Drug Metabolism and Disposition: 22 (3)

May 01, 1994; Volume 22,Issue 3

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Are routine tissue distribution studies justifiable for approval of human drugs?
A M Monro

Drug Metabolism and Disposition May 1994, 22 (3) 341-342;
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Inactivation of purified rat liver cytochrome P-450 2B1 and rabbit liver cytochrome P-450 2B4 by N-methylcarbazole.
S C Kuemmerle, T Shen and P F Hollenberg

Drug Metabolism and Disposition May 1994, 22 (3) 343-351;
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In vitro metabolism of zatosetron. Interspecies comparison and role of CYP 3A.
B J Ring, C J Parli, M C George and S A Wrighton

Drug Metabolism and Disposition May 1994, 22 (3) 352-357;
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Pharmacokinetics and kinetic-dynamic modeling of an 8-aminoquinoline candidate anticyanide and antimalarial drug (WR242511).
M T Marino, J O Peggins, L D Brown, M R Urquhart and T G Brewer

Drug Metabolism and Disposition May 1994, 22 (3) 358-366;
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Carbonyl reductase activity for acetohexamide in human erythrocytes.
M Kishimoto, R Kawamori, T Kamada and T Inaba

Drug Metabolism and Disposition May 1994, 22 (3) 367-370;
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Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.
R J Ferguson, M A Doll, T D Rustan, K Gray and D W Hein

Drug Metabolism and Disposition May 1994, 22 (3) 371-376;
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Binding of dorzolamide and its metabolite, N-deethylated dorzolamide, to human erythrocytes in vitro.
T Hasegawa, K Hara and S Hata

Drug Metabolism and Disposition May 1994, 22 (3) 377-382;
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Indole-3-carbinol and beta-naphthoflavone induction of aflatoxin B1 metabolism and cytochromes P-450 associated with bioactivation and detoxication of aflatoxin B1 in the rat.
D M Stresser, G S Bailey and D E Williams

Drug Metabolism and Disposition May 1994, 22 (3) 383-391;
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Indole-3-carbinol induces a rat liver glutathione transferase subunit (Yc2) with high activity toward aflatoxin B1 exo-epoxide. Association with reduced levels of hepatic aflatoxin-DNA adducts in vivo.
D M Stresser, D E Williams, L I McLellan, T M Harris and G S Bailey

Drug Metabolism and Disposition May 1994, 22 (3) 392-399;
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Nonlinear kinetics of alendronate. Plasma protein binding and bone uptake.
J H Lin, I W Chen and F A deLuna

Drug Metabolism and Disposition May 1994, 22 (3) 400-405;
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Disposition kinetics of d- and l-amphetamine following intravenous administration of racemic amphetamine to rats.
A Hutchaleelaha, J Sukbuntherng, H H Chow and M Mayersohn

Drug Metabolism and Disposition May 1994, 22 (3) 406-411;
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Hepatic microsomal azoreductase activity. Reactivity of azo dye substrates is determined by their electron densities and redox potentials.
S Zbaida, C F Brewer and W G Levine

Drug Metabolism and Disposition May 1994, 22 (3) 412-418;
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Reversible and irreversible interactions of a cisplatin analog bearing a 1,2-diphenylethylenediamine ligand with plasma and plasma proteins in vitro.
P J Bednarski, N A Kratochwil and A M Otto

Drug Metabolism and Disposition May 1994, 22 (3) 419-427;
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Preclinical pharmacology of the natural marine product dolastatin 10 (NSC 376128).
R A Newman, A Fuentes, J M Covey and J A Benvenuto

Drug Metabolism and Disposition May 1994, 22 (3) 428-432;
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Metabolism of thapsigargin in rat hepatocytes.
M S Nielsen, C E Olsen, J Dich, S B Christensen and N Grunnet

Drug Metabolism and Disposition May 1994, 22 (3) 433-437;
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Urinary and biliary disposition of the lactone and carboxylate forms of 20(S)-camptothecin in rats.
D O Scott, D S Bindra, S C Sutton and V J Stella

Drug Metabolism and Disposition May 1994, 22 (3) 438-442;
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Brain uptake and biotransformation of remacemide hydrochloride, a novel anticonvulsant.
H Heyn, D J McCarthy, S H Curry, M S Eisman and M W Anders

Drug Metabolism and Disposition May 1994, 22 (3) 443-446;
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Studies on the renal excretion mechanisms of cefadroxil.
L Granero, M J Gimeno, F Torres-Molina, J Chesa-Jiménez and J E Peris

Drug Metabolism and Disposition May 1994, 22 (3) 447-450;
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Differences in the pharmacokinetic properties of orally administered all-trans-retinoic acid and 9-cis-retinoic acid in the plasma of nude mice.
C C Achkar, J M Bentel, J F Boylan, H I Scher, L J Gudas and W H Miller

Drug Metabolism and Disposition May 1994, 22 (3) 451-458;
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Percutaneous absorption, biotransformation, and systemic disposition of parathion in vivo in swine. I. Comprehensive pharmacokinetic model.
G L Qiao, P L Williams and J E Riviere

Drug Metabolism and Disposition May 1994, 22 (3) 459-471;
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Kinetic mechanism of the detoxification of the organophosphate paraoxon by human serum A-esterase.
J A Vitarius and L G Sultatos

Drug Metabolism and Disposition May 1994, 22 (3) 472-478;
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A new analysis method for disposition kinetics of enterohepatic circulation of diclofenac in rats.
T Fukuyama, K Yamaoka, Y Ohata and T Nakagawa

Drug Metabolism and Disposition May 1994, 22 (3) 479-485;
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N-hydroxylation of the antiprotozoal drug pentamidine catalyzed by rabbit liver cytochrome P-450 2C3 or human liver microsomes, microsomal retroreduction, and further oxidative transformation of the formed amidoximes. Possible relationship to the biological oxidation of arginine to NG-hydroxyarginine, citrulline, and nitric oxide.
B Clement and F Jung

Drug Metabolism and Disposition May 1994, 22 (3) 486-497;
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Cocaine pharmacokinetics in ethanol-pretreated rats.
B S Levine and I R Tebbett

Drug Metabolism and Disposition May 1994, 22 (3) 498-500;

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