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Abstract

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

C H Yun, R A Okerholm and F P Guengerich
Drug Metabolism and Disposition May 1993, 21 (3) 403-409;

Article Information

vol. 21 no. 3 403-409
PubMed 
8100494
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online May 1, 1993.

Author Information

  1. C H Yun,
  2. R A Okerholm and
  3. F P Guengerich
  1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.

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    Abstract

    Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

    C H Yun, R A Okerholm and F P Guengerich
    Drug Metabolism and Disposition May 1, 1993, 21 (3) 403-409;
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