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Drug Metabolism & Disposition

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Table of Contents

December 01, 1995; Volume 23,Issue 12
  • You have access
    Reduction and glucuronidation of naftazone by human and rat liver microsomes.
    R Herber, B Hercelin, J Van Cantfort, J De Graeve, S Fournel-Gigleux, T Taguchi and J Magdalou
    Drug Metabolism and Disposition December 1995, 23 (12) 1305-1314;
  • You have access
    Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability.
    A Lampen, U Christians, F P Guengerich, P B Watkins, J C Kolars, A Bader, A K Gonschior, H Dralle, I Hackbarth and K F Sewing
    Drug Metabolism and Disposition December 1995, 23 (12) 1315-1324;
  • You have access
    Microsomal metabolism of the 5-lipoxygenase inhibitors L-746,530 and L-739,010 to reactive intermediates that covalently bind to protein: the role of the 6,8-dioxabicyclo[3.2.1]octanyl moiety.
    N Chauret, D Nicoll-Griffith, R Friesen, C Li, L Trimble, D Dubé, R Fortin, Y Girard and J Yergey
    Drug Metabolism and Disposition December 1995, 23 (12) 1325-1334;
  • You have access
    Relative potency of mexiletine, lidocaine, and tocainide as inhibitors of rat liver CYP1A1 activity.
    X Wei, C M Loi, E J Jarvi and R E Vestal
    Drug Metabolism and Disposition December 1995, 23 (12) 1335-1338;
  • You have access
    Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe.
    Z Zhang, M J Fasco, Z Huang, F P Guengerich and L S Kaminsky
    Drug Metabolism and Disposition December 1995, 23 (12) 1339-1346;
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    Enzyme- and sex-specific differences in the intralobular localizations and distributions of aryl sulfotransferase IV (tyrosine-ester sulfotransferase) and alcohol (hydroxysteroid) sulfotransferase a in rat liver.
    G Chen, J Baron and M W Duffel
    Drug Metabolism and Disposition December 1995, 23 (12) 1346-1353;
  • You have access
    Slow acetylation in mice is caused by a labile and catalytically impaired mutant N-acetyltransferase (NAT2 9).
    J H De Leon, K J Martell, K P Vatsis and W W Weber
    Drug Metabolism and Disposition December 1995, 23 (12) 1354-1361;
  • You have access
    Synthesis, pharmacokinetics, and biodistribution of 67GA deferoxamineacetyl-cysteinylbiotin.
    M Hashmi and S F Rosebrough
    Drug Metabolism and Disposition December 1995, 23 (12) 1362-1367;
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    Pharmacokinetics of sodium mercaptoundecahydrododecaborate after intravenous injection in rats.
    S C Mehta, F D Boudinot and D R Lu
    Drug Metabolism and Disposition December 1995, 23 (12) 1368-1371;
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    Transport and metabolism of delta sleep-inducing peptide in cultured human intestinal epithelial cell monolayers.
    P F Augustijns and R T Borchardt
    Drug Metabolism and Disposition December 1995, 23 (12) 1372-1378;
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    Enhanced rates of cytochrome P450 metabolic-intermediate complex formation from nonmacrolide amines in rifampicin-treated rabbit liver microsomes.
    M R Franklin
    Drug Metabolism and Disposition December 1995, 23 (12) 1379-1382;
  • You have access
    The pharmacokinetics of valproic acid in pregnant sheep after maternal and fetal intravenous bolus administration.
    J D Gordon, K W Riggs, D W Rurak, E Kwan, C Hall and F S Abbott
    Drug Metabolism and Disposition December 1995, 23 (12) 1383-1389;
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    Oxidation of aldehydes catalyzed by pig liver flavin-containing monooxygenase.
    G P Chen, L L Poulsen and D M Ziegler
    Drug Metabolism and Disposition December 1995, 23 (12) 1390-1393;
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    Pharmacokinetics of O6-benzylguanine in rats and its metabolism by rat liver microsomes.
    S K Roy, E Gupta and M E Dolan
    Drug Metabolism and Disposition December 1995, 23 (12) 1394-1399;
  • You have access
    Immunoglobulin G, F(AB')2, and fab fragment uptake kinetics in isolated perfused rat liver and rat hepatic cells.
    M Bazin-Redureau, P Gires, P Chapelle, M Martinet and J M Scherrmann
    Drug Metabolism and Disposition December 1995, 23 (12) 1400-1406;
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    Effect of cimetidine on hepatic cytochrome P450: evidence for formation of a metabolite-intermediate complex.
    M Levine and G D Bellward
    Drug Metabolism and Disposition December 1995, 23 (12) 1407-1411;
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    Metabolism of bromodichloroacetate in B6C3F1 mice.
    G Xu, D K Stevens and R J Bull
    Drug Metabolism and Disposition December 1995, 23 (12) 1412-1416;
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    Biotransformation of amitriptyline by Cunninghamella elegans.
    D Zhang, F E Evans, J P Freeman, B Duhart and C E Cerniglia
    Drug Metabolism and Disposition December 1995, 23 (12) 1417-1425;
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    Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1.
    K J Garton, P Yuen, J Meinwald, K E Thummel and E D Kharasch
    Drug Metabolism and Disposition December 1995, 23 (12) 1426-1430;
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    Selectivity of flavin-containing monooxygenase 5 for the (S)-sulfoxidation of short-chain aralkyl sulfides.
    M B Fisher, M P Lawton, E Atta-Asafo-Adjei, R M Philpot and A E Rettie
    Drug Metabolism and Disposition December 1995, 23 (12) 1431-1433;
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    Benzyloxyresorufin as a specific substrate for the major phenobarbital-inducible dog liver cytochrome P450 (P4502B11).
    P A Klekotka and J R Halpert
    Drug Metabolism and Disposition December 1995, 23 (12) 1434-1435;
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In this issue

Drug Metabolism and Disposition
Vol. 23, Issue 12
1 Dec 1995
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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