Drug Metabolism and Disposition: 21 (5)

September 01, 1993; Volume 21,Issue 5

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Comparison of human and rhesus monkey in vitro phase I and phase II hepatic drug metabolism activities.
J C Stevens, L A Shipley, J R Cashman, M Vandenbranden and S A Wrighton

Drug Metabolism and Disposition September 1993, 21 (5) 753-760;
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Disposition of sumatriptan in laboratory animals and humans.
C M Dixon, D A Saynor, P D Andrew, J Oxford, A Bradbury and M H Tarbit

Drug Metabolism and Disposition September 1993, 21 (5) 761-769;
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Temporal effects of 1,1-dichloroethylene on nonprotein sulfhydryl content in murine lung and liver.
P G Forkert and M Moussa

Drug Metabolism and Disposition September 1993, 21 (5) 770-776;
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Rat liver microsomal cytochrome P-450 responsible for reductive metabolism of zonisamide.
H Nakasa, M Komiya, S Ohmori, T Rikihisa and M Kitada

Drug Metabolism and Disposition September 1993, 21 (5) 777-781;
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Effect of nutritional obesity on the induction of CYP2B enzymes following phenobarbital treatment.
P N Zannikos, A M Bandyopadhyay, L W Robertson and R A Blouin

Drug Metabolism and Disposition September 1993, 21 (5) 782-787;
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Metabolism of benzophenone-3 in rats.
C S Okereke, A M Kadry, M S Abdel-Rahman, R A Davis and M A Friedman

Drug Metabolism and Disposition September 1993, 21 (5) 788-791;
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N-glucuronidation reactions. I. Tetrazole N-glucuronidation of selected angiotensin II receptor antagonists in hepatic microsomes from rats, dogs, monkeys, and humans.
S E Huskey, R R Miller and S H Chiu

Drug Metabolism and Disposition September 1993, 21 (5) 792-799;
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Uptake of alendronate by bone tissue in hypocalcemic and hypercalcemic rats.
J H Lin, I W Chen and F A Deluna

Drug Metabolism and Disposition September 1993, 21 (5) 800-804;
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Differences in the stereoselective pharmacokinetics of pazinaclone (DN-2327), a new anxiolytic, and its active metabolite after intravenous and oral single doses to dogs.
Z Hussein, D J Mulford, B A Bopp and G R Granneman

Drug Metabolism and Disposition September 1993, 21 (5) 805-810;
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Model systems for oxidative drug metabolism studies. Catalytic behavior of water-soluble metalloporphyrins depends on both the intrinsic robustness of the catalyst and the nature of substrates.
M Vidal, M Bonnafous, S Defrance, P Loiseau, J Bernadou and B Meunier

Drug Metabolism and Disposition September 1993, 21 (5) 811-817;
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Disposition of the 3H-labeled gonadotropin-releasing hormone analog buserelin in rats.
H Berger, J Sandow, N Heinrich, E Albrecht, U Kertscher and J Oehlke

Drug Metabolism and Disposition September 1993, 21 (5) 818-822;
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Effect of anticancer drugs on the glucuronidation of 3'-azido-3'-deoxythymidine in human liver microsomes.
J F Rajaonarison, B Lacarelle, J Catalin, A Durand and J P Cano

Drug Metabolism and Disposition September 1993, 21 (5) 823-829;
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N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system.
J P Uetrecht, N H Shear and N Zahid

Drug Metabolism and Disposition September 1993, 21 (5) 830-834;
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Pharmacokinetics and pharmacodynamics of idrapril in rats, dogs, and humans.
M Criscuoli, A Lippi, G Mengozzi, G Sardelli, A Subissi and A Giachetti

Drug Metabolism and Disposition September 1993, 21 (5) 835-840;
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Targeting of 6-mercaptopurine to the kidneys. Metabolism and kidney-selectivity of S-(6-purinyl)-L-cysteine analogs in rats.
A A Elfarra and I Y Hwang

Drug Metabolism and Disposition September 1993, 21 (5) 841-845;
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Pharmacokinetics of cobalt chloride and cobalt-protoporphyrin.
D W Rosenberg

Drug Metabolism and Disposition September 1993, 21 (5) 846-849;
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Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes.
G Lhoëst, N Maton and R K Verbeeck

Drug Metabolism and Disposition September 1993, 21 (5) 850-854;
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Pharmacokinetics and metabolism of 3'-azido-2',3'-dideoxy-5-methylcytidine in rhesus monkeys.
F D Boudinot, R F Schinazi, K J Doshi, H M McClure and C K Chu

