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Drug Metabolism & Disposition

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Table of Contents

November 01, 1992; Volume 20,Issue 6
  • You have access
    Peroxisome proliferators, a unique set of drug-metabolizing enzyme inducers: commentary on a symposium.
    D E Moody, G G Gibson, D F Grant, J Magdalou and M S Rao
    Drug Metabolism and Disposition November 1992, 20 (6) 779-791;
  • You have access
    Induction of P-450 cytochromes 2E2, 1A1, and 1A2 by imidazole in neonatal rabbits.
    X Ding, H M Peng, S J Pernecky, C J Davis and M J Coon
    Drug Metabolism and Disposition November 1992, 20 (6) 792-796;
  • You have access
    Phenobarbital and dexamethasone induce expression of cytochrome P-450 genes from subfamilies IIB, IIC, and IIIA in mouse liver.
    L Corcos
    Drug Metabolism and Disposition November 1992, 20 (6) 797-801;
  • You have access
    Cyclosporin A metabolism in human liver, kidney, and intestine slices. Comparison to rat and dog slices and human cell lines.
    A E Vickers, V Fischer, S Connors, R L Fisher, J P Baldeck, G Maurer and K Brendel
    Drug Metabolism and Disposition November 1992, 20 (6) 802-809;
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    Pharmacokinetics and pharmacodynamics of valproate analogs in rats. III. Pharmacokinetics of valproic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid in the bile-exteriorized rat.
    M J Liu, K L Brouwer and G M Pollack
    Drug Metabolism and Disposition November 1992, 20 (6) 810-815;
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    Metabolism of 3-tert-butyl-4-hydroxyanisole by horseradish peroxidase and hydrogen peroxide.
    K Tajima, M Hashizaki, K Yamamoto and T Mizutani
    Drug Metabolism and Disposition November 1992, 20 (6) 816-820;
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    Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of enalkiren (Abbott-64662, a new renin inhibitor). I: Single dose study.
    S K Gupta, G R Granneman, R S Boger, N K Hollenberg and R R Luther
    Drug Metabolism and Disposition November 1992, 20 (6) 821-825;
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    Pharmacokinetic profile of theophylline in isolated perfused liver of rabbits at different ages. Development of drug-metabolizing activity during ontogenesis.
    M Corada, A Bortolotti, M M Barzago, A Celardo, M Bonati and A Guaitani
    Drug Metabolism and Disposition November 1992, 20 (6) 826-831;
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    Stereoselective sulfoxidation by human flavin-containing monooxygenase. Evidence for catalytic diversity between hepatic, renal, and fetal forms.
    A J Sadeque, A C Eddy, G P Meier and A E Rettie
    Drug Metabolism and Disposition November 1992, 20 (6) 832-839;
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    Characterization of metabolites of xylazine produced in vivo and in vitro by LC/MS/MS and by GC/MS.
    A E Mutlib, Y C Chui, L M Young and F S Abbott
    Drug Metabolism and Disposition November 1992, 20 (6) 840-848;
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    Metabolism and disposition of gemcitabine, and oncolytic deoxycytidine analog, in mice, rats, and dogs.
    L A Shipley, T J Brown, J D Cornpropst, M Hamilton, W D Daniels and H W Culp
    Drug Metabolism and Disposition November 1992, 20 (6) 849-855;
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    Pharmacokinetics of oral methamphetamine and effects of repeated daily dosing in humans.
    C E Cook, A R Jeffcoat, B M Sadler, J M Hill, R D Voyksner, D E Pugh, W R White and M Perez-Reyes
    Drug Metabolism and Disposition November 1992, 20 (6) 856-862;
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    Pharmacokinetic analysis of the metabolism of cocaine to norcocaine and N-hydroxynorcocaine in mice.
    C S Boyer and D R Petersen
    Drug Metabolism and Disposition November 1992, 20 (6) 863-868;
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    Metabolism of a new HIV-1 reverse transcriptase inhibitor, 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (L-696,229), in rat and liver slices.
    S K Balani, S M Pitzenberger, L R Kauffman, B H Arison, H G Ramjit, M E Goldman, J A O'Brien, J D King, J M Hoffman and C S Rooney
    Drug Metabolism and Disposition November 1992, 20 (6) 869-876;
