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Drug Metabolism & Disposition

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Table of Contents

May 01, 1993; Volume 21,Issue 3
  • You have access
    Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.
    C H Yun, R A Okerholm and F P Guengerich
    Drug Metabolism and Disposition May 1993, 21 (3) 403-409;
  • You have access
    In vitro differential metabolism of merbarone by xanthine oxidase and microsomal flavoenzymes. The role of reactive oxygen species.
    J F Muindi, Y W Stevens, R P Warrell and C W Young
    Drug Metabolism and Disposition May 1993, 21 (3) 410-414;
  • You have access
    Metabolic profiling of clobazam, a 1,5-benzodiazepine, in rats.
    A G Borel and F S Abbott
    Drug Metabolism and Disposition May 1993, 21 (3) 415-427;
  • You have access
    Influence of temperature and plasma protein on doxorubicin uptake by isolated lungs.
    R D Bongard, D L Roerig, M R Johnston, J H Linehan and C A Dawson
    Drug Metabolism and Disposition May 1993, 21 (3) 428-434;
  • You have access
    Presystemic elimination of the beta-blocker pafenolol in the rat after oral and intraperitoneal administration and identification of a main metabolite in both rats and humans.
    H Lennernäs, L Renberg, K J Hoffmann and C G Regårdh
    Drug Metabolism and Disposition May 1993, 21 (3) 435-440;
  • You have access
    Sulfamethazine as a model compound to assess sex hormone-dependent cytochrome P-450 activity in rats.
    R F Witkamp, S M Nijmeijer, H Yun, J Noordhoek and A S van Miert
    Drug Metabolism and Disposition May 1993, 21 (3) 441-446;
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    Absorption, disposition, and metabolism of [14C]didanosine in the beagle dog.
    S Kaul, W C Shyu, U A Shukla, K A Dandekar and R H Barbhaiya
    Drug Metabolism and Disposition May 1993, 21 (3) 447-453;
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    The biotransformation of the ergot derivative CQA 206-291 in human, dog, and rat liver slice cultures and prediction of in vivo plasma clearance.
    A E Vickers, S Connors, M Zollinger, W A Biggi, A Larrauri, J P Vogelaar and K Brendel
    Drug Metabolism and Disposition May 1993, 21 (3) 454-459;
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    Toxicokinetics of allynitrile in rats.
    M Y Farooqui, B Ybarra and J Piper
    Drug Metabolism and Disposition May 1993, 21 (3) 460-466;
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    In vivo and in vitro metabolism studies on a class III antiarrhythmic agent.
    S Vickers, C A Duncan, P H Kari, C F Homnick, J M Elliott, S M Pitzenberger, M Hichens and K P Vyas
    Drug Metabolism and Disposition May 1993, 21 (3) 467-473;
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    Increased renal drug metabolism in treadmill-exercised Fischer-344 male rats.
    T S Piatkowski, W W Day and M Weiner
    Drug Metabolism and Disposition May 1993, 21 (3) 474-479;
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    Pharmacokinetics and metabolism of vigabatrin following a single oral dose of [14C]vigabatrin in healthy male volunteers.
    S L Durham, J F Hoke and T M Chen
    Drug Metabolism and Disposition May 1993, 21 (3) 480-484;
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    Hepatic and extrahepatic metabolism of salbutamol in anesthetized rabbits.
    S Perreault, L Dumont, V Villiere, H Ong, A Adam and P du Souich
    Drug Metabolism and Disposition May 1993, 21 (3) 485-491;
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    Stereo- and regioselective N- and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes.
    J R Cashman, Z Yang, L Yang and S A Wrighton
    Drug Metabolism and Disposition May 1993, 21 (3) 492-501;
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    Pharmacokinetics, absolute bioavailability, and disposition of [14C]nefazodone in the dog.
    U A Shukla, P H Marathe, K A Pittman and R H Barbhaiya
    Drug Metabolism and Disposition May 1993, 21 (3) 502-507;
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    Qualitative and quantitative influences of ortho chlorine substituents on the microsomal metabolism of 4-toluidines.
    B Tyrakowska, S Boeren, B Geurtsen and I M Rietjens
    Drug Metabolism and Disposition May 1993, 21 (3) 508-519;
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    Modulation of rat hepatic CYP3A1 induction by the interferon inducer polyinosinic acid-polycytidylic acid (polyic).
    E Delaporte, A E Cribb and K W Renton
    Drug Metabolism and Disposition May 1993, 21 (3) 520-523;
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    Metabolic N-demethylation of 1,3-bis[[1-cycloheptyl-3-(p- dimethylaminophenyl)ureido]methyl]benzene dihydrochloride, a novel acyl-coenzyme A:cholesterol acyltransferase inhibitor.
    T Uchida, T Usui, T Teramura, T Watanabe and S Higuchi
    Drug Metabolism and Disposition May 1993, 21 (3) 524-529;
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    Metabolism of the experimental antitumor agent acridine carboxamide in the mouse.
    I G Robertson, B D Palmer, J W Paxton and T J Bland
    Drug Metabolism and Disposition May 1993, 21 (3) 530-536;
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    Inhibition by ethanol of the metabolism of cocaine to benzoylecgonine and ecgonine methyl ester in mouse and human liver.
    S M Roberts, R D Harbison and R C James
    Drug Metabolism and Disposition May 1993, 21 (3) 537-541;
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    Enantiomer-enantiomer interaction on N-monodemethylation of diuretic in rat liver microsomes.
    M Nakano, T Chikai and T Matsubara
    Drug Metabolism and Disposition May 1993, 21 (3) 542-543;
  • You have access
    2',3'-Dideoxyinosine is not metabolized in human placenta.
    J T Dalton and J L Au
    Drug Metabolism and Disposition May 1993, 21 (3) 544-546;
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    Characterization of nonlinear elimination of the xanthine-related drug ethimizol in 3-methylcholanthrene-induced rat liver by the "parallel-tube" model.
    M Kukan, T F Woolf, M Melus and S Bezek
    Drug Metabolism and Disposition May 1993, 21 (3) 547-550;
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    Conditions influencing the rat liver microsomal metabolism of 2,2,-dichloro-1,1,1-trifluoroethane (HCFC-123).
    C S Godin, J M Drerup and A Vinegar
    Drug Metabolism and Disposition May 1993, 21 (3) 551-553;
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In this issue

Drug Metabolism and Disposition
Vol. 21, Issue 3
1 May 1993
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Most Cited
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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