Drug Metabolism and Disposition September 1993, 21 (5) 855-860;
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Characterization of verlukast metabolites arising from an epoxide intermediate produced with hepatic microsomes from beta-naphthoflavone-treated rodents (P-4501A1).
D A Nicoll-Griffith, N Chauret, J A Yergey, L A Trimble, L Favreau, R Zamboni, S J Grossman, J Drey and E Herold

Drug Metabolism and Disposition September 1993, 21 (5) 861-867;
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Drug metabolism studies using "intrinsic" and "extrinsic" labels. A demonstration using 15N vs. Cl in midazolam.
H Song and F Abramson

Drug Metabolism and Disposition September 1993, 21 (5) 868-873;
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Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference.
T F Woolf, W F Pool, S M Bjorge, T Chang, O P Goel, C F Purchase, M C Schroeder, K L Kunze and W F Trager

Drug Metabolism and Disposition September 1993, 21 (5) 874-882;
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Enzymatic ring-opening reactions of the chiral cardioprotective agent (+) (S)-ICRF-187 and its (-) (R)-enantiomer ICRF-186 by dihydropyrimidine amidohydrolase.
B B Hasinoff

Drug Metabolism and Disposition September 1993, 21 (5) 883-888;
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Identification of carbamoylated thiol conjugates as metabolites of the antineoplastic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, in rats and humans.
A G Borel and F S Abbott

Drug Metabolism and Disposition September 1993, 21 (5) 889-901;
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Glucuronidation as a transient intermediate metabolic step in the elimination of (-)-carbovir. Identification of (-)-carbovir-5'-O-glucuronide in rat bile.
C L Zimmerman, K R Iyer, A L Faudskar and R P Remmel

Drug Metabolism and Disposition September 1993, 21 (5) 902-910;
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A strategy for characterization of polyethylene glycol-derivatized proteins. A mass spectrometric analysis of the attachment sites in polyethylene glycol-derivatized superoxide dismutase.
M M Vestling, C M Murphy, D A Keller, C Fenselau, J Dedinas, D L Ladd and M A Olsen

Drug Metabolism and Disposition September 1993, 21 (5) 911-917;
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Metabolism and elimination of oxazepam in B6C3F1 and Swiss-Webster mice.
R J Griffin and L T Burka

Drug Metabolism and Disposition September 1993, 21 (5) 918-926;
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Rates of excretion of cotinine, nicotine glucuronide, and 3-hydroxycotinine glucuronide in rat bile.
M J Seaton, G A Kyerematen and E S Vesell

Drug Metabolism and Disposition September 1993, 21 (5) 927-932;
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Relationship between lipophilicity and hepatic dispersion and distribution for a homologous series of barbiturates in the isolated perfused in situ rat liver.
C H Chou, A M Evans, G Fornasini and M Rowland

Drug Metabolism and Disposition September 1993, 21 (5) 933-938;
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Identification of cytochrome P-450 isozymes involved in the hydroxylation of dantrolene by rat liver microsomes.
Z Jayyosi, J Villoutreix, J M Ziegler, A M Batt, F De Maack, G Siest and P E Thomas

Drug Metabolism and Disposition September 1993, 21 (5) 939-945;
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Reduction of 3'-azido-2',3'-dideoxynucleosides to their 3'-amino metabolite is mediated by cytochrome P-450 and NADPH-cytochrome P-450 reductase in rat liver microsomes.
E M Cretton and J P Sommadossi

Drug Metabolism and Disposition September 1993, 21 (5) 946-950;
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Disposition of tirilazad (U74006F), a 21-aminosteroid, in the plasma, heart, brain, and liver of the rat.
S C Laizure, L K Franklin, D G Kaiser, C L Williams, R C Stevens, P L Sanders and M Miller

Drug Metabolism and Disposition September 1993, 21 (5) 951-954;
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Detection and identification of human urinary metabolites of biantrazole (CI-941).
J Blanz, U Renner, K Schmeer, G Ehninger and K P Zeller

Drug Metabolism and Disposition September 1993, 21 (5) 955-961;
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NG-nitro-L-arginine pharmacokinetics in rats after a single intravascular and oral dose: an appearance of secondary concentration time peaks.
V K Piotrovskij, Z Kállay, K Krejcy, J Horecký, T Trnovec and G Raberger

Drug Metabolism and Disposition September 1993, 21 (5) 962-964;
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N-acetylation polymorphism in liver and pancreas of inbred rats.
K J Martell and W W Weber

Drug Metabolism and Disposition September 1993, 21 (5) 965-966;
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Nitrite ion is not an active intermediate in the vascular metabolism of organic nitrates and organic nitrites to nitric oxide.
E A Kowaluk, S J Chung and H L Fung

Drug Metabolism and Disposition September 1993, 21 (5) 967-969;

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