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    Specific and enantioselective sulfoxidation of an aryl-trifluoromethyl sulfide by rat liver cytochromes P-450.
    E Benoit, T Cresteil, J L Riviere and P Delatour
    Drug Metabolism and Disposition November 1992, 20 (6) 877-881;
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    Microbial models of mammalian metabolism. N-dealkylation of furosemide to yield the mammalian metabolite CSA using Cunninghamella elegans.
    M Hezari and P J Davis
    Drug Metabolism and Disposition November 1992, 20 (6) 882-888;
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    Role of guinea pig and rabbit hepatic aldehyde oxidase in oxidative in vitro metabolism of cinchona antimalarials.
    C Beedham, Y al-Tayib and J A Smith
    Drug Metabolism and Disposition November 1992, 20 (6) 889-895;
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    Studies on tertiary amine UDP-glucuronosyltransferases from human and rabbit hepatic microsomes.
    P B Styczynski, M D Green, B Coffman and T R Tephly
    Drug Metabolism and Disposition November 1992, 20 (6) 896-901;
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    Substrates for microsomal azoreductase. Hammett substituent effects, NMR studies, and response to inhibitors.
    S Zbaida, C F Brewer and W G Levine
    Drug Metabolism and Disposition November 1992, 20 (6) 902-908;
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    Pharmacokinetics of D(+)-usnic acid in rabbits after intravenous and oral administration.
    D R Krishna and D Venkataramana
    Drug Metabolism and Disposition November 1992, 20 (6) 909-911;
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    Oxidation of carbovir, a carbocyclic nucleoside, by rat liver cytosolic enzymes. Enantioselectivity and enantiomeric inhibition.
    J E Patanella and J S Walsh
    Drug Metabolism and Disposition November 1992, 20 (6) 912-919;
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    Disposition and metabolism of triprolidine in mice.
    D L Deal, P Chandrasurin, J Shockcor, D J Minick, J W Findlay and M J McNulty
    Drug Metabolism and Disposition November 1992, 20 (6) 920-927;
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    Disposition of triprolidine in the male beagle dog.
    M J McNulty, D L Deal, T L Page, P Chandrasurin and J W Findlay
    Drug Metabolism and Disposition November 1992, 20 (6) 928-935;
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    Clinical pharmacology of combined oral uracil and ftorafur.
    D H Ho, W P Covington, R Pazdur, N S Brown, J Kuritani, R A Newman, M N Raber and I H Krakoff
    Drug Metabolism and Disposition November 1992, 20 (6) 936-940;
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    Investigation of conjugated metabolites of 4-hydroxyandrost-4-ene-3,17-dione in patient urine by liquid chromatography-atmospheric pressure ionization mass spectrometry.
    G K Poon, Y C Chui, M Jarman, M G Rowlands, P S Kokkonen, W M Niessen and J van der Greef
    Drug Metabolism and Disposition November 1992, 20 (6) 941-947;
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    Oxidation of aldose reductase inhibitors ALO-4114 and ALO-3152 catalyzed by liver microsomes.
    A D Kiss, K Haggard, J C Veltman and D M Ziegler
    Drug Metabolism and Disposition November 1992, 20 (6) 948-953;
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    Disposition of the human immunodeficiency virus Tat inhibitor, Ro 5-3335, in rats and dogs.
    C Town, D Chang, L Henderson and W A Garland
    Drug Metabolism and Disposition November 1992, 20 (6) 954-957;
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    Formation of indenesulfonylureas in the metabolism of the anticancer agent sulofenur in rats, monkeys, and humans.
    W J Ehlhardt, J L Zimmermann, J E Ray and J E Toth
    Drug Metabolism and Disposition November 1992, 20 (6) 958-961;
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    Covalent binding of etodolac acyl glucuronide to albumin in vitro.
    P C Smith, W Q Song and R J Rodriguez
    Drug Metabolism and Disposition November 1992, 20 (6) 962-965;
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In this issue

Drug Metabolism and Disposition
Vol. 20, Issue 6
1 Nov 1992
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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