Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

C H Yun; R A Okerholm; F P Guengerich

Article Information

vol. 21 no. 3 403-409

PubMed

8100494

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0090-9556

Online ISSN

1521-009X

History

Published online May 1, 1993.

Author Information

C H Yun,
R A Okerholm and
F P Guengerich

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.

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Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

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Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

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Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

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Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

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Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

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