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Drug Metabolism & Disposition

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Table of Contents

May 01, 1994; Volume 22,Issue 3
  • You have access
    Are routine tissue distribution studies justifiable for approval of human drugs?
    A M Monro
    Drug Metabolism and Disposition May 1994, 22 (3) 341-342;
  • You have access
    Inactivation of purified rat liver cytochrome P-450 2B1 and rabbit liver cytochrome P-450 2B4 by N-methylcarbazole.
    S C Kuemmerle, T Shen and P F Hollenberg
    Drug Metabolism and Disposition May 1994, 22 (3) 343-351;
  • You have access
    In vitro metabolism of zatosetron. Interspecies comparison and role of CYP 3A.
    B J Ring, C J Parli, M C George and S A Wrighton
    Drug Metabolism and Disposition May 1994, 22 (3) 352-357;
  • You have access
    Pharmacokinetics and kinetic-dynamic modeling of an 8-aminoquinoline candidate anticyanide and antimalarial drug (WR242511).
    M T Marino, J O Peggins, L D Brown, M R Urquhart and T G Brewer
    Drug Metabolism and Disposition May 1994, 22 (3) 358-366;
  • You have access
    Carbonyl reductase activity for acetohexamide in human erythrocytes.
    M Kishimoto, R Kawamori, T Kamada and T Inaba
    Drug Metabolism and Disposition May 1994, 22 (3) 367-370;
  • You have access
    Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.
    R J Ferguson, M A Doll, T D Rustan, K Gray and D W Hein
    Drug Metabolism and Disposition May 1994, 22 (3) 371-376;
  • You have access
    Binding of dorzolamide and its metabolite, N-deethylated dorzolamide, to human erythrocytes in vitro.
    T Hasegawa, K Hara and S Hata
    Drug Metabolism and Disposition May 1994, 22 (3) 377-382;
  • You have access
    Indole-3-carbinol and beta-naphthoflavone induction of aflatoxin B1 metabolism and cytochromes P-450 associated with bioactivation and detoxication of aflatoxin B1 in the rat.
    D M Stresser, G S Bailey and D E Williams
    Drug Metabolism and Disposition May 1994, 22 (3) 383-391;
  • You have access
    Indole-3-carbinol induces a rat liver glutathione transferase subunit (Yc2) with high activity toward aflatoxin B1 exo-epoxide. Association with reduced levels of hepatic aflatoxin-DNA adducts in vivo.
    D M Stresser, D E Williams, L I McLellan, T M Harris and G S Bailey
    Drug Metabolism and Disposition May 1994, 22 (3) 392-399;
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    Nonlinear kinetics of alendronate. Plasma protein binding and bone uptake.
    J H Lin, I W Chen and F A deLuna
    Drug Metabolism and Disposition May 1994, 22 (3) 400-405;
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    Disposition kinetics of d- and l-amphetamine following intravenous administration of racemic amphetamine to rats.
    A Hutchaleelaha, J Sukbuntherng, H H Chow and M Mayersohn
    Drug Metabolism and Disposition May 1994, 22 (3) 406-411;
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    Hepatic microsomal azoreductase activity. Reactivity of azo dye substrates is determined by their electron densities and redox potentials.
    S Zbaida, C F Brewer and W G Levine
    Drug Metabolism and Disposition May 1994, 22 (3) 412-418;
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    Reversible and irreversible interactions of a cisplatin analog bearing a 1,2-diphenylethylenediamine ligand with plasma and plasma proteins in vitro.
    P J Bednarski, N A Kratochwil and A M Otto
    Drug Metabolism and Disposition May 1994, 22 (3) 419-427;
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    Preclinical pharmacology of the natural marine product dolastatin 10 (NSC 376128).
    R A Newman, A Fuentes, J M Covey and J A Benvenuto
    Drug Metabolism and Disposition May 1994, 22 (3) 428-432;
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    Metabolism of thapsigargin in rat hepatocytes.
    M S Nielsen, C E Olsen, J Dich, S B Christensen and N Grunnet
    Drug Metabolism and Disposition May 1994, 22 (3) 433-437;
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    Urinary and biliary disposition of the lactone and carboxylate forms of 20(S)-camptothecin in rats.
    D O Scott, D S Bindra, S C Sutton and V J Stella
    Drug Metabolism and Disposition May 1994, 22 (3) 438-442;
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    Brain uptake and biotransformation of remacemide hydrochloride, a novel anticonvulsant.
    H Heyn, D J McCarthy, S H Curry, M S Eisman and M W Anders
    Drug Metabolism and Disposition May 1994, 22 (3) 443-446;
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    Studies on the renal excretion mechanisms of cefadroxil.
    L Granero, M J Gimeno, F Torres-Molina, J Chesa-Jiménez and J E Peris
    Drug Metabolism and Disposition May 1994, 22 (3) 447-450;
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    Differences in the pharmacokinetic properties of orally administered all-trans-retinoic acid and 9-cis-retinoic acid in the plasma of nude mice.
    C C Achkar, J M Bentel, J F Boylan, H I Scher, L J Gudas and W H Miller
    Drug Metabolism and Disposition May 1994, 22 (3) 451-458;
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    Percutaneous absorption, biotransformation, and systemic disposition of parathion in vivo in swine. I. Comprehensive pharmacokinetic model.
    G L Qiao, P L Williams and J E Riviere
    Drug Metabolism and Disposition May 1994, 22 (3) 459-471;
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    Kinetic mechanism of the detoxification of the organophosphate paraoxon by human serum A-esterase.
    J A Vitarius and L G Sultatos
    Drug Metabolism and Disposition May 1994, 22 (3) 472-478;
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    A new analysis method for disposition kinetics of enterohepatic circulation of diclofenac in rats.
    T Fukuyama, K Yamaoka, Y Ohata and T Nakagawa
    Drug Metabolism and Disposition May 1994, 22 (3) 479-485;
  • You have access
    N-hydroxylation of the antiprotozoal drug pentamidine catalyzed by rabbit liver cytochrome P-450 2C3 or human liver microsomes, microsomal retroreduction, and further oxidative transformation of the formed amidoximes. Possible relationship to the biological oxidation of arginine to NG-hydroxyarginine, citrulline, and nitric oxide.
    B Clement and F Jung
    Drug Metabolism and Disposition May 1994, 22 (3) 486-497;
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    Cocaine pharmacokinetics in ethanol-pretreated rats.
    B S Levine and I R Tebbett
    Drug Metabolism and Disposition May 1994, 22 (3) 498-500;
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In this issue

Drug Metabolism and Disposition
Vol. 22, Issue 3
1 May 1994
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Bile Acids in Germ-Free Mice
  • Physiology of the Neonatal Gastrointestinal System
  • Tissue Drug Concentrations: Beyond the Free Drug Hypothesis
  • Pharmacokinetics and Disposition of Biologics
  • Metabolism and Disposition of Volanesorsen across Species
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