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Drug Metabolism & Disposition

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Table of Contents

November 01, 1995; Volume 23,Issue 11
  • You have access
    The 1994 Bernard B. Brodie Award Lecture. Structure, mechanism, and inhibition of cytochrome P450.
    P R Ortiz de Montellano
    Drug Metabolism and Disposition November 1995, 23 (11) 1181-1187;
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    Metabolites of N-ethylbenzamide, N,N-diethylbenzamide and related compounds detected in rat urine by NMR spectroscopy.
    W G Taylor, T W Hall and D D Vedres
    Drug Metabolism and Disposition November 1995, 23 (11) 1188-1194;
  • You have access
    In vitro studies to elucidate the metabolic pathway of (+)-S-145, a thromboxane A2 receptor antagonist, in rats. Evidence for two independent pathways in peroxisomal beta-oxidation.
    Y Yamaguchi, T Baba, A Touchi and T Matsubara
    Drug Metabolism and Disposition November 1995, 23 (11) 1195-1201;
  • You have access
    Dichloroacetic acid: metabolism in cytosol.
    J C Lipscomb, D A Mahle, W T Brashear and H A Barton
    Drug Metabolism and Disposition November 1995, 23 (11) 1202-1205;
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    Pharmacokinetics and metabolic pattern after intravenous infusion and oral administration to healthy subjects.
    J Schmid, U Busch, G Heinzel, G Bozler, S Kaschke and M Kummer
    Drug Metabolism and Disposition November 1995, 23 (11) 1206-1213;
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    Pharmacokinetics of YM175, a new bisphosphonate, in rats and dogs.
    T Usui, T Watanabe and S Higuchi
    Drug Metabolism and Disposition November 1995, 23 (11) 1214-1219;
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    Quantitative relationship between structure and peritoneal membrane transport based on physiological pharmacokinetic concepts for acidic drugs.
    E Nakashima, R Matsushita, T Ohshima, A Tsuji and F Ichimura
    Drug Metabolism and Disposition November 1995, 23 (11) 1220-1224;
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    Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans.
    C M Dixon, P V Colthup, C J Serabjit-Singh, B M Kerr, C C Boehlert, G R Park and M H Tarbit
    Drug Metabolism and Disposition November 1995, 23 (11) 1225-1230;
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    Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey.
    J E Sharer, L A Shipley, M R Vandenbranden, S N Binkley and S A Wrighton
    Drug Metabolism and Disposition November 1995, 23 (11) 1231-1241;
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    Metabolism and pharmacokinetics of a double prodrug of ganciclovir in the rat and monkey.
    H C Krasny, L Beauchamp, T A Krenitsky and P de Miranda
    Drug Metabolism and Disposition November 1995, 23 (11) 1242-1247;
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    Time-dependent increase in nitric oxide formation concurrent with vasodilation induced by sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-N-acetylpenicillamine but not by glyceryl trinitrate.
    G S Marks, B E McLaughlin, S L Jimmo, M Poklewska-Koziell, J F Brien and K Nakatsu
    Drug Metabolism and Disposition November 1995, 23 (11) 1248-1252;
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    Oxidative metabolism of zolpidem by human liver cytochrome P450S.
    L Pichard, G Gillet, C Bonfils, J Domergue, J P Thénot and P Maurel
    Drug Metabolism and Disposition November 1995, 23 (11) 1253-1262;
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    Major factors for the susceptibility of guinea pig to the pyrrolizidine alkaloid jacobine.
    W G Chung and D R Buhler
    Drug Metabolism and Disposition November 1995, 23 (11) 1263-1267;
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    Purification and characterization of a dog cytochrome P450 isozyme belonging to the CYP2D subfamily and development of its antipeptide antibody.
    A Nakamura, Y Yamamoto, T Tasaki, C Sugimoto, M Masuda, A Kazusaka and S Fujita
    Drug Metabolism and Disposition November 1995, 23 (11) 1268-1273;
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    Quantitative differences in phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes.
    S Ekins, G I Murray, M D Burke, J A Williams, N C Marchant and G M Hawksworth
    Drug Metabolism and Disposition November 1995, 23 (11) 1274-1279;
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    Pharmacokinetics, tissue distribution, and excretion of cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3- dioxolane]platinum(II) in dogs.
    Y B Cho, K H Kim and D K Kim
    Drug Metabolism and Disposition November 1995, 23 (11) 1280-1285;
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    Dexamethasone induction of taxol metabolism in the rat.
    C D Anderson, J Wang, G N Kumar, J M McMillan, U K Walle and T Walle
    Drug Metabolism and Disposition November 1995, 23 (11) 1286-1290;
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    Induction of "male-specific" cytochrome P450 isozymes in female rats by oxandrolone.
    M J Waskiewicz, S Choudhuri, S M Vanderbeck, X J Zhang and P E Thomas
    Drug Metabolism and Disposition November 1995, 23 (11) 1291-1296;
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    Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond.
    R J Boado, Y S Kang, D Wu and W M Pardridge
    Drug Metabolism and Disposition November 1995, 23 (11) 1297-1300;
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    Debrisoquine/sparteine-type polymorphic drug metabolism in wild Clethrionomys rufocanus.
    H Hoshi, M Masuda, Y Yamamoto, Y Suimamoto, A Kazusaka and S Fujita
    Drug Metabolism and Disposition November 1995, 23 (11) 1301-1303;
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In this issue

Drug Metabolism and Disposition
Vol. 23, Issue 11
1 Nov 1995
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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