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Drug Metabolism & Disposition

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Table of Contents

January 01, 1993; Volume 21,Issue 1
  • You have access
    The 1992 Bernard B. Brodie Award Lecture. Bioactivation and detoxication of toxic and carcinogenic chemicals.
    F P Guengerich
    Drug Metabolism and Disposition January 1993, 21 (1) 1-6;
  • You have access
    In vivo and in vitro effect of cimetidine, inflammation, and hypoxia on propofol kinetics.
    G Audibert, C G Saunier and P du Souich
    Drug Metabolism and Disposition January 1993, 21 (1) 7-12;
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    Uptake, 3-, and 6-glucuronidation of morphine in isolated cells from stomach, intestine, colon, and liver of the guinea pig.
    P Déchelotte, A Sabouraud, P Sandouk, I Hackbarth and M Schwenk
    Drug Metabolism and Disposition January 1993, 21 (1) 13-17;
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    Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta-hydroxylation of testosterone in human liver microsomes.
    A W Harrell, S M Wheeler, M Pennick, S E Clarke and R J Chenery
    Drug Metabolism and Disposition January 1993, 21 (1) 18-23;
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    Oxidation of desmethylpromethazine catalyzed by pig liver flavin-containing monooxygenase. Number and nature of metabolites.
    B Clement, K L Lustig and D M Ziegler
    Drug Metabolism and Disposition January 1993, 21 (1) 24-29;
  • You have access
    Reduction of cisplatin nephrotoxicity by sodium selenite. Lack of interaction at the pharmacokinetic level of both compounds.
    N P Vermeulen, G S Baldew, G Los, J G McVie and J J De Goeij
    Drug Metabolism and Disposition January 1993, 21 (1) 30-36;
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    Evidence for peroxidase-mediated metabolism of cyclophosphamide.
    S Kanekal and J P Kehrer
    Drug Metabolism and Disposition January 1993, 21 (1) 37-42;
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    Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.
    H P Eugster, M Probst, F E Würgler and C Sengstag
    Drug Metabolism and Disposition January 1993, 21 (1) 43-49;
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    Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family.
    T Ebner and B Burchell
    Drug Metabolism and Disposition January 1993, 21 (1) 50-55;
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    Inducibility of enzyme activities associated with the cytochrome P-450 1A family, ethoxyresorufin O-deethylase, and methoxyresorufin O-demethylase in human hepatocyte lines derived from normal liver tissue.
    E A Roberts, Z W Xie, S Yang and J Lipa
    Drug Metabolism and Disposition January 1993, 21 (1) 56-61;
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    Pharmacokinetics and disposition in the rat of a DNA intercalator 502U83.
    D K Patel, R P Lewis, M L Hinton, D H Schroeder, J P Shockcor, R L Johnson and C W Sigel
    Drug Metabolism and Disposition January 1993, 21 (1) 62-70;
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    Altered pharmacokinetics of recombinant human deoxyribonuclease in rats due to the presence of a binding protein.
    M Mohler, J Cook, D Lewis, J Moore, D Sinicropi, A Championsmith, B Ferraiolo and J Mordenti
    Drug Metabolism and Disposition January 1993, 21 (1) 71-75;
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    Stereoselective sulfation of albuterol in humans. Biosynthesis of the sulfate conjugate by HEP G2 cells.
    T Walle, U K Walle, K R Thornburg and K L Schey
    Drug Metabolism and Disposition January 1993, 21 (1) 76-80;
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    Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans.
    T Wikberg, A Vuorela, P Ottoila and J Taskinen
    Drug Metabolism and Disposition January 1993, 21 (1) 81-92;
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    Main urinary metabolites of two cysteamine-containing 2-(chloroethyl) nitrosoureas in rats.
    D Godeneche, P Labarre, M F Moreau, J C Madelmont, M Rapp, J Papon and A Veyre
    Drug Metabolism and Disposition January 1993, 21 (1) 93-99;
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    Clearance and tissue uptake following 4-hour and 24-hour infusions of pamidronate in rats.
    M Pongchaidecha and P T Daley-Yates
    Drug Metabolism and Disposition January 1993, 21 (1) 100-104;
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    Fluorine NMR studies of the metabolism of flumecinol (3-trifluoromethyl-alpha-ethylbenzhydrol).
    L A Sylvia and J T Gerig
    Drug Metabolism and Disposition January 1993, 21 (1) 105-113;
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    Metabolic inversion of (R)-ibuprofen. Formation of ibuprofenyl-coenzyme A.
