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Drug Metabolism & Disposition

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Table of Contents

July 01, 1994; Volume 22,Issue 4
  • You have access
    Metabolism and toxicity of 2-bromo-(diglutathion-S-yl)-hydroquinone and 2-bromo-3-(glutathion-S-yl)hydroquinone in the in situ perfused rat kidney.
    M I Rivera, L M Hinojosa, B A Hill, S S Lau and T J Monks
    Drug Metabolism and Disposition July 1994, 22 (4) 503-510;
  • You have access
    Gas-uptake pharmacokinetics of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123).
    G D Loizou, G Urban, W Dekant and M W Anders
    Drug Metabolism and Disposition July 1994, 22 (4) 511-517;
  • You have access
    Disposition of magnolol after intravenous bolus and infusion in rabbits.
    T H Tsai, C J Chou and C F Chen
    Drug Metabolism and Disposition July 1994, 22 (4) 518-521;
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    Urinary excretion of chromium by humans following ingestion of chromium picolinate. Implications for biomonitoring.
    M L Gargas, R L Norton, D J Paustenbach and B L Finley
    Drug Metabolism and Disposition July 1994, 22 (4) 522-529;
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    Kinetic interactions of lidocaine, diphenhydramine, and verapamil with diltiazem. A study using isolated perfused rat liver.
    M D Hussain, Y K Tam, M R Gray and R T Coutts
    Drug Metabolism and Disposition July 1994, 22 (4) 530-536;
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    Chronic voluntary exercise may alter hepatobiliary clearance of endogenous and exogenous chemicals in rats.
    J B Watkins, S T Crawford and R A Sanders
    Drug Metabolism and Disposition July 1994, 22 (4) 537-543;
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    Metabolic chiral inversion of stiripentol in the rat. I. Mechanistic studies.
    K Zhang, C Tang, M Rashed, D Cui, F Tombret, H Botte, F Lepage, R H Levy and T A Baillie
    Drug Metabolism and Disposition July 1994, 22 (4) 544-553;
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    Metabolic chiral inversion of stiripentol in the rat. II. Influence of route of administration.
    C Tang, K Zhang, F Lepage, R H Levy and T A Baillie
    Drug Metabolism and Disposition July 1994, 22 (4) 554-560;
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    Alterations in the pharmacokinetics and protein binding of enprofylline in Eisai hyperbilirubinemic rats.
    M Nadai, T Hasegawa, L Wang, O Tagaya and T Nabeshima
    Drug Metabolism and Disposition July 1994, 22 (4) 561-565;
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    Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes.
    Y Li, E Wang, C J Patten, L Chen and C S Yang
    Drug Metabolism and Disposition July 1994, 22 (4) 566-571;
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    Evidence that the biotransformation of dapsone and monoacetyldapsone to their respective hydroxylamine metabolites in rat liver microsomes is mediated by cytochrome P450 2C6/2C11 and 3A1.
    C Vage and C K Svensson
    Drug Metabolism and Disposition July 1994, 22 (4) 572-577;
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    Evidence for new metabolic pathways of chloramphenicol in the duck.
    J P Cravedi, M Baradat, L Debrauwer, J Alary, J Tulliez and G Bories
    Drug Metabolism and Disposition July 1994, 22 (4) 578-583;
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    Theoretical kinetics of sequential metabolism in vitro. Study of the formation of 16 alpha-hydroxyandrostenedione from testosterone by purified rat P450 2C11.
    K Sugiyama, K Nagata, J R Gillette and J F Darbyshire
    Drug Metabolism and Disposition July 1994, 22 (4) 584-591;
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    Metabolism of L-alpha-methyldopa in cultured human intestinal epithelial (Caco-2) cell monolayers. Comparison with metabolism in vivo.
    P J Chikhale and R T Borchardt
    Drug Metabolism and Disposition July 1994, 22 (4) 592-600;
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    Pharmacokinetics of RU44403, an active form of newly developed angiotensin-converting enzyme inhibitor (RU44570) in the rat.
    M Hirayama, A Kurihara, T Manabe and Y Hasegawa
    Drug Metabolism and Disposition July 1994, 22 (4) 601-606;
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    Genetic and developmental diversity of hepatic cytochromes P450. Warfarin and progesterone metabolism by hepatic microsomes from four inbred strains of rat.
    S Kitareewan and F G Walz
    Drug Metabolism and Disposition July 1994, 22 (4) 607-615;
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    Metabolic fate of [3H]-l-menthol in the rat.
    T Yamaguchi, J Caldwell and P B Farmer
    Drug Metabolism and Disposition July 1994, 22 (4) 616-624;
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    Disposition and metabolism of the hypoglycemic agent pioglitazone in rats.
    P A Krieter, A E Colletti, G A Doss and R R Miller
    Drug Metabolism and Disposition July 1994, 22 (4) 625-630;
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    Disposition of MK-852, a fibrinogen receptor antagonist, in rats and dogs.
    S Vickers, C A Duncan, A S Yuan and K P Vyas
    Drug Metabolism and Disposition July 1994, 22 (4) 631-636;
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    Disposition and metabolism of O6-alkylguanine-DNA alkyltransferase inhibitor in nude mice bearing human melanoma.
    C Cussac, E Mounetou, M Rapp, J C Madelmont, J C Maurizis, P Labarre, P Chollet, J L Chabard, D Godeneche and J P Baudry
    Drug Metabolism and Disposition July 1994, 22 (4) 637-642;
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    Transport limits cellular entry of hepatic arterially injected 5-[18F]fluoro-2'-deoxyuridine in human intrahepatic tumors.
    J R Bading, E R Sigurdson, R D Finn, S D Yeh, J Ginos, N E Kemeny and S M Larson
    Drug Metabolism and Disposition July 1994, 22 (4) 643-650;
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    N-glucuronidation reactions. II. Relative N-glucuronidation reactivity of methylbiphenyl tetrazole, methylbiphenyl triazole, and methylbiphenyl imidazole in rat, monkey, and human hepatic microsomes.
    S W Huskey, G A Doss, R R Miller, W R Schoen and S H Chiu
    Drug Metabolism and Disposition July 1994, 22 (4) 651-658;
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    N-glucuronidation reactions. III. Regioselectivity of N-glucuronidation of methylbiphenyl tetrazole, methylbiphenyl triazole, and methylbiphenyl imidazole using human and rat recombinant UDP-glucuronosyltransferases stably expressed in V79 cells.
    S E Huskey, J Magdalou, M Ouzzine, G Siest and S H Chiu
    Drug Metabolism and Disposition July 1994, 22 (4) 659-662;
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    Induction of murine cytochrome P4503A by the lichen constituents usnic and vulpinic acids.
    G J Mannering and J A Shoeman
    Drug Metabolism and Disposition July 1994, 22 (4) 663-665;
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In this issue

Drug Metabolism and Disposition
Vol. 22, Issue 4
1 Jul 1994
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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