Drug Metabolism and Disposition: 22 (2)

March 01, 1994; Volume 22,Issue 2

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Disposition of the angiotensin II receptor antagonist L-158,809 in rats and rhesus monkeys.
A E Colletti and P A Krieter

Drug Metabolism and Disposition March 1994, 22 (2) 183-188;
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Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxyguanine analogs as prodrugs of an antiviral agent.
A W Harrell, S M Wheeler, P East, S E Clarke and R J Chenery

Drug Metabolism and Disposition March 1994, 22 (2) 189-193;
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Absorption and disposition of SDZ IMM 125, a new cyclosporine derivative, in rats after single and repeated administration.
A Bruelisauer, R Kawai, P Misslin and M Lemaire

Drug Metabolism and Disposition March 1994, 22 (2) 194-199;
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Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans.
S K Balani, L R Kauffman, B H Arison, T V Olah, M E Goldman, S L Varga, J A O'Brien, H G Ramjit, C S Rooney and J M Hoffman

Drug Metabolism and Disposition March 1994, 22 (2) 200-205;
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Solvolytic formation of 1,2-dichloro-3,4-epoxybutane from butadiene monoxide under physiological conditions.
X Cheng, C Maniglier-Poulet, D Ross and J A Ruth

Drug Metabolism and Disposition March 1994, 22 (2) 206-210;
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Disposition of [14C]acitretin in humans following oral administration.
F Rubio, B K Jensen, L Henderson, W A Garland, A Szuna and C Town

Drug Metabolism and Disposition March 1994, 22 (2) 211-215;
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Dispositional characteristics of a tyrosine kinase inhibitor (RG 14620) in rats and rabbits following intravenous administration or dermal application.
V K Khetarpal, P M Markham and J A Ziemniak

Drug Metabolism and Disposition March 1994, 22 (2) 216-223;
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Bile flow but not enterohepatic recirculation influences the pharmacokinetics of ranitidine in the rat.
A B Suttle and K L Brouwer

Drug Metabolism and Disposition March 1994, 22 (2) 224-232;
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The pharmacokinetics of 1,3-di(4-imidazolino-2-methoxyphenoxy) propane.lactate (DMP.lactate), a new agent against opportunistic infections, in male beagle dogs.
I Bekersky, R J Puhl, G Hanson and S Mong

Drug Metabolism and Disposition March 1994, 22 (2) 233-236;
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Metabolic kinetics of pseudoracemic propranolol in human liver microsomes. Enantioselectivity and quinidine inhibition.
P H Marathe, D D Shen and W L Nelson

Drug Metabolism and Disposition March 1994, 22 (2) 237-247;
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Induction and regulation of CYP2E1 in murine liver after acute and chronic acetone administration.
P G Forkert, Z M Redza, S Mangos, S S Park and S P Tam

Drug Metabolism and Disposition March 1994, 22 (2) 248-253;
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Effect of cimetidine, probenecid, and ketoconazole on the distribution, biliary secretion, and metabolism of [3H]taxol in the Sprague-Dawley rat.
R W Klecker, C A Jamis-Dow, M J Egorin, K Erkmen, R J Parker, R Stevens and J M Collins

Drug Metabolism and Disposition March 1994, 22 (2) 254-258;
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Metabolism of isbufylline in humans. Isolation, identification, and synthesis of plasma and urine metabolites.
O Agostini, G Bonacchi, G Coppini, E Toja, A Triolo, S Manzini, G Pieraccini and G Moneti

Drug Metabolism and Disposition March 1994, 22 (2) 259-268;
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The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron.
V Fischer, A E Vickers, F Heitz, S Mahadevan, J P Baldeck, P Minery and R Tynes

Drug Metabolism and Disposition March 1994, 22 (2) 269-274;
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Pharmacokinetic study of p-chloronitrobenzene in rat.
T Yoshida

Drug Metabolism and Disposition March 1994, 22 (2) 275-280;
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In vitro metabolism of L-696,229, an HIV-1 reverse transcriptase inhibitor in rats and humans. Hepatic and extrahepatic metabolism and identification of enzymes involved in the hepatic metabolism.
T Prueksaritanont, L M Dwyer, S K Balani and A D Theoharides

Drug Metabolism and Disposition March 1994, 22 (2) 281-288;
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Pharmacokinetics of the neuroprotective glutamate antagonist NBQX (6-nitro-7-sulfamoyl-benzo(f)quinoxaline-2,3-dione) in mice, rats, and dogs. Interactions with probenecid.
L Dalgaard, R K Hjortkjaer, B Regnier and L Nordholm

Drug Metabolism and Disposition March 1994, 22 (2) 289-293;
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Pharmacokinetics of SM-10888 and its metabolites depending on their physicochemical properties.
M Yabuki, T Mine, K Iba, I Nakatsuka and A Yoshitake

Drug Metabolism and Disposition March 1994, 22 (2) 294-297;
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Milacemide metabolism in rat liver and brain slices by solids NMR.
J R Garbow, W P Ridley, V Bork, Y Pan and J Schaefer

Drug Metabolism and Disposition March 1994, 22 (2) 298-303;
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Characterization of the metabolites of the antidepressant drug nefazodone in human urine and plasma.
R F Mayol, C A Cole, G M Luke, K L Colson and E H Kerns

Drug Metabolism and Disposition March 1994, 22 (2) 304-311;
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Pharmacokinetics of tetraplatin administered intraperitoneally with reduced glutathione in mice.
Y Kido, A R Khokhar, M Yoshida, G W Thai and Z H Siddik

Drug Metabolism and Disposition March 1994, 22 (2) 312-317;
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Salicylate inhibits the renal transport of inorganic sulfate in rat membrane vesicle preparations.
I M Darling, M L Mammarella, Q Chen and M E Morris

Drug Metabolism and Disposition March 1994, 22 (2) 318-323;
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NADPH-dependent, regioselective S-oxidation of a thionosulfur- and thioether-containing xenobiotic, diethyldithiocarbamate methyl ester by rat liver microsomes.
A Madan and M D Faiman

Drug Metabolism and Disposition March 1994, 22 (2) 324-330;
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Cytochrome P-450-dependent biotransformation of 2-acetylaminofluorene in cell-free preparations of human embryonic hepatic, adrenal, renal, pulmonary, and cardiac tissues.
M J Namkung, H L Yang and M R Juchau

Drug Metabolism and Disposition March 1994, 22 (2) 331-337;
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NG-nitro-L-arginine is not involved in enterohepatic cycling in rats.
V K Piotrovskij, Z Kállay, J Horecký, T Trnovec, G Raberger and K Krejcy

Drug Metabolism and Disposition March 1994, 22 (2) 338-339;

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