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Drug Metabolism & Disposition

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Table of Contents

May 01, 1995; Volume 23,Issue 5
  • You have access
    Induction of nasal carboxylesterase in F344 rats following inhalation exposure to pyridine.
    K J Nikula, R F Novak, I Y Chang, A R Dahl, D A Kracko, R C Zangar, S G Kim and J L Lewis
    Drug Metabolism and Disposition May 1995, 23 (5) 529-535;
  • You have access
    The duration of induction and species influences the downregulation of cytochrome P450 by the interferon inducer polyinosinic acid-polycytidylic acid.
    M R Anari, A E Cribb and K W Renton
    Drug Metabolism and Disposition May 1995, 23 (5) 536-541;
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    The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P4503A via the formation of a stable metabolic intermediate complex. Studies in primary hepatocyte cultures and liver microsomes of the pig.
    R F Witkamp, S M Nijmeijer, M Monshouwer and A S Van Miert
    Drug Metabolism and Disposition May 1995, 23 (5) 542-547;
  • You have access
    Identification of phenobarbital N-glucuronides as urinary metabolites of phenobarbital in mice.
    S M Neighbors and W H Soine
    Drug Metabolism and Disposition May 1995, 23 (5) 548-552;
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    Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture.
    M T Donato, J V Castell and M J Gómez-Lechón
    Drug Metabolism and Disposition May 1995, 23 (5) 553-558;
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    Acetylation and its role in the mutagenicity of the antihypertensive agent hydralazine.
    L E Lemke and C A McQueen
    Drug Metabolism and Disposition May 1995, 23 (5) 559-565;
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    Disposition and reactivity of ibuprofen and ibufenac acyl glucuronides in vivo in the rhesus monkey and in vitro with human serum albumin.
    M Castillo and P C Smith
    Drug Metabolism and Disposition May 1995, 23 (5) 566-572;
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    An improved pharmacodynamic model for formation of methemoglobin by antimalarial drugs.
    A A Fasanmade and W J Jusko
    Drug Metabolism and Disposition May 1995, 23 (5) 573-576;
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    Selectivity and kinetics of inactivation of rabbit hepatic cytochromes P450 2B4 and 2B5 by N-aralkylated derivatives of 1-aminobenzotriazole.
    S W Grimm, J R Bend and J R Halpert
    Drug Metabolism and Disposition May 1995, 23 (5) 577-583;
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    Presystemic elimination of morphine in anesthetized rabbits. Contribution of the intestine, liver, and lungs.
    C Abdallah, J G Besner and P Du Souich
    Drug Metabolism and Disposition May 1995, 23 (5) 584-589;
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    Covalent binding of carbamazepine oxidative metabolites to neutrophils.
    S M Furst, P Sukhai, R A McClelland and J P Uetrecht
    Drug Metabolism and Disposition May 1995, 23 (5) 590-594;
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    Oxidation at C-1 controls the cytotoxicity of 1,1-dichloro-2,2- bis(p-chlorophenyl)ethane by rabbit and human lung cells.
    W K Nichols, C M Terry, N S Cutler, M L Appleton, P K Jesthi and G S Yost
    Drug Metabolism and Disposition May 1995, 23 (5) 595-599;
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    Identification of two regioisomeric monocarboxylic acid metabolites of losoxantrone (DuP 941; Biantrazole) excreted in human urine.
    L E Richards and J H Sun
    Drug Metabolism and Disposition May 1995, 23 (5) 600-602;
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    Pharmacokinetics and presystemic hepatic first-pass elimination of a novel sigma receptor antagonist, DuP 734, in the rat.
    R P Kapil and G N Lam
    Drug Metabolism and Disposition May 1995, 23 (5) 603-606;
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In this issue

Drug Metabolism and Disposition
Vol. 23, Issue 5
1 May 1995
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Most Cited
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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