    T S Tracy, D P Wirthwein and S D Hall
    Drug Metabolism and Disposition January 1993, 21 (1) 114-120;
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    A simplified methodology for quantitation of butadiene metabolites. Application to the study of 1,3-butadiene metabolism by rat liver microsomes.
    X Cheng and J A Ruth
    Drug Metabolism and Disposition January 1993, 21 (1) 121-124;
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    A pharmacokinetic study of phenylcyclohexyldiethylamine. An analog of phencyclidine.
    A K Cho, M Hiramatsu, D A Schmitz, E M Landaw, A S Chang, S Ramamurthy and D J Jenden
    Drug Metabolism and Disposition January 1993, 21 (1) 125-132;
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    Metabolism of N,N-diethylbenzamide and N,N-diethyl-alpha,alpha'-13C-benzamide by rat liver microsomes.
    W G Taylor, T W Hall and D D Vedres
    Drug Metabolism and Disposition January 1993, 21 (1) 133-140;
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    Effect of atropine on gastrointestinal motility and the bioavailability of cyclosporine A in rats.
    R F Quijano, N Ohnishi, K Umeda, F Komada, S Iwakawa and K Okumura
    Drug Metabolism and Disposition January 1993, 21 (1) 141-143;
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    Pharmacokinetics of recombinant human follicle stimulating hormone after intravenous, intramuscular, and subcutaneous administration in monkeys, and comparison with intravenous administration of urinary follicle stimulating hormone.
    H C Porchet, J Y Le Cotonnec, S Canali and G Zanolo
    Drug Metabolism and Disposition January 1993, 21 (1) 144-150;
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    In vivo glucuronidation in rat and humans of 5,6-dihydro-7-(1H-imidazol-1-yl)-naphthalene-2-carboxylic acid, a selective inhibitor of thromboxane synthase.
    J Thomassin, R Battaglia, C Allievi, M G Castelli and M Strolin Benedetti
    Drug Metabolism and Disposition January 1993, 21 (1) 151-155;
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    Effects of propranolol on the disposition and negative dromotropic activity of diltiazem in the dog during multiple dosing.
    C Maskasame, S M Lankford and S A Bai
    Drug Metabolism and Disposition January 1993, 21 (1) 156-161;
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    Biotransformation of the antiviral agent 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and characteristics of a mesoionic ribose metabolite.
    W J Ehlhardt, W J Wheeler, A P Breau, S H Chay and G M Birch
    Drug Metabolism and Disposition January 1993, 21 (1) 162-170;
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    Disposition of oral [14C]cefcanel daloxate hydrochloride in healthy male subjects.
    B Edwall, A Arvidsson, D Lake-Bakaar, K Lanbeck-Vallén and W Yisak
    Drug Metabolism and Disposition January 1993, 21 (1) 171-177;
  • You have access
    Caffeine metabolism in liver slices during postnatal development in rats.
    T Bienvenu, G Pons, E Rey, G Thiroux and G Olive
    Drug Metabolism and Disposition January 1993, 21 (1) 178-180;
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    Inhibition of human red blood cell N-acetyltransferase.
    R A Voice, M Manis and W W Weber
    Drug Metabolism and Disposition January 1993, 21 (1) 181-183;
  • You have access
    Hepatic elimination in the rat of ditekiren (U-71038), a renin inhibitor pseudohexapeptide.
    A Adedoyin, P R Perry and G R Wilkinson
    Drug Metabolism and Disposition January 1993, 21 (1) 184-188;
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    Zidovudine bioavailability and linear pharmacokinetics in female B6C3F1 mice.
    J M Trang, J D Prejean, R H James, R D Irwin, T J Goehl and J G Page
    Drug Metabolism and Disposition January 1993, 21 (1) 189-193;
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    Biometabolic elimination and organ retention profile of argemone alkaloid, sanguinarine, in rats and guinea pigs.
    S Tandon, M Das and S K Khanna
    Drug Metabolism and Disposition January 1993, 21 (1) 194-197;
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    Identification of two novel indolic metabolites of (R),(R)-labetalol in monkey urine.
    K B Alton, T M Chan and B Pramanik
    Drug Metabolism and Disposition January 1993, 21 (1) 198-199;
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    Zonal differences in the thermal lability of adrenal microsomal monooxygenases.
    H D Colby, M Levitt and I W Larson
    Drug Metabolism and Disposition January 1993, 21 (1) 200-202;
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In this issue

Drug Metabolism and Disposition
Vol. 21, Issue 1
1 Jan 1993
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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