, and 1,3-glyceryl dinitrate in tolerant and nontolerant rats.
K E Torfgård, J Ahlner, K L Axelsson, B Norlander and A Bertler

Drug Metabolism and Disposition July 1992, 20 (4) 553-558;
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Correlation between N-acetyltransferase activities in uroepithelia and in vivo acetylator phenotype.
J C Pink, E M Messing, C A Reznikoff, G T Bryan and S Swaminathan

Drug Metabolism and Disposition July 1992, 20 (4) 559-565;
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12 alpha-hydroxytestosterone. A hitherto unidentified testosterone metabolite produced by cytochrome P-450 2A2.
S J Smith, K R Korzekwa, T Aoyama, F J Gonzalez, J F Darbyshire, K Sugiyama and J R Gillette

Drug Metabolism and Disposition July 1992, 20 (4) 566-571;
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Effect of miconazole on warfarin disposition in rabbits.
A P D'Mello, R V Venkataramanan and T R Bates

Drug Metabolism and Disposition July 1992, 20 (4) 572-577;
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3'-azido-3'-deoxythymidine drug interactions. Screening for inhibitors in human liver microsomes.
J F Rajaonarison, B Lacarelle, J Catalin, M Placidi and R Rahmani

Drug Metabolism and Disposition July 1992, 20 (4) 578-584;
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Pharmacokinetic analysis of enterohepatic circulation of 4-[2-(4-isopropylbenzamido)ethoxy]benzoic acid. Effect of intramolecular rearrangement of its acyl glucuronide.
H Komura, H Fukui, H Sasaki and A Morino

Drug Metabolism and Disposition July 1992, 20 (4) 585-591;
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Pharmacokinetics and tissue distribution of human urinary tumor necrosis factor binding protein in mice.
M P Gascon, H C Porchet, J Y Le Cotonnec, A Ythier, D Wallach, P F Piguet and G E Grau

Drug Metabolism and Disposition July 1992, 20 (4) 592-595;
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Identification of urinary metabolites of 8-methyl-8-azabicyclo- 3,2,1] octan-3-yl 3,5-dichlorobenzoate (MDL 72,222) in the dog and monkey.
W P Gordon, H Cheng, D L Larsen, J A Ragner and N G Landmesser

Drug Metabolism and Disposition July 1992, 20 (4) 596-602;
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Pharmacokinetics and metabolism of the 5-hydroxytryptamine antagonist tropisetron after single oral doses in humans.
V Fischer, J P Baldeck and F L Tse

Drug Metabolism and Disposition July 1992, 20 (4) 603-607;
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Renal handling of alendronate in rats. An uncharacterized renal transport system.
J H Lin, I W Chen, F A Deluna and M Hichens

Drug Metabolism and Disposition July 1992, 20 (4) 608-613;
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Phenol sulfotransferase activity in rat liver parenchymal cells cultured on collagen gels.
D Utesch and F Oesch

Drug Metabolism and Disposition July 1992, 20 (4) 614-615;
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Metabolism of alachlor by rat and monkey liver and nasal turbinate tissue.
A A Li, K J Asbury, W E Hopkins, P C Feng and A G Wilson

Drug Metabolism and Disposition July 1992, 20 (4) 616-618;

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