Drug Metabolism and Disposition: 21 (3)

May 01, 1993; Volume 21,Issue 3

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Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.
C H Yun, R A Okerholm and F P Guengerich

Drug Metabolism and Disposition May 1993, 21 (3) 403-409;
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In vitro differential metabolism of merbarone by xanthine oxidase and microsomal flavoenzymes. The role of reactive oxygen species.
J F Muindi, Y W Stevens, R P Warrell and C W Young

Drug Metabolism and Disposition May 1993, 21 (3) 410-414;
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Metabolic profiling of clobazam, a 1,5-benzodiazepine, in rats.
A G Borel and F S Abbott

Drug Metabolism and Disposition May 1993, 21 (3) 415-427;
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Influence of temperature and plasma protein on doxorubicin uptake by isolated lungs.
R D Bongard, D L Roerig, M R Johnston, J H Linehan and C A Dawson

Drug Metabolism and Disposition May 1993, 21 (3) 428-434;
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Presystemic elimination of the beta-blocker pafenolol in the rat after oral and intraperitoneal administration and identification of a main metabolite in both rats and humans.
H Lennernäs, L Renberg, K J Hoffmann and C G Regårdh

Drug Metabolism and Disposition May 1993, 21 (3) 435-440;
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Sulfamethazine as a model compound to assess sex hormone-dependent cytochrome P-450 activity in rats.
R F Witkamp, S M Nijmeijer, H Yun, J Noordhoek and A S van Miert

Drug Metabolism and Disposition May 1993, 21 (3) 441-446;
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Absorption, disposition, and metabolism of [14C]didanosine in the beagle dog.
S Kaul, W C Shyu, U A Shukla, K A Dandekar and R H Barbhaiya

Drug Metabolism and Disposition May 1993, 21 (3) 447-453;
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The biotransformation of the ergot derivative CQA 206-291 in human, dog, and rat liver slice cultures and prediction of in vivo plasma clearance.
A E Vickers, S Connors, M Zollinger, W A Biggi, A Larrauri, J P Vogelaar and K Brendel

Drug Metabolism and Disposition May 1993, 21 (3) 454-459;
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Toxicokinetics of allynitrile in rats.
M Y Farooqui, B Ybarra and J Piper

Drug Metabolism and Disposition May 1993, 21 (3) 460-466;
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In vivo and in vitro metabolism studies on a class III antiarrhythmic agent.
S Vickers, C A Duncan, P H Kari, C F Homnick, J M Elliott, S M Pitzenberger, M Hichens and K P Vyas

Drug Metabolism and Disposition May 1993, 21 (3) 467-473;
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Increased renal drug metabolism in treadmill-exercised Fischer-344 male rats.
T S Piatkowski, W W Day and M Weiner

Drug Metabolism and Disposition May 1993, 21 (3) 474-479;
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Pharmacokinetics and metabolism of vigabatrin following a single oral dose of [14C]vigabatrin in healthy male volunteers.
S L Durham, J F Hoke and T M Chen

Drug Metabolism and Disposition May 1993, 21 (3) 480-484;
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Hepatic and extrahepatic metabolism of salbutamol in anesthetized rabbits.
S Perreault, L Dumont, V Villiere, H Ong, A Adam and P du Souich

Drug Metabolism and Disposition May 1993, 21 (3) 485-491;
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Stereo- and regioselective N- and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes.
J R Cashman, Z Yang, L Yang and S A Wrighton

Drug Metabolism and Disposition May 1993, 21 (3) 492-501;
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Pharmacokinetics, absolute bioavailability, and disposition of [14C]nefazodone in the dog.
U A Shukla, P H Marathe, K A Pittman and R H Barbhaiya

Drug Metabolism and Disposition May 1993, 21 (3) 502-507;
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Qualitative and quantitative influences of ortho chlorine substituents on the microsomal metabolism of 4-toluidines.
B Tyrakowska, S Boeren, B Geurtsen and I M Rietjens

Drug Metabolism and Disposition May 1993, 21 (3) 508-519;
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Modulation of rat hepatic CYP3A1 induction by the interferon inducer polyinosinic acid-polycytidylic acid (polyic).
E Delaporte, A E Cribb and K W Renton

Drug Metabolism and Disposition May 1993, 21 (3) 520-523;
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Metabolic N-demethylation of 1,3-bis[[1-cycloheptyl-3-(p- dimethylaminophenyl)ureido]methyl]benzene dihydrochloride, a novel acyl-coenzyme A:cholesterol acyltransferase inhibitor.
T Uchida, T Usui, T Teramura, T Watanabe and S Higuchi

Drug Metabolism and Disposition May 1993, 21 (3) 524-529;
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Metabolism of the experimental antitumor agent acridine carboxamide in the mouse.
I G Robertson, B D Palmer, J W Paxton and T J Bland

Drug Metabolism and Disposition May 1993, 21 (3) 530-536;
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Inhibition by ethanol of the metabolism of cocaine to benzoylecgonine and ecgonine methyl ester in mouse and human liver.
S M Roberts, R D Harbison and R C James

Drug Metabolism and Disposition May 1993, 21 (3) 537-541;
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Enantiomer-enantiomer interaction on N-monodemethylation of diuretic in rat liver microsomes.
M Nakano, T Chikai and T Matsubara

Drug Metabolism and Disposition May 1993, 21 (3) 542-543;
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2',3'-Dideoxyinosine is not metabolized in human placenta.
J T Dalton and J L Au

Drug Metabolism and Disposition May 1993, 21 (3) 544-546;
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Characterization of nonlinear elimination of the xanthine-related drug ethimizol in 3-methylcholanthrene-induced rat liver by the "parallel-tube" model.
M Kukan, T F Woolf, M Melus and S Bezek

Drug Metabolism and Disposition May 1993, 21 (3) 547-550;
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Conditions influencing the rat liver microsomal metabolism of 2,2,-dichloro-1,1,1-trifluoroethane (HCFC-123).
C S Godin, J M Drerup and A Vinegar

Drug Metabolism and Disposition May 1993, 21 (3) 551-553